|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diet,ageing and genetic factors in the pathogenesis of diverticular disease显示文摘Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK.This high prevalence ranks it as one of the most common bowel disorders in western nations.The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum.Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality.In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber.In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development.We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal.We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease. | Daniel Martin Commane Ramesh Pulendran Arasaradnam Sarah Mills John Cummings Mathers Mike Bradburn | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 2 | The Early-Middle Pleistocene Transition: characterization and proposed guide for the defining boundary显示文摘 | Martin J. Head Brad Pillans Sarah A. Farquhar | 2008 | Episodes2008，31，2： | 5 |
| 3 | Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography显示文摘Background:To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities(IRMAs)in response to anti-vascular endothelial growth factor(anti-VEGF)treatment,documented by optical coherence tomography angiography(OCTA)in diabetic eyes.Methods:In this retrospective study,IRMAs were evaluated with multimodal imaging(fundus photography,fluorescein angiography,OCTA)in treatment-naïve diabetic eyes before and after anti-VEGF treatment for diabetic macular edema(DME)and/or proliferative diabetic retinopathy(PDR)and compared to diabetic control eyes with similar diabetic retinopathy(DR)severity that did not receive anti-VEGF therapy.The morphological characteristics of IRMAs on enface OCTA imaging were graded by masked readers at baseline,then after anti-VEGF therapy in treated eyes or after observation in control eyes.Characterization of interval changes in an IRMA were based on the following parameters:branching,vessel caliber and area of adjacent capillary non-perfusion.Results:The treated group included 45 IRMA foci from 15 eyes of 11 patients,while the control group included 27 IRMA foci from 15 eyes of 14 patients.Following anti-VEGF treatment,enface OCTA demonstrated that 14 foci of IRMA(31%)demonstrated regression with normalization of appearance of the capillary bed,20 IRMAs(44%)remained unchanged,six IRMAs(13%)progressed with enlargement or development of new IRMAs and five IRMAs(11%)demonstrated complete obliteration defined as IRMA disappearance with advancing capillary drop-out.In the control group,17 IRMA(63%)remained stable,8 IRMAs(29.6%)progressed and 2 experienced total obliteration(7.4%).The difference in rank order between the two groups was statistically significant(p=0.022).Conclusions:In eyes with DR status post anti-VEGF therapy,foci of IRMAs have a variable course demonstrating one of four possible outcomes:regression,stabilit,progression or complete obliteration.In contrast,none of the untreated control diabetic eyes demonstrated regression of IRMAs,consistent with known progression of DR severity in high risk eyes.Morphologic evaluation of IRMAs with OCTA may help to monitor changes in retinal blood flow as well as the response to anti-VEGF treatment. | Osama A.Sorour Nihaal Mehta Caroline R.Baumal Akihiro Ishibazawa Keke Liu Eleni K.Konstantinou Sarah Martin Phillip Braun A.Yasin Alibhai Malvika Arya Andre J.Witkin Jay S.Duker Nadia K.Waheed | 2020 | Eye and Vision2020，7，1： | 4 |
| 4 | The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression显示文摘 | Thomas Derrien Rory Johnson Giovanni Bussotti Andrea Tanzer Sarah Djebali Hagen Tilgner Gregory Guernec David Martin Angelika Merkel David G. Knowles Julien Lagarde Lavanya Veeravalli Xiaoan Ruan Yijun Ruan Timo Lassmann Piero Carninci James B. Brown Leon | 2012 | Genome Research2012，，9： | 3 |
| 5 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 6 | PSMA配体的前列腺癌PET显像显示文摘近年来,用68Ga和18F标记PET显像剂靶向前列腺特异膜抗原(PSMA)逐渐受到重视。多项回顾性研究指出,与常规影像相比,PSMA配体前列腺癌PET/CT显像具有较高的检测效能,前列腺癌生化复发已被世界多个地区确立为PSMA配体前列腺癌PET/CT显像的临床适应证。对于高危原发前列腺癌,越来越多的证据表明该显像方式有助于探测隐匿性淋巴结和前列腺癌骨转移;对于原发和复发性前列腺癌的临床适应证,初步研究证实其对临床管理有着重要影响;另有证据表明,其对前列腺内的肿瘤定位、治疗分期和特定临床情况下的晚期病灶治疗监测将成为未来的适应证。随着有关生理性和病理性摄取模式和误区文献数量的剧增,PSMA配体PET显像报告的标准也在不断改进。文章旨在对PSMA配体PET显像的现状进行概述,包括显像程序和解释、临床适应证、诊断潜力及其对治疗计划的影响。 | 黎翔(译) 杨卫东(译) 汪静(审校) Sarah M.Schwarzenboeck Isabel Rauseher Christina Bluemel Wolfgang P.Fendler Steven P. Rowe Martin G.Pomper Ali Asfhar-Oromieh Ken Herrrnann Matthias Eiber | 2019 | 中华核医学与分子影像杂志2019，39，2： | 3 |
| 7 | Impact of postoperative intravenous fluid administration on complications following elective hepato-pancreato-biliary surgery显示文摘Background: The impact of perioperative intravenous fluid administration on surgical outcomes has been documented in literature, but not specifically studied in the context of hepato-pancreato-biliary(HPB) surgery. This study aimed to investigate the impact of postoperative intravenous fluid administration on intensive care unit(ICU), in this subgroup of patients. Methods: A single-center retrospective cohort of 241 HPB patients was assessed, focusing on intravenous fluid administration in ICU, during the first 24 h. Intravenous fluid variables were compared to hospital stay and postoperative complications. Data were assessed using Spearman's correlation test for bivariate correlations and logistic regression for multivariate analysis. Results: The median volume of intravenous fluid administered in the first 24 h postoperatively was 4380 mL, of which 2200 mL was crystalloid, 1500 mL colloid and 680 mL 'other' fluid. Patients with one or more complications had a higher median total intravenous fluid input(4790 vs. 4300 mL), higher colloid volume(20 0 0 vs. 150 0 mL), lower urine output(1595 vs. 1900 mL) and greater overall fluid balance( + 3040 vs. + 2553 mL) than those without complications. There were correlations between total intravenous fluid volume administered( r = 0.278, P < 0.001), intravenous colloid input( r = 0.278, P < 0.001), urine output( r =-0.295, P < 0.001), positive fluid balance( r = 0.344, P < 0.001) and length of hospital stay. Logistic regression model was constructed to predict the occurrence of one or more complications; total intravenous fluid volume and overall fluid balance were both independent significant predictors(OR = 2.463, P = 0.007; OR = 1.001, P = 0.011; respectively). Conclusions: Administration of high volumes of intravenous fluids in the first 24 hours post-HPB surgery, along with higher positive fluid balance is associated with a higher rate of complications and longer hospital stay. Moreover, lower urine output is associated with longer hospital stay. Whether these are the cause of complications or the result of them remains unclear. | Daniel Martin Panagis M.Lykoudis Gabriel Jones David Highton Alan Shaw Sarah James Qiang Wei Giuseppe Fusai | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，5： | 2 |
| 8 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 9 | Role of the vagus nerve on the development of postoperative ileus显示文摘 | Zhirong Gao Mario H. Müller Martina Karpitschka Sarah Mittler Michael S. Kasparek Bernhard Renz Andrej Sibaev J?rg Glatzle Yongyu Li Martin E. Kreis | 2010 | Langenbeck’s Archives of Surgery2010，，4： | 1 |
| 10 | Historical prevalence and distribution of avian influenza virus A (H7N9) among wild birds 显示文摘 | Sarah H Olson Martin Gilbert | 2013 | Emerg Infect Dis2013，19，12： | 1 |
| 11 | Emotion regulation as a scientific construct: metho-dological challenges and directions for child development research显示文摘 | Pamela M Sarah E Martin T A | 2004 | Child Development2004，75，2： | 1 |
| 12 | The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression显示文摘 | Thomas Derrien Rory Johnson Giovanni Bussotti Andrea Tanzer Sarah Djebali Hagen Tilgner Gregory Guernec David Martin Angelika Merkel David G. Knowles Julien Lagarde Lavanya Veeravalli Xiaoan Ruan Yijun Ruan Timo Lassmann Piero Carninci James B. Brown Leon | 2012 | Genome Research2012，，9： | 1 |
| 13 | A Versatile Gene-Based Test for Genome-wide Association Studies显示文摘 | Jimmy Z. Liu Allan F. Mcrae Dale R. Nyholt Sarah E. Medland Naomi R. Wray Kevin M. Brown Nicholas K. Hayward Grant W. Montgomery Peter M. Visscher Nicholas G. Martin Stuart Macgregor | 2010 | The American Journal of Human Genetics2010，，1： | 1 |
| 14 | Simulating the Impact of Oxygen Enrichment in a CementRotary Kiln Using Advanced Computational Methods显示文摘 | Ovidiu Martin Olivier Charon Jacques Dugue Sarah Dukhan Wei Zhou | 2001 | Combustion Science and Technolo- gy2001，164，： | 1 |
| 15 | A Versatile Gene-Based Test for Genome-wide Association Studies显示文摘 | Jimmy Z. Liu Allan F. Mcrae Dale R. Nyholt Sarah E. Medland Naomi R. Wray Kevin M. Brown Nicholas K. Hayward Grant W. Montgomery Peter M. Visscher Nicholas G. Martin Stuart Macgregor | 2010 | The American Journal of Human Genetics2010，，1： | 1 |
| 16 | Enhanced Detection of Thromboemboli With the Use of Targeted Microbubbles显示文摘 | Matthew J. Martin Emma M.L. Chung Alison H. Goodall Alberto Della Martina Kumar V. Ramnarine Lingke Fan Sarah V. Hainsworth A Ross Naylor David H. Evans | 2007 | Stroke2007，，10： | 1 |
| 17 | Survival following HIV infection of a cohort followed up from seroconversion in the UK显示文摘 | Fiona M Ewings Krishnan Bhaskaran Ken McLean David Hawkins Martin Fisher Sarah Fidler Richard Gilson Demelza Nock Ray Brettle Margaret Johnson Andrew Phillips Kholoud Porter | 2008 | AIDS2008，，1： | 1 |
| 18 | BDNF gene effects on brain circuitry replicated in 455 twins显示文摘 | Ming-Chang Chiang Marina Barysheva Arthur W. Toga Sarah E. Medland Narelle K. Hansell Michael R. James Katie L. McMahon Greig I. de Zubicaray Nicholas G. Martin Margaret J. Wright Paul M. Thompson | 2010 | Neuroimage2010，，2： | 1 |
| 19 | Diffusion imaging quality control via entropy of principal direction distribution显示文摘 | Mahshid Farzinfar Ipek Oguz Rachel G. Smith Audrey R. Verde Cheryl Dietrich Aditya Gupta Maria L. Escolar Joseph Piven Sonia Pujol Clement Vachet Sylvain Gouttard Guido Gerig Stephen Dager Robert C. McKinstry Sarah Paterson Alan C. Evans Martin A. Styner | 2013 | Neuroimage2013，，： | 1 |
| 20 | Effect of anionic hydration on counterion incorporation in poly(3,4-ethylenedioxythiophene): An X-ray photoelectron spectroscopy study显示文摘 | Sarah Spanninga David Martin Zhen Chen | 2010 | Journal of Physical Chemistry B2010，114，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员