|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer显示文摘Hepatocellular carcinoma(HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by responses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progression may be delayed and long term durable responses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management. | Joanne Marie O'Rourke Vandana Mridhu Sagar Tahir Shah Shishir Shetty | 2018 | World Journal of Gastroenterology2018，24，39： | 8 |
| 2 | Effects of Topography and Land use on Woody Plant Species Composition and Beta Diversity in an Arid Trans-Himalayan Landscape, Nepal显示文摘Distribution patterns of plant species are believed to be impacted by small-scale habitat heterogeneity. However, there have been few comparative studies examining how woody vegetation composition and diversity varies with aspects of different orientations in the Trans-Himalayan region at a local scale. Here, we examined the effects of incoming solar radiation on variation in woody species composition and compared the diversity between the northeast- and southwest-facing slopes in a Trans-Himalayan valley of Nepal. We also examined the implicit interactions between slope orientation and land use in determining the compositional variations between the slopes. We selected two pairs of northeast- and southwest-facing slopes where the first pair has a similar land use and differs in exposure only(Pisang site) while the other pair has clear differences in land use in addition to slope exposure(Braka site). In each site, we sampled 72 plots(36 on each slope) in which the presence and absence of woody species, environmental variables, and disturbance were recorded. Correspondence Analysis(CA) results suggested that the woody species composition significantly varied between northeast- and southwest-facing slopes at both sites, and was significantly correlated with measured environmental variables such as radiation index, altitude, and canopy openness. In the Braka site,mean alpha diversity was significantly higher on southwest-facing slopes. In contrast, beta diversity and gamma diversity were greater on northeast-facing slopes at both sites. Our results suggest that topographic variables(e.g., radiation index) affect species composition between the slopes, likely due to their influence on small scale abiotic environmental variables. However, the effects of land use, such as livestock browsing/grazing may interact with the effects of slope exposure, effectively reducing differences in species composition within slopes but enhancing the differences in beta diversity between contrasting slopes in the Braka. We conclude that slope orientation and land use are important factors in structuring the woody species composition and diversity in the arid Trans-Himalayan region. We suggest that both environmental and land use variables should be taken into consideration in future studies on plant community structure along the cultural landscapes. | Shishir PAUDEL Ole R VETAAS | 2014 | Journal of Mountain Science2014，11，5： | 5 |
| 3 | Role of locking plates in treatment of difficult ununited fractures: a clinical study显示文摘我们在长骨头与锁在长骨头破裂的 10 困难的 nonunions 锁板固定的 plateMethodsRetrospective 评估折断的困难的 ununited 的处理的经验被做的在场的 ObjectiveTo。固定为大腿骨的柄骨折( 3 个病人)用完了锁住的板腿节的 supracondylar 骨折(差距不属于工会)两根前臂骨头(半径和尺骨)的锁骨骨折的骨折胫骨的骨干的肱骨骨折的柄的尺骨骨折的骨折和肱骨的 supracondylar 骨折(一耐心的各个)。五破裂有超过一以前的没有通过的内部固定。一个病人感染了不属于工会它被清创术管理,演员组固定与在六个星期锁板由固定列在后面。七破裂是衰退的二是寡营养的,一个人是 hypertrophic。腓骨的自体移植在 2 种情况和在所有 patientsResultsMinimum 后续使用的肠骨的冠 cancellous 骨头接枝中被使用是 6 月(范围, 6 月到 2.5 年) 。联合的平均时间是 3.4 月(范围 2.5 ~ 6 月) 。任何一个都没与与锁压缩板,过细的软织物解剖,可接受的减小,好固定技术和骨头 grafting 完成稳定性病人让板相关的复杂并发症或手术后的创伤 infections.ConclusionAlong 能帮助在困难的不属于工会的盒子中完成联合。尽管锁住的板不由自己做,保证多骨的联合,我们发现了它是我们为对待困难的破裂 nonunions 的一套设备的另一有用增加。 | Ashok Kumar Himanshu Gupta Chandra Shekhar Yadav Shah Alam Khan Shishir Rastogi | 2013 | Chinese Journal of Traumatology2013，16，1： | 5 |
| 4 | RECENT PROGRESS IN STORM SURGE FORECASTING显示文摘This report briefly summarizes recent progress in storm surge forecasts, one of topics discussed during the fourth International Workshop on Tropical Cyclone Landfall Process(IWTCLP 4) held during 5-8 December, 2017. In the workshop, improvement of storm surge forecasting system was mainly discussed with relevance to the problem of estimating the impacts of tropical cyclone landfall.To deal with storm surges, accurate TC condition(predictions and forecasts) as input, reasonable storm surge predictions(with forecasting systems), and effective advisories/warnings(i.e. useful information products) are necessary. Therefore, we need to improve storm surge related matters systematically: input, prediction system, and ef fective information.This report tries to highlight recent progress in the field of storm surges in relation to three key points: improvement in storm surge forecasting models/system, TC conditions as input for storm surge predictions, and informative products for end users. | NADAO KOHNO SHISHIR K.DUBE MIKHAIL ENTEL S.H.M.FAKHRUDDIN DIANA GREENSLADE MARIE-DOMINIQUE LEROUX JAMIE RHOME NGUYEN BA THUY | 2018 | Tropical Cyclone Research and Review2018，7，2： | 4 |
| 5 | Ethanol mediated As(Ⅲ) adsorption onto Zn-loaded pinecone biochar:Experimental investigation,modeling,and optimization using hybrid artificial neural network-genetic algorithm approach显示文摘Organic matters(OMs) and their oxidization products often influence the fate and transport of heavy metals in the subsurface aqueous systems through interaction with the mineral surfaces. This study investigates the ethanol(EtO H)-mediated As(Ⅲ) adsorption onto Zn-loaded pinecone(PC) biochar through batch experiments conducted under Box–Behnken design. The effect of EtO H on As(Ⅲ) adsorption mechanism was quantitatively elucidated by fitting the experimental data using artificial neural network and quadratic modeling approaches. The quadratic model could describe the limiting nature of EtO H and pH on As(Ⅲ) adsorption,whereas neural network revealed the stronger influence of Et OH(64.5%) followed by pH(20.75%)and As(Ⅲ) concentration(14.75%) on the adsorption phenomena. Besides, the interaction among process variables indicated that Et OH enhances As(Ⅲ) adsorption over a pH range of2 to 7, possibly due to facilitation of ligand–metal(Zn) binding complexation mechanism.Eventually, hybrid response surface model–genetic algorithm(RSM–GA) approach predicted a better optimal solution than RSM, i.e., the adsorptive removal of As(Ⅲ)(10.47 μg/g) is facilitated at 30.22 mg C/L of Et OH with initial As(Ⅲ) concentration of 196.77 μg/L at pH 5.8. The implication of this investigation might help in understanding the application of biochar for removal of various As(Ⅲ) species in the presence of OM. | Mohd.Zafar N.Van Vinh Shishir Kumar Behera Hung-Suck Park | 2017 | Journal of Environmental Sciences2017，29，4： | 3 |
| 6 | Bipolar radiofrequency ablation of tibialchondroblastomas: A report of three cases显示文摘Chondroblastoma is a rare benign cartilaginous neoplasm of bone. The recurrence rate is high and complications are frequent following open curettage with bone grafting which is the standard treatment forchondroblastomas. We performed radiofrequency ablation in three cases of tibialchondroblastoma using the bipolar system. One patient experienced residual pain for which repeat ablation was performed. No other complications were observed during follow-up. Radiofrequency ablation may offer an effective alternative for the treatment of selected cases of chondroblastoma. The lesion characteristics which are likely to influence treatment outcome and the advantages offered by the bipolar system are discussed. | Prathiba Rajalakshmi Deep N Srivastava Shivanand Gamanagatti Pramod Kumar Julka Sushma Bhatnagar Shishir Rastogi | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 7 | 印度Leh地区沙棘果实脂肪酸的初步研究显示文摘本文用气相色谱分析法对Leh地区沙棘果油中脂肪酸成分(含量)进行了分析测定。结果表明:沙棘果油中脂肪(酸)含量为24.9%,其中主要成分为棕榈油酸(42.06%)、棕榈酸(28.11%)和油酸 (12.29%)。 | Shishir Tandon R.C.Sawhney 赵梅霞 | 2005 | 国际沙棘研究与开发2005，3，4： | 2 |
| 8 | Novel biomarkers and the future of targeted therapies in cholangiocarcinoma:a narrative review显示文摘Background and Objectives:Cholangiocarcinoma is a highly aggressive and heterogenous group of biliary malignancies arising from any site in the biliary tree,comprising 15%of all primary liver cancers.The nature of the disease and nonspecific presentation leads to late diagnosis and ultimately poor outcomes for patients.Combination gemcitabine and cisplatin has been the standard of care for cholangiocarcinoma(CCA)since 2010,with a median overall survival of 11.7 months.The five-year survival for CCA remains 5-10%,revealing a clear need for improved treatment options.Methods:This targeted review highlights the role of next generation sequencing in CCA and the clinically relevant tumor biomarkers that have become the focus of therapeutic development.Key Content and Findings:These tumor biomarkers or actionable mutations hold the potential to enable earlier diagnosis,provide prognostic information,and guide treatment decisions for patients with CCA.Specifically,the FGFR2 fusion and IDH1 mutation have shown considerable promise in development of targeted therapies.Clinical trials with inhibitors targeting FGFR2 fusion and IDH1 mutation have created expectations that these drugs will soon enter clinical practice.Other biomarkers including KRAS and B-raf protooncogenes,Her2/neu genes,and BRCA1 and 2 tumor-suppressor genes have also been touted as potential targets for future therapies,with early data showing promise for new drug development.Conclusions:The discovery of these actionable mutations and identification of targeted therapies have challenged the notion of a“one-size fits all”for treatment of CCA,and generated optimism that these novel treatments will soon be available for patients with CCA. | Nishant Munugala Shishir K.Maithel Rachna T.Shroff | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 2 |
| 9 | Importance of Low Preoperative Platelet Count in Selecting Patients for Resection of Hepatocellular Carcinoma: A Multi-Institutional Analysis显示文摘 | Shishir K. Maithel Peter J. Kneuertz David A. Kooby Charles R. Scoggins Sharon M. Weber Robert C.G. Martin Kelly M. McMasters Clifford S. Cho Emily R. Winslow William C. Wood Charles A. Staley | 2011 | Journal of the American College of Surgeons2011，，4： | 2 |
| 10 | An empirical L-band scintillation model for a mid-latitude station,Weihai, China during the low solar activity period显示文摘Mid-latitude ionospheric scintillation has been studied in very poor proportion as compared to the equatorial and high latitude ionospheric scintillation. Mid-latitude ionospheric scintillations are often associated with either day time photo-ionization or due to the storm enhanced density. Using the phase screen model and the wave propagation theory in random media, we have identified the orientation of the ionospheric irregularities over Weihai with the local geomagnetic field. Amplitude and phase scintillation data observed using global positioning system(GPS) scintillation receiver deployed at the mid-latitude observation station Weihai, have been used along with K-index derived from the horizontal magnetic field component of the local magnetometer. The proposed model uses the scintillation indices relationship with the local K-index. We identified the scintillation dependence over local K-index during geomagnetic quiet and disturbed condition. This dependence coefficient is used on the real scintillation data for modeling. The presented scintillation model has been validated by comparing it to the real observations. The co-relation coefficient is more than 90% during the disturbed as well as quiet geomagnetic conditions. | PRIYADARSHI Shishir ZHANG Qing-He WANG Yong | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 11 | A comprehensive review of the application of nano-silica in oil well cementing显示文摘Oil and Gas Industry is a Multi-Billion Dollar Industry.Drilling a well is costly,right from exploration to drilling and production to Enhanced Oil Recovery(EOR).Nanotechnology has the potential to introduce revolutionary changes in several areas of the oil and gas industry,such as exploration,drilling,cementation,production,EOR,etc.Use of Nanotechnology in the cement slurry can also achieve solutions to some of the problems pertaining to oil well cementation.Nano-silica is a better alternative compared to conventional additives like calcium chloride and silica,because as compared to calcium chloride and silica,the amount of nano-silica to be added is very small.Nano-silica acts as a multi-functional additive.Upon addition of nano-silica to cement slurry,there is a decrease in the thickening time,an increase in the compressive strength,decrease in porosity and permeability within the cement and also a decrease in the fluid loss.Incorporation of nano-silica ensures proper cementation and greater integrity of the well.Nano-silica helps in decreasing the wait on cement(WOC)time and therefore reduces the overall capital cost.Nano-silica is highly recommended for deep offshore wells where high temperature and high pressure are often encountered.This paper discusses the behavior of Nano-silica at high temperatures and also reviews effects of Nano-silica on various properties of cement. | Akshar Thakkar Aakash Raval Shishir Chandra Manan Shah Anirbid Sircar | 2020 | Petroleum2020，6，2： | 2 |
| 12 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 13 | 几种沙棘果实与种子中脂肪酸成分分析显示文摘对来自拉浩地区 (半干旱地区 )与斯皮特 (干旱地区 )的 8年生沙棘种子与果肉粗提物中脂肪酸组成进行了研究。所选的中亚沙棘产自拉浩与斯皮特 ,同时研究的还有来自拉浩地区的柳叶沙棘与HI 1型沙棘 (外来品种 ) ,该外来品种种植在喜马偕尔邦农业大学高山农业研究与推广中心。该研究中心位于拉浩 斯皮特地区的拉浩谷地的库坎姆西瑞 (海拔 2 730m) ,处于印度温和干燥的喜马拉雅山地区。在所有种类的果肉油脂中 ,不饱和脂肪酸含量的比例 (5 2 8%~ 6 0 7% )高于饱和脂肪酸 (10 6 %~ 2 9 9% )。同样 ,除了柳叶沙棘以外 ,种子油脂中不饱和脂肪酸含量 (5 1 7%~ 86 5 % )要高于饱和脂肪酸含量(12 5 %~ 2 7 2 % )。在果肉油脂中 ,主要的饱和脂肪酸是棕榈油酸 (37 1%~ 4 6 4 % )、亚油酸 (6 4 %~15 0 % )、油酸 (4 0 %~ 6 9% )和软脂酸 (9 1%~ 2 8 1% )。柳叶沙棘果肉油脂中含有丰富的亚油酸(15 0 % )和α 亚麻酸 (1 3% )。棕榈油酸是最主要的不饱和脂肪酸 (37 1%~ 4 6 4 % ) ,在拉浩种群中含量最高 (4 6 4 % )。软脂酸是主要的饱和脂肪酸 ,除了斯皮特种群 (9 1% ) ,其他类型中的含量基本相同(2 6 4 %~ 2 8 1% )。在种子油脂中 ,斯皮特种群中含量最丰富的是亚油酸 (39 8% )和α | Virendra Singh Rajesh Kr.Gupta Shishir Tandon R.C.Sawhney | 2004 | 国际沙棘研究与开发2004，2，3： | 2 |
| 14 | Clinical and Economic Validation of the International Study Group of Pancreatic Fistula (ISGPF) Classification Scheme显示文摘 | Wande B. Pratt Shishir K. Maithel Tsafrir Vanounou Zhen S. Huang Mark P. Callery Charles M. Vollmer | 2007 | Annals of Surgery2007，，3： | 2 |
| 15 | Postoperative pancreatic fistulas are not equivalent after proximal, distal, and central pancreatectomy显示文摘 | Wande Pratt B.A. Shishir K. Maithel M.D. Tsafrir Vanounou M.D. Mark P. Callery M.D. Charles M. Vollmer M.D | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 2 |
| 16 | Laparoscopic Distal Pancreatectomy: Trends and Lessons Learned Through an 11-Year Experience显示文摘 | Peter J. Kneuertz Sameer H. Patel Carrie K. Chu Sarah B. Fisher Shishir K. Maithel Juan M. Sarmiento Sharon M. Weber Charles A. Staley David A. Kooby | 2012 | Journal of the American College of Surgeons2012，，2： | 2 |
| 17 | Ursolie acid inhibits nucledr fac- tor- kappa B activation induced by carcinogenic agents through suppression of I kappa B alpha kinase and p65 phosphorylation: correlation with down - regulation of cyclooxygenase 2, matrix met- alloproteinase 9, and cyclin D1 显示文摘 | Shishir S Sekhar M Sanjeev B | 2003 | Cancer Res2003，63，15： | 1 |
| 18 | Influence of physico-chemical changes on enzymatic digestibility of ionic liquid and AFEX pretreated corn stover显示文摘 | Chenlin Li Gang Cheng Venkatesh Balan Michael S. Kent Markus Ong Shishir P.S. Chundawat Leonardo daCosta Sousa Yuri B. Melnichenko Bruce E. Dale Blake A. Simmons Seema Singh | 2011 | Bioresource Technology2011，，13： | 1 |
| 19 | Evolution of ‘designed’ industrial symbiosis networks in the Ulsan Eco-industrial Park: ‘research and development into business’ as the enabling framework显示文摘 | Shishir Kumar Behera Jung-Hoon Kim Sang-Yoon Lee Sangwon Suh Hung-Suck Park | 2012 | Journal of Cleaner Production2012，，： | 1 |
| 20 | Mappingthe cavitation intensity in an ultrasonic bath using theacoustic emission显示文摘 | Vijayanand S M Shishir P S Aniruddha B P | 2000 | AICHE J2000，46，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员