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| 1 | A Mitochondrial Magnesium Transporter Functions in Arabidopsis Pollen Development显示文摘镁是在植物房间的一个丰富的二价的阳离子并且在许多生理的过程起一个关键作用。我们以前描述了编码通常认为的镁运输(MGT ) 的一个 10 成员 Arabidopsis 基因家庭的鉴定蛋白质。这里,我们报导那 MGT 家庭,的一个成员 AtMGT5,作为以一种集中依赖者方式操作的双功能的 Mg 搬运工作,也就是,它在 micromolar 层次用作一个 Mg 进口商并且在 millimolar 范围便于流出。AtMGT5 蛋白质在线粒体是局部性的,建议 AtMGT5 调停在 cytosol 和线粒体之间的 Mg-trafficking。AtMGT5 基因只在花开发的早阶段在花药被表示。AtMGT5 基因的二独立 T-DNA insertional 异种的检查证明 AtMGT5 为花粉开发和男富饶起了一个必要作用。这研究在植物在男 gametogenesis 为在 cytosol 和线粒体之间的 Mg2+ 运输建议一个关键角色。 | Le-Gong Li Lubomir N. Sokolov Yong-Hua Yang Dong-Ping Li Julie Ting Girdhar K. Pandy Sheng Luan | 2008 | Molecular Plant2008，1，4： | 14 |
| 2 | KIT exon 11 codon 557/558 deletion/insertion mutations define a subset of gastrointestinal stromal tumors with malignant potential显示文摘AIM: To study the association of the frequency and pattern of KIT and PDGFRA mutations and clinicopathological factors in a group of patients with gastrointestinal stromal tumors (GIST). METHODS: Thirty patients with GIST were examined. Exons 9, 11, 13, and 17 of the KIT and exons 12 and 18 of the PDGFRA gene were analyzed for the presence of mutations by PCR amplification and direct sequencing. RESULTS: KIT or PDGFRA mutations were detected in 21 of the 30 patients (70%). Sixteen patients had mutations within KIT exon 11, three within KIT exon 9, and two within PDGFRA exon 18. GISTs with KIT exon 9 mutations were predominantly located in the small intestine, showed a spindle cell phenotype, and were assessed as potentially malignant. GISTs with KIT exon 11 mutations were located in the stomach and intestine, showed mainly a spindle cell phenotype, and were scored as potentially malignant (P < 0.05). Tumors with KIT exon 11 codon 557/558 deletion/insertion mutations were found to be associated with a potentially malignant clinical behaviour (P < 0.003). GISTs with PDGFRA mutations located in stomach showed a mixedcell phenotype and were classified as of very low or low moderate malignant potential. CONCLUSION: Determination of KIT and PDGFRA mutations should be additional parameters for the better prediction of GISTs clinical behaviour. Tumors with deletion/insertion mutations affecting codons 557/558 of the KIT gene seem to represent a distinct subset of malignant GISTs. | Katerina Kontogianni-Katsarou Euthimios Dimitriadis Constantina Lariou Evi Kairi-Vassilatou Nikolaos Pandis Agatha Kondi-Paphiti | 2008 | World Journal of Gastroenterology2008，14，12： | 4 |
| 3 | Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration显示文摘The circadian clock participates in maintaining homeostasis in peripheral tissues,including intervertebral discs(IVDs).Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration(IDD).Based on the rhythmic daily loading pattern of rest and activity,we hypothesized that abnormal mechanical loading could dampen the IVD clock,contributing to IDD.Here,we investigated the effects of abnormal loading on the IVD clock and aimed to inhibit compression-induced IDD by targeting the core clock molecule brain and muscle Arnt-like protein-1(BMAL1).In this study,we showed that BMAL1 KO mice exhibit radiographic features similar to those of human IDD and that BMAL1 expression was negatively correlated with IDD severity by systematic analysis based on 149 human IVD samples.The intrinsic circadian clock in the IVD was dampened by excessive loading,and BMAL1 overexpression by lentivirus attenuated compression-induced IDD.Inhibition of the RhoA/ROCK pathway by Y-27632 or melatonin attenuated the compression-induced decrease in BMAL1 expression.Finally,the two drugs partially restored BMAL1 expression and alleviated IDD in a diurnal compression model.Our results first show that excessive loading dampens the circadian clock of nucleus pulposus tissues via the RhoA/ROCK pathway,the inhibition of which potentially protects against compression-induced IDD by preserving BMAL1 expression.These findings underline the importance of the circadian clock for IVD homeostasis and provide a potentially effective therapeutic strategy for IDD. | Dong Wang Pandi Peng Michal Dudek Xueyu Hu Xiaolong Xu Qiliang Shang Di Wang Haoruo Jia Han Wang Bo Gao Chao Zheng Jianxin Mao Chu Gao Xin He Pengzhen Cheng Huanbo Wang Jianmin Zheng Judith A.Hoyland Qing-Jun Meng Zhuojing Luo Liu Yang | 2022 | Bone Research2022，10，2： | 2 |
| 4 | In vitro antibacterial activity of the metal oxide nanoparticles against urinary tract infectious bacterial pathogens显示文摘 | Sundaram Ravikumar Ramasamy Gokulakrishnan Pandi Boomi | 2012 | Asian Pacific Journal of Tropical Disease2012，，2： | 2 |
| 5 | Liana community and functional trait analysis in tropical dry evergreen forest of India显示文摘Aim lianas are abundant and diverse throughout the world and consti-tute an important structural and functional component of tropical forests.This study aims to investigate liana diversity,abundance and their functional traits in Indian tropical dry evergreen forest(TDEF).Methods a total of ten 1-ha plots,one each in 10 Indian TDEF sites were demarcated.Each 1-ha plot was divided into one-hundred 10-×10-m quadrats to facilitate woody species inventory.all lianas≥1 cm diameter measured at 130 cm from the rooting point and all trees≥10-cm girth at breast height(gbh)were recorded from the study sites to analyze the patterns of liana diversity and abundance and also to compare the contribution of lianas to the total woody species richness,density and basal area.liana variables across the study sites were compared using one-way analysis of variance.The qualitative functional traits of inventoried lianas and trees were assessed on the field and referring to pertinent field manuals.Important Findingsa total of 9237 liana individuals(ranged from 408-1658 individu-als ha^(−1))representing 52 species,45 genera and 28 families were encountered from the 10 study sites.liana species richness ranged from 11-31 species ha^(−1) in 10 sites,which averaged 23.4(±5.7)species ha^(−1).The total basal area of lianas in the study sites was 7.3 m^(2)(0.20-1.76 m^(2) ha^(−1)).There was a significant variation in liana species richness,density and basal area across the studied sites.on the whole,lianas contributed 52%,49.3%and 4.1%to the total woody species(lianas and trees)richness,density and basal area,respectively.liana trait analysis revealed the majority(50%)of lianas belonged to brevi-deciduous type.stem twining was the chief climbing mechanism,exhibited by 21 species(52.6%of total abundance).more than half of the liana species(34 species;6925 individuals)had microphyllous leaves.Fleshy-fruited lianas mostly bearing berries and drupes constituted the major fruit type in the studied sites.Zoochory was the predominant dispersal mode observed in 63.4% of species.Considering the ecological and func-tional role of lianas in Indian TDEF,the need for conservation is emphasized. | Pandi Vivek Narayanaswamy Parthasarathy | 2015 | Journal of Plant Ecology2015，8，5： | 2 |
| 6 | A parameter optimization approach for the optimal control of large-scale musculoskeletal systems 显示文摘 | Pandy M G Anderson F C | 1992 | J Bio Eng Trans of the ASME1992，114，11： | 1 |
| 7 | Insights into the chemistry of new particle formation and growth events in Pittsburgh based on aerosol mass spectrometry 显示文摘 | Zhang Q Stanier C O Canagaratna M R Jayne J T Worsnop D R Pandis S N Jimenez J L | 2004 | Environ Sci Technol2004，38，18： | 1 |
| 8 | Determination and the- oretical evaluation of selectivity coefficients of monovalent anions in anion-exchange polymer inclusion membrane 显示文摘 | SODAYE S SURESH G PANDY A K | 2007 | Membrane Sci- ence2007，295，： | 1 |
| 9 | Atmospheric chemistry and physics : from air pollution to climate change 显示文摘 | Seinfeld J H Pandis S N | 2006 | Environment: Science and Policy for Sustainable Development2006，51，： | 1 |
| 10 | Chromium (VI) removal from aqueous solutions by Mg-A1-C03 hydrotalcite:sorption-des- orption kinetic and equilibrium studies显示文摘 | Lazaridis N K Pandi T A MatisK A | 2004 | Industrial and Engi- neering Chemistry Research2004，43，9： | 1 |
| 11 | Evaluation of secondary organic aerosol formation in winter 显示文摘 | STRADER R LURMANN F PANDIS S N | 1999 | Atmospheric Environment1999，33，29： | 1 |
| 12 | Melatonin: nature's most versatile biological signal?显示文摘 | Pandi PSR Srinivasan V Maestroni GJM | 2006 | FEBS J2006，273，3： | 1 |
| 13 | Senescence, sleep, and circadian rhythms 显示文摘 | Pandi - Perumal SR Seils LK Kayumov L | 2002 | Ageing Res Rev2002，1，3： | 1 |
| 14 | Periodontal condition of the mandibular anterior dentition in patients with conventional and self-ligating brackets显示文摘 | Pandis N Vlachopoulos K Polych ronopoulou A | 2008 | Orthod Craniofac Res2008，11，4： | 1 |
| 15 | A comparative assessment of torque generated by lingual and conventional brackets 显示文摘 | Sifakakis I Pandis N Makou M | 2013 | Eur J Orthod2013，35，3： | 1 |
| 16 | Copper(II) removal from aqueous solutions by fly ash 显示文摘 | Pandy K K Prasad Gur Singh V N | 1985 | Wat Res1985，19，7： | 1 |
| 17 | Aerosol formation in the photooxidation of isoprene and 15-pinene 显示文摘 | Pandis S N Paulson S E Seinfeld J H Flagan R C | 1991 | Atmos Environ1991，25，56： | 1 |
| 18 | Highly Conduc- ting Poly(methyl methacrylate)/Carbon Nanotubes Com- posites: Investigation on Their Thermal, Dynamic-me- chanical, Electrical and Dielectric Properties 显示文摘 | Logakis E Pandis C H Pissis P | 2011 | Com- posites Science and Technology2011，71，6： | 1 |
| 19 | Self-ligating vs convention-al brackets in the treatment of mandibular crowing : A prospectiveclinical trial of treatment duration and dental effects 显示文摘 | Pandis N Polychronopoulou A Eliades | 2007 | Am JOrthod Dentofacial Orthop2007，132，2： | 1 |
| 20 | Damage detection from changes in curvature mode shapes 显示文摘 | Pandy A K Biswas M Samman M M | 1991 | Journal of Sound and Vibration1991，145，2： | 1 |
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