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| 1 | Giant primary angiosarcoma of the small intestine showing severe sepsis显示文摘Primary malignant tumors of the small intestine are rare,comprising less than 2%of all gastrointestinal tumors.An 85-year-old woman was admitted with fever of 40℃ and marked abdominal distension.Her medical history was unremarkable,but blood examination showed elevated inflammatory markers.Abdominal computed tomography showed a giant tumor with central necrosis,extending from the epigastrium to the pelvic cavity.Giant gastrointestinal stromal tumor of the small intestine communicating with the gastrointestinal tract or with superimposed infection was suspected.Because no improvement occurred in response to antibiotics,surgery was performed.Laparotomy revealed giant hemorrhagic tumor adherent to the small intestine and occupying the peritoneal cavity.The giant tumor was a solid tumor weighing 3490 g,measuring24 cm×17.5 cm×18 cm and showing marked necrosis.Histologically,the tumor comprised spindle-shaped cells with anaplastic large nuclei.Immunohistochemical studies showed tumor cells positive for vimentin,CD31,and factorⅧ-related antigen,but negative for c-kit and CD34.Angiosarcoma was diagnosed.Although no postoperative complications occurred,the patient experienced enlargement of multiple metastatic tumors in the abdominal cavity and died 42 d postoperatively.The prognosis of small intestinal angiosarcoma is very poor,even after volume-reducing palliative surgery. | Mizuna Takahashi Masanori Ohara Noriko Kimura Hiromitsu Domen Takumi Yamabuki Kazuteru Komuro Takahiro Tsuchikawa Satoshi Hirano Nozomu Iwashiro | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 2 | Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer显示文摘A perioperative multimodal strategy including combination chemotherapy and radiotherapy, in addition to surgical resection, has been acknowledged to improve patient prognosis. However chemotherapy has not been actively applied as an immunomodulating modality because of concerns about various immunosuppressive effects. It has recently been shown that certain chemotherapeutic agents could modify tumor microenvironment and host immune responses through several underlying mechanisms such as immunogenic cell death, local T-cell infiltration and also the eradication of immune-suppressing regulatory cells such as regulatory T cells(Tregs) and myeloid-derived suppressor cells. With the better understanding of the cell components in the tumor microenvironment and the effect of chemotherapy to improve tumor microenvironment, it has been gradually clear that the chemotherapeutic agents is two-edged sword to have both immune promoting and suppressing effects. The cellular components of the tumor microenvironment include infiltrating T lymphocytes, dendritic cells, regulatory T cells, tumor associated macrophages, myeloid derived suppressor cells and cancer associated fibroblasts. Based on the better understanding of tumor microenvironment following chemotherapy, the treatment protocol could be modified as personalized medicine and the prognosis of pancreas cancer would be more improved utilizing multimodal chemotherapy. Here we review the recent advances of chemotherapy to improve tumor microenvironment of pancreatic cancer, introducing the unique feature of tumor microenvironment of pancreatic cancer, interaction between anti-cancer reagents and these constituting cells and future prospects. | Takahiro Tsuchikawa Shintaro Takeuchi Toru Nakamura Toshiaki Shichinohe Satoshi Hirano | 2016 | World Journal of Gastrointestinal Oncology2016，8，11： | 3 |
| 3 | Hilar cholangiocarcinoma with intratumoral calcification: A case report显示文摘This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first,hepatolithiasis was diagnosed,and he underwent endoscopic stone extraction via the transpapillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital,and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification,while no stones were found. To the best of our knowledge,only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here,we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features. | Kazuho Inoko Takahiro Tsuchikawa Takehiro Noji Yo Kurashima Yuma Ebihara Eiji Tamoto Toru Nakamura Soichi Murakami Keisuke Okamura Toshiaki Shichinohe Satoshi Hirano | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 4 | Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma显示文摘Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended. | Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 5 | Advances in the sur- gical treatment of hilar cholangiocarcinoma 显示文摘 | Tsuchikawa T Hirano S Okamura K | 2015 | Expert Rev Gas- troenterol Hepatol2015，9，3： | 1 |
| 6 | A review of recent near infrared research for wood and paper(Part 2)显示文摘 | Tsuchikawa S Schwanninger M | 2012 | Appl Spectrosc Rev2012，48，7： | 1 |
| 7 | A study of intracyto- plasmic inclusions in myeloma cells from two patients with multiple myeloma显示文摘 | Tsuchikawa K Yokomichi H Satoh I | 1987 | Tohoku J Exp Med1987，153，1： | 1 |
| 8 | Safety of combined resection of the middle hepatic artery in right hemihepatectomy for hilar biliary malignancy显示文摘 | Satoshi Hirano Satoshi Kondo Eiichi Tanaka Toshiaki Shichinohe Takahiro Tsuchikawa Kentaro Kato | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 1 |
| 9 | Discriminant analysis of wood-based materials using near-infrared spectroscopy显示文摘 | Satoru Tsuchikawa Kaori Yamato Kinuyo Inoue | 2003 | Journal of Wood Science2003，，3： | 1 |
| 10 | Down- regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients显示文摘 | TANAKA K TSUCHIKAWA T MIYAMOTO M | 2012 | J Clin Oncol2012，40，4： | 1 |
| 11 | Role of Hepatectomy in the Treatment of Hilar Bile Duct Carcinoma显示文摘 | Takahiro Tsuchikawa Satoshi Kondo Satoshi Hirano Eiichi Tanaka Yoshiyasu Anbo Toshiaki Morikawa Shunichi Okushiba Hiroyuki Katoh | 2004 | Surgery Today2004，，5： | 1 |
| 12 | Portal vein resection using the no‐touch technique with a hepatectomy for hilar cholangiocarcinoma显示文摘 | Eiji Tamoto Satoshi Hirano Takahiro Tsuchikawa Eiichi Tanaka Masaki Miyamoto Joe Matsumoto Kentaro Kato Toshiaki Shichinohe | | HPB0，，1： | 1 |
| 13 | Application of near- infrared spectroscopy to wood discrimination 显示文摘 | Tsuchikawa S Inoue K Noma J | 2003 | Journal of wood Science2003，49，1： | 1 |
| 14 | Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortality显示文摘 | Satoshi Hirano Satoshi Kondo Eiichi Tanaka Toshiaki Shichinohe Takahiro Tsuchikawa Kentaro Kato Joe Matsumoto Ryosuke Kawasaki | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，4： | 1 |
| 15 | A review of recent near-infrared re- search for wood and paper ( part 2 ) 显示文摘 | Tsuchikawa S Schwanninger M | 2013 | Applied Spectroscopy Re- views2013，48，7： | 1 |
| 16 | No-touch resection of hilar malignancies with right hepatectomy and routine portal reconstruction显示文摘 | Satoshi Hirano Satoshi Kondo Eiichi Tanaka Toshiaki Shichinohe Takahiro Tsuchikawa Kentaro Kato | 2009 | Journal of Hepato-Biliary-Pancreatic Surgery2009，，4： | 1 |
| 17 | Important technical remarks on distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer (with video)显示文摘 | Eiichi Tanaka Satoshi Hirano Takahiro Tsuchikawa Kentaro Kato Joe Matsumoto Toshiaki Shichinohe | 2012 | Journal of Hepato - Biliary - Pancreatic Sciences2012，，2： | 1 |
| 18 | Near infrared spectroscopic observations of the aging process in archaeological wood using a deuterium exchange method 显示文摘 | Tsuchikawa S A Yonenobu H Siesler H W | 2005 | Analyst2005，130，： | 1 |
| 19 | Down-regulation of Human Leukocyte Antigen class Ⅰ heavy chain in tumors is associated with a poor prognosisin advanced esophageal cancer patients显示文摘 | Tanaka K Tsuchikawa T Miyamoto M | 2012 | Int J Oncol2012，40，4： | 1 |
| 20 | Important technical remarks on distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer (with video)显示文摘 | Tanaka E Hirano S Tsuchikawa T | 2012 | J Hepatobiliary Pancreat Sci2012，19，2： | 1 |
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