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| 1 | Effect of phosphorus fluctuation caused by river water dilution in eutrophic lake on competition between blue-green alga Microcystis aeruginosa and diatom Cyclotella sp.显示文摘Tega-numa (Lake Tega) is one of the eutrophic lakes in Japan. For the improvement of water quality in Lake Tega, the North-chiba Water Conveyance Channel was constructed in 2000, which transfer water from Tone River into the lake. After 2000, the dominant species of diatoms, mainly Cyclotella sp., have been replacing blue-green algae, mainly Microcystis aeruginosa in Lake Tega. This transition of dominant species would be due to the dilution, but the detail mechanism has not been understood yet. This study examined the relationship between phosphorus fluctuation caused by river water dilution to Lake Tega and dominance of algal species, M. aeruginosa or Cyclotella sp. based on the single-species and the mixed-species culture experiments. The single-species culture experiment showed that the half-saturation constant and uptake rate of phosphorus were one order lower and seven times higher for M. aeruginosa than those for Cyclotella sp. These findings implied that M. aeruginosa would possess a potential for the growth and survival over Cyclotella sp. in the phosphorus limited condition. The superiority of M. aeruginosa was reflected in the outcome of the mixed-species culture experiment, i.e., dominance of M. aeruginosa, even phosphorus concentration was lowered to 0.01 mg-P/L. Therefore, it could be concluded that the decrease in phosphorus concentration due to the river water dilution to Lake Tega would be interpreted as a minor factor for the transition of dominant species from M. aeruginosa to Cyclotella sp. | Yoshimasa Amano Yusuke Sakai Takumi Sekiya Kimitaka Takeya Kazuo Taki Motoi Machida | 2010 | Journal of Environmental Sciences2010，22，11： | 16 |
| 2 | Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis显示文摘Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease. | Kazuya Okushin Takeya Tsutsumi Kazuhiko Ikeuchi Akira Kado Kenichiro Enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike | 2018 | World Journal of Gastroenterology2018，24，32： | 15 |
| 3 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 4 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 5 | Eucalyptone from Eucalyptus globulus显示文摘 | Kenji Osawa Hideyuki Yasuda Hiroshi Morita Koichi Takeya Hideji Itokawa | 1995 | Phytochemistry1995，，1： | 2 |
| 6 | Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart显示文摘 | Hideyuki Kinoshita Koichiro Kuwahara Motohiro Nishida Zhong Jian Xianglu Rong Shigeki Kiyonaka Yoshihiro Kuwabara Hitoshi Kurose Ryuji Inoue Yasuo Mori Yuhao Li Yasuaki Nakagawa Satoru Usami Masataka Fujiwara Yuko Yamada Takeya Minami Kenji Ueshima Kazuwa | 2010 | Circulation Research2010，，12： | 2 |
| 7 | Frequent β-catenin aberration in human hepatocellular carcinoma显示文摘 | Hajime Fujie Kyoji Moriya Yoshizumi Shintani Takeya Tsutsumi Tadatoshi Takayama Masatoshi Makuuchi Satoshi Kimura Kazuhiko Koike | 2001 | Hepatology Research2001，，1： | 2 |
| 8 | Isolation and characterization of a novel eonnexin gene, Cx-60, in porcine ovarian follicles 显示文摘 | Itahana K Takeya T Morikazu Y | 1998 | Endocrinology1998，139，1： | 1 |
| 9 | Measurements of physical properties of gas hydrates and in situ observations of formation and decomposition processes via Raman spectroscopy and X-ray diffraction 显示文摘 | Uchida T Takeya S Wilson L D Tulk C A Ripmeester J A Nagao J Ebinuma T Narita l-I | 2003 | Canadian Journal of Physics2003，81，12： | 1 |
| 10 | Co-localization of tissue factor and tissue factor pathway inhibitor in coronary atherosclerosis 显示文摘 | Kaikita K Takeya M Ogawa H | 1999 | J Pathol1999，188，1： | 1 |
| 11 | Effect of dilution rate on competitive interactions between the cyanobacterium Microcystis novacekii and the green alga scenedesmus quadricauda in mixed chemostat cultures显示文摘 | KAORU TAKEYA AKIRA KUWATA MAKOTO YOSHIDA | 2004 | Journal of Plankton Research2004，26，1： | 1 |
| 12 | Retrovirus -mediated, stable scavenger -receptor gene transfer leads to functional endocytotic receptor expression, foam cell formation, and increased susceptibility to apoptosis in rabbit aortic smooth muscle cells显示文摘 | Lehtolainen P Takeya M Yla - Herttuala S | 2000 | Arterioscler Thromb Vasc Biol2000，20，1： | 1 |
| 13 | Phase equilibrium measurements and crystallographic analyses on structure-H type gas hydrate formed from the CH4-CO2-neohexane-water system显示文摘 | Uchida T Ohmura R Ikeda I Y Nagao J Takeya S Hori A | 2006 | The Journal of Physical Chemistry B2006，110，10： | 1 |
| 14 | Capillarisin,a constituent from Artemisia capillaris Herba显示文摘 | Takeya K Makoto T Haruji O | 1975 | Chem Pharm Bull1975，23，6： | 1 |
| 15 | Molecular composition and regulation of the NOX family NADPH oxidases显示文摘 | Sumimoto H Miyano K Takeya R | 2005 | Biochem Biophys Res Commun2005，338，1： | 1 |
| 16 | Clinical significance of mac- rophage heterogeneity in human malignant tumors显示文摘 | Komohara Y Jinushi M Takeya M | 2014 | Cancer Sci2014，105，1： | 1 |
| 17 | Two antitumour bicyclic hexapeptides from Rubia cordifolia 显示文摘 | Takeya K Yamamiya T Morita H | 1993 | Phytochemtry1993，33，3： | 1 |
| 18 | Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells显示文摘 | Takeya H Gabazza EC Aoki S | 2003 | Blood2003，102，5： | 1 |
| 19 | Thionation of segetalins A and B, cyclic peptides with estrogen- like activity from seeds of Vaccaria segetalis 显示文摘 | Morita H Yun Y S Takeya K | 1997 | Bioorganic b-Medicinal Chemistry1997，5，3： | 1 |
| 20 | Structures of isoagastachoside and agastachin, new glucosylflavones isolated from Agastache rugosa 显示文摘 | Itokawa H Suto K Takeya K | 1981 | Chem Pharm Bull1981，29，6： | 1 |
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