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| 1 | Analysis of the risk factors for severity in post endoscopic retrograde cholangiopancreatography pancreatitis: The indication of prophylactic treatments显示文摘AIM To determine the risk factors of severe post endoscopic retrograde cholangiopancreatography pancreatitis(s PEP) and clarify the indication of prophylactic treatments.METHODS At our hospital, endoscopic retrograde cholangiopancreatography(ERCP) was performed on 1507 patients from May 2012 to December 2015. Of these patients, we enrolled all 121 patients that were diagnosed with post endoscopic retrograde PEP. Fourteen of 121 patients diagnosed as s PEP were analyzed.RESULTS Forty-one patients had contrast media remaining in the pancreatic duct after completion of ERCP. Seventy-one patients had abdominal pain within three hours after ERCP. These were significant differences for s PEP(P < 0.05). The median of Body mass index, the median time for ERCP, the median serum amylase level of the next day, past histories including drinking and smoking, past history of pancreatitis, sphincter of Oddi dysfunction, whether emergency or not, expertise of ERCP procedure, diverticulum nearby Vater papilla, whether there was sphincterotomy or papillary balloon dilation, pancreatic duct cannulation, use of intraductal ultrasonography enforcement, and transpapillary biopsies had no significant differences with s PEP.CONCLUSION Contrast media remaining in the pancreatic duct and the appearance of abdominal pain within three hours after ERCP were risk factors of s PEP. | Hiroshi Matsubara Fumihiro Urano Yuki Kinoshita Shozo Okamura Hiroki Kawashima Hidemi Goto Yoshiki Hirooka | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 12 |
| 2 | Risk factors for intraoperative perforation during endoscopic submucosal dissection of superficial esophageal squamous cell carcinoma显示文摘AIM To identify the risk factors and clarify the subsequent clinical courses.METHODS This study retrospectively analyzed consecutive patients with esophageal squamous cell carcinoma( ESCC) treated using endoscopic submucosal dissection(ESD) between April 2008 and October 2012. We divided the ESCC lesions into perforation cases and non-perforation cases, and compared characteristics and endoscopic findings between the two groups. 'Intraoperative perforation' was defined as the detection of a perforation site during ESD and the presence of mediastinal emphysema.RESULTS In total, 147 patients with 156 ESCC lesions were treated by ESD. Intraoperative perforation was recorded for nine lesions(5.8%) from nine patients. Multivariate analysis identified mucosal deficiency larger than 75% of the circumference of the esophagus as an independent risk factor for intraoperative perforation(OR = 7.37, 95%CI: 1.45-37.4, P = 0.016). The predominant site of perforation was the left wall [6/9(67%)]. Six of nine perforation sites were successfully closed by clips during the procedures. Two of nine cases required drainage for pleural effusions; however, all nine cases recovered with conservative treatment and without surgical intervention. At the median follow up of 42 mo after ESD, no cases of local recurrence or distant organ metastasis had been observed.CONCLUSION This study suggests that mucosal deficiency larger than 75% of the luminal circumference is a risk factor for intraoperative perforation during ESD for ESCC. | Masaaki Noguchi Tomonori Yano Tomoji Kato Tomohiro Kadota Maomi Imajoh Hiroyuki Morimoto Shozo Osera Atsushi Yagishita Tomoyuki Odagaki Yusuke Yoda Yasuhiro Oono Hiroaki Ikematsu Kazuhiro Kaneko | 2017 | World Journal of Gastroenterology2017，23，3： | 12 |
| 3 | New anti-proliferative agent,MK615,from Japanese apricot “Prunus mume” induces striking autophagy in colon cancer cells in vitro显示文摘AIM: To investigate the anti-neoplastic effects of MK615, an extract from the Japanese apricot (Prunus mume), against colon cancer cells. METHODS: Three colon cancer cell lines, SW480, COLO, and WiDr, were cultured with MK615. Growth inhibition was evaluated by cell proliferation assay and killing activity was determined by lactate dehydrogenase assay. Induction of apoptosis was evaluated by annexin Ⅴ flow cytometry. Morphological changes were studied by light and electron microscopy, and immunofluorescence staining with Atg8. RESULTS: MK615 inhibited growth and lysed SW480, COLO and WiDr cells in a dose-dependent manner. Annexin Ⅴ flow cytometry showed that MK615 induced apoptosis after 6 h incubation, at which point the occurrence of apoptotic cells was 68.0%, 65.7% and 64.7% for SW480, COLO, and WiDr cells, respectively. Light and electron microscopy, and immunofluorescence staining with Atg8 revealed that MK615 induced massive cytoplasmic vacuoles (autophagosomes) in all three cell lines. CONCLUSION: MK615 has an anti-neoplastic effect against colon cancer cells. The effect may be exerted by induction of apoptosis and autophagy. | Shozo Mori Tokihiko Sawada Toshie Okada Tatsushi Ohsawa Masakazu Adachi Kubota Keiichi | 2007 | World Journal of Gastroenterology2007，13，48： | 9 |
| 4 | Homeostasis of Brassinosteroids Regulated by DRL1, a Putative Acyltransferase in Arabidopsis显示文摘在调整工厂生长和开发并且在对多样的环境暗示作出回应的各种各样的方面的 Brassinosteroids (BR ) 戏必需品角色,和他们的新陈代谢是在工厂调整他们的动态平衡的一个重要方法。这里,我们识别了主导的异种,矮子和圆 leaf-1 (drl1-D ) ,它展出弱 BR 缺乏或 BR 感觉迟钝的变异的显型,包括短、圆的叶子,延长老朽,相形见绌的形状,和 BR 应答的基因的改变的表示层次。胚轴长度和根抑制试金建议 drl1-D 异种通常对 BR 作出回应,但是减少了 BR 发信号产量。几 BR,包括的 typhasterol (TY ) , 6-deoxotyphasterol (6-deoxoTY ) ,和 6-deoxocastasterone (6-deoxoCS ) 的内长的层次,比在在 drl1-D 异种是显著地更低的野类型。DRL1 基因编码 acyltransferase 并且是广泛地在叶子,根,花,和 siliques 表示了。没有 DRL1 和它的相当或相同的事物的植物是更大的,提高的 BR 发信号。DRL1 的表示被 eBL 导致并且由骆驼毛的织物禁止了。DRL1 被通过酯化作用催化 BR 变化形式多半涉及 BR 新陈代谢,它在调整 BR 动态平衡并且在 Arabidopsis 对不能生活的压力作出回应起重要作用。 | Wenjiao Zhu Haijiao Wang Shozo Fujioka Tao Zhou Hailong Tian Weisheng Tian Xuelu Wang | 2013 | Molecular Plant2013，6，2： | 7 |
| 5 | 精力的文学评论为执行 laparoscopic colorectal 外科采购原料显示文摘 Laparoscopic surgery for colorectal disease has become widespread as a minimally invasive treatment.This is important because the increasing availability of new devices allows us to perform procedures with a reduced length of surgery and decreased blood loss.We herein report the results of a literature review of energy sources for laparoscopic colorectal surgery,focused especially on 6 studies comparing ultrasonic coagulating shears(UCS) and other instruments.We also describe our laparoscopic dissection techniques using UCS for colorectal cancer.The short-term outcomes of surgeries using UCS and Ligasure for laparoscopiccolorectal surgery were superior to conventional electrosurgery.Some authors have reported that the length of surgery or blood loss when Ligasure was used for laparoscopic colorectal surgery is less than when UCS was used.On the other hand,a recent study demonstrated that there were no significant differences between the short-term outcomes of UCS and Ligasure for laparoscopic colorectal surgery.It is therefore suggested that the choice of technique used should be made according to the surgeon’s preference.We also describe our laparoscopic dissection techniques using UCS(Harmonic ACE) for colorectal cancer with regard to the retroperitoneum dissection,dissection technique,dissection technique around the feeding artery,and various other dissection techniques.We therefore review the outcomes of using various energy sources for laparoscopic colorectal surgery and describe our laparoscopic dissection techniques with UCS(Harmonic ACE) for colorectal cancer. | Tsukasa Hotta Katsunari Takifuji Shozo Yokoyama Kenji Matsuda Takashi Higashiguchi Toshiji Tominaga Yoshimasa Oku Takashi Watanabe Toru Nasu Tadamichi Hashimoto Koichi Tamura Junji Ieda Naoyuki Yamamoto Hiromitsu Iwamoto Hiroki Yamaue | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 4 |
| 6 | Sub-classification of intermediate-stage(Barcelona Clinic Liver Cancer stage-B) hepatocellular carcinomas显示文摘Hepatocellular carcinoma(HCC), the fifth most common cancer in the world, shows increasing incidence worldwide. Curative treatments such as hepatectomy,liver transplantation, and radiofrequency ablation are applied in only 30%-60% of cases. Most remaining patients receive transarterial chemoembolization(TACE).Patients with intermediate-stage HCCs are regarded as good candidates for TACE. However, the intermediate stage includes non-homogeneous patients. Some movements are underway to stratify patients using prognostic factors to identify patient groups exhibiting greater benefit from TACE than other patient groups.This review describes two substaging systems that subclassify intermediate-stage HCCs and discusses the importance of dividing intermediate-stage patients. | Koichiro Yamakado Shozo Hirota | 2015 | World Journal of Gastroenterology2015，21，37： | 4 |
| 7 | A Survey of Steel Arch Bridges in China显示文摘 | Baochun Chen Kangming Chen Shozo Nakamura Qiu Zhao | 2011 | Journal of Civil Engineering and Architecture2011，5，9： | 4 |
| 8 | Prediction of acute left main coronary artery obstruction by 12-lead electrocardiography显示文摘 | Hirosuke Yamaji Kohichiro Iwasaki Shozo Kusachi Takashi Murakami Ryouichi Hirami Hiromi Hamamoto Kazuyoshi Hina Toshimasa Kita Noburu Sakakibara Takao Tsuji | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 9 | 高灵敏度的涂层破损探测系统──MS迈克尔显示文摘开发了地下管线涂层破损探测系统。通过采用随机信号模拟探测信号,明显地减少了来自外部的杂音影响,探测灵敏度得以提高。挖开、检查地下管线涂层破损处也证实,该系统的探测灵敏度是相当高的。 | Shozo Hatanaka 张守本 | 2001 | 国外油田工程2001，17，6： | 2 |
| 10 | Expression analysis of anthocyanin biosynthetic genes in apple skin: Effect of UV-B and temperature显示文摘 | Benjamin Ewa Ubi Chikako Honda Hideo Bessho Satoru Kondo Masato Wada Shozo Kobayashi Takaya Moriguchi | 2005 | Plant Science2005，，3： | 2 |
| 11 | Flavonoid biosynthesis-related genes in grape skin are differentially regulated by temperature and light conditions显示文摘 | Akifumi Azuma Hiroshi Yakushiji Yoshiko Koshita Shozo Kobayashi | 2012 | Planta2012，，4： | 2 |
| 12 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 13 | Advanced glycation end products-induced reactive oxygen species generation is partly through NF-kappa B activation in human aortic endothelial cells显示文摘 | Miwa Morita Shozo Yano Toru Yamaguchi Toshitsugu Sugimoto | 2012 | Journal of Diabetes and Its Complications2012，，： | 2 |
| 14 | A static analysis-based method for estimating the maximum out-of- plane inelastic seismic response of steel arch bridges显示文摘 | Osman Tunc Cetinkaya Shozo Nakamura and Kazuo Takahashi | 2006 | Engineering Structures2006，28，5： | 1 |
| 15 | Analysis of solute distribution in dendrites of carbon steel with 8/7 transformation during solidifieation显示文摘 | Yoshiyuki Ueshima Shozo Mizoguchi Tooru Matsumiya | 1986 | Metallurgical Transactions1986，17，： | 1 |
| 16 | Comparison of ^18F-fluoromethylcholine and 2- deoxy-D-glucose in the distribution of tumor and inflammation 显示文摘 | Kazuo Kubota Shozo Furumoto Ren Iwata | 2006 | Annals of Nuclear Medicine2006，20，8： | 1 |
| 17 | physical development of Surgiclly treated patients with primary spontaneons preumothorax显示文摘 | Shozo Fujino Shubei Inone Norialci | 1999 | chest1999，116，4： | 1 |
| 18 | Bending behavior of short steel cylinders under axial force fluctuations显示文摘 | Osman T C Shozo N Kazuo T | 2008 | Engineering Structures2008，30，3： | 1 |
| 19 | So-Called Carcinosarcoma of the Gallbladder; Spindle Cell Carcinoma of the Gallbladder: Report of a Case显示文摘 | Tsukasa Hotta Hiroshi Tanimura Shozo Yokoyama Kimiko Ura Hiroki Yamaue | 2002 | Surgery Today2002，，5： | 1 |
| 20 | Precipitation behavior of MnS during δ/γ transformation in Fe?Si alloys显示文摘 | Yoshiyuki Ueshima Yasushi Sawada Shozo Mizoguchi Hiroyuki Kajioka | 1989 | Metallurgical Transactions A1989，，8： | 1 |
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