|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma显示文摘AIM:To determine significant indicators for the efficacy of sorafenib in patients with advanced hepatocellular carcinoma(HCC).METHODS:A total of 46 patients with Barcelona Clinic Liver Cancer stage C who received sorafenib for more than 30 d at the Iizuka Hospital from June 2009 to December 2012 were enrolled in this study.Multivariate and univariate analyses were performed to evaluate the associations of hepatic function according to Child-Pugh grade,location and size of the largest tumor and adverse events of sorafenib treatment,such as hand-foot syndrome(HFS),hypertension,diarrhea,and alopecia,with the efficacy of treatment,as measured by overall survival(OS)and time to progression(TTP).RESULTS:Patients included 39 men and 7 women whose ages ranged from 48 to 85 years(70.6±9.6years).HCC was classified according to etiology as follows:hepatitis C virus(n=26),hepatitis B virus(n=9),and other(n=11).Liver function in patients was categorized as Child-Pugh grade A(n=30)or B(n=16).Tumors were categorized by size[<5 cm(n=33)or>5 cm(n=13)]and the location of the largest tumor was used to categorize patients with intrahepatic(n=28)or extrahepatic(n=18)HCC.HFS,hypertension,diarrhea,and alopecia were present in22(47.8%),19(41.3%),15(32.6%)and 7 patients(15.2%),respectively.The median OS of all patients was 373 d and the median TTP was 112 d.The etiology of HCC did not correlate with the median OS and TPP.The median OS of patients with tumors<5 cm was significantly longer than those with larger tumors(496 vs 245 d;HR=0.19,95%CI:0.07-0.48;P<0.01).According to the results of a multivariate analysis,the size of the largest tumor affected OS(HR=0.22,95%CI:0.08-0.59;P<0.01).The median TTP was significantly longer in patients with extrahepatic compared to intrahepatic major HCC(224 vs 98 d;HR=0.32;95%CI:0.14-0.67;P<0.01).The median TTP of patients with HFS was significantly longer than those without it(195 d vs 83 d;HR=0.41,95%CI:0.20-0.82;P<0.05),and the median TTP was significantly longer in patients with hypertension(195 d vs84 d;HR=0.43,95%CI:0.21-0.84;P<0.05).According to the results of the multivariate analysis,extrahepatic major HCC(HR=0.36,P<0.01)and HFS(HR=0.44,P<0.05)prolonged TTP.CONCLUSION:Extrahepatic major HCC and HFS are associated with prolonged TTP and are useful indicators for judging the efficacy of sorafenib treatment. | Masayoshi Yada Akihide Masumoto Kenta Motomura Hirotaka Tajiri Yusuke Morita Hideo Suzuki Takeshi Senju Toshimasa Koyanagi | 2014 | World Journal of Gastroenterology2014，20，35： | 7 |
| 2 | Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound显示文摘Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,respectively.The foam was instantly formed by interaction of polyols and diisocyanate.Hydroxypropyl methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing sheets.Although the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active components.Among natural polyols formulations,foam sheets with alginate showed the highest silver and AS release.Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed.Antimicrobial testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations.In pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions.In conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment. | Nantaporn Namviriyachote Vimolmas Lipipun Yada Akkhawattanangkul Phingphol Charoonrut Garnpimol C.Ritthidej | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 6 |
| 3 | Benefit of laparoscopic liver resection in high body mass index patients显示文摘AIM: To explore the impact of body mass index(BMI) on surgical outcomes in patients undergoing laparoscopic liver resection(LLR).METHODS: From January 2010 to February 2015, sixty-eight patients who underwent primary partial liver resection in our institute were retrospectively reviewed. Surgical outcomes of LLR were compared with those of open liver resection(OLR). In addition, we analyzed associations with BMI and surgical outcomes.RESULTS: Among 68 patients, thirty-nine patients underwent LLR and 29 were performed OLR. Significant difference in operation time, blood loss, and postoperative hospital stay was observed. There were no signi ficant di fferences in mortali ty and morbidity in two groups. Twenty-two patients(32.4%) were classified as obese(BMI ≥ 25). A statistically significant correlation was observed between BMI and operation time, between BMI and blood loss in OLR, but not in LLR. The operation time and blood loss of OLR were significantly higher than that of LLR in obese patients. Open liver resection and BMI were independent predictors for prolonged operation time and increased blood loss in multivariate analysis.CONCLUSION: The present study demonstrated that BMI had influenced to surgical outcomes of OLR. LLR was less influenced by BMI and had great benefit in obese patients. | Hiroki Uchida Yukio Iwashita Kunihiro Saga Hiroomi Takayama Kiminori Watanabe Yuichi Endo Kazuhiro Yada Masayuki Ohta Masafumi Inomata | 2016 | World Journal of Gastroenterology2016，22，10： | 4 |
| 4 | Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca^(2+) signaling in neuropeptide Y neurons of the arcuate nucleus显示文摘AIM: To explore the mechanism for interactions of leptin with ghrelin and orexin in the arcuate nucleus (ARC) activating neuropeptide Y (NPY) neurons during physiological regulation of feeding. METHODS: Single neurons from ARC of adult rats with matured feeding function were isolated. [Ca2+]i was measured to monitore their activities. The time course of leptin effects on ghrelin-induced versus orexin-induced [Ca2+]i increases in NPY neurons was studied. RESULTS: Administration of ghrelin or orexin-A at 10-10 mol/L increased cytosolic Ca2+ concentration ([Ca2+]i) in NPY neurons isolated from the ARC of adult rats. Upon administration of leptin at 10-14-10-12 mol/L, ghrelin-induced [Ca2+]i increases were initially (< 10 min) inhibited but later restored, exhibiting a transient pattern of inhibition. In contrast, orexin-induced [Ca2+]i increases were inhibited by leptin in a longlasting manner. Furthermore, a prior administration of leptin inhibited orexin action but not ghrelin action to increase [Ca2+]i. CONCLUSION: Leptin counteracted ghrelin effects transiently and orexin effects long-lastingly in NPY neurons. The transient property with which leptin counteracts ghrelin action in NPY neurons may allow the fasting-associated increase in ghrelin levels to activate NPY neurons in the presence of physiological leptin and to stimulate feeding. | Daisuke Kohno Shigetomo Suyama Toshihiko Yada | 2008 | World Journal of Gastroenterology2008，14，41： | 4 |
| 5 | The Current State of Diagnosis and Treatment for Early Gastric Cancer显示文摘 | Tomoyuki Yada Chizu Yokoi Naomi Uemura Tony C. K. Tham | 2013 | Diagnostic and Therapeutic Endoscopy2013，，： | 3 |
| 6 | Diagnostic value of antigenemia assay for cytomegalovirus gastrointestinal disease in immunocompromised patients显示文摘AIM:To investigate the utility of the cytomegalovirus(CMV)antigenemia assay for the diagnosis of CMV gastrointestinal disease(GID). METHODS:One hundred and thirty immunocompromised patients were enrolled in this study.Patients with a history of anti-CMV treatment and who had not undergone examination using the antigenemia assay were excluded.CMV-GID was defined as the detection of large cells with intranuclear inclusions alone or associated with granular cytoplasmic inclusions by biopsy.Biopsy sections were stained with hematoxylin and eosin and immunohistochemically stained with anti-CMV.We evaluated the association between CMV-GID and patient characteristics(symptoms,underlying disease,medication,leukocyte counts,and antigenemia assay).All patients were checked with an human immunodeficiency virus(HIV)antibody test before endoscopic examination.White blood cell(WBC)counts were obtained from medical records within 1 wk of endoscopy.Leukopenia was defined as a total WBC count<5000 cells/mm 3 . For HIV patients,we also checked CD4+counts from medical records. RESULTS:A total of 99 patients were retrospectively selected for analysis.Of the immunocompromised patients,19 had malignant disease,18 had autoimmune disease,19 had disorders of biochemical homeostasis, three had undergone transplantation,and 45 had HIV infection.A total of 50 patients had received immunosuppressive therapy.No patients had inflammatory bowel disease.Fifty-five patients were diagnosed as having CMV-GID.Univariate analysis indicated an association between HIV infection,leukopenia,and positive antigenemia and CMV-GID(P<0.05).Multivariate analysis using logistic regression revealed that HIV infection and positive antigenemia were the only independent factors related to CMV-GID(P<0.01).The sensitivity,specificity,positive predictive value,and negative predictive value of antigenemia for CMV-GID were 65.4%,93.6%, 91.9%,and 71.0%,respectively.In a subgroup analy-sis,patients with leukopenia displayed low sensitivity and high specificity.Minimal differences in accuracy were seen among patients with or without leukopenia. HIV-infected patients displayed low sensitivity and high specificity.Accuracy barely differed between HIV-positive and-negative patients.In HIV-infected patients, CD4 count<50 cells/μL resulted in low sensitivity and high specificity.Differences in accuracy among patients were minor,regardless of CD4 count.In patients who had undergone both quantitative real-time polymerase chain reaction(PCR)and antigenemia assay,real-time PCR was slightly more accurate in terms of sensitivity than the antigenemia assay;however,this difference was not statistically significant(P=0.312). CONCLUSION:If the antigenemia test is positive,endoscopic lesions are acceptable for the diagnosis of CMVGID without biopsy.The accuracy is not affected by HIV infection and leukopenia.Either PCR or the antigenemia assay are valid. | Naoyoshi Nagata Masao Kobayakawa Takuro Shimbo Kazufusa Hoshimoto Tomoyuki Yada Takuji Gotoda Junichi Akiyama Shinichi Oka Naomi Uemura | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 7 | 组合使用应变和剪切波成像诊断肝脏疾病患者的纤维化和炎症活动度显示文摘【据《Dig Dis》2017年10月报道】题:组合使用应变和剪切波成像诊断肝脏疾病患者的纤维化和炎症活动度(作者Yada N等)
进行剪切波成像是简单的,但是当存在炎症、黄疸和充血时可能很困难。因此,在轻度至中度纤维化病例中,单纯使用剪切波成像对肝纤维化的正确诊断可能是困难的。应变成像可以诊断肝纤维化而不受炎症的影响。 | Yada N 付兴 | 2017 | 临床肝胆病杂志2017，33，12： | 2 |
| 8 | Effects of Deformation and Phase Transformation Microstructures on Springback Behavior and Biocompatibility in β-Type Ti-15Mo Alloy显示文摘This study examined the mechanical properties, springback behavior from three-point bending loading–unloading tests and biocompatibility from human osteoblast cell adhesion and proliferation experiments in Ti-15Mo alloy with different microstructures. The springback ratio increased after the appearance of deformation microstructures including {332} < 113 > twins and dislocations, due to the increased bending strength and unchanged Young’s modulus. By contrast, the change in springback ratio was dependent on the competing effect of the simultaneous increase in bending strength and Young’s modulus after phase transformation, namely, the isothermal ω-phase formation. Good cell adhesion and proliferation were observed on the alloy surface, and they were not significantly affected by the deformation twins, dislocations and isothermal ω-phase.The diversity of deformation and phase transformation microstructures made it possible to control the springback behavior effectively while keeping the biocompatibility of the alloy as an implant rod used for spinal fixation devices. | Sujie Zhang Xiaohua Min Yada Li Weiqiang Wang Ping Li Mingjia Li | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，4： | 2 |
| 9 | Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control显示文摘 | M. Nakata S. Nagasaka I. Kusaka H. Matsuoka S. Ishibashi T. Yada | 2006 | Diabetologia2006，，8： | 2 |
| 10 | Factors Associated with the Clinical Impact of Capsule Endoscopy in Patients with Overt Obscure Gastrointestinal Bleeding显示文摘 | Motohiro Esaki Takayuki Matsumoto Shinichiro Yada Ritsuko Yanaru-Fujisawa Tetsuji Kudo Shunichi Yanai Shotaro Nakamura Mitsuo Iida | 2010 | Digestive Diseases and Sciences2010，，8： | 2 |
| 11 | SREBP-1c, regulated by the insulin and AMPK signaling pathways, playsa role in nonalcoholic fatty liver disease显示文摘 | Motoyuki Kohjima Nobito Higuchi Masaki Kato Kazuhiro Kotoh Tsuyoshi Yoshimoto Tatsuya Fujino Masayoshi Yada Ryoko Yada Naohiko Harada Munechika Enjoji Ryoichi Takayanagi Makoto Nakamuta | 2008 | International Journal of Molecular Medicine2008，，4： | 2 |
| 12 | Studies on formalde- hyde in Cortinellus Shiitake显示文摘 | Yada M K lwaida M Kobayashi T | 1970 | Shokuhin Eiseigaku Zassi1970，11，： | 1 |
| 13 | Targeting apoptotic tumorcells to FcγR provides efficient and versatile vaccination againsttumors by dendritic cells显示文摘 | Akiyama K Ebihara S Yada A | 2003 | J Immunol2003，170，4： | 1 |
| 14 | Dynamic γ→α Transformation During Hot Deformation in Iron-Nickel-Carbon Alloys显示文摘 | Yada Hiroshi LI Chun-ming Yamagata Hiroshi | 2000 | ISIJ International2000，40，2： | 1 |
| 15 | Hormonal control of osmoregulation in the channel catfish Ictalurus punctatus显示文摘 | Eckert S M Yada T Shepherd B S | 2001 | Gen Comp Endocrinol2001，122，： | 1 |
| 16 | Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo 显示文摘 | Yada T Shimokawa H Hiramatsu O | 2005 | J Am Coll Cardiol2005，45，4： | 1 |
| 17 | Effect of abutment tooth color,cement color,and ceramic thickness on the resulting optical color of a CAD/CAM glass-ceramic lithium disilicate reinforced crown显示文摘 | Yada Chaiyabutr John C Kois Dene LeBeau | 2011 | J Prosthet Dent2011，105，： | 1 |
| 18 | Influence of preparation design and existing condition of tooth structure on load to failure of ceramic laminate veneers显示文摘 | Kyle K. Schmidt Yada Chiayabutr Keith M. Phillips John C. Kois | 2011 | The Journal of Prosthetic Dentistry2011，，6： | 1 |
| 19 | Anthocyanins as food colorants-a review显示文摘 | Jackman RL Yada RY Tung MA | 1987 | Journal of Food Biochemistry1987，11，： | 1 |
| 20 | Marked decrease in serum pepsinogen II levels resulting from endoscopic resection of a large duodenal tumor显示文摘 | Yada T Ito K Suzuki K | 2014 | Clin J Gas- troenterol2014，7，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员