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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Differential roles of EPS8 in carcinogenesis:Loss of protein expression in a subset of colorectal carcinoma and adenoma显示文摘AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells.METHODS:We studied 8 colon cancer cell lines and 58 colorectal tumors(19 adenomas and 39 carcinomas).We performed expression microarray analysis of colon cancer cell lines followed by loss of heterozygosity(LOH)analysis and immunohistochemistry for EPS8 expression in colon tumors.Subsequently,we performed mutation analysis by direct sequencing and methylation analysis by bisulfite sequencing and methylation-specific polymerase chain reaction assays.RESULTS:Expression microarray analysis of colon cancer cell lines showed overexpression of EPS8 transcript in all lines but RKO.Genome wide loss of heterozygosity(LOH) analysis of colon tumors,showed considerable LOH at the EPS8 gene locus.Immunohistochemically,EPS8 was constitutively expressed in normal colonic mucosa with a dot-like supranuclear localization with accentuation at the luminal surface supporting its proposed role in epithelial maturation.Nineteen colon tumors(4 adenoma,15 carcinoma) out of 51(37%) showed strikingly tumor specific EPS8 protein loss.Of the remaining tumors,5/51(2 adenoma,and 3 carcinoma,10%) showed marked overexpression,while 27/51 tumors(53%) showed retained expression.Mutation analysis revealed a missense mutation(c.794C>T,p.R265C) in exon 8 in RKO.The EPS8 promoter was also methylated in RKO,but there was no significant methylation in other cell lines or carcinoma specimens.CONCLUSION:The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers,a finding which could have applications in diagnosis and treatment. | Wael M Abdel-Rahman Salla Ruosaari Sakari Knuutila Pivi Peltomki | 2012 | World Journal of Gastroenterology2012，18，29： | 5 |
| 3 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 4 | Targeted Resequencing Reveals ALK Fusions in Non-Small Cell Lung Carcinomas Detected by FISH, Immunohistochemistry, and Real-Time RT-PCR: A Comparison of Four Methods显示文摘 | Katja Tuononen Virinder Kaur Sarhadi Aino Wirtanen Mikko R?nty Kaisa Salmenkivi Aija Knuuttila Satu Remes Aino I. Telaranta-Keerie Stuart Bloor Pekka Ellonen Sakari Knuutila Akanchha Kesari | 2013 | BioMed Research International2013，，： | 1 |
| 5 | Towards a heart disease diagnosing system based on force sensitive chair's measurement, biorthogonal wavelets and neural networks 显示文摘 | Alireza A Sakari J Mikko K | 2007 | Engineering Applications of Artificial Intelligence (S1873-6769)2007，20，4： | 1 |
| 6 | Effect of age at operation, location of testis and preoperative hormonal treatment on testicular growth after eryptorehidism显示文摘 | Setto T Sakari | 1997 | J Urol1997，158，： | 1 |
| 7 | The androgen receptor in health and disease显示文摘 | Matsumoto T Sakari M Okada M | 2013 | Annu Rev Physiol2013，75，： | 1 |
| 8 | Hot deformation and recrystallization behaviour of a SiCp/6061 Al composite显示文摘 | Xia X Sakaris P McQueen H J | 1993 | Metal/Matrix Composites1993，1，： | 1 |
| 9 | Chronic achilles tendon overuse in jury:complications after surgical treatment显示文摘 | Paavola Sakari Orava | 2000 | Am J Sports Med2000，28，1： | 1 |
| 10 | The Lumbar Multifidus Muscle Five Years After Surgery for a Lumbar Intervertebral Disc Herniation显示文摘 | Jussi Rantanen Matti Hurme Bj?rn Falck Hannu Alaranta Finn Nykvist Matti Lehto Sakari Einola Hannu Kalimo | 1993 | Spine1993，，5： | 1 |
| 11 | Premature ovarian failure in androgen receptor - deficient mice 显示文摘 | Shiina H Matsumoto T Sato T Igarashi K Miyamoto J Takemasa S Sakari M Takada I Nakamura T Metzger D Chambon P Kanno J | 2006 | Proc Natl Acad Sci U S A2006，103，： | 1 |
| 12 | Gas chromatography-mass spectrometry analysis of various organic extracts of Merremia borneensis from Sabah显示文摘Objective:To analyse the chemical composition of different extracts of Merremia borneensis(M. borneensis) by gas chromatography-mass spectrometry(GC-MS).Methods:The dried leaves powder was extracted with methanol at room temperature by using Soxhlet extractor.Methanol crude extracts of M.borneensis were extrastel with hexane,chloroform,ethyl acetate and butanol. Results:Qualitative analyses of various organic crude extracts showed that majority of these are flavonoids,terpeniods,alkaloids and glycosides.Most of the identified compounds by GCMS are biologically important.Further the M.borneensii leaf possesses certain characteristics that can be ascribed to cultivation on a domestic plantation.Conclusions:The suitable extracts for respective compounds can be chosen on the basis of above GC-MS analysis.All the major compounds from different extracts are biologically active molecules.Thus the identification of a good number of compounds from various extracts M.borneensis might have some ecological significance. | M Amzad Hossain Muhammad Dawood Shah Mahyar Sakari | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 1 |
| 13 | Splicing potentiation by growth factor signals via estrogen receptor phosphorylation显示文摘 | MASUHIRO Y MEZAKI Y SAKARI M | 2005 | Proceed-ings of the National Academy of Sciences of the United States of Ameri-ca2005，102，23： | 1 |
| 14 | The androgen receptor in health and disease显示文摘 | Matsumoto T Sakari M Okada M | 2013 | Annu Rev Physiol2013，75，： | 1 |
| 15 | Occurrence of symptoms and depressive mood among working-aged coronary heart disease patients显示文摘 | Markku PT S Sakari B S Markku J K | 2004 | Heahh and Quality of Life Outcomes2004，，2： | 1 |
| 16 | A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis显示文摘 | Swarnali Acharyya Thordur Oskarsson Sakari Vanharanta Srinivas Malladi Juliet Kim Patrick G. Morris Katia Manova-Todorova Margaret Leversha Nancy Hogg Venkatraman E. Seshan Larry Norton Edi Brogi Joan Massagué | 2012 | Cell2012，，： | 1 |
| 17 | DNA Copy Number Losses in Human Neoplasms显示文摘 | Sakari Knuutila Yan Aalto Kirsi Autio Anna-Maria Bj?rkqvist Wa’el El-Rifai Samuli Hemmer Tarja Huhta Eeva Kettunen Sonja Kiuru-Kuhlefelt Marcelo L. Larramendy Tamara Lushnikova Outi Monni Heini Pere Johanna Tapper Maija Tarkkanen Asta Varis Veli-Matti Was | 1999 | The American Journal of Pathology1999，，3： | 1 |
| 18 | The androgen receptor in health and disease显示文摘 | Matsumoto T Sakari M Okada M | 2013 | Annu Rev Physiol2013，75，： | 1 |
| 19 | Competitive interactions among raptors in boreal forests显示文摘 | Harri Hakkarainen Sakari Mykr? Sami Kurki Risto Tornberg Sven Jungell | 2004 | Oecologia2004，，3： | 1 |
| 20 | Performance of different spectral and textural aerial photograph features in multi-source forest inventory显示文摘 | SAKARI T ANSSI P | 2005 | Remote Sensing of Environment2005，94，： | 1 |
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