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| 1 | Future Directions in Formulaic Language Research显示文摘Research tends to go in cycles of innovation,consolidation and confirmation,then reflection.Formulaic language research seems currently to be moving into a reflective phase,offering considerable potential for new ideas feeding the next round of innovation.Research into formulaic language goes back 150 years at least,with several strands developing somewhat independently,including patterns in native language (including first language acquisition),language disorders and second language learning.My own work was an attempt to identify a single explanation that accounted for them all.New technologies now provide additional ways to explore and evaluate the evidence,most notably through corpus linguistics,and eye and brain activity monitoring.Five key claims,all with potential implications for L2 research and teaching,indicate the scope for future research:1.Although we talk of an 'idiomatic' nativelike way of speaking,in fact there is considerable variation in what is idiomatic:what should be taught? 2.The acquisition of idiomaticity is driven by the need to belong and survive:can this be replicated in the classroom? 3.Although formulaic language seems to reduce the speaker' s processing,the hearer' s processing may be the more important consideration:does 'accommodation' affect the learner's experience adversely? 4.Corpus linguistics forces a careful evaluation of the true role of frequency in idiomaticity:are materials writers beguiled by corpus data? 5.We cannot consider formulaic language patterns independently of knowing the purpose of the text in which they occur,including its genre:are L2 teaching materials broad enough?There are key opportunities for researchers in China to exploit aspects of the Chinese writing system and approach to education,to answer questions that cannot be easily answered in the west.Issues include the role of memorisation in language learning,the role of literacy in our perception of linguistic units,and the universality of patterns in acquired language disorders. | Alison Wray | 2009 | 外国语2009，32，6： | 16 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | Formulaic language in learners and native speakers显示文摘 | Alison Wray | 1999 | Language Teaching1999，，4： | 6 |
| 4 | ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis显示文摘Cancer metastasis is largely incurable and accounts for 90%of breast cancer deaths,especially for the aggressive basal-like or triple negative breast cancer(TNBC).Combining patient database analyses and functional studies,we examined the association of integrin family members with clinical outcomes as well as their connection with previously identified microRNA regulators of metastasis,such as miR-206 that inhibits stemness and metastasis of TNBC.Here we report that the integrin receptor CD49b-encoding ITGA2,a direct target of miR-206,promotes breast cancer stemness and metastasis.ITGA2 knockdown sup-pressed self-renewal related mammosphere formation and pluripotency marker expression,in-hibited cell cycling,compromised migration and invasion,and therefore decreased lung metastasis of breast cancer.ITGA2 overexpression reversed miR-206-caused cell cycle arrest in G1.RNA sequencing analyses revealed that ITGA2 knockdown inhibits genes related to cell cycle regulation and lipid metabolism,including CCND1 and ACLY as representative targets,respectively.Knockdown of CCND1 or ACLY inhibits mammosphere formation of breast cancer cells.Overexpression of CCND1 rescues the phenotype of ITGA2 knockdown-induced cell cycle arrest.ACLY-encoded ATP citrate lyase is essential to maintain cellular acetyl-CoA levels.CCND1 knockdown further mimics 1TGA2 knodkdown in abolishing lung colonization of breast cancer cells.We identified that the low levels of miR-206 as well as high expression levels of 1TGA2,ACLY and CCND1 are associated with an unf avor able relapse-free survival of the pa-tients with estrogen receptor-negative or high grade breast cancer,especially basal-like or TNBC,possibly serving as potential biomarkers of cancer stemness and thera peutic targets of breast cancer metastasis. | Valery Adorno-Cruz Andrew D.Hoffmann Xia Liu Nurmaa K.Dashzeveg Rokana Taftaf Brian Wray Ruth A.Keri Huiping Liu | 2021 | Genes & Diseases2021，8，4： | 4 |
| 5 | PACAP对豚鼠离体胆囊平滑肌的作用显示文摘目的探讨 VIP 族神经肽PACAP 对胆囊运动的影响。方法将豚鼠胆囊制备成1.2mm×10mm 的平滑肌条标本4条,固定在组织浴槽中,并连接等张换能器。以 pH7.4的 Krebs-Ringer缓冲液灌流,温度37℃,并通与95% O_2和5% CO_2。胆囊条对神经肽的效应,用ACh 作标准化处理。结果 VIP 对胆囊条有浓度依赖性的舒张作用;PACAP 则呈现出浓度依赖性收缩反应,PACAP38的作用弱于 PACAP27。结论 PACAP 和 VIP 在对离体胆囊运动的作用方面,呈相反的效应。 | 魏睦新 Satoru Naruse 尾崎毅 轩原清史 安藤英治 Victor Wray | 1996 | 新消化病学杂志1996，4，5： | 3 |
| 6 | 减重手术前后的营养风险和不足:最佳饮食管理建议显示文摘本文旨在总结最新文献中的主要观点,以帮助中国减肥外科医生及其团队对患者进行最佳的营养管理。越来越多的证据表明在患者在减重手术前后如果没有经过合理的治疗,将存在营养缺乏的风险。本文将重点关注最普遍和最严重的营养缺乏后果。为避免限制性饮食相关并发症和体质量大幅度变化的发生,除术后营养随访外,手术前的营养检查也非常有必要^([1])。提倡术前提供饮食咨询,以解决术前的营养缺乏问题;适当使用术前极低卡路里饮食(VLCD)模式;术后饮食方案和适当的营养素补充也是非常重要的。确保患者了解并接受术后限制性饮食改变和改变生活方式对于手术的长期成功至关重要。此外,长期饮食的随访可以监测患者的饮食依从性,避免极端的营养缺乏。结论除了坚持终身营养补充方案外,减重手术前后的营养筛查和长期营养随访对于术后取得并维持良好效果至关重要。 | Amanda Wray Rachel Davis Nicholas Wray 关炳生(翻译) 庄景燊(翻译) 王存川(审校) 张鹏(审校) | 2018 | 中华肥胖与代谢病电子杂志2018，4，4： | 3 |
| 7 | Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction显示文摘 | Manal M. Hassan Ahmed Kaseb Carol J. Etzel Hashem El‐Serag Margaret R. Spitz Ping Chang Katherine S. Hale Mei Liu Asif Rashid Mohamed Shama James L. Abbruzzese Evelyne M. Loyer Harmeet Kaur Hesham M. Hassabo Jean‐Nicolas Vauthey Curtis J. Wray Basmah S. H | 2013 | Mol Carcinog2013，，1： | 2 |
| 8 | The functions of formulaic language: an integrated model显示文摘 | Alison Wray Michael R. Perkins | 1999 | Language and Communication1999，，1： | 2 |
| 9 | A formulaic approach to translation at the post office: reading the signs显示文摘 | Alison Wray Stephen Cox Mike Lincoln Judy Tryggvason | 2003 | Language and Communication2003，，1： | 2 |
| 10 | Formulaic sequences in second language teaching: principle and practice显示文摘 | A Wray | 2000 | Applied Linguistics2000，，： | 2 |
| 11 | Possible key residues that determine left gastric artery blood flow response to PACAP in dogs显示文摘AIM:To determine the effect of pituitary adenylate cy-clase-activating polypeptide (PACAP) on left gastric artery (LGA) flow and to unveil the structural or functional important sites that may be critical for discrimination of different receptor subtypes. METHODS: Peptides, including PACAP-27, PACAP-38, amino acid substituted PACAP-27 and C-terminus truncated analogues PACAP (27-38), were synthesized by a simultaneous multiple solid-phase peptide synthesizer. Flow probes of an ultrasound transit-time blood flowmeter were placed around the LGA of beagle dogs. Whenpeptides were infused intravenously, the blood flow was measured.RESULTS: [Ala4, Val5]-PACAP-27 caused a concentration-dependent vasodepressor action which was similar to that caused by PACAP-27. The LGA blood flow response to [Ala4, Val5]-PACAP-27 was significantly higher than that to PACAP-27, which was similar to that to vasoactive intestinal polypeptide (VIP) at the same dose. [Ala6]-PACAP-27 did not increase the peak LGA ? ow. [Gly8]-PACAP-27 showed a similar activity to VIP. [Asn24, Ser25, Ile26]-PACAP-27 did not change the activity of peptides at all doses. CONCLUSION: NH2 terminus is more important to biological activity of peptides and specifi c receptor recognition than COOH-terminus. | Mu-Xin Wei Ping Hu Ping Wang Satoru Naruse Kiyoshi Nokihara Victor Wray Tsuyoshi Ozaki | 2010 | World Journal of Gastroenterology2010，16，38： | 2 |
| 12 | Surgery for Pancreatic Cancer: Recent Controversies and Current Practice显示文摘 | Curtis J. Wray Syed A. Ahmad Jeffrey B. Matthews Andrew M. Lowy | 2005 | Gastroenterology2005，，6： | 2 |
| 13 | Catabolic response to stress and potential benefits of nutrition support显示文摘 | WRAY CJ JOSHUA MV HASSELGREN P | 2002 | Nutrifion2002，18，： | 1 |
| 14 | Formulaic sequences in second language teaching: Princi- ple and practice 显示文摘 | Wray A | 2000 | Applied Linguistics2000，，4： | 1 |
| 15 | Higher quality of life in living donor kidney transplantation:prospective cohort study 显示文摘 | Lumsdaine JA Wray A Power MJ | 2005 | Transplant International2005，18，8： | 1 |
| 16 | Quinidine syncope, paroxysmal ventricu- lar fibrillation occurring during tretment of chronic atrial ar- rhythmias显示文摘 | Selzer A Wray HW | 1964 | Circulation1964，30，： | 1 |
| 17 | Pediatric craniopharyngio mas:elassifieation and treatment according to the degree of lay pothalamic involvement显示文摘 | Puget S Garnett M Wray A | 2007 | J Neurosurg2007，106，1： | 1 |
| 18 | A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs显示文摘 | Lindsay S. Wray Jelena Rnjak-Kovacina Biman B. Mandal Daniel F. Schmidt Eun Seok Gil David L. Kaplan | 2012 | Biomaterials2012，，36： | 1 |
| 19 | Positional effects of the knee and ankle on the ends of acute Achilles tendon ruptures显示文摘 | Wray WH 3rd Pegan C Patel S | 2009 | Foot Ankle Spec2009，2，5： | 1 |
| 20 | Patron-focused services in three US libraries: collaborative interlibrary loan, collection development and acquisitions显示文摘 | Megan Allen Suzanne M Ward Tanner Wray | 2003 | Interlending & Document Supply2003，31，2： | 1 |
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