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| 1 | Elite interlocks in three US sectors:Nonprofit corporate and government显示文摘 | Gwen Moore Sarah Sobieraj J Allen Whitt Olga Mayorova and Daniel Beaulieu | | 0,,03: | 1 |
| 2 | Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA Affects Developmental Timing and Patterning in Arabidopsis显示文摘 | Noah Fahlgren Taiowa A. Montgomery Miya D. Howell Edwards Allen Sarah K. Dvorak Amanda L. Alexander James C. Carrington | 2006 | Current Biology2006,,9: | 1 |
| 3 | Mass size distributions and size resolved chemical composition of fine particulate matter at the Pittsburgh supersite显示文摘 | Juan C. Cabada Sarah Rees Satoshi Takahama Andrey Khlystov Spyros N. Pandis Cliff I. Davidson Allen L. Robinson | 2004 | Atmospheric Environment2004,,20: | 1 |
| 4 | Elite interlocks in three US sectors: Nonprofit, corporate and government显示文摘 | Gwen Moore Sarah Sobieraj J Allen Whitt Olga Mayorova and Daniel Beaulieu | 2002 | Social Science Quarterly2002,83,3: | 1 |
| 5 | Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo- p -dioxin显示文摘 | Sarah Hicks Allgeier Chad M. Vezina Tien-Min Lin Robert W. Moore Allen E. Silverstone Motoko Mukai Jerrie Gavalchin Paul S. Cooke Richard E. Peterson | 2009 | Toxicology and Applied Pharmacology2009,,1: | 1 |
| 6 | Determination of the eutectic structure in the Ag-Cu-Sn system 显示文摘 | Sarah Allen Michael Notis | 2002 | Electron Mater2002,31,2: | 1 |
| 7 | Determination of the eutectic structure in the Ag-Cu-Sn system显示文摘 | Daniel Lewis Sarah Allen Michael Notis Adam Scotch | 2002 | Journal of Electronic Materials2002,,2: | 1 |
| 8 | Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA Affects Developmental Timing and Patterning in Arabidopsis显示文摘 | Noah Fahlgren Taiowa A. Montgomery Miya D. Howell Edwards Allen Sarah K. Dvorak Amanda L. Alexander James C. Carrington | 2006 | Current Biology2006,,9: | 1 |
| 9 | Sustained Benefits from Ranibizumab for Macular Edema Following Branch Retinal Vein Occlusion: 12-Month Outcomes of a Phase III Study显示文摘 | David M. Brown Peter A. Campochiaro Robert B. Bhisitkul Allen C. Ho Sarah Gray Namrata Saroj Anthony P. Adamis Roman G. Rubio Wendy Yee Murahashi | 2011 | Ophthalmology2011,,8: | 1 |
| 10 | Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients显示文摘 | Adam S. Greenstein Kaivan Khavandi Sarah B. Withers Kazuhiko Sonoyama Olivia Clancy Maria Jeziorska Ian Laing Allen P. Yates Philip W. Pemberton Rayaz A. Malik Anthony M. Heagerty | 2009 | Circulation2009,,12: | 1 |
| 11 | Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42显示文摘AIM:To understand the interaction of human IQGAP1 and CDC42,especially the effects of phosphorylation and a cancer-associated mutation. METHODS:Recombinant CDC42 and a novel C-termi- nal fragment of IQGAP1 were expressed in,and puri- fied from,Escherichia coli.Site directed mutagenesis was used to create coding sequences for three phos- phomimicking variants(S1441E,S1443D and S1441E/ S1443D)and to recapitulate a cancer-associated mu- tation(M1231I).These variant proteins were also ex- pressed and purified.Protein-protein crosslinking using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide was used to investigate interactions between the C-terminal fragment and CDC42.These interactions were quanti- fied using surface plasmon resonance measurements.Molecular modelling was employed to make predictions about changes to the structure and flexibility of the protein which occur in the cancer-associated variant. RESULTS:The novel,C-terminal region of human IQGAP1 (residues 877-1558)is soluble following expression and purification.It is also capable of binding to CDC42,as judged by crosslinking experiments.Interaction appears to be strongest in the presence of added GTP.The three phosphomimicking mutants had different affini- ties for CDC42.S1441E had an approximately 200-fold reduction in affinity compared to wild type.This was caused largely by a dramatic reduction in the associa- tion rate constant.In contrast,both S1443D and the double variant S1441E/S1443D had similar affinities to the wild type.The cancer-associated variant,M1231I, also had a similar affinity to wild type.However,in the case of this variant,both the association and dis- sociation rate constants were reduced approximately 10-fold.Molecular modelling of the M1231I variant, based on the published crystal structure of part of the C-terminal region,revealed no gross structural changes compared to wild type(root mean square deviation of 0.564over 5556 equivalent atoms).However,pre- dictions of the flexibility of the polypeptide backbone suggested that some regions of the variant protein had greatly increased rigidity compared to wild type.One such region is a loop linking the proposed CDC42 bind- ing site with the helix containing the altered residue.It is suggested that this increase in rigidity is responsible for the observed changes in association and dissocia- tion rate constants. CONCLUSION:The consequences of introducing nega- tive charge at Ser-1441 or Ser-1443 in IQGAP1 are dif- ferent.The cancer-associated variant M1231I exerts its effects partly by rigidifying the protein. | Sarah F Elliott George Allen David J Timson | 2012 | World Journal of Biological Chemistry2012,3,3: | 1 |
| 12 | Dispositional variables and work–family conflict: A meta-analysis显示文摘 | Tammy D. Allen Ryan C. Johnson Kristin N. Saboe Eunae Cho Soner Dumani Sarah Evans | 2011 | Journal of Vocational Behavior2011,,1: | 1 |
| 13 | Effect of butyrolactone I on the producing fungus, Aspergillus terreus显示文摘 | TIMOTHY G SCHIMMEI ALLEN D COFFMAN SARAH J PARSONS | 1998 | Applied and Environmental Microbioligy1998,64,10: | 1 |
| 14 | IL-17RC:a partner in IL-17 signaling and beyond显示文摘 | Allen WH Sarah L | | 0,,01: | 1 |
| 15 | Oligonucleotide Microarray Analysis of Genomic Imbalance in Children with Mental Retardation显示文摘 | J.M. Friedman ágnes Baross Allen D. Delaney Adrian Ally Laura Arbour Jennifer Asano Dione K. Bailey Sarah Barber Patricia Birch Mabel Brown-John Manqiu Cao Susanna Chan David L. Charest Noushin Farnoud Nicole Fernandes Stephane Flibotte Anne Go William T. | 2006 | The American Journal of Human Genetics2006,,3: | 1 |
| 16 | Mass size distributions and size resolved chemical composition of fine particulate matter at the Pittsburgh super site 显示文摘 | Cabada Juan C Rees Sarah Takahama Satoshi Khlystov Andrey Pandisa Spyros N Davidson Cliff I Robinson Allen L | 2004 | Atmospheric Environment2004,38,: | 1 |
| 17 | The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study显示文摘 | Elisa De Franco Sarah E Flanagan Jayne AL Houghton Hana Lango Allen Deborah JG Mackay I Karen Temple Sian Ellard Andrew T Hattersley | 2015 | The Lancet . 2015 (9997)2015,,9997: | 1 |
| 18 | Adenomyosis and endometriosis in the California Teachers Study显示文摘 | Claire Templeman Sarah F. Marshall Giske Ursin Pamela L. Horn-Ross Christina A. Clarke Mark Allen Dennis Deapen Argyrios Ziogas Peggy Reynolds Rosemary Cress Hoda Anton-Culver Dee West Ronald K. Ross Leslie Bernstein | 2008 | Fertility and Sterility2008,,2: | 1 |
| 19 | Oligonucleotide Microarray Analysis of Genomic Imbalance in Children with Mental Retardation显示文摘 | J.M. Friedman ágnes Baross Allen D. Delaney Adrian Ally Laura Arbour Jennifer Asano Dione K. Bailey Sarah Barber Patricia Birch Mabel Brown-John Manqiu Cao Susanna Chan David L. Charest Noushin Farnoud Nicole Fernandes Stephane Flibotte Anne Go William T. | 2006 | The American Journal of Human Genetics2006,,3: | 1 |
| 20 | Maternal Parenting Behaviors and Adolescent Depression: The Mediating Role of Rumination显示文摘 | MichaelA. Gaté EdwardR. Watkins JulianG. Simmons MichelleL. Byrne OrliS. Schwartz Sarah Whittle LisaB. Sheeber NicholasB. Allen | 2013 | Journal of Clinical Child & Adolescent Psychology2013,,3: | 1 |