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| 1 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart显示文摘 | Hideyuki Kinoshita Koichiro Kuwahara Motohiro Nishida Zhong Jian Xianglu Rong Shigeki Kiyonaka Yoshihiro Kuwabara Hitoshi Kurose Ryuji Inoue Yasuo Mori Yuhao Li Yasuaki Nakagawa Satoru Usami Masataka Fujiwara Yuko Yamada Takeya Minami Kenji Ueshima Kazuwa | 2010 | Circulation Research2010，，12： | 2 |
| 3 | Metachronous penile metastasis from rectal cancer after total pelvic exenteration显示文摘Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal cancer sixteen months earlier, demonstrated an abnormal uptake within his penis by positron emission tomography/computed tomography. A single elastic nodule of the middle penis shaft was noted deep within Bucks fascia. No other obvious recurrent site was noted except the penile lesion. Total penectomy was performed as a curative resection based on a diagnosis of isolated penile metastasis from rectal cancer. A histopathological examination revealed an increase of well differentiated adenocarcinoma in the corpus spongiosum consistent with his primary rectal tumor. The immunohistochemistry of the tumor cells demonstrated positive staining for cytokeratin 20 and negative staining for cytokeratin 7, which strongly supported a diagnosis of penile metastasis from the rectum. The patient is alive more than two years without any recurrence. | Yuta Kimura Keiichi Nasu Hiroki Matsunaga Masahiro Warabi Satoru Inoue | 2012 | World Journal of Gastroenterology2012，18，38： | 2 |
| 4 | Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma显示文摘 | Tadaaki Arizumi Kazuomi Ueshima Haruhiko Takeda Yukio Osaki Masahiro Takita Tatsuo Inoue Satoshi Kitai Norihisa Yada Satoru Hagiwara Yasunori Minami Toshiharu Sakurai Naoshi Nishida Masatoshi Kudo | 2014 | Journal of Gastroenterology2014，，12： | 1 |
| 5 | Differential Diagnosis of Hepatic Tumors: Value of Contrast-Enhanced Harmonic Sonography Using the Newly Developed Contrast Agent, Sonazoid显示文摘 | Hatanaka Kinuyo Kudo Masatoshi Minami Yasunori Ueda Taisuke Tatsumi Chie Kitai Satoshi Takahashi Shunsuke Inoue Tatsuo Hagiwara Satoru Chung Hobyung Ueshima Kazuomi Maekawa Kiyoshi | 2008 | Intervirology2008，，： | 1 |
| 6 | Discriminant analysis of wood-based materials using near-infrared spectroscopy显示文摘 | Satoru Tsuchikawa Kaori Yamato Kinuyo Inoue | 2003 | Journal of Wood Science2003，，3： | 1 |
| 7 | Bilateral multiple pulmonary sclerosing hemangioma显示文摘 | Jun Hanaoka Masatsugu Ohuchi Shuhei Inoue Satoru Sawai Noriaki Tezuka Shozo Fujino | 2005 | The Japanese Journal of Thoracic and Cardiovascular Surgery2005，，3： | 1 |
| 8 | High Twist expression is involved in infiltrative endometrial cancer and affects patient survival显示文摘 | Satoru Kyo Junko Sakaguchi Satoshi Ohno Yasunari Mizumoto Yoshiko Maida Manabu Hashimoto Mitsuhiro Nakamura Masahiro Takakura Miki Nakajima Kenkichi Masutomi Masaki Inoue | 2006 | Human Pathology2006，，4： | 1 |
| 9 | Age-related changes of p75 Neurotrophin receptor-positive adipose-derived stem cells显示文摘 | Takaaki Yamada Hirohiko Akamatsu Seiji Hasegawa Naoki Yamamoto Tomohisa Yoshimura Yuichi Hasebe Yu Inoue Hiroshi Mizutani Tohru Uzawa Kayoko Matsunaga Satoru Nakata | 2010 | Journal of Dermatological Science2010，，1： | 1 |
| 10 | T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma显示文摘 | Moriwaki Atsushi Inoue Hiromasa Nakano Takako Matsunaga Yuko Matsuno Yukiko Matsumoto Takafumi Fukuyama Satoru Kan-o Keiko Matsumoto Koichiro Tsuda-Eguchi Miyuki Nagakubo Daisuke Yoshie Osamu Yoshimura Akihiko Kubo Masato Nakanishi Yoichi | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，4： | 1 |
| 11 | Influence of Overweight on Surgical Complications for Gastric Cancer: Results From a Randomized Control Trial Comparing D2 and Extended Para-aortic D3 Lymphadenectomy (JCOG9501)显示文摘 | Toshimasa Tsujinaka MD Mitsuru Sasako MD Seiichiro Yamamoto PhD Takeshi Sano MD Yukinori Kurokawa MD Atsushi Nashimoto MD Akira Kurita MD Hitoshi Katai MD Toshio Shimizu MD Hiroshi Furukawa MD Satoru Inoue MD Masahiro Hiratsuka MD Taira Kinoshita MD Kuniy | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 12 | Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction显示文摘 | Teiji Nishio Aya Miyatake Kazumasa Inoue Tomoko Gomi-Miyagishi Ryosuke Kohno Satoru Kameoka Keiichi Nakagawa Takashi Ogino | 2008 | Radiological Physics and Technology2008，，1： | 1 |
| 13 | A giant left circumflex coronary artery – right atrium arteriovenous fistula detected by multislice spiral computed tomography显示文摘 | Yuichi Sato Masayasu Mitsui Hiroshi Takahashi Takuya Miyazawa Hiroyuki Okabe Fumio Inoue Junji Kusama Toshiyuki Horie Naoya Matsumoto Yoshitaka Hori Satoru Furuhashi Motoichiro Takahashi Katsuo Kanmatsuse | 2004 | Heart and Vessels2004，，1： | 1 |
| 14 | Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT显示文摘 | Tatsuo Inoue Masatoshi Kudo Mina Komuta Sosuke Hayaishi Taisuke Ueda Masahiro Takita Satoshi Kitai Kinuyo Hatanaka Norihisa Yada Satoru Hagiwara Hobyung Chung Toshiharu Sakurai Kazuomi Ueshima Michiie Sakamoto Osamu Maenishi Tomoko Hyodo Masahiro Okada Se | 2012 | Journal of Gastroenterology2012，，9： | 1 |
| 15 | Discriminant analysis of wood-based materials using near-infrared spectroscopy显示文摘 | SATORU TSUCHIKAWA KAORI YAMATO KINUYO INOUE | 2003 | Journal of Wood Science2003，49，3： | 1 |
| 16 | Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Masafumi Inoue Seiji Kawano Daisuke Tanioka Takao Tsuzuki Satoru Yagi Jun Kato Masayuki Uemura Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Kazuhide Yamamoto | 2008 | Gastrointestinal Endoscopy2008，，5： | 1 |
| 17 | Influence of Overweight on Surgical Complications for Gastric Cancer: Results From a Randomized Control Trial Comparing D2 and Extended Para-aortic D3 Lymphadenectomy (JCOG9501)显示文摘 | Toshimasa Tsujinaka MD Mitsuru Sasako MD Seiichiro Yamamoto PhD Takeshi Sano MD Yukinori Kurokawa MD Atsushi Nashimoto MD Akira Kurita MD Hitoshi Katai MD Toshio Shimizu MD Hiroshi Furukawa MD Satoru Inoue MD Masahiro Hiratsuka MD Taira Kinoshita MD Kuniy | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 18 | New roots to formation of nanostructures on glass surface through anodie oxidation of sputtered aluminum 显示文摘 | Satoru Inoue Song-Zhu Chu Hajime Haneda | 2003 | Sci Technol Adv Mater2003，4，： | 1 |
| 19 | Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin显示文摘 | Keiichi Kontani Osamu Taguchi Yoshitomo Ozaki Jun Hanaoka Satoru Sawai Shuhei Inoue Hajime Abe Kazuyoshi Hanasawa Shozo Fujino | 2003 | International Journal of Molecular Medicine2003，，4： | 1 |
| 20 | Pharmacokinetics of Paclitaxel in Ovarian Cancer Patients and Genetic Polymorphisms of CYP2C8, CYP3A4, and MDR1显示文摘 | Miki Nakajima Yuto Fujiki Satoru Kyo Taro Kanaya Mitsuhiro Nakamura Yoshiko Maida Masaaki Tanaka Masaki Inoue Tsuyoshi Yokoi | 2005 | The Journal of Clinical Pharmacology2005，，6： | 1 |
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