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| 1 | Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. | Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 2 | Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?显示文摘BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethyl- enetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1 weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin ≥1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffé's post-hoc test after two-way repeated measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio.CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB- DTPA. | Masahiro Okada Kazunari Ishii Kazushi Numata Tomoko Hyodo Seishi Kumano Masayuki Kitano Masatoshi Kudo Takamichi Murakami | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 13 |
| 3 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 5 |
| 4 | Ultrasonographic evaluation in patients with autoimmune-related pancreatitis显示文摘 | Naoko Hyodo Takafumi Hyodo | 2003 | Journal of Gastroenterology2003，，12： | 3 |
| 5 | Contrast-enhanced intraductal ultrasonography for thickened bile duct wall显示文摘 | Takafumi Hyodo Naoko Hyodo Takeo Yamanaka Michio Imawari | 2001 | Journal of Gastroenterology2001，，8： | 2 |
| 6 | Right anterior segmental hepatic duct emptying directly into the cystic duct in a living donor显示文摘A 35-year-old mother was scheduled to be the living donor for liver transplantation to her second son,who suffered from biliary atresia complicated with biliary cirrhosis at the age of 2 years.The operative plan was to recover the left lateral segment of the mother's liver for living donor transplantation.With the use of cholangiography at the time of surgery,we found the right anterior segmental duct(RASD) emptying directly into the cystic duct,and the catheter passed into the RASD.After repairing the incision in the cystic duct,transplantation was successfully performed.Her postoperative course was uneventful.Biliary anatomical variations were frequently encountered,however,this variation has very rarely been reported.If the RASD was divided,the repair would be very difficult because the duct will not dilate sufficiently in an otherwise healthy donor.Meticulous preoperative evaluation of the living donor's biliary anatomy,especially using magnetic resonance cholangiography and careful intraoperative techniques,is important to prevent bile duct injury and avoid the risk to the healthy donor. | Yasunao Ishiguro Masanobu Hyodo Takehito Fujiwara Yasunaru Sakuma Nobuyuki Hojo Koichi Mizuta Hideo Kawarasaki Alan T Lefor Yoshikazu Yasuda | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 7 | Present status and perspectives of colorectal cancer in Asia:colorectal cancer working group report at the 30th Asia-Pacific cancer conference显示文摘 | Hyodo I Suzuki H Takahashi K | | Japanese Journal of Clinical Oncology0，，： | 2 |
| 8 | Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer显示文摘 | Yoshito Komatsu Takayuki Yoshino Kentaro Yamazaki Satoshi Yuki Nozomu Machida Takahide Sasaki Ichinosuke Hyodo Yutaka Yachi Hiroshi Onuma Atsushi Ohtsu | 2014 | Investigational New Drugs2014，，3： | 2 |
| 9 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 10 | Reliability of Relative Paleointensity Recorded in Chinese Loess-Paleosol Sediments显示文摘A detailed paleomagnetic and rock-magnetic investigation spanning loess L7 to paleosol S8 has been carried out at the Baoji and Xifeng sections. Results of anisotropy of magnetic susceptibility confirm that the studied loess-paleosol sediments retain primary sedimentary fabrics. Stepwise thermal demagnetization shows that two well-defined magnetization components can be isolated from both loess and paleosol specimens. A low-temperature component, isolated between 100°C and 200°C, is consistent with the present geomagnetic field direction, and a high-temperature component, isolated between 200-300°C and 620-680°C, includes clearly normal and reversed polarities. Isothermal remanent magnetization and thermomagnetic analyses indicate that characteristic remanent magnetization is mainly carried by magnetite and hematite. The Day plot, together with the stratigraphic variations of rock-magnetic parameters, shows that the uniformity of magnetic mineralogy and grain size fulfills the criteria for relative paleointensity (RPI) studies. RPI records have been constructed using natural remanent magnetization (NRM) intensity after thermal demagnetization at 300°C normalized by low-frequency magnetic susceptibility (NRM 300 /χ). The results show that the RPI record from the Baoji section, where pedogenesis is quite weak, is compatible with the stacked PISO-1500 paleointensity record, suggesting that it might reflect the paleointensity variation of the geomagnetic field. The RPI record from the Xifeng section, where pedogenesis is rather strong, indicates a clear dissimilarity with the stacked PISO-1500 paleointensity record, implying that it does not reflect the paleointensity variation of the geomagnetic field. Our new results show that the NRM 300 /χ from the strongly pedogenetic paleosols does not completely eliminate the pedogenetic (climatic) influence, so it might be unsuitable for a reliable paleointensity study. | YANG Tianshui LI Haiyan WU Huaichun YANG Zhenyu ZHANG Shihong HYODO Masayuki | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 2 |
| 11 | 2D and 3D refraction-based visualization of breast cancer for early clinical check显示文摘Ductal carcinoma in-situ (DCIS) has been visualized by 2D XDFI (X-ray dark-field imaging) and further by a 3D X-ray CT, and the data was acquired by the X-ray optics DEI (diffraction-enhanced imaging). A newly made algorithm was used for CT. Data of 900 projections with interval of 0.2 degrees were used. Ductus lactiferi, microcalci-fication in a 3D form have been clearly visible. The spatial resolution available was approximately 30μm. | Masami ANDO Anton MAKSIMENKO Tetsuya YUASA Eiko HASHIMOTO Katsuhito YAMASAKI Shu IHIHARA Hiroshi SUGIYAMA Tokiko ENDO LI Gang CHEN Zhihua Kazuyuki HYODO Ei UENO | 2006 | Nuclear Science and Techniques2006，17，6： | 2 |
| 12 | An investigation of water-gas transport processes in the gas-diffusion-layer of a PEM fuel cell by a multiphase multiple-relaxation-time lattice Boltzmann model显示文摘 | Xiao-Dong Niu Toshihisa Munekata Shi-Aki Hyodo Kazuhiko Suga | 2007 | Journal of Power Sources2007，，2： | 2 |
| 13 | Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients显示文摘 | Takatoshi Kakuta Reika Tanaka Toru Hyodo Hajime Suzuki Genta Kanai Mikako Nagaoka Hiroo Takahashi Nobuhito Hirawa Yoichi Oogushi Toshio Miyata Hiroyuki Kobayashi Masafumi Fukagawa Akira Saito | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 14 | U-50488H,a selective kappa-opioid receptor agonist,improves carbon monoxide-induced delayed amnesia in mice显示文摘 | Hyodo T Kameyama T | 1996 | Eur J Pharmacol1996，315，2： | 1 |
| 15 | Detection of glomerular and nonglomerular red blood cells by antomatet urinary sediment analyzer显示文摘 | Hyodo T Kumanok Haga M | 1998 | Clin Lab Sci1998，11，1： | 1 |
| 16 | Clinical significance of plasma vascular endothelial growth factor in gasa'ointestinal cancer显示文摘 | Hyodo I Doi T Endo H | 1998 | Eur J Cancer1998，34，13： | 1 |
| 17 | Basic research on the mechanical behavior of methane hydrate- sediments mixture显示文摘 | HYODO M NAKATA Y YOSHIMOTO N | 2005 | Soils and Foundations2005，45，1： | 1 |
| 18 | P-type electrical conduction in transparent thin films of CuAlO2显示文摘 | Kawazoe H Yasukawa M Hyodo H | 1997 | Nature1997，，389： | 1 |
| 19 | 查看详情显示文摘 | Yamamoto S Hyodo S | | 0，，： | 1 |
| 20 | Resection of peripheral branches of the posterior nasal nerve compared to conventional posterior neureetomy in severe allergic rhinitis 显示文摘 | Kobayashi T Hyodo M Nakamura K | 2012 | Auris Nasus Larynx2012，39，6： | 1 |
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