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| 1 | 欧洲新生儿呼吸窘迫综合征防治共识指南:2016版显示文摘新生儿呼吸窘迫综合征(RDS)是早产儿的重要疾病,尽管治疗手段不断成熟,低龄早产儿存活率逐渐增高,但支气管肺发育不良(BPD)发病率也随之升高,其中部分原因是减少了出生后激素的使用.2006年以来,来自欧洲许多国家的新生儿专家每3年一次回顾最新文献,就RDS或有RDS风险早产儿的防治达成共识,立志于改善欧洲新生儿的预后.欧洲RDS防治指南2007年开始发布,2010年和2013年进行了更新,期间获得了欧洲围产医学学会的大力支持.RDS是由于肺表面活性物质(PS)缺乏导致生后早期出现呼吸窘迫,典型临床表现随着防治手段的改进发生了巨大变化. | DavidG.Sweet Virgilio Carnielli Gorm Greisen Mikko Hallman Eren Ozek Richard Plavka Ola Didrik Saugstad Umberto Simeoni Christian P. Speer Maximo Vento Gerard H. A. Visser Henry L. Halliday | 2017 | 中华儿科杂志2017，55，3： | 90 |
| 2 | Irritable bowel syndrome symptom severity improves equally with probiotic and placebo显示文摘AIM To determine the effects of Lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited according to Rome Ⅲ criteria received 109 or 1010 colony-forming units of NCFM or placebo daily for 12 wk. IBS Symptom Severity Score(IBS-SSS), which constituted the primary outcome, and secondary outcomes, including individual IBS symptoms, IBS-related QoL questionnaire, anxiety and depression, defecation frequency, and stool consistency, were assessed at baseline at the end of the 8-wk runin period, after 4 and 12 wk of intervention, and after a 4-wk washout.RESULTS A total of 340 of 391 randomized volunteers completed the trial. IBS-SSS improved over 12 wk of treatment in all treatment groups, decreasing by a mean ± SD of 44.0 ± 80.2, 50.8 ± 82.4, and 48.3 ± 72.2 in the placebo, active low-dose, and active high-dose groups, respectively. Similarly, secondary outcomes did not differ between treatment groups. However, in a post hoc analysis of volunteers with moderate to severe abdominal pain at baseline(VAS > 35/100), the treatment significantly reduced the sensation of abdominal pain. Pain scores fell by 20.8 ± 22.8, 29.4 ± 17.9, and 31.2 ± 21.9 in the placebo, active low-dose, and active high-dose groups, respectively(P value for placebo vs combined active doses = 0.0460).CONCLUSION NCFM alleviates moderate to severe abdominal pain, consistent with earlier observations of this strain mitigating visceral pain through increased analgesic receptor expression. | Anna Lyra Markku Hillila Teppo Huttunen Sofia Mannikko Mikko Taalikka Julia Tennila Anneli Tarpila Sampo Lahtinen Arthur C Ouwehand Lea Veijola | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 3 | 面向大规模定制的家具模块编码与配置技术显示文摘针对面向大规模定制的家具模块编码与配置技术进行了探讨与分析,并以芬兰某企业的模块配置器为例,阐述其配置原理与流程,以期为国内家具企业实现从大规模生产向大规模定制的模式转换,提供路径指导与技术支持。 | 李兵 Seppo Torvinen 关惠元 Mikko Koho | 2012 | 木材工业2012，26，4： | 6 |
| 4 | Metallic mineral deposits in the Nordic countries显示文摘 | Paer Weihed Pasi Eilu Rune B. Larsen Henrik Stendal Mikko Tontti | 2008 | Episodes2008，31，1： | 6 |
| 5 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 6 | Cardiorenal Syndrome显示文摘 | Claudio Ronco Mikko Haapio Andrew A. House Nagesh Anavekar Rinaldo Bellomo | 2008 | Journal of the American College of Cardiology2008，，19： | 5 |
| 7 | 全干式光缆松套管工艺的几个研究显示文摘水对光纤通信的危害是众所周知的,为了阻止水分进入光纤套管内,传统的工艺是在套管内填充阻水的油膏,但油膏容易污染环境,并且在制作组件和接头时非常难以清理,增加了工作难度和光纤熔接的质量,使得安装和连接成本大大增加,特别在FTTH光缆越来越多进入家庭时,全干式光缆的出现使得光缆的制造和连接更环保和简易,工作量大大减少,并降低了成本。本文介绍芬兰麦拉菲尔公司对于全干式光缆中关键的工艺——无油膏松套管工艺的研究。其中借助于阻水纱技术进行阻水处理,并对于松套管制造过程中的余长稳定控制、直径和圆整度控制进行详尽的研究,并提出一些新的解决方案,例如通过在生产线中增加一台紧压式牵引机来消除套管的收缩来维持余长的稳定、并通过专利的增滑添加剂注入技术使得阻水纱和光纤在套管内滑动更合理和稳定,这样使得我们可以进行全干式光缆的最优化生产,以达到光纤容量最大、套管尺寸最小的目的。 | Mikko I.Lahti 吴云杰 | 2008 | 现代传输2008，，4： | 4 |
| 8 | 基于反向方法的船体冰载荷研究(英文)显示文摘船舶碰撞海冰引起的冰载荷分布是十分复杂的。文章选取Thikhonov正则化这一反向方法,根据极地科考补给船S.A Agulhas II号于2013-2014年间南极航行时实测的数据,分析得到了船体艉肩部的冰载荷。通过应用三种独立的冰载荷离散方式来模拟海冰的自然特性,在有限元中得到模型的影响矩阵,并应用Matlab对Thikhonov正则化方程进行了优化。研究结果表明,反向方法可以克服数据处理过程中的不适定性,并计算得到船体冰载荷。 | 刘瀛昊 SUOMINEN Mikko KUJALA Pentti | 2016 | 船舶力学2016，20，12： | 4 |
| 9 | Activation of microbial secondary metabolic pathways:Avenues and challenges显示文摘Microbial natural products are a tremendous source of new bioactive chemical entities for drug discovery.Next generation sequencing has revealed an unprecedented genomic potential for production of secondary metabolites by diverse micro-organisms found in the environment and in the microbiota.Genome mining has further led to the discovery of numerous uncharacterized‘cryptic’metabolic pathways in the classical producers of natural products such as Actinobacteria and fungi.These biosynthetic gene clusters may code for improved biologically active metabolites,but harnessing the full genetic potential has been hindered by the observation that many of the pathways are‘silent’under laboratory conditions.Here we provide an overview of the various biotechnological methodologies,which can be divided to pleiotropic,biosynthetic gene cluster specific,and targeted genome-wide approaches that have been developed for the awakening of microbial secondary metabolic pathways. | Bikash Baral Amir Akhgari Mikko Metsä-Ketelä | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 4 |
| 10 | 可穿戴式柔性天线显示文摘可穿戴式柔性天线是一种新概念天线,它利用柔性材料的特点使得整个天线结构具有柔软和易弯曲性。描述了天线弯曲是如何影响可穿戴式编织材料天线性能的,重点研究了因天线弯曲而产生的天线谐振频率的波动和输入匹配带宽的变化,同时还分析了其对辐射方向图畸变和辐射效率的影响,最后给出了常规贴片天线、电磁带隙天线和双频段U型槽天线三种不同天线的研究结果。 | Pekka Salonen Mikko Keskilammi 郭玉春(翻译) 曹国英(审校) | 2010 | 通信对抗2010，，2： | 4 |
| 11 | Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure显示文摘Few effective treatments for chronic Keshan disease have been available till now.The efficacy of long-term selenium supplementation in the treatment of chronic Keshan disease with congestive heart failure is inconclusive.This study aimed to determine whether selenium supplementation is associated with a decreased risk of cardiac death in chronic Keshan disease with congestive heart failure by ten years of follow-up.A retrospective long-term follow-up analysis was performed on a monitored cohort consisting of 302 chronic Keshan disease patients with a mean age of 40.8±11.4 years.Of the 302 chronic Keshan disease patients,170(56.3%)were given selenium supplementation until the end point of follow-up.Cox proportional hazards regression models were used to identify the independent predictors of cardiac events.Our results showed that during the follow-up,there were 101 deaths of patients with chronic Keshan disease in the selenium supplementation group(101/170,59.4%)and 98 in non-selenium supplementation group(98/132,74.2%).Multivariate analyses suggested that selenium supplementation was associated with a decreased risk of cardiac death(HR 0.39,95%CI 0.28-0.53)after adjustment for baseline age,sex,cigarette smoking,family history of Keshan disease,body mass index(BMI),heart rate,electrocardiogram(ECG)abnonnalities,blood pressure,initial cardiothoracic ratio,left ventricular可ection fractions(LVEF)and whole-blood selenium concentration.Our ten-year follow-up analysis indicated that selenium supplementation,specifically combined with the use of angiotensinconverting cnzyme inhibitor and beta blocker therapy,improved the survival of patients with chronic Keshan disease with congestive heart failure.BMI,selenium deficiency,male,combined ECG abnonnalities,LVEF,and fast heart rate increased the risk of cardiac events. | Yan-he ZHU Xin-feng WANG Guang YANG Jin WEI Wu-hong TAN Li-xin WANG Xiong GUO Mikko J.Lammi Jie-hua XU | 2019 | Current Medical Science2019，39，2： | 4 |
| 12 | Cardiorenal Syndrome显示文摘 | Claudio Ronco Mikko Haapio Andrew A. House Nagesh Anavekar Rinaldo Bellomo | 2008 | Journal of the American College of Cardiology2008，，19： | 3 |
| 13 | Dissecting Abscisic Acid Signaling Pathways Involved in Cuticle Formation显示文摘表皮是在植物和环境之间的天线植物表面和一个重要相互作用点的外部物理障碍。许多环境压力影响表皮形成,然而,包含的规章的小径仍然保持未定义。我们在 Arabidopsis thaliana 使用了遗传和基因表达式分析定义表明断然经由表明小径的核心骆驼毛的织物调整表皮形成的循环的 abscisic 酸(骆驼毛的织物) ,包括 PYR/PYL 受体, PP2C 磷酸酶,和 SNF1 相关的蛋白质 Kinase (SnRK ) 2.2/SnRK2.3/SnRK2.6。SnRK2 kinases 下游,表皮形成没被骆驼毛的织物应答的元素绑定抄写因素,但是由相当调整使脱蜡, MYB16, MYB94,和 MYB96。另外,低空气湿度增加了核心骆驼毛的织物小径和表明表皮生合成基因的稀释表示的房间 death/reactive 氧种类的表皮形成独立人士。在 Physcomitrella 圣餐盘,外长的骆驼毛的织物压制了表皮相关的基因的表示, orthologs 是其 Arabidopsis 导致骆驼毛的织物。因此,调整表皮形成的机制被保存但是在陆地植物复杂。与表皮缺乏有关明确地发信号被识别在表明小径异种到增加的湿度并且在 modulating 的骆驼毛的织物的改编起一个主要作用他们的免疫到在 Arabidopsis 的 Botrytis cinerea。这些结果在表明调整回答到外部环境的小径的 ABA 定义一个表皮特定的下游的分支。 | Fuqiang Cui Mikael Brosche Mikko T. Lehtonen Ali Amiryousefi Enjun Xu Matleena Punkkinen Jari P.T. Valkonen Hiroaki Fujii Kirk Overmyer | 2016 | Molecular Plant2016，9，6： | 3 |
| 14 | Control of exterior ballistic properties of spin-stabilized bullet by optimizing internal mass distribution显示文摘This paper introduces a novel approach for controlling the exterior ballistic properties of spin-stabilized bullets by optimizing their internal mass distributions. Specifically, the properties of interest are the bullets’ stability characteristics that are examined through dynamic and gyroscopic stability parameters.New analytical expressions for aerodynamic quantities are also derived to address the compressibility of air. These expressions are utilized in a bullet model that enables efficient computation of the stability parameters for a given mass distribution. The bullet model is used in the formulation of nonlinear optimization problems that provide optimal mass distributions with respect to given goals, i.e., desired stability characteristics. The bullet types investigated in this paper are a long range bullet and a limited range training bullet. In the optimization of the mass distribution of the long range bullet, the goal is that the bullet stays stable for as long as possible. The mass distribution of the training bullet is optimized such that the bullet is stable at launch but becomes unstable shortly afterwards. The global optimal solutions obtained with the new approach fulfill the desired stability characteristics better than currently used uniformly filled bullets. Overall, the optimization approach reveals a new goal focused philosophy for bullet design compared to current trial and error design practices. | Janne Lahti Timo Sailaranta Mikko Harju Kai Virtanen | 2019 | Defence Technology(防务技术)2019，15，1： | 3 |
| 15 | European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants - 2013 Update显示文摘 | Sweet David G Carnielli Virgilio Greisen Gorm Hallman Mikko Ozek Eren Plavka Richard Saugstad Ola D Simeoni Umberto Speer Christian P Vento Maximo Halliday Henry L | 2013 | Neonatology2013，，4： | 3 |
| 16 | Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test显示文摘Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system(thighbone, knee joints, and costal cartilage) were significantly higher than those in the heart, liver, and kidneys(P < 0.05). The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system(thighbone and costal cartilage) were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%. | YU Fang Fang LIN Xia Lu YANG Lei LIU Huan WANG Xi FANG Hua Mikko J.LAMMI GUO Xiong | 2017 | Biomedical and Environmental Sciences2017，30，11： | 3 |
| 17 | 中文版临床学习环境量表的信效度评定显示文摘目的:翻译、修订中文版护生临床学习环境评估量表,初步评价其效度及信度,为评估我国护生临床学习环境质量,进一步提高临床教学质量提供一种科学、有效的工具。方法:通过直译、回译、专家咨询和预试验对CLES+T进行翻译和文化调试,形成中文版CLES+T。采取方便抽样对太原市内4所三级甲等医院抽取的220名护生进行调查,分析评价量表的信、效度。通过项目分析、验证性因素分析检验量表的项目鉴别力和结构效度,对40名护生间隔两周重测,评定重测信度;Cronbach'sα系数计算内部一致性信度。结果:(1)中文版量表各条目与总得分的相关系数r=0.31-0.70,P〈0.01;(2)量表总Cronbach'sα系数为0.942,各因子的Cronbach'sα系数为0.689-0.872,重测信度和分半信度分别为0.922和0.883;(3)量表的内容效度比为0.96;经过验证性因子分析结果显示,各拟合指数均在可接受范围内。结论:调试后的CLES+T具有良好的信效度,适合中国文化背景下护生临床学习环境的评估与测量。但今后还需要进一步的研究对量表进行评估。 | 杨濡 张培莉 Mikko Saarikoski | 2015 | 中国医学创新2015，12，27： | 3 |
| 18 | Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis显示文摘AIM:To investigate matrix metalloproteinases(MMPs) and their tissue inhibitors(TIMPs) in pouch mucosa of pediatric onset ulcerative colitis(UC).METHODS:In this cross-sectional study,28 patients with pediatric onset UC underwent ileal pouch biopsy 13 years(median) after proctocolectomy.Expression of MMPs-3,-7,-8,-9,-12 and-26 and TIMPs-1,-2 and-3 in samples was examined using immunohistochemichal methods,and another biopsy was used to evaluate the grade of histological inflammation.Two investigators independently graded the immunohistochemical specimens in a semiquantitative fashion,using a scale marking staining intensity as follows:0 = less than 20 positive cells;1 = 20-50 positive cells;2 = 50-200 positive cells;3 = over 20 positive cells.Fecal calprotectin and blood inflammatory markers [serum C-reactive protein(CRP) and erythrocyte sedimentation rate] were determined during a follow-up visit to examine correlations between these markers and the expression of MMPs and TIMPs.RESULTS:Of the 28 patients with pediatric onset UC,nine had not experienced pouchitis,whereas thirteen reported a single episode,and six had recurrent pouchitis(≥ 4 episodes).At the time of the study,six patients required metronidazole.In all of the others,the most recent episode of pouchitis had occurred over one month earlier,and none were on antibiotics.Only four samples depicted no sign of inflammation,and these were all from patients who had not had pouchitis.Two samples were too small to determine the grade of inflammation,but both had suffered pouchitis,the other recurrent.No sample depicted signs of colonic metaplasia.Most pouch samples showed expression of epithelial(e) and stromal(s) MMP-3(e,n = 22;s,n = 20),MMP-7(e,n = 28;s,n = 27),MMP-12(e,n = 20;s,n =24),TIMP-2(e,n = 23;s,n = 23) and MMP-3(e,n = 23;s,n = 28) but MMP-8(e,n = 0;s,n = 1),MMP-9(e,n = 0;s,n = 9) and MMP-26(e,n = 0;s,n = 3) and TIMP-1(n = 0,both) were lacking.In samples with low grade of inflammatory activity,the epithelial MMP-3 and MMP-7 expression was increased(r =-0.614 and r =-0.472,respectively,P < 0.05 in both).MMPs and TIMPs did not correlate with the markers of inflammation,fecal calprotectin,erythrocyte sedimentation rate,or CRP,with the exception of patients with low fecal calprotectin(< 100 μg/g) in whom a higher expression of epithelial MMP-7 was found no differences in MMPor TIMP-profiles were seen in patients with a history of pouchitis compared to ones with no such episodes.Anastomosis with either straight ileoanal anastomosis or ileoanal anastomosis with J-pouch did depict differences in MMP-or TIMP-expression.CONCLUSION:The expression of MMPs pediatric UC pouch in the long-term shares characteristics with inflammatory bowel disease,but inflammation cannot be classified as a reactivation of the disease. | Laura Mkitalo Maija Piekkala Merja Ashorn Mikko Pakarinen Antti Koivusalo Riitta Karikoski Johanna Natunen Ulpu Saarialho-Kere Risto Rintala Kaija-Leena Kolho | 2012 | World Journal of Gastroenterology2012，18，30： | 2 |
| 19 | The Impact of CEO Characteristics on Corporate Social Performance显示文摘 | Mikko H. Manner | 2010 | Journal of Business Ethics2010，，1： | 2 |
| 20 | Theoretical study on the factors controlling the accessibility of cationic metal centers in zirconocene polymerization catalysts显示文摘 | Mikko Lirmolahti Tapani A Pakkanen | 2000 | Macromolecules2000，33，： | 1 |
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