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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment显示文摘 | Florian K.P. Sutter Judy M. Simpson Mark C. Gillies | 2004 | Ophthalmology2004，，11： | 3 |
| 3 | Factors affecting shoot development in apically dominant Acer cultivars in vitro显示文摘 | Marks T R Simpson S E | 1994 | Journal of Horticultural Science1994，69，3： | 1 |
| 4 | Isolation and identification of 2 - methoxy - 3,5 - dimethyrazine, a potent musty compound from wine corks 显示文摘 | Robert F Simpson Dimitra L Capone Mark A Sefton | 2004 | J Agric Food of Chem2004，52，： | 1 |
| 5 | Reduced phenolic oxidation at cul- ture in it iation in vitro following the exposure of field-grown stock plants to darkness or low level of irradiance 显示文摘 | Marks T R Simpson S E | 1990 | Horti- cluture Science1990，65，： | 1 |
| 6 | Factors affecting shoot development in apically dominant Acer cultivars in vitro显示文摘 | Marks T R Simpson S E | 1994 | J hort Sci1994，69，3： | 1 |
| 7 | Interaction of explant type and indole-3-butyric acid during rooting in vitro in a range of difficult and easy-toroot woody plants显示文摘 | Tim R Marks Sally E Simpson | 2000 | Plant cell tissue and organ culture2000，62，： | 1 |
| 8 | Atopy phenotypes in the childhood asthma prevention study (CAPS) cohort and the relation- ship with allergic disease: clinical mechanisms in allergic disease 显示文摘 | Garden FL Simpson JM Marks GB | 2013 | Clin Exp Allergy2013，43，6： | 1 |
| 9 | MicroRNA regulation of lymphocyte tolerance and autoimmunity显示文摘 | Simpson Laura J Ansel K Mark | 2015 | Journal of Clinical Investigation2015，，6： | 1 |
| 10 | Intravitreal Triamcinolone for Refractory Diabetic Macular Edema显示文摘 | Mark C. Gillies Florian K.P. Sutter Judy M. Simpson Jorgen Larsson Haipha Ali Meidong Zhu | 2006 | Ophthalmology2006，，9： | 1 |
| 11 | Atopy phenotypes in the childhood asthma prevention study (CAPS) cohort and the relationship with allergic disease: clinical mechanisms in allergic disease 显示文摘 | Garden FL Simpson JM Marks GB | 2013 | Clin Exp Allergy2013，43，6： | 1 |
| 12 | Discrimination between six species of canine microfilariae by a single polymerase chain reaction显示文摘 | Mark Rishniw Stephen C. Barr Kenny W. Simpson Marguerite F. Frongillo Marc Franz Jose Luis Dominguez Alpizar | 2005 | Veterinary Parasitology2005，，3： | 1 |
| 13 | Factors affecting shoot development in apically dominant Acer cultivars in vitro 显示文摘 | MARKS T R SIMPSON S E | 1994 | Journal of Horticultural Science1994，69，54： | 1 |
| 14 | The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts显示文摘 | Olga Aprelikova Xiang Yu John Palla Bih-Rong Wei Simone John Ming Yi Robert Stephens R. Mark Simpson John I. Risinger Amir Jazaeri John Niederhuber | 2010 | Cell Cycle2010，，21： | 1 |
| 15 | Cloning and functional characterization of the mouse fructose transporter, GLUT5显示文摘 | Christopher P. Corpe Floris J. Bovelander Christina M. Munoz J.Hans Hoekstra Ian A. Simpson Oran Kwon Mark Levine Charles F. Burant | 2002 | BBA - Gene Structure and Expression2002，，1： | 1 |
| 16 | Factors affecting shoot development in apically dominant Acer cultivars in vitro 显示文摘 | Marks T R Simpson S E | 1994 | Journal of Horticultural Science1994，69，3： | 1 |
| 17 | A Randomized Clinical Trial of a Single bose of Intravitreal Triamcinolone Acetonide for Neovascular Age- Related Macular Degeneration: One - Year Results显示文摘 | Gillies Mark C Simpson Judy M Luo Wei | 2003 | Arch Ophthalmol2003，121，5： | 1 |
| 18 | Novel Mutation in Desmoplakin Causes Arrhythmogenic Left Ventricular Cardiomyopathy显示文摘 | Mark Norman Michael Simpson Jens Mogensen Anthony Shaw S?an Hughes Petros Syrris Srijita Sen-Chowdhry Edward Rowland Andrew Crosby William J. McKenna | 2005 | Circulation2005，，5： | 1 |
| 19 | increases in circulating effector memory CD4^+ T cells that express cutaneous lymphocyte antigen 显示文摘 | Efalizumab therapy for atopic dermatitis causes marked Harper EG Simpson EL Takiguchi RH | 2008 | J Invest Dermatol2008，128，5： | 1 |
| 20 | Gene delivery of AAV2-neurturin for Parkinson’s disease: a double-blind, randomised, controlled trial显示文摘 | William J Marks Raymond T Bartus Joao Siffert Charles S Davis Andres Lozano Nicholas Boulis Jerrold Vitek Mark Stacy Dennis Turner Leonard Verhagen Roy Bakay Raymond Watts Barton Guthrie Joseph Jankovic Richard Simpson Michele Tagliati Ron Alterman Matthe | 2010 | Lancet Neurology2010，，12： | 1 |
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