|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic response assessment of RFA for HCC:Contrast-enhanced US,CT and MRI显示文摘Radiofrequency ablation(RFA)is commonly applied for the treatment of hepatocellular carcinoma(HCC)because of the facile procedure,and the safety and effectiveness for the treatment of this type of tumor.On the other hand,it is believed that HCC cells should spread predominantly through the blood flow of the portal vein,which could lead to the formation of intrahepatic micrometastases.Therefore,monitoring tumor response after the treatment is quite important and accurate assessment of treatment response is critical to obtain the most favorable outcome after the RFA.Indeed,several reports suggested that even small HCCs of≤3 cm in diameter might carry intrahepatic micrometastases and/or microvascular invasion.From this point of view,for preventing local recurrences,RFA should be performed ablating a main tumor as well as its surrounding non-tumorous liver tissue where micrometastases and microvascular invasion might exist.Recent advancement of imaging modalities such as contrast-enhanced ultrasonic,computed tomography,and magnetic resonance imaging are playing an important role on assessing the therapeutic effects of RFA.The local recurrence rate tends to be low in HCC patients who were proven to have adequate ablation margin after RFA;namely,not only disappearance of vascular enhancement of main tumor,but also an adequate ablation margin.Therefore,contrast enhancement gives important findings for the diagnosis of recurrent HCCs on each imaging.However,hyperemia of non-tumorous liver surrounding the ablated lesion,which could be attributed to an inflammation after RFA,may well obscure the findings of local recurrence of HCCs after RFA.Therefore,we need to carefully address to these imaging findings given the fact that diagnostic difficulties of local recurrence of HCC.Here,we give an overview of the current status of the imaging assessment of HCC response to RFA. | Yasunori Minami Naoshi Nishida Masatoshi Kudo | 2014 | World Journal of Gastroenterology2014，20，15： | 26 |
| 2 | Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Long-term outcomes after removal of a self-expandable metal stent显示文摘AIM To assess the long-term outcomes of this procedure after removal of self-expandable metal stent(SEMS). The efficacy and safety of endoscopic ultrasoundguided gallbladder drainage(EUS-GBD) with SEMS were also assessed.METHODS Between January 2010 and April 2015, 12 patients with acute calculous cholecystitis, who were deemed unsuitable for cholecystectomy, underwent EUSGBD with a SEMS. EUS-GBD was performed under the guidance of EUS and fluoroscopy, by puncturing the gallbladder with a needle, inserting a guidewire, dilating the puncture hole, and placing a SEMS. TheSEMS was removed and/or replaced with a 7-Fr plastic pigtail stent after cholecystitis improved. The technical and clinical success rates, adverse event rate, and recurrence rate were all measured.RESULTS The rates of technical success, clinical success, and adverse events were 100%, 100%, and 0%, respectively. After cholecystitis improved, the SEMS was removed without replacement in eight patients, whereas it was replaced with a 7-Fr pigtail stent in four patients. Recurrence was seen in one patient(8.3%) who did not receive a replacement pigtail stent. The median follow-up period after EUS-GBD was 304 d(78-1492).CONCLUSION EUS-GBD with a SEMS is a possible alternative treatment for acute cholecystitis. Long-term outcomes after removal of the SEMS were excellent. Removal of the SEMS at 4-wk after SEMS placement and improvement of symptoms might avoid migration of the stent and recurrence of cholecystitis due to food impaction. | Ken Kamata Mamoru Takenaka Masayuki Kitano Shunsuke Omoto Takeshi Miyata Kosuke Minaga Kentaro Yamao Hajime Imai Toshiharu Sakurai Tomohiro Watanabe Naoshi Nishida Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，4： | 15 |
| 3 | Current status in remnant gastric cancer after distal gastrectomy显示文摘Remnant gastric cancer(RGC) and gastric stump cancer after distal gastrectomy(DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori(H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis. | Masaichi Ohira Takahiro Toyokawa Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Masakazu Yashiro Naoyoshi Onoda Kosei Hirakawa | 2016 | World Journal of Gastroenterology2016，22，8： | 15 |
| 4 | Antiviral therapy for chronic hepatitis B: Combination of nucleoside analogs and interferon显示文摘The ideal goal of chronic hepatitis B(CHB) treatment should be suppression of emergence of hepatocellular carcinoma through the disappearance of hepatitis B s antigen(HBs Ag) rather than the control of serum hepatitis B virus-DNA level. For this purpose, various types of combination therapies using nucleoside analogs(NAs) and interferon(IFN) have been conducted. The therapeutic effects of combination of two different kinds of agents are better than those of the monotherapy using NAs or IFN alone, probably because different pharmaceutical properties might act in a coordinated manner. Recently, combination therapies with NAs and IFN and sequential therapies with NAs administration followed by IFN therapy have been routinely employed. We previously reported that combination therapy using entecavir(ETV) and pegylated(PEG)-IFN showed antiviral effects in 71% of CHB patients; the effect of this combination was better than that using lamivudine(LAM) and PEG-IFN. This is partially explained by the better antiviral effects of ETV than those of LAM. In our analysis, the cohort of CHB consisted of the patients who showed a flare-up of hepatitis before antiviral therapy, and their baseline HBs Ag levels were relatively low. Therefore, in addition to the combination of the agents, the appropriate selection of patients is critical to achieve a good viral response. | Satoru Hagiwara Naoshi Nishida Masatoshi Kudo | 2015 | World Journal of Hepatology2015，7，23： | 11 |
| 5 | 高强度管线钢及其焊管的性能研究显示文摘目前X80级管线钢管已在大口径输送管线中得到应用,使得对进一步提高管线钢强度(X100~X120级)的需求也更迫切了.使用高强度管线钢目的是拟通过提高管道的输送压力来提高其输送效率和降低铺设管线费用.为将这两点期望变为现实,高强度管线钢管及其焊接热影响区(HAZ)应具备良好的低温韧性和现场焊接(环焊)性能,所以,必须综合应用合理的合金成分设计,超纯净冶炼,控轧、控冷(TMCP)等工艺,改善焊接热影响区工艺等多方面的技术和措施,以得到同时具备高强度、良好的低温韧性和现场焊接性能的管线钢. | Naoshi Ayukawa Yoshio Terada Takuya Hara Hitoshi Asahi | 2005 | 焊管2005，28，2： | 8 |
| 6 | Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma显示文摘AIM: To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography(CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma.METHODS: All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled.In the primary analysis, patients with successful EUSfine needle aspiration(FNA) were included. The lymph nodes were assessed by several standard EUS variables(short and long axis lengths, shape, edge characteristic and echogenicity), color Doppler EUS variable [central intranodal blood vessel(CIV) presence] and CH-EUS variable(heterogeneous/homogeneous enhancement patterns). The diagnostic accuracy relative to EUSFNA was calculated. In the second analysis, N-stage diagnostic accuracy of CH-EUS was compared with EUS-FNA in patients who underwent surgical resection.RESULTS: One hundred and nine patients(143 lymph nodes) fulfilled the criteria. The short axis cutoff ≥ 13 mm predicted malignancy with a sensitivity and specificity of 72% and 85%, respectively. These values were 72% and 63% for the long axis cut-off ≥ 20 mm, 62% and 75% for the round shape variable, 81% and 30% for the sharp edge variable, 66% and 61% for the hypoechogenicity variable, 70% and 72% for the CIV-absent variable, and 83% and 91% for the heterogeneous CH-EUS-enhancement variable, respectively. CH-EUS was more accurate than standard and color Doppler EUS, except the short axis cut-off. Notably, three patients excluded because of EUS-FNA failure were correctly N-staged by CH-EUS.CONCLUSION: CH-EUS complements standard and color Doppler EUS and EUS-FNA for assessment of lymph node metastases. | Takeshi Miyata Masayuki Kitano Shunsuke Omoto Kumpei Kadosaka Ken Kamata Hajime Imai Hiroki Sakamoto Naoshi Nisida Yogesh Harwani Takamichi Murakami Yoshifumi Takeyama Yasutaka Chiba Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 7 | 冷鲜猪肉的三维荧光光谱特征研究显示文摘利用三维荧光光谱技术,研究了冷鲜猪肉三维荧光光谱特征,主要探讨了不同温度存储条件下冷鲜猪肉荧光峰的位置和荧光峰所处区域内荧光强度平均值随存储时间变化的规律,并初步判断了荧光物质的种类,为实现基于三维荧光光谱技术快速、无损检测冷鲜猪肉新鲜度奠定了理论基础。实验结果表明,不同温度存储条件下样本的三维荧光光谱图中均含有2个明显的荧光峰(Peak A和Peak B),它们所在位置的激发波长(λ_(ex))/发射波长(λ_(em))范围分别为:λ_(ex)/λ_(em)约为250~310nm/300~400nm和约为300~450nm/400~550nm。其中,Peak A为类蛋白荧光,Peak B为脂质氧化产物荧光。此外,实验还发现,两个荧光峰在各自所处区域内荧光强度的平均值随存储时间变化的趋势不受存储温度影响,均是Peak A在λ_(ex)/λ_(em)=250~310nm/300~400nm区域内荧光强度的平均值(IA)逐渐下降,Peak B在λ_(ex)/λ_(em)=300~450nm/400~550nm区域内荧光强度的平均值(IB)逐渐上升。但I_A和I_B的变化速率受存储温度影响,冷藏条件下比室温条件下变化慢。 | 任梦佳 丁城桥 Naoshi Kondo 吴华林 崔笛 | 2018 | 光谱学与光谱分析2018，38，11： | 4 |
| 8 | Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection显示文摘BACKGROUND Risk factors for local recurrence after polypectomy, endoscopic mucosal resection(EMR), and endoscopic submucosal dissection(ESD) have not been identified.Additionally, the appropriate interval for endoscopic surveillance of colorectal tumors at high-risk of local recurrence has not been established.AIM To clarify the clinicopathological characteristics of recurrent lesions after endoscopic colorectal tumor resection and determine the appropriate interval.METHODS Three hundred and sixty patients(1412 colorectal tumors) who underwent polypectomy, EMR, or ESD and received endoscopic surveillance subsequently for more than one year to detect local recurrence were enrolled in this study. The clinicopathological factors associated with local recurrence were determined via univariate and multivariate analyses.RESULTS Local recurrence was observed in 31 of 360(8.6%) patients [31 of 1412(2.2%)lesions] after colorectal tumor resection. Piecemeal resection, tumor size of more than 2 cm, and the presence of villous components were associated with colorectal tumor recurrence after endoscopic resection. Of these three factors, the piecemeal resection procedure was identified as an independent risk factor for recurrence. Colorectal tumors resected into more than five pieces were associated with a high risk of recurrence since the average period from resection torecurrence in these cases was approximately 3 mo. The period to recurrence in cases resected into more than 5 pieces was much shorter than that in those resected into less than 4 pieces(3.8 ± 1.9 mo vs 7.9 ± 5.0 mo, P < 0.05).CONCLUSION Local recurrence of endoscopically treated colorectal tumors depends upon the outcome of first endoscopic procedure. Piecemeal resection was the only significant risk factor associated with local recurrence after endoscopic resection. | Yoriaki Komeda Tomohiro Watanabe Toshiharu Sakurai Masashi Kono Kazuki Okamoto Tomoyuki Nagai Mamoru Takenaka Satoru Hagiwara Shigenaga Matsui Naoshi Nishida Naoko Tsuji Hiroshi Kashida Masatoshi Kudo | 2019 | World Journal of Gastroenterology2019，25，12： | 4 |
| 9 | Wind characteristics of a strong typhoon显示文摘 | Shuyang Cao Yukio Tamura Naoshi Kikuchi Mamoru Saito Ikuo Nakayama Yutaka Matsuzaki | 2008 | Journal of Wind Engineering & Industrial Aerodynamics2008，，1： | 3 |
| 10 | Clinical implications of the dual blockade of the PD-1/PD-L1 and vascular endothelial growth factor axes in the treatment of hepatocellular carcinoma显示文摘Currently,liver cancer is the fourth most common cause of cancer mortality worldwide.The overwhelming majority of liver cancers are hepatocellular carcinomas(HCC),developing on the background of chronic liver diseases,including chronic hepatitis B,chronic hepatitis C,and non-alcoholic steatohepatitis(1).Despite the recent progress in the treatment of HCC,it remains largely refractory,with a high recurrence rate even after therapeutic intervention(2).Numerous agents,including tyrosine-kinase inhibitors(TKIs),antibodies blocking the vascular endothelial growth factor(VEGF)/VEGF receptor(VEGFR)axis,and immune checkpoint inhibitors,are now available for the treatment of advanced stage HCC(3).However,their antitumor responses are still unsatisfactory. | Naoshi Nishida | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 3 |
| 11 | Basic constitution of a robot for agricultural use 显示文摘 | Naoshi Kondo Mitsuji Monta Tateshi Fujiura | 1996 | Advanced Robotics1996，10，4： | 2 |
| 12 | Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy显示文摘 | Akiko Miki Naoshi Kondo Suiho Yanagisawa Hiroaki Bessho Shigeru Honda Akira Negi | 2013 | Ophthalmology2013，，： | 2 |
| 13 | Vitamin D receptor expression is associated with colon cancer in ulcerativecolitis显示文摘 | Koji Wada Hiroaki Tanaka Kiyoshi Maeda Toru Inoue Eiji Noda Ryosuke Amano Naoshi Kubo Kazuya Muguruma Nobuya Yamada Masakazu Yashiro Tetsuji Sawada Bunzo Nakata Masaichi Ohira Kosei Hirakawa | 2009 | Oncology Reports2009，，5： | 2 |
| 14 | Large-scale Modeling of Carbon-nanotube Composites by a Fast Multipole Boundary Element Method显示文摘 | Yijun Liu Naoshi Nishimura Yoshihiro Otani | 2005 | Computational Materials Science2005，34，2： | 1 |
| 15 | Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease显示文摘 | Teiko Kimpara A. Takeda Koichi Watanabe Yasuto Itoyama Shuntaro Ikawa Minro Watanabe Hiroyuki Arai Hidetada Sasaki Susumu Higuchi Naoshi Okita Sadao Takase Hiroshi Saito Kazuhiro Takahashi Shigeki Shibahara | 1997 | Human Genetics1997，，1： | 1 |
| 16 | Wind characteristic of a strong typhoon 显示文摘 | CAO S Y TAMURA YUKIO KIKUCHI NAOSHI | 2009 | Journal of Wind Engineering and Industrial Aerodynamics2009，97，1： | 1 |
| 17 | Implications of p53 protein expression in experimental spinal cord injury 显示文摘 | Naoshi S Teiji Y Takako W | 2000 | Neurotrauma2000，17，2： | 1 |
| 18 | Flame-extinguishing concentrations and peak concentrations of N2, Ar, CO2 and their mixtures for hydrocarbon fuels显示文摘 | Saito Naoshi Ogawa Yoshio Saso Yuko | 1996 | Fire Safety Journal1996，27，： | 1 |
| 19 | Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma显示文摘 | Tadaaki Arizumi Kazuomi Ueshima Haruhiko Takeda Yukio Osaki Masahiro Takita Tatsuo Inoue Satoshi Kitai Norihisa Yada Satoru Hagiwara Yasunori Minami Toshiharu Sakurai Naoshi Nishida Masatoshi Kudo | 2014 | Journal of Gastroenterology2014，，12： | 1 |
| 20 | Machine vision based quality evaluation of Iyokan orange fruit using neural networks显示文摘 | Naoshi Kondo Usman Ahmad Mitsuji Monta | 2000 | Computers and Electronics in Agriculture2000，29，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员