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| 1 | Chemopreventive Effects of Black Tea Polyphenols in Mouse Skin Model of Carcinogenesis显示文摘In the present investigations, the antitumorigenic effect of black tea polyphenols (BTP) in twcrstage mouse skin model of carcinogenesis was studied. The animals were initiated with a single 'subcarcinogenic' topical dose (52 μg/200 μl acetone ) of 7, 12-dimethylbenzanthracene (DMBA). To evaluate the anti-tumour initiating activity, BTP was topically applied twice a week for three weeks prior to DMBA application, followed by topical treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA) (5 μg/200 μl acetone, 2x/wk. ) as promoter. For evaluation of antitumor promoting activity, BTP was applied prior to each treatment of TPA. BTP application showed marked inhibitory effect as antitumour initiator as well as antitumour promoter in mouse skin medel of two-stage carcinogenesis. Since initiation involves genetic pathway and tumour promotion involves epigenetic pathway, it seems that BTP exerts its antitumorigenic effect by altering both genetic and epigenetic | SEEMA JAVED N. K. MEHROTRA AND YOGESHWER SHUKLA(Laboratory of Environmental Chrcinogenesis, Industrial Toxicology Research Centre, M. G. Marg, P. O. Box 80,Lucknow - 226001, India) | 1998 | Biomedical and Environmental Sciences1998，11，4： | 15 |
| 2 | Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study显示文摘Background:Following combat-related,extensive soft tissue injury from gunshot wounds or blasts,prolonged duration from injury to full wound closure is associated with infection,increased morbidity and mortality,failure to mobilize,poor functional outcome and increased cost.The purpose of this study was to evaluate a novel treatment enabling early primary closure of combat wounds.Methods:This was a retrospective study of 10 soldiers and civilians with extensive combat-related soft tissue limb injuries(5 gunshot wounds,5 blasts)treated using the TopClosure^(■)Tension Relief System(TRS)with simultaneous administration of regulated oxygen-enriched and irrigation negative pressure-assisted wound therapy(ROINPT)via the Vcareα^(■)device.Results:Nine patients were treated during the acute phase of injury and one was treated following removal of a flap due to deep infection 20 years after injury and flap reconstruction.Two patients had upper limb injury and the rest lower limb injury.With the aid of the TRS and/or ROINPT,immediate primary closure during reconstruction was achieved in 6 patients and delayed primary closure in three.Only one patient required a skin graft to close a small area of the wound after most of the wound had been closed by delayed primary closure.Wound closure was achieved within 0–37 days(median:12.5 days,interquartile range:2.75–19.75)from injury.Conclusions:The TRS is a novel device for effective,early skin stretching and secure wound closure through the application of stress relaxation and mechanical creep,achieving primary closure of large defects using a simplified surgical technique and reducing the need for closure using skin grafts and flaps and the use of tissue expanders.Delivering supplemental oxygen to the wound by ROINPT reverses the reduced oxygen levels inherent in conventional negative pressure-assisted wound therapy,mitigating anaerobic contamination and reducing infection.Irrigation may accelerate the evacuation of infectious material from the wound and provide a novel method for antibiotic administration.The combination of TRS and ROINPT devices allow for early primary closure with improved functionality of combat-related limb injuries. | Moris Topaz Itamar Ashkenazi Oren Barzel Seema Biswas Dan Atar Nurit Shadmi Itzhak Siev-Ner | 2021 | Burns & Trauma2021，9，1： | 7 |
| 3 | Update on pathology of retinoblastoma显示文摘Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13 q14 and encodes retinoblastoma protein that acts as a tumor suppressor. Histopathological high-risk features of retinoblastoma are predictive of metastasis or local recurrence. The focus of this update is to emphasize the recent advances in pathology, various molecular key pathways and genome wide approaches for newer potential therapeutic future targets associated with retinoblastoma tumor biology. This review article highlights the new biomarkers expressed by the retinoblastoma tumor for the better survival of patients. | Lata Singh Seema Kashyap | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 5 |
| 4 | Extraocular retinoblastoma in Indian children:clinical,imaging and histopathological features显示文摘AIM:To study eyes with extraocular dissemination(EORB),with the following aims:first to establish the mean lag period and to understand various reasons for delayed presentation,second to study their imaging profiles and third to analyze histopathological features of eyes enucleated after neoadjuvant chemotherapy.·METHODS:Prospective study of clinical and imaging features of EORBs(stage Ⅲ and Ⅳ International Retinoblastoma Staging System) presenting to a tertiary eye care centre.Histopathological features of eyes enucleated after receiving neoadjuvant chemotherapy were analyzed.A pictorial illustration of the varied imaging profile of EORB was also presented.·RESULTS:Over a period of one year,97 eyes were diagnosed with retinoblastoma;32 children(36 eyes)(37.1%) had EORB.Mean age 3.6±1.9 years,71.9% males,71.9% unilateral,3.1% with positive family history and40.6% with metastasis.On imaging,there was extrascleral involvement in 22.2%,involvement of orbital part of optic nerve in 33.3%,involvement of central nervous system in 27.8% and orbital wall involvement in2.9% eyes.On histopathological analysis of eyesenucleated after neoadjuvant chemotherapy,25.0% had no residual viable tumour tissue and rest all tumours were poorly differentiated.·CONCLUSION:There are very few human malignancies where definitive treatment is started without any confirmed histopathological diagnosis and imaging plays an important role in diagnosis and appropriate staging of the disease.Chemotherapy has a variable effect on EORB,75.0% of eyes with EORB had residual viable tumour tissue when enucleated after receiving neoadjuvant chemotherapy. | Sumita Sethi Neelam Pushker Seema Kashyap Sanjay Sharma Mridula Mehta Sameer Bakhshi Saurbhi Khurana Supriyo Ghose | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 5 |
| 5 | Assessment of tumor markers CA 19-9,CEA,CA 125,and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer显示文摘BACKGROUND Gallbladder cancer(GBC)is one of the leading and aggressive cancers in this region of India.It is very difficult to diagnose in the early stage,as it lacks typical early signs and symptoms;thus,the diagnosis is often in the advanced stage,which ultimately leads to a poor 5-year survival outcome.Tumor markers including carbohydrate antigen 19-9(CA 19-9),carcinoembryonic antigen(CEA),CA 125,CA 242,and alpha fetoprotein are used as indicators in the diagnosis and prognosis of GBC.AIM To compare tumor marker levels between GBC and benign GB diseases(GBDs)and to assess the combined use of tumor markers to increase the diagnostic accuracy for GBC.METHODS Patients of either sex aged≥18 years,with suspected GBC(GB polyp,irregular thick GB wall,GB mass,porcelain GB)on the basis of radiological imaging were included in this study.GB wall thickness using ultrasonography and tumor markers CEA,CA 125,CA 19-9,and CA 242 in all patients were recorded.All cases after surgical intervention were divided into two groups,GBC and benign GBD,according to histopathological examination findings.The cases were followed up and clinical findings,radiological findings,and levels of tumor markers were assessed.RESULTS A total of 200 patients were included in this study,of whom 80 patients had GBC and 120 patients had benign GBD.The median(interquartile range)age was 52.0(41.0-60.0)years and the majority of patients(132,66.0%)were women.Tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly elevated in patients with GBC(P<0.001).There was a significant reduction in tumor markers at 3 and 6 mo from baseline(P<0.001).The mean survival of patients with normal and elevated levels of tumor markers CA 125,CA 19-9,and CEA was comparable;however lymph node metastasis and CA 242 expression level were independent prognostic factors.CONCLUSION Serum levels of tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly associated with GBC.However,no significant association was observed between the presence of elevated levels of any tumor marker with respect to survival.Tumor marker assessment during follow-up may represent a treatment response. | Seema Rani Sinha Prem Prakash Rakesh Kumar Singh Dinesh Kumar Sinha | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 5 |
| 6 | Natural History of Pediatric-onset Inflammatory Bowel Disease: A Systematic Review显示文摘 | Bincy P. Abraham Seema Mehta Hashem B. El-Serag | 2012 | Journal of Clinical Gastroenterology2012，，7： | 5 |
| 7 | Anti-endothelial cell antibody rich sera from rheumatic heart disease patients induces proinflammatory phenotype and methylation alteration in endothelial cells显示文摘Rheumatic heart disease(RHD)is a major cause of cardiovascular morbidity and mortality in developing nations like India.RHD commonly affects the mitral valve which is lined by a single layer of endothelial cells(ECs).The role of ECs in mitral valve damage during RHD is not well elucidated.In here,anti-endothelial cell antibody from RHD patients has been used to stimulate the ECs(HUVECs and HMVECs).ECs proinflammatory phenotype with increased expression of TNFa,IL-6,IL-8,IFNg,IL-1b,ICAM1,VCAM1,E-selectin,laminin B,and vimentin was documented in both ECs.The promoter hypomethylation of various key inflammatory cytokines(TNFa,IL-6,and IL-8),integrin(ICAM1)associated with leukocyte transendothelial migration,and extracellular matrix genes(vimentin,and laminin)were also observed.Further,the in-vitro data was in accordance with ex-vivo observations which correlated significantly with the etiological factors such as smoking,socioeconomic status,and housing.Thus,the study sheds light on the role of ECs in RHD which is a step forward in the elucidation of disease pathogenesis. | Mukul Rastogi Subendu Sarkar Ankita Makol Rana Sandip Singh Uma Nahar Saikia Dibyajyoti Banerjee Seema Chopra Anuradha Chakraborti | 2018 | Genes & Diseases2018，5，3： | 5 |
| 8 | Identification, occurrence, and validation of DRE and ABRE Cis-regulatory motifs in the promoter regions of genes of Arabidopsis thaliana显示文摘Plants posses a complex co-regulatory network Researchwhich helps them to elicit a response under diverse adverse conditions.We used an in silico approach to identify the genes with both DRE and ABRE motifs in their promoter regions in Arabidopsis thaliana.Our results showed that Arabidopsis contains a set of 2,052 genes with ABRE and DRE motifs in their promoter regions.Approximately 72%or more of the total predicted 2,052 genes had a gap distance of less than 400 bp between DRE and ABRE motifs.For positional orientation of the DRE and ABRE motifs,we found that the DR form(one in direct and the other one in reverse orientation)was more prevalent than other forms.These predicted 2,052 genes include 155 transcription factors.Using microarray data from The Arabidopsis Information Resource(TAIR)database,we present 44 transcription factors out of 155 which are upregulated by more than twofold in response to osmotic stress and ABA treatment.Fifty-one transcripts from the onepredicted above were validated using semiquantitative expression analysis to support the microarray data in TAIR.Taken together,we report a set of genes containing both DRE and ABRE motifs in their promoter regions in A.thaliana,which can be useful to understand the role of ABA under osmotic stress condition. | Sonal Mishra Aparna Shukla Swati Upadhyay Sanchita Pooja Sharma Seema Singh Ujjal J.Phukan Abha Meena Feroz Khan Vineeta Tripathi Rakesh Kumar Shukla Ashok Shrama | 2014 | Journal of Integrative Plant Biology2014，56，4： | 5 |
| 9 | Yucca:A medicinally significant genus with manifold therapeutic attributes显示文摘The genus Yucca comprising of several species is dominant across the chaparrals,canyons and deserts of American South West and Mexico.This genus has long been a source of sustenance and drugs for the Native Americans.In the wake of revived interest in drug discovery from plant sources,this genus has been investigated and startling nutritive and therapeutic capacities have come forth.Apart from the functional food potential,antioxidant,antiinflammation,antiarthritic,anticancer,antidiabetic,antimicrobial,and hypocholesterolaemic properties have also been revealed.Steroidal saponins,resveratrol and yuccaols have been identified to be the active principles with myriad biological actions.To stimulate further research on this genus of multiple food and pharmaceutical uses,this updated review has been prepared with references extracted from MEDLINE database. | Seema PATEL | 2012 | Natural Products and Bioprospecting2012，2，6： | 5 |
| 10 | 含笑属植物所含化学成分与其生物活性的综述(英文)显示文摘属木兰科的含笑属植物大约有80多个种类,它们大都分布在南亚国家。这些植物被当地人用于治疗各种疾病,如发烧、绞痛、麻风病、眼疾、炎症以及解蝎子毒。从9种含笑属植物中分离出94种化合物,例如倍半萜烯、类固醇、黄酮类、阿扑啡类、苯酚、酯类、生物碱和苯环型化合物等,它们具有抗菌、抗癌以及抗疟原虫活性。本文详细地论述了含笑属植物所含化学成分的生物及化学性能。 | Dinesh Kumar Sunil Kumar Seema Taprial Deepak Kashyap Ajay Kumar Om Prakash | 2012 | 中西医结合学报2012，10，12： | 4 |
| 11 | Transcriptional Activation and Production of Tryptophan-Derived Secondary Metabolites in Arabidopsis Roots Contributes to the Defense against the Fungal Vascular Pathogen Verticillium Iongisporum显示文摘忍受土壤的真菌的病原体 Verticillium longisporum 在象 oilseed 强奸那样的 Brassicaceae 主人植物上引起脉管的疾病。真菌开拓殖民地于根木部并且向上搬到疾病症状变得可见的叶子。为早基因正式就职把 Arabidopsis 用作一个模型,我们分别地在孢子萌芽以后并且在根外皮的穿入期间立即响应菌丝的生长执行了根 transcriptome 分析。感染的根显示出象抄写因素的激活那样的基因表示的快速的 reprogramming,应力 -- ,并且防卫相关的基因。这里,我们集中了于导致导出色氨酸的第二等的代谢物的生产的高度协调的基因正式就职。在叶子的以前的研究证明 CYP81F2 和 PEN2 (PENETRATION2 ) 编码的酶执行抗真菌的吲哚 glucosinolate (IGS ) 的形成代谢物。在感染 Verticillium 的根,我们发现 transcriptional CYP81F2 和 PEN2 的激活相当或相同的事物 PEL1 (PEN2-LIKE1 ) ,而是抗真菌的 IGS 故障产品的没有增加。相反, indole-3-carboxylic 酸(I3CA ) 和 phytoalexin camalexin 在感染的根积累了,但是仅仅 camalexin 在 vitro 禁止了 Verticillium 生长。而导致 camalexin 或 CYP81F2 依赖的 IGS 代谢物的单个新陈代谢的小径的基因混乱没改变导致 Verticillium 的疾病症状, cyp79b2 cyp79b3 异种在两个分支损害了导致了显著地提高的危险性。因此,我们的数据提供卓见进根特定的早防卫并且对脉管的病原体作为活跃抗真菌的混合物建议导出色氨酸的代谢物。 | Tim Iven Stefanie Konig Seema Singh Susanna A. Braus-Stromeyer Matthias Bischoff Lutz F. Tietze Gerhard H. Braus Volker Lipka Ivo Feussner Wolfgang Droge-Laser | 2012 | Molecular Plant2012，5，6： | 4 |
| 12 | 西喜马拉雅地区气候变化与果蝇分布界限的移动显示文摘在长时间尺度上研究环境变化条件下的种群动态,有助于确定不同物种如何对新的生物和非生物条件做出反应。采纳类似的采集方法在相同的地点,分别于1961-1962年和2003-2004年在西喜马拉雅地区对果蝇种类进行了两次野外调查,对两次调查获得的种类的相对丰富度和优势度指数进行了比较。最近50年的气象数据显示西喜马拉雅平均气温(Tave)发生了显著变化,对该地区的果蝇种类组成及分布界限产生了影响。本研究发现在低海拔的地带Drosophila nepalensis及其他一些冷适应种类的数量明显下降;而Drosophila ananassae及其他一些暖适应种类则进入了低海拔和中海拔地带。D.nepalensis的丰富度与所调查地点的平均气温负相关(r=-0.93±0.03),而对于D.ananassaez则是相反趋势(r=0.90±0.05)。据此认为长期(42年)的气候变化已对西喜马拉雅地区的果蝇种类的分布格局产生了影响。 | Subhash RAJPUROHIT Ravi PARKASH Seema RAMNIWAS | 2008 | 昆虫学报2008，51，3： | 4 |
| 13 | Eosinophilic Gastroenteritis显示文摘 | Seema Khan Susan R. Orenstein | 2008 | Gastroenterology Clinics of North America2008，，2： | 3 |
| 14 | Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis显示文摘 | Iris M. Otani Arjun A. Anilkumar Robert O. Newbury Monica Bhagat Lisa Y. Beppu Ranjan Dohil David H. Broide Seema S. Aceves | 2013 | The Journal of Allergy and Clinical Immunology2013，，6： | 3 |
| 15 | Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats显示文摘Objective Toxic metal ions have been implicated in the generation of reactive oxygen species (ROS) and nitric oxide (NO). Metallothionines (MT) and plant flavonoids have been reported in the intervention against oxidative damage. We investigated the effect of zinc induced MT and green tea polyphenol (GTP) in reducing the oxidative responses induced by nickel and platinum. Methods Zinc (10 mg/kg b. wt, sc) was administered to rats twice at a gap of 24hrs and GTP (10 mg/100 mL in drinking water) was fed ad libitum for 8 days. Nickel chloride (150 umol/kgb.wt, ip) and cisplatin (50 mmol/kg b.wt, sc) was administered to rats 24 h after Zn or GTP pre-treatment. Animals of all the groups were sacrificed 16 hrs after treatment and biochemical markers for toxicity were monitored. Results Zinc or GTP pre-treatment caused significant protection against nickel or cisplatin enhanced mortality in rats, and reduction in lipid peroxidation and NO. Conclusion It is proposed that inhibition of ROS and NO by GTP and zinc may prove useful as a selective pharmacological agent in the amelioration of metal toxicity. | SEEMA JOSHI S. K. HASAN RAMESH CHANDRA M. M. HUSAIN R. C. SRIVASTAVA | 2004 | Biomedical and Environmental Sciences2004，17，4： | 3 |
| 16 | Manuka honey: an emerging natural food with medicinal use显示文摘The health value of honey is universally acknowledged from time immemorial.Manuka(Leptospermum scoparium)is a tree,indigenous to New Zealand and South East Australia,and from the myrtle family,Myrtaceae.The honey produced from its flowers is a uni-floral honey largely produced in New Zealand.It is becoming increasingly popular as a functional food,seen in the aisles of health stores as its displays superior nutritional and phytochemistry profile over other varieties of honey.Examining existing research databases revealed its biological properties ranging from anti-oxidant,anti-inflammatory,anti-bacterial,anti-viral,anti-biotic and wound healing to immune-stimulatory properties.Methylglyoxal is the unique compound in the honey responsible for some of its potent anti-microbial properties.Further,propolis another component of honey contains chiefly flavonoids(i.e.galangin,pinocembrin),phenolic acids and their esters that may also contribute to its immuno-stimulant properties.Recent findings of the biological roles have been discussed with emphasis on the underlying mechanisms.The hurdles associated in its development as a functional food and also nutraceutical with future scopes have also been mentioned.Relevant data published in MEDLINE,Cochrane library,and EMBASE in the past decade have been gathered to formulate this review. | Seema PATEL Simon CICHELLO | 2013 | Natural Products and Bioprospecting2013，3，4： | 3 |
| 17 | Esophageal remodeling in pediatric eosinophilic esophagitis显示文摘 | Seema S. Aceves Robert O. Newbury Ranjan Dohil John F. Bastian David H. Broide | 2007 | The Journal of Allergy and Clinical Immunology2007，，1： | 3 |
| 18 | Analysing the outcome of surgery for chronic Achilles tendinopathy over the last 50 years显示文摘AIM: To determine an association between when the study was performed, the robustness of the study and the outcomes for insertional and non-insertional Achilles tendinopathy surgery. METHODS: We performed a systematic review in accordance with the PRISMA guidelines to assess the methodology of studies investigating the outcome of surgery in chronic Achilles tendinopathy over the last 50 years to identify any trends that would account for the variable results. The Coleman Methodology Scores were correlated with the reported percentage success rates and with the publication year to determine any trends using Pearson's correlation. RESULTS: We identified 62 studies published between 1964 and 2014 reporting on a total of 2923 surgically treated Achilles tendinopathies. The average followup time was 40 mo(range 5-204 mo), and the mean reported success rate was 83.5%(range 36%-100%). The Coleman Methodology Scores were highly reproducible(r = 0.99, P < 0.01), with a mean of 40.1(SD 18.9, range 2-79). We found a negative correlation between reported success rate and overall methodology scores(r =-0.40, P < 0.001), and a positive correlation between year of publication and overall methodology scores(r = 0.46, P < 0.001). CONCLUSION: We conclude that although the success rate of surgery for chronic Acilles tendinopathy described in the literature has fallen over the last 50 years, this is probably due to a more rigorous methodology of the studies. | Wasim S Khan Seema Malvankar Jagmeet S Bhamra Ioannis Pengas | 2015 | World Journal of Orthopedics2015，6，6： | 3 |
| 19 | Functional materials by electrospinning of polymers显示文摘 | Seema Agarwal Andreas Greiner Joachim H. Wendorff | 2013 | Progress in Polymer Science2013，，： | 3 |
| 20 | 不同气候适应类型果蝇体色黑化可塑性的适应性变化(英文)显示文摘变温昆虫果蝇 Drosophila 深受热选择( 即遗传效应) 或表型诱导效应( 即可塑性) 的影响。表型可塑性是不同生物进行适应的有效方法,但是它在不同的果蝇种中较少受到关注。我们分析了不同发育温度范围和地理分布的果蝇的黑化反应模式。嗜凤梨果蝇 D. ananassae 和蒲桃果蝇 D. jambulina 对低温敏感,这些物种可在 18 ~32℃下饲育。相反,D. nepalensis 为耐冷且对热敏感的物种,可在 12 ~25℃下饲育。世界广为分布的黑腹果蝇 D. melanogaster 的温度范围宽( 13 ~31℃) ,该物种前 3 个腹节和后 3 个腹节的黑化反应模式未见明显差异。D. nepalensis 的全部 6 个腹节( 第 2 ~7 节) 均具有高度的可塑性。不过,黑腹果蝇 D. melanogaster 只有后 3 个腹节具有可塑性。相反,热带物种嗜凤梨果蝇 D. ananassae 的所有腹节均不具有可塑性。世界广为分布的黑腹果蝇,即使来自冷得多的气候环境,其体色也不加深,与 D. nepalensis 中观察到的体色接近。本研究的目的旨在认识引起体色的形态多样性的过程以及果蝇对不同地理区域的适应性。最后,将体色黑化与物种系统发育谱系的比较表明,在不同的演化谱系中不断发生遗传多态性或表型可塑性两种不同模式的适应。 | Ravi PARKASH Seema RAMNIWAS Chanderkala LAMBHOD Babita KAJLA | 2011 | 昆虫学报2011，54，10： | 3 |
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