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| 1 | IMbrave150研究:免疫抑制剂治疗首次取得晚期肝细胞癌一线治疗成功显示文摘【据The New England Journal of Medicine 2020年5月报道】题:阿特朱单抗联合贝伐单抗在无法手术切除的晚期肝细胞癌中的疗效(作者Finn RS等)索拉非尼和仑伐替尼是目前晚期肝细胞癌(HCC)的标准一线治疗方案,可适当提高患者总生存率,但不良反应较多。PD-1抑制剂、阿特朱单抗(PD-L1抑制剂)以及贝伐单抗在Ⅰb期和Ⅱ期临床试验中显示出良好的客观缓解率。该研究探索了阿特朱单抗联合贝伐单抗对比单药索拉非尼治疗无法手术切除的晚期HCC的疗效和安全性。 | 刘昊天 钟鉴宏 FINN RS QIN S IKEDA M | 2020 | 临床肝胆病杂志2020，36，9： | 460 |
| 2 | 中国收入不平等:发展、转型和政策显示文摘描述了中国改革开放以来收入不平等变动的主要趋势,并将其归因于如下四种因素的相互影响:第一,由传统的发展理论所刻画,以结构转型、市场扩展、剩余劳动力吸收和收入差距的库兹涅茨“倒U型”路径等为主要影响的发展因素。第二,经济制度的转型变化因素。在经济体制从计划经济向市场经济的转型过程中经济活动决策过程的微观化,多种所有制经济的出现,以及收入分配机制的变化引起了收入分配格局的改变。第三,经济体制转型不彻底和不完善的因素。这导致了寻租、设租和隐性收入的产生,带来收入差距扩大和收入分配不平等。第四,社会保障制度和再分配政策的逐步完善因素。这在一定程度上起到了缓解收入分配不平等的作用。 | 李实 Terry Sicular Finn Tarp | 2020 | 北京工商大学学报(社会科学版)2020，35，4： | 33 |
| 3 | 点击化学--释义与目标显示文摘点击化学i自2001年由Sharpless提出以来,引起广泛的重视,并得以蓬勃的发展。许多综述对此领域的进展进行了归纳ii,赵卫光,李正名等在《有机化学》中发表中文综述介绍了点击化学的一些基本概念和应用iii。作为点击化学的提出者,Sharpless最近写了一篇文章深入浅出地阐释了点击化学的思想与愿景。该文由北山隆翻译成日文,并于日本化学会的《化学と工業》发表iv。Sharpless希望此文也能以中文的形式与中国读者见面。受Sharpless之托,我们将此文翻译成中文,以冀与更多同行分享。 | M. G. Finn Hartmuth C. Kolb Valery V. Fokin K. Barry Sharpless 张欣豪 吴云东 | 2008 | 化学进展2008，20，1： | 19 |
| 4 | Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis显示文摘The cultivated strawberry(Fragaria×ananassa)is consumed worldwide for its flavor and nutritional benefits.Genetic analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this species.Although several quantitative trait loci(QTL)have been previously detected for fruit quality and flowering traits using low-density genetic maps,clarity on the sub-genomic locations of these QTLs was missing.Recent discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism(SNP)array,enabling high-density genetic maps and finer resolution QTL analysis.In this study,breeder-specified traits were evaluated in the Eastern(Michigan)and Western(Oregon)United States for a common set of breeding populations during 2 years.Several QTLs were validated for soluble solids content(SSC),fruit weight(FWT),pH and titratable acidity(TA)using a pedigree-based QTL analysis approach.For fruit quality,a QTL for SSC on linkage group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B were detected.In addition,a large-effect QTL for flowering was detected at the distal end of LG 4A,coinciding with the FaPFRU locus.Marker haplotype analysis in the FaPFRU region indicated that the homozygous recessive genotype was highly predictive of seasonal flowering.SNP probes in the FaPFRU region may help facilitate marker-assisted selection for this trait. | Sujeet Verma Jason D Zurn Natalia Salinas Megan M Mathey Beatrice Denoyes James F Hancock Chad E Finn Nahla V Bassil Vance M Whitaker | 2017 | Horticulture Research2017，4，1： | 10 |
| 5 | The Mesozoic of Western Scandinavia and East Greenland显示文摘 | Arvid NФttvedt Erik P. Johannessen Finn Surlyk | 2008 | Episodes2008，31，1： | 3 |
| 6 | The importance of avoiding unnecessary right ventricular pacing in clinical practice显示文摘Symptomatic bradycardia is effectively treated with the implantation of a cardiac pacemaker. Although a highly successful therapy, during recent years there has been a focus on the negative effects associated with longterm pacing of the apex of the right ventricle(RV). It has been shown in both experimental and clinical studies that RV pacing leads to ventricular dyssynchrony, similar to that of left bundle branch block, with subsequent detrimental effects on cardiac structure and function, and in some cases adverse clinical outcomes such as atrial fibrillation, heart failure and death. There is substantial evidence that patients with reduced left ventricular function(LVEF) are at particular high risk of suffering the detrimental clinical effects of long-term RV pacing. The evidence is, however, incomplete, coming largely from subanalyses of pacemaker and implantable cardiac defibrillator studies. In this group of patients with reduced LVEF and an expected high amount of RV pacing, biventricular pacing(cardiac resynchronization therapy) devices can prevent the negative effects of RV pacing and reduce ventricular dyssynchrony. Therefore, cardiac resynchronization therapy has emerged as an attractive option with promising results and more clinical studies are underway. Furthermore, specific pacemaker algorithms, which minimize RV pacing, can also reduce the negative effects of RV stimulation on cardiac function and may prevent clinical deterioration. | Finn Akerstrm Miguel A Arias Marta Pachón Jesús Jiménez-López Alberto Puchol Justo Juliá-Calvo | 2013 | World Journal of Cardiology2013，5，11： | 3 |
| 7 | Alendronate treatment does not inhibit bone formation within biphasic calcium phosphate ceramics in posterolateral spinal fusion: an experimental study in porcine model显示文摘背景 Biphasic 钙磷酸盐(BCP ) 陶艺作为一个 osteoconductive 矩阵有一个潜在的优点并且让最佳的再吞为骨头形成评价。在针的熔化期间把 BCP 陶艺用作骨头接枝要求在材料并且提供长期的 support.Bisphosphonates 的在邻近的 vertebraes 之间的随后的衔接以内的成骨被报导了延长骨头愈合的过程。在在未知的针的熔化遗体的 BCP 陶艺以内的骨头形成上的 bisphosphonate 治疗的影响。这研究的目的是在 posterolateral 在 BCP 成骨上评估 alendronate 的影响针的有小花梗螺丝钉固定的 fusion.Methods Posterolateral 针的熔化在 22 pigs.BCP 陶艺在腰部的脊骨被执行作为骨头接枝被使用获得在邻近的横向的过程之间的骨头熔化。在处理的十一头猪组织 receivedoral alendronate 为三个月的 10 mg/d 手术后地。在控制组的十一头猪没与 alendronate 接受处理。所有动物经历了 posterolateral 有 BCP 陶艺的针的熔化。熔化率被评估在熔化率由 X 光检查评估了的 operation.Results 以后的三个月在处理组是 27.3% , 20% 在控制组织。用组织学的评估的熔化率在处理组是 18.2% , 20% 在控制组织。熔化质量的吝啬的体积是(3.64 敩 ? 景戠敲獡 ? 慣据牥愠摮搠瑥牥業楮杮琠敨漠瑰浩污琠敲瑡敭瑮趸 ? 趸吗?? | XUE Qing-yun JI Quan LI Hai-sheng ZOU Xue-nong Niels Egund Martin Lind Finn B Christensen Cody Bringer | 2009 | Chinese Medical Journal2009，，22： | 3 |
| 8 | 湍流边界层脉动压力对声强测量的影响研究(英文)显示文摘实际声强测量时常常存在风流或水流,如在飞机或船舶上进行测量,声强探头将受到湍流边界层脉动压力的影响。如何评估该影响以及如何修正测量结果是人们十分关心的工程实用问题。该文首先简要介绍了建立的由湍流边界层脉动压力诱发声强的理论模型。接着利用现有的湍流边界层脉动压力频率-波数谱模型,对湍流边界层脉动压力及其诱发的声强进行了数值分析。为了验证理论模型及数值结果,设计制作了一套实验装置,对湍流边界层脉动压力及其产生的声强进行了具体测量分析。结果表明,湍流边界层脉动压力的测量结果与数值结果吻合良好,测量得到的边界层脉动压力诱发的声强特性与计算结果也十分一致,但必须注意对测量传感器的空间响应进行修正。 | 史小军 Finn JACOBSEN | 2010 | 船舶力学2010，14，3： | 2 |
| 9 | 湍流对流动管道中声强测量的影响(英文)显示文摘实际声强测量大多是在流动环境条件下进行,因此湍流对声强测量的影响是人们十分关心的工程实用问题。文章结合声强和湍流边界层等相关领域的技术,对流动条件下的声强技术进行了研究分析,导出了由湍流边界层引起的声强的具体表达式。应用Corcos建立的湍流边界层脉动压力模型,对湍流边界层脉动压力诱导的声强进行了数值计算分析,分析了测量传感器间距、马赫数等对声强测量的影响。 | 史小军 Finn JACOBSEN | 2008 | 船舶力学2008，12，3： | 2 |
| 10 | Subcutaneous implantable defibrillator: State-of-the art 2013显示文摘The subcutaneous implantable cardioverter-defibrillator(S-ICD)has recently been approved for commercial use in Europe,New Zealand and the United States.It is comprised of a pulse generator,placed subcutaneously in a left lateral position,and a parasternal subcutaneous lead-electrode with two sensing electrodes separated by a shocking coil.Being an entirely subcutaneous system it avoids important periprocedural and long-term complications associated with transvenous implantable cardioverter-defibrillator(TV-ICD)systems as well as the need for fluoroscopy during implant surgery.Suitable candidates include pediatric patients with congenital heart disease that limits intracavitary lead placements,those with obstructed venous access,chronic indwelling catheters or high infection risk,as well as young patients with electrical heart disease(e.g.,Brugada Syndrome,long QT syndrome,and hypertrophic cardiomyopathy).Nevertheless,given the absence of intracavitary leads,the S-ICD is unable to offer pacing(apart from shortterm post-shock pacing).It is therefore not suitable in patients with an indication for antibradycardia pacing or cardiac resynchronization therapy,or with a history of repetitive monomorphic ventricular tachycardia that would benefit from antitachycardia pacing.Current data from initial clinical studies and post-commercialization'real-life'case series,including over 700 patients,have so far been promising and shown that the S-ICD successfully converts induced and spontaneous ventricular tachycardia/ventricular fibrillation episodes with associated complication and inappropriate shock rates similar to that of TV-ICDs.Furthermore,by using far-field electrograms better tachyarrhythmia discrimination when compared to TV-ICDs has been reported.Future results from ongoing clinical studies will determine the S-ICD system’s long-term performance,and better define suitable patient profiles. | Finn Akerstrm Miguel A Arias Marta Pachón Alberto Puchol Jesús Jiménez-Lópezl | 2013 | World Journal of Cardiology2013，5，9： | 2 |
| 11 | 挪威海底公路隧道经验——施工、运行、 费用和维护(英文)显示文摘根据2002年关于挪威海底公路隧道的一论文集(挪威公路管理局公路技术部编辑,题目为'论文集98——挪威海底公路隧道',将详细阐述挪威海底隧道的施工建造等经验。挪威第一条海底公路隧道是在1983年通车的,随后建成了另外24条海底公路隧道,至今共有25条海底公路隧道建成通车,总长度达100km。几条新的海底公路隧道目前正在建设中,还有几条则在规划当中,其中最长将达24km。大多数条海底公路隧道是单洞双线,但是当坡度大于6%时,有些隧道就增加一条线。海底公路隧道都位于沿海岸线的干线公路上,以代替原有的繁忙的轮渡,并建立大陆与当地之间的无轮渡连接。据此,主要介绍这些隧道工程中得到的经验,总的来说,海底公路隧道的建设费用逐渐降低,但是各工程间差异很大,各个隧道的运行和维护的费用也相差悬殊,再投资和设备花费也特别高。经验表明,随着渗水量逐年减少,因而抽出渗透水的要求也降低了。介绍了1996年前17条海底隧道中发生的事故和火灾,对19起造成人身伤害的事故进行了分析。其事故发生率极低,只有0.09(每年每一百万车辆每公里发生的事故次数),最高的事发率是在陡坡的年平均日通车量(AADT)低于1500的隧道中。挪威海底隧道中只发生过3起火灾事故,低于交通事故率10%,而这项研究只包括了17条隧道中发生的19起事故。 | HENNING Jan Eirik MELBY Karl фVSTEDAL Erik AMUNDSEN Finn H RANES Guro | 2007 | 岩石力学与工程学报2007，26，11： | 2 |
| 12 | RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops显示文摘The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the U.S.In 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural quality.However,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in breeding.The RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research Initiative.RosBREED was designed to enable the routine application of modern genomics and genetics technologies in U.S.rosaceous crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural quality.This review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future needs.Enabling technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic tests.Examples of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection advancement.The chasm is now bridged,accelerating rosaceous crop genetic improvement. | Amy F.Iezzoni Jim McFerson James Luby Ksenija Gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina Gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva Linge Stijn Vanderzande Thomas M.Davis Lise L.Mahoney Chad Finn Cameron Peace | 2020 | Horticulture Research2020，7，1： | 2 |
| 13 | An effective stress model for liquefaction显示文摘 | Finn W D L Lee K W Martin G R | 1977 | Journal of the Geotechnical Engineering Division ASCE1977，103，6： | 2 |
| 14 | THE POLITICAL ECONOMY OF GREEN GROWTH: CASES FROM SOUTHERN AFRICA显示文摘 | Danielle Resnick Finn Tarp James Thurlow | 2012 | Public Admin Dev2012，，3： | 2 |
| 15 | Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer显示文摘 | Egloff AM Vella LA Finn OJ | 2006 | Cancer Res2006，66，： | 1 |
| 16 | Tumor associated trypsin inhibitor as a prognostic factor during follow up of bladder cancer显示文摘 | Kelloniemi E Rintala E Finne P | 2003 | Urology2003，62，2： | 1 |
| 17 | Pathology of drug-elu-ting stents in humans:delayed healing and late thrombotic risk显示文摘 | Finn AV Farb A | 2006 | J Am CoIl Cardiol2006，48，1： | 1 |
| 18 | M/M/1 queue with working vacations (M/M/1/WV) 显示文摘 | Servi L Finn S | 2002 | Performance Eva-luation2002，，50： | 1 |
| 19 | M/M/1 queue with working vacations (M/M/1/WV)显示文摘 | Servi L D Finn S G | 2002 | Performance Evaluation2002，50，14： | 1 |
| 20 | Click chemistry: diverse chemical function from a few good reactions显示文摘 | KOLB H C FINN M G SHARPLESS K B | 2001 | Angew Chem Int Ed2001，40，11： | 1 |
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