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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 3 | Effects of Duhuojisheng Tang and combined therapies on prolapse of lumbar intervertebral disc:a systematic review of randomized control trails显示文摘OBJECTIVE:A systematic review of the literature was conducted to evaluate the curative effect and safety of Duhuojisheng Tang on prolapse of the lumbar intervertebral disc.METHODS:The databases of PubMed,China National Knowledge Infrastructure(CNKI),Chinese Scientific Journals Database(VIP),Chinese Biomedical Literature Database(CBM) and Chinese Medical Citation Index(CMCI) were searched up to January 30,2012.Randomized controlled trials were selected to compare Duhuojisheng Tang with one or more of the following treatments:traction,acupuncture,massage,cupping and Western medical treatment.The quality-evaluating standard and the software RevMan 5.1 in Cochrane coordinative net were used to analyze the data.The effective indexes of the results were clinical curative rate,effectiveness of alleviating clinical symptoms and adverse reaction.RESULTS:Thirty-one randomized controlled trials of low quality,involving 3915 patients were systematically evaluated.Statistical analyses showed that good curative effect was achieved in both the group using Duhuojisheng Tang alone and with combined therapies.CONCLUSION:Using Duhuojisheng Tang alone or combined with other therapies can effectively improve pain,leg-raising height and other clinical symptoms of patients with prolapse of lumbar intervertebral disc.Due to low methodological quality of the articles,no exact recommendations can be made. | Yanxu Ma Minghua Huang Jingyan Cui Kai Meng Yuhao Zhao | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 27 |
| 4 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 5 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 6 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 7 | Ultralow-loss geometric phase and polarization shaping by ultrafast laser writing in silica glass显示文摘Polarization and geometric phase shaping via a space-variant anisotropy has attracted considerable interest for fabrication of flat optical elements and generation of vector beams with applications in various areas of science and technology.Among the methods for anisotropy patterning,imprinting of self-assembled nanograting structures in silica glass by femtosecond laser writing is promising for the fabrication of space-variant birefringent optics with high thermal and chemical durability and high optical damage threshold.However,a drawback is the optical loss due to the light scattering by nanograting structures,which has limited the application.Here,we report a new type of ultrafast laser-induced modification in silica glass,which consists of randomly distributed nanopores elongated in the direction perpendicular to the polarization,providing controllable birefringent structures with transmittance as high as 99% in the visible and near-infrared ranges and >90% in the UV range down to 330 nm.The observed anisotropic nanoporous silica structures are fundamentally different from the femtosecond laser-induced nanogratings and conventional nanoporous silica.A mechanism of nanocavitation via interstitial oxygen generation mediated by multiphoton and avanlanche defect ionization is proposed.We demonstrate ultralow-loss geometrical phase optical elements,including geometrical phase prism and lens,and a vector beam convertor in silica glass. | Masaaki Sakakura Yuhao Lei Lei Wang Yan-Hao Yu Peter G.Kazansky | 2020 | Light(Science & Applications)2020，9，1： | 14 |
| 8 | Few-layer Tellurium:one-dimensional-like layered elementary semiconductor with striking physical properties显示文摘Few-layer Tellurium, an elementary semiconductor, succeeds most of striking physical properties that black phosphorus(BP) offers and could be feasibly synthesized by simple solution-based methods. It is comprised of non-covalently bound parallel Te chains, among which covalent-like feature appears.This feature is, we believe, another demonstration of the previously found covalent-like quasi-bonding(CLQB) where wavefunction hybridization does occur. The strength of this inter-chain CLQB is comparable with that of intra-chain covalent bonding, leading to closed stability of several Te allotropes. It also introduces a tunable bandgap varying from nearly direct 0.31 eV(bulk) to indirect 1.17 eV(2L) and four(two) complex, highly anisotropic and layer-dependent hole(electron) pockets in the first Brillouin zone.It also exhibits an extraordinarily high hole mobility(~10~5 cm^2/Vs) and strong optical absorption along the non-covalently bound direction, nearly isotropic and layer-dependent optical properties, large ideal strength over 20%, better environmental stability than BP and unusual crossover of force constants for interlayer shear and breathing modes. All these results manifest that the few-layer Te is an extraordinary-high-mobility, high optical absorption, intrinsic-anisotropy, low-cost-fabrication, tunable bandgap, better environmental stability and nearly direct bandgap semiconductor. This ‘‘one-dimen sion-like' few-layer Te, together with other geometrically similar layered materials, may promote the emergence of a new family of layered materials. | Jingsi Qiao Yuhao Pan Feng Yang Cong Wang Yang Chai Wei Ji | 2018 | Science Bulletin2018，63，3： | 12 |
| 9 | Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis:a multi-center,single-blind,randomized controlled trial显示文摘PURPOSE: To observe the efficacy and safety of Shaoyang Xibi decoction(SYXBD) in patients with knee osteoarthritis(KOA), and to verify that the theory of 'Shaoyang dominating bone' in Traditional Chinese Medicine(TCM) can be applied to KOA treatment.METHODS: Participants were randomly allocated to two groups: SYXBD(treatment group, n = 66)and Meloxicam(control group, n = 66). Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and 36-Item Short Form Health Survey(SF-36) were used to assess efficacy before the treatment and 8 weeks after the treatment.RESULTS: Baseline data before the treatment between the two groups were similar. The WOMAC scores significantly decreased and the SF-36 scores significantly increased after 8-week treatment in both groups compared with before the treatment(P < 0.05). SYXBD significantly decreased pain scores(P < 0.001), physical function scores(P <0.001) and the total scores(P < 0.001) in WOMAC compared to Meloxicam. SYXBD significantly improved physical function(P = 0.021), bodily pain(P = 0.002) and general health(P = 0.014), with no significant difference in role emotional(P = 0.053),role physical(P = 0.517), vitality(P = 0.241), social function(P = 0.712) and mental health(P = 0.800)in SF-36 compared to Meloxicam. No adverse events were reported in the treatment group while13 adverse events happened in the control group during the study.CONCLUSION: SYXBD, prepared based on the theory of 'Shaoyang dominating bone', has a better curative efficay and safety in patients with KOA compared with Meloxicam. The TCM theory of 'Shaoyang dominating bone' may be useful in KOA treatment. | Si Yuhao Ma Yong Guo Yang Pan Yalan Zheng Suyang Xu Guihua Da Weiwei Xu Lili | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 11 |
| 10 | Synthesis of hydrophobic carbon nanotubes/reduced graphene oxide composite films by flash light irradiation显示文摘 | Kai Wang Jinbo Pang Liwei Li Shengzhe Zhou Yuhao Li Tiezhu Zhang | 2018 | Frontiers of Chemical Science and Engineering2018，12，3： | 10 |
| 11 | 生姜乙醇提取物改善果糖所致大鼠脂肪肝的作用机制研究显示文摘目的观察姜提取物改善果糖所致大鼠脂肪肝的作用,并探讨其可能的作用机制。方法取SD大鼠24只,随机分为4组,每组6只,即正常对照组(给予正常饮食饮水),模型组(给予10%果糖水),姜提取物低、高剂量组20,50 mg·kg^(-1),给予姜提取物灌胃,连续28 d。用酶法和ELISA检测血浆葡萄糖、甘油三酯(TG)、胆固醇(TC)和胰岛素含量,苏木精-伊红(HE)染色和油红-O染色观察肝脏组织中的脂肪沉积程度,RT-PCR和Western blot法检测肝脏相关基因和蛋白表达。结果姜提取物逆转了果糖过量消耗引起的大鼠肝脏甘油三酯的过度堆积(P<0.05)、肝细胞空泡化的增加和肝脏油红-O染色面积的增加(P<0.05)。然而,姜提取物并不影响大鼠食物摄入量和体质量。姜提取物能够抑制肝脏二脂酰甘油酰基转移酶(DGAT)-2 mRNA和蛋白的过表达(P<0.05),但对肝X受体(LXR)、DGAT-1、单酰甘油酰基转移酶(MGAT)-1、MGAT-2、激素敏感脂肪酶(HSL)和脂肪甘油三酯脂肪酶(ATGL)mRNA的表达无影响。结论姜提取物可能通过抑制介导肝脏甘油三酯生物合成的关键酶DGAT-2的过表达,从而改善果糖所致大鼠脂肪肝。 | 陈婷 姚玲 柯大智 左国伟 曹纬国 王尚 马朋 蒋丽蓉 Johji Yamahara Yuhao Li 王建伟 | 2016 | 中药新药与临床药理2016，27，1： | 10 |
| 12 | Recent progress in preventive effect of collagen peptides on photoaging skin and action mechanism显示文摘Ultraviolet(UV)-induced photoaging skin has become an urgent issue.The functional foods and cosmetics aiming to improve skin photoaging are developing rapidly,and the demand is gradually increasing year by year.Collagen peptides have been proven to display diverse physiological activities,such as excellent moisture retention activity,hygroscopicity,tyrosinase inhibitory activity and antioxidant activity,which indicates that they have great potential in amelioration of UV-induced photoaging.The main objective of this article is to recap the main mechanisms to improve photoaging skin by collagen peptides and their physiological activities in photo-protection.Furthermore,the extraction and structural characteristics of collagen peptides are overviewed.More importantly,some clinical trials on the beneficial effect on skin of collagen peptides are also discussed.In addition,prospects and challenges of collagen peptides are emphatically elucidated in this review.This article implies that collagen peptides have great potential as an effective ingredient in food and cosmetics industry with a wide application prospect. | Chongyang Li Yu Fu Hongjie Dai Qiang Wang Ruichang Gao Yuhao Zhang | 2022 | Food Science and Human Wellness2022，11，2： | 7 |
| 13 | Chromatin-remodeling factor OsINO80 is involved in regulation of gibberellin biosynthesis and is crucial for rice plant growth and development显示文摘The phytohormone gibberellin(GA) plays essential roles in plant growth and development. Here,we report that OsINO80, a conserved ATP-dependent chromatin-remodeling factor in rice(Oryza sativa), functions in both GA biosynthesis and diverse biological processes. OsINO80-knockdown mutants, derived from either T-DNA insertion or RNA interference, display typical GA-deficient phenotypes, including dwarfism, reduced cell length, late flowering, retarded seed germination and impaired reproductive development. Consistently, transcriptome analyses reveal that OsINO80 knockdown results in downregulation by more than two-fold of over 1,000 genes, including the GA biosynthesis genes CPS_1 and GA_3ox_2, and the dwarf phenotype of OsINO80-knockdown mutants can be rescued by the application of exogenous GA3. Chromatin immunoprecipitation(Ch IP) experiments show that OsINO80 directly binds to the chromatin of CPS1 and GA_3ox_2 loci. Biochemical assays establish that OsINO80 specially interacts with histone variant H_2A.Z and the H_2A.Z enrichments at CPS_1 and GA_3ox_2 are decreased in OsINO80-knockdown mutants. Thus, our study identified a rice chromatin-remodeling factor,OsINO80, and demonstrated that OsINO80 is involved in regulation of the GA biosynthesis pathway and plays critical functions for many aspects of rice plant growth and development. | Chao Li Yuhao Liu Wen-Hui Shen Yu Yu Aiwu Dong | 2018 | Journal of Integrative Plant Biology2018，60，2： | 7 |
| 14 | Improved TQWT for marine moving target detection显示文摘Under the conditions of strong sea clutter and complex moving targets,it is extremely difficult to detect moving targets in the maritime surface.This paper proposes a new algorithm named improved tunable Q-factor wavelet transform(TQWT)for moving target detection.Firstly,this paper establishes a moving target model and sparsely compensates the Doppler migration of the moving target in the fractional Fourier transform(FRFT)domain.Then,TQWT is adopted to decompose the signal based on the discrimination between the sea clutter and the target’s oscillation characteristics,using the basis pursuit denoising(BPDN)algorithm to get the wavelet coefficients.Furthermore,an energy selection method based on the optimal distribution of sub-bands energy is proposed to sparse the coefficients and reconstruct the target.Finally,experiments on the Council for Scientific and Industrial Research(CSIR)dataset indicate the performance of the proposed method and provide the basis for subsequent target detection. | PAN Meiyan SUN Jun YANG Yuhao LI Dasheng XIE Sudao WANG Shengli CHEN Jianjun | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 6 |
| 15 | Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis显示文摘Polycomb group proteins are important repressors of numerous genes in higher eukaryotes. However, the mechanism by which Polycomb group proteins are recruited to specific genes is poorly understood. In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1(LHP1), also known as TERMINAL FLOWER 2, was originally proposed as a subunit of polycomb repressive complex 1(PRC1) that could bind the tri-methylated lysine 27 of histone H3(H3K27me3) established by the PRC2. In this work, we show that LHP1 mainly functions with PRC2 to establish H3K27me3, but not with PRC1 to catalyze monoubiquitination at lysine 119 of histone H2 A. Our results show that complexes of the transcription factors ASYMMETRIC LEAVES 1(AS1) and AS2 could help to establish the H3K27me3 modification at the chromatin regions of Class-I KNOTTED1-like homeobox(KNOX) genes BREVIPEDICELLUS andKNAT2 via direct interactions with LHP1. Additionally, our transcriptome analysis indicated that there are probably more common target genes of AS1 and LHP1 besides Class-I KNOX genes during leaf development in Arabidopsis. | Zhongfei Li Bin Li Jian Liu Zhihao Guo Yuhao Liu Yan Li Wen-Hui Shen Ying Huang Hai Huang Yijing Zhang Aiwu Dong | 2016 | Journal of Integrative Plant Biology2016，58，12： | 6 |
| 16 | Magnetic manganese-based composites with multiple loss mechanisms towards broadband absorption显示文摘The weak dielectric properties and the lack of magnetic loss of manganese-based absorbers are obstructed as the new generation of electromagnetic wave absorption(EMA)materials applying in microelectronic devices.Herein,the sulfuration and subsequent compounding strategies have been employed to enhance the EMA performance of multi-shell nanosphere-shaped Mn_(2)O_(3)materials.With the narrow bandgap,the as-obtained MnS possesses reinforced electrical conductivity,which is conducive to conductivity loss.More importantly,the presence of potential difference between different phases will form space charge region at the heterogeneous interface,thus favoring interfacial polarization.Additionally,the improvement of magnetic loss is attributed to the presence of Co_(3)O_(4)nanoparticles.Consequently,the composites present enhanced EMA performance than original Mn_(2)O_(3).Specifically,the minimum reflection loss of as-prepared composites is−51.4 dB at the thickness of 1.8 mm and the broad effective absorption bandwidth reaches 6.2 GHz at 1.9 mm.The low matching thickness and high absorption efficiency in this work can provide a convincing reference when designing distinguished manganese-based absorbers. | Yue Liu Zirui Jia Qianqian Zhan Yuhao Dong Qimeng Xu Guanglei Wu | 2022 | Nano Research2022，15，6： | 6 |
| 17 | Autonomous driving: cognitive construction and situation understanding显示文摘Autonomous vehicle is a kind of typical complex artificial intelligence system. In current research of autonomous driving, the most widely adopted technique is to use a basic framework of serial information processing and computations, which consists of four modules: perception, planning, decision-making, and control. However, this framework based on data-driven computing performs low computational efficiency,poor environmental understanding and self-learning ability. A neglected problem has long been how to understand and process environmental perception data from the sensors referring to the cognitive psychology level of the human driving process. The key to solving this problem is to construct a computing model with selective attention and self-learning ability for autonomous driving, which is supposed to possess the mechanism of memorizing, inferring and experiential updating, enabling it to cope with traffic scenarios with high noise, dynamic, and randomness. In addition, for the process of understanding traffic scenes,the efficiency of event-related mechanism is more significant than single-attribute scenario perception data.Therefore, an effective self-driving method should not be confined to the traditional computing framework of‘perception, planning, decision-making, and control’. It is necessary to explore a basic computing framework that conforms to human driver’s attention, reasoning, learning, and decision-making mechanism with regard to traffic scenarios and build an autonomous system inspired by biological intelligence. In this article, we review the basic methods and main progress in current data-driven autonomous driving technologies, deeply analyze the limitations and major problems faced by related algorithms. Then, combined with authors’ research, this study discusses how to implement a basic cognitive computing framework of self-driving with selective attention and an event-driven mechanism from the basic viewpoint of cognitive science. It further describes how to use multi-sensor and graph data with semantic information(such as traffic maps and a spatial correlation of events) to realize the associative representations of objects and drivable areas, as well as the intuitive reasoning method applied to understanding the situations in different traffic scenarios. The computing framework of autonomous driving based on a selective attention mechanism and intuitive reasoning discussed in this study can adapt to a more complex, open, and dynamic traffic environment. | Shitao CHEN Zhiqiang JIAN Yuhao HUANG Yu CHEN Zhuoli ZHOU Nanning ZHENG | 2019 | Science China(Information Sciences)2019，62，8： | 6 |
| 18 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 19 | Catalytic Co9S8 decorated carbon nanoboxes as efficient cathode host for long-life lithium-sulfur batteries显示文摘Lithium sulfur(Li-S)batteries with high specific capacity and energy density can bring enormous opportunities for the nextgeneration energy storage systems.However,the severe dissolution and shuttle effect of lithium polysulfides(LiPSs)is still the key issue that seriously impedes the development of practical Li-S batteries.Here,polar Co9S8 inlaid carbon nanoboxes(Co9S8@C NBs)have been investigated as cathode host for high-performance Li-S batteries.In this integrated structure,Co9S8 nanocrystals not only provide strong chemisorptive capability for polar LiPSs,but also act as a catalyst to accelerate polysulfide redox reactions;while carbon nanobox with large inner space can offer enough space to relieve the volume expansion and physically confine LiPSs’dissolution.As a result,the S/Co9S8@C NBs cathode exhibits high specific capacity at 1C and the capacity retention was^83%after 400 cycles,corresponding to an average decay rate of only^0.043%per cycle. | Weiwei Sun Yujie Li Shuangke Liu Qingpeng Guo Yuhao Zhu Xiaobin Hong Chunman Zheng Kai Xie | 2020 | Nano Research2020，13，8： | 5 |
| 20 | Survey of reefs based on Landsat 8 operational land imager(OLI)images in the Nansha Islands, South China Sea显示文摘A detailed survey of the reefs in the Nansha Islands' sea that are of strategic importance is conducive to their future development. In this study, a total of 50 Landsat 8 operational land imager(OLI) images were used to analyze the geological features and spectral characteristics of the Nansha reefs. The exposed islands/sandbanks,reef flats and sub-tidal reefs were identified with the near-infrared band, the red and green bands, and the blue band, respectively. Based on the relationships among various characteristics and bands illustrated in the OLI images, the maximum between-cluster variance threshold algorithm(OTSU method) and the mathematical morphology were employed to extract characteristic parameters of the spatial geometry of the reefs from top to bottom, which were subsequently operated by a series of post-processing methods such as vectorization,simplification and topological analysis. Among the 132 standalone reefs and 16 atolls that are identified in the study, four reefs have yet to be named in the Standard Names of Various Islands in the South China Sea and the website Nansha Islands Online(http://gffzzd4db47f6efa542b8h9b6ff6xwq66u6x9k.ffgz.tsg.suse.edu.cn/). Another 24 ones are exposed to the atmosphere even during high tides. Taiping Island with an area of 0.57 km^2 represents the largest exposed geological feature. This study demonstrated the applicability of medium-resolution satellite images to derive the coral reef information effectively and thus provided information for the related departments that are responsible to manage the coast.An improved resolution of multispectral bands with the panchromatic band in higher spatial resolution(15 m for OLI image) is expected to provide an optimum satellite based approach to map marine habitats. | DUAN Yuewei LIU Yongxue LI Manchun ZHOU Minxi YANG Yuhao | 2016 | Acta Oceanologica Sinica2016，35，10： | 5 |
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