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| 1 | Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy显示文摘 | Ruben JD Dally M Bailey M Smith R McLean CA Fedele P | 2006 | 中国神经肿瘤杂志2006，4，3： | 15 |
| 2 | 地震正演模型应用(Ⅰ):用叠后地震正演模拟方法精确解释东河砂岩尖灭点(英文)显示文摘叠后正演模拟不仅能更好地解释平缓构造背景下的地震数据,而且有助于描述地震资料无法分辨的地质体。东河砂岩是塔里木盆地已知的储集层,横向展布不均匀,由于地震分辨率的限制,很难准确描述东河砂岩的空间展布。用叠后地震正演模拟方法研究东河砂岩尖灭点分布,发现合成地震振幅能量首先增强,然后衰减,其中还存在地层上拉和假倾角现象。这些特征有助于对东河砂岩尖灭点进行地震解释。 | Ben F Mclean 戴金星 罗平 | 2005 | 石油勘探与开发2005，32，5： | 9 |
| 3 | Smashing Tissue Extraction and GC Analysis of Active Fatty Acids from Oil Cake of Perilla Seeds显示文摘Objective To optimize the extraction technology of perilla seeds oil from the oil cake of perilla seeds(OCPS)by using the contents of active fatty acids as evaluation standard.Methods The fatty acids were extracted from OCPS,the residue of perilla seeds after cold-press,by smashing tissue extraction(STE),the new technology selected through comparing with classical leaching extraction(LE),Soxhlet extraction(SE),ultrasonic extraction(UE),and supercritical-CO2 fluid extraction(SFE).For optimized condition of STE,orthogonal test was designed and completed.The contents of five fatty acids in extracted oil and OCPS were determined by GC.Results The optimized extraction parameters were smashing for 1.5 min under extraction power of 150 W and 1:6 of the material/solvent ratio.The contents of five fatty acids in the oils extracted by five techniques from OCPS and determined by GC were as follows:α-linolenic acid(41.12%-51.81%),linoleic acid(15.38%-16.43%),oleic acid (18.93%-27.28%),stearic acid(2.56%-4.01%),and palmitic acid(7.38%-10.77%).Conclusion The results show that STE is the most efficient technology with the highest yield(LE:0.57%;SE:1.03%;UE:0.61%;SFE:0.80%;STE: 1.17%)and shortest time(LE:720 min;SE:360 min;UE:30 min;SFE:120 min;STE:1.5 min)among five tested extraction technologies.It is first reported using STE to extract herbal oil enriched with active fatty acids. | SUN Yan-ling1,LIU Yan-ze2,3,XIAO Han4,WEI Ying-feng4,ZHAO Yu-qing1,5 1.Shenyang Pharmaceutical University,Shenyang 110006,China 2.Bio-organic and Natural Product Laboratory,MRC 311,McLean Hospital/Harvard Medical School,Belmont,MA 02478,USA 3.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China 4.Liaoning Jiashi Nutritional Plant Oil Development Co.Ltd.,Shenyang 110035,China 5.Key Laboratory of Structure-Based Drug Design&Discovery,Shenyang Pharmaceutical University,Ministry of Education,Shenyang 110016,China | 2011 | Chinese Herbal Medicines2011，3，1： | 5 |
| 4 | Smashing Tissue Extraction and HPLC Determination of Paclitaxel and 10-Deacetylbaccatin from Taxus x media显示文摘Objective To optimize the extraction technology of Taxus x media by using the contents of Paclitaxel and 10-deacetylbaccatin(10-DAB) ,two representative active diterpene alkaloids of taxane type from T.x media,as evaluation standard.Methods The smashing tissue extraction(STE) of Paclitaxel and 10-DAB from T.x media,was investigated by comparing with ultrasonic extraction(UE) which was one of the modern technologies of extraction.Results STE was more efficient than UE,and the contents of 10-DAB and Paclitaxel in the extracts obtained by STE were higher than those by UE.Conclusion STE is a fast,high-performance,and energy-saving technology for the extraction of diterpene alkaloids of taxane type.STE also provides a simple,component-safe,workable,and highly efficient method for the extraction of active natural product. | LIU Yan-ze1,2,GAO Wen-qin3,WANG Ji-wen4,ZHANG Yu3,ZHAO Yu-qing4,5 1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China 2.Bio-Organic and Natural Product Laboratory,McLean Hospital/Harvard Medical School,MA 02478,USA 3.Shenyang Pharmaceutical University,Shenyang 110006,China 4.Shenyang Tianfeng Bioengineer Technology Co.,Ltd.,Shenyang 110015,China 5.Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China | 2011 | Chinese Herbal Medicines2011，3，3： | 4 |
| 5 | Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Jonathan C Craig Anthony S McLean | 2007 | The Lancet Infectious Diseases2007，，3： | 3 |
| 6 | Molecular isoform distribution and glycosylation of acetycholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease显示文摘 | Saez-Valero J Sberna G Mclean A | 1999 | Neurochem1999，72，4： | 2 |
| 7 | Embryo-mediated genome editing for accelerated genetic improvement of livestock显示文摘Selecting beneficial DNA variants is the main goal of animal breeding.However,this process is inherently inefficient because each animal only carries a fraction of all desirable variants.Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains.To realize rapid genetic gain,precise edits need to be introduced into genomicallyselected embryos,which minimizes the genetic lag.However,embryo-mediated precision editing by homology-directed repair(HDR)mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos.This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos.It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism,enable multiplex editing and multiply rare elite genotypes.Such a breeding strategy would enable a more targeted,accelerated approach for livestock improvement that allows stacking of beneficial variants,even including novel traits from outside the breeding population,in the most recent elite genetic background,essentially within a single generation. | Zachariah MCLEAN Björn OBACK Götz LAIBLE | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 2 |
| 8 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Barry J Shelp Alan W Bown Michael D McLean | 1999 | Trends in Plant Science1999，，11： | 2 |
| 9 | Evidence-Based Guidelines for Prevention of Perioperative Hypothermia显示文摘 | Shawn S. Forbes Cagla Eskicioglu Avery B. Nathens Darlene S. Fenech Claude Laflamme Richard F. McLean Robin S. McLeod | 2009 | Journal of the American College of Surgeons2009，，4： | 2 |
| 10 | Reciprocal connections between the amygdala and parabrachial nuclei:ultrastructural demonstration by degeneration and axonal transport of horseradish peroxidase in the cat 显示文摘 | Takeuchi Y McLean J H Hopkins D A | 1982 | Brain Res1982，239，： | 2 |
| 11 | Protein degradation pathways in Parkinson’s disease: curse or blessing显示文摘 | Darius Ebrahimi-Fakhari Lara Wahlster Pamela McLean | 2012 | Acta Neuropathologica2012，，2： | 2 |
| 12 | Use of Solid State Carbothermic Reduction in Production of Transition Metals and Their Carbides显示文摘Many transition metals are produced by pyrometallurgical procedures which require very considerable amounts of energy, commonly electrical. On the other hand, some transition metals are obtained by employing very complex hydrometallurgical process routes. Solid state carbothermic reduction offers an alternative route for the production of both the metals and their carbides for energy saving and process step elimination.
Consequently, it seemed worth to review the work carried out in this area The metals covered in this brief review are chromium, tungsten, titanium, manganese, niobium and molybdenum. Silicon is also mentioned although it is not a transition metal. | YANG Yin-dong SOMMERVILLE I D JOHNSTON R F McLEAN A | 2000 | Journal of Iron and Steel Research(International)2000，7，2： | 2 |
| 13 | 地震正演模型应用(Ⅱ):用地震正演叠前炮集记录模拟方法定量解释薄砂岩的各向异性(英文)显示文摘叠前地震正演模拟可以获得比叠后正演更多的有用信息,例如能够用于含有各向异性特征的精细速度建模的信息。塔里木盆地下石炭统存在砂泥岩互层,偶见石膏、砾岩和煤层。砂泥岩薄互层中的速度差异可能导致各向异性,但是利用常规的地震方法很难识别和定量描述各向异性。由叠前各向同性正演获得的炮集,证明砂泥岩中存在各向异性,通过迭代生成的理论合成炮集与实际原始炮集相对比,可以定量描述各向异性,结果证明在该区砂泥岩层存在5%的横向各向同性,其高速传播方向为水平面。 | Ben F Mclean 戴金星 姚蓬昌 | 2005 | 石油勘探与开发2005，32，6： | 2 |
| 14 | Effect of Carbon Properties on Melting Behavior of Mold Fluxes for Continuous Casting of Steels显示文摘During continuous casting of steel, the properties of mold fluxes strongly affect the casting performance, steel quality and environment of casting operation. The high temperature microscopy technique was used to investigate the melting behaviour of mold fluxes, and drip test method was used to determine their melting rate. The results showed that free carbon is a dominant factor in governing the melting behaviour of fluxes, and the melting rate is increased with increasing carbon reactivity and decreasing carbon content. | I. D. Sommerville A. McLean | 2006 | Journal of Iron and Steel Research(International)2006，13，2： | 2 |
| 15 | Adenoid cystic carcinoma of the head and neck显示文摘 | Shaheel Chummun N.R. McLean C.G. Kelly P.J.D.K. Dawes Sheila Fellows D. Meikle J.V. Soames | 2001 | British Journal of Plastic Surgery2001，，6： | 2 |
| 16 | P450 BM3:the very model of a modern flavocytochrome 显示文摘 | MUNRO A W LEYS D G MCLEAN K J | 2002 | Trends Biochem Sci2002，27，5： | 1 |
| 17 | An approach for measuring semantic similarity between words using multiple information sources 显示文摘 | LI YUHUA BANDAR Z McLEAN D | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，4： | 1 |
| 18 | Possible demographic consequences of HIV/AIDS显示文摘 | May R M Anderson R M McLean A R | 1988 | Math Biosci1988，90，： | 1 |
| 19 | A higher strength porcelain for crown and bridge work显示文摘 | Hughes TH | 1965 | Br Dent J1965，119，251： | 1 |
| 20 | Hoxa4 expression in developing mouse hair follicles and skin显示文摘 | Packer A I Jane-Wit D McLean L | 2000 | Mech Dev2000，99，： | 1 |
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