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| 1 | 中国19个狂犬病病毒街毒分离株N基因的序列分析显示文摘测定了 30年来从不同动物中分离的 19个中国狂犬病病毒街毒株N基因的部分核酸序列 ,并对其核苷酸差异做了比较分析。可将中国狂犬病病毒街毒株分为 4个组群 ,各组间的同源性为 83 45 %~ 88 6 2 %。除广西地区分离的狂犬病病毒街毒株彼此差异较大外 ,其余街毒株的地理分布与其N基因核酸序列差异的距离是密切相关的 ,基本上可按其地理分布分为东。 | 徐葛林 Li Ku 吴杰 C.A.De Mattos 郑新雄 薛经刚 胡巧玲 刘锦彦 朱家鸿 C.C.De Mattos J S.Smith | 2002 | 病毒学报2002，18，1： | 46 |
| 2 | The characteristics of CO_2 assimilation of photosynthesis and chlorophyll fluorescence in transgenic PEPC rice显示文摘With PEPC, PPDK, NADP-ME and PEPC+ PPDK transgenic and untransformed rice (Orysa sativa L.), the activities of related C4 photosynthesis enzymes, the chlorophyll fluorescence parameters, CO2 exchange and other physiological indexes were compared, in which the physiological characteristics of PEPC transgenic rice were mainly studied. The results were as follows: (i) The activities of PEPC in PEPC transgenic rice were 20-fold higher than those in untransformed rice; the light-saturation photosynthetic rates and the carboxylation efficiency of PEPC transgenic rice were increased by 55% and 50% more than those of untransformed rice, respectively, while the CO2 compensation point decreased by 27%. (ii) The PS II photochemical efficiency (Fv/Fm) and photochemical quenching (qp) of transgenic PEPC rice decreased less in comparison with those of untransformed rice after the treatment with high light intensity (3 h) or methyl viologen (MV), a photooxidative reagent, which demonstrated that the tolerance of PEPC | JIAO Demao, LI Xia, HUANG Xueqing, CHI Wei, KUANG Tingyun & Ku SB Maurice1. Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences, Nangjing 210014, China 2. Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China 3. Botany Department, Washington State University, Pullman, WA 99164-4236, USA | 2001 | Chinese Science Bulletin2001，46，13： | 29 |
| 3 | Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA显示文摘INTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostprevalentmalignantdiseasesencounteredintheworld,kilingupto1milionpeoplea... | Jae Ho Lee 1, Ja Lok Ku 1, Young Jin Park 1,2 , Kuhn Uk Lee 2, Woo Ho Kim 3 and Jae Gahb Park 1,2 | 1999 | World Journal of Gastroenterology1999，5，4： | 28 |
| 4 | Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity显示文摘AIM:To observe the effects of traditional anti-inflammatory medicine Lonicerae Flos (LF) on rat reflux esophagitis (RE) induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, α-tocopherol.METHODS:Rats were pretreated with three different dosages of LF (500, 250 and 125 mg/kg) orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), myeloperoxidase and glutathione (GSH) levels, and collagen contents (marker of flexibility) were observed on the esophageal and fundic histopathology. The results were compared with an α-tocopherol (once orally, 1 h before operation, 30 mg/kg) treated group in which the effects on RE were already conf irmed.RESULTS: Pylorus and forestomach ligations caused marked increases of gross esophageal and gastric mucosa lesion areas, which corresponded with histopathological changes. In addition, increases of esophageal lipid peroxidation, decreases of SOD, CAT, and GSH-free radical scavengers, increases of collagen were observed. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 500, 250 and 125 mg/kg of LF extract, mediated by antioxidant effects. RE at 250 mg/kg showed similar effects α-tocopherol.CONCLUSION: The results suggest that antioxidant effects of LF could attenuate the severity of RE and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease. | Sae-Kwang Ku Bu-Il Seo Ji-Ha Park Gyu-Yeol Park Young-Bae Seo Jae-Soo Kim Hyeung-Sik Lee Seong-Soo Roh | 2009 | World Journal of Gastroenterology2009，15，38： | 19 |
| 5 | On linking climate to Chinese dynastic change: Spatial and temporal variations of monsoonal rain显示文摘The causal correlation or linkage between the East Asian Monsoon (EAM) intensity and rise/fall of Chinese dynasties recently proposed by high-resolution paleoclimate reconstructions is examined in detail. Aside from many exceptions to the correlation, both instrumental and historical climate records show strong spatial variations of rainfall on annual-to-decadal scales over eastern China. The relationship between rainfall and EAM intensity also exhibits regional disparity. These observations suggest: (1) Tak-ing paleo-proxy records from a single locality in eastern China to imply changes in drought/wetness as to affect the cultural and political history of China is fraught with uncertainty. (2) On annual-to-decadal scales, the thesis that δ18O in speleothems can be used as a proxy for the EAM strength lacks empirical underpinnings. | ZHANG DeEr1, LI Hong-Chun2,3, KU Teh-Lung2,4 & LU LongHua5 1 National Climate Center, Beijing 100081, China 2 Department of Earth Sciences & Research Center of Ocean Environment and Technology, Cheng-Kung University, Tainan 70101, Taiwan, China 3 School of Geographical Sciences, Southwest University of China, Chongqing 400715, China 4 Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089, USA 5 Chinese Academy of Meteorological Sciences, Beijing 100081, China | 2010 | Chinese Science Bulletin2010，55，1： | 19 |
| 6 | Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues显示文摘AIM: To verify the expression and methylation status o the MAGE-A1 and MAGE-A3 genes in colorectal cance tissues and cancer cell lines. METHODS: We evaluated promoter demethylation status of the MAGE-A1 and MAGE-A3 genes by RT-PCR analysis and methylation-specific PCR (MS-PCR), as we as sequencing analysis, after sodium bisulfite modifica tion in 32 colorectal cancer cell lines and 87 cancer tis sues. RESULTS: Of the 32 cell lines, MAGE-A1 and MAGE-A3 expressions were observed in 59% and 66%, respective ly. Subsequent to sodium bisulfite modification and MS PCR analysis, the promoter hypomethylation of MAGE-A1 and MAGE-A3 was confirmed in both at 81% each Promoter hypomethylation of MAGE-A1 and MAGE-A3 in colorectal cancer tissues was observed in 43% and 77% respectively. Hypomethylation of MAGE-A1 and MAGE-A3 genes in corresponding normal tissues were observed in 2% and 6%, respectively. CONCLUSION: The promoter hypomethylation of MAGE genes up-regulates its expression in colorectal carcino mas as well as in gastric cancers and might play a signif icant role in the development and progression of human colorectal carcinomas. | Kyung-Hee Kim Jin-Sung Choi Il-Jin Kim Ja-Lok Ku Jae-Gahb Park | 2006 | World Journal of Gastroenterology2006，12，35： | 17 |
| 7 | Neuroinflammation and cytokine abnormality in major depression:Cause or consequence in that illness?显示文摘Depression results from changes in the central nervous system(CNS) that may result from immunological abnormalities.The immune system affects the CNS through cytokines,which regulate brain activities and emotions.Cytokines affect two biological systems that are most associated with the pathophysiology of depression:The hypothalamic-pituitary-adrenal axis and the catecholamine/sympathetic nervous system.Neuroinflammation and cytokines affect the brain signal patterns involved in the psychopathology of depression and the mechanisms of antidepressants,and they are associated with neurogenesis and neural plasticity.These observations suggest that neuroinflammation and cytokines might cause and/or maintain depression,and that they might be useful in the diagnosis and prognosis of depression.This psychoneuroimmunologic perspective might compensate for some of the limitations of the monoamine theory by suggesting that depression is a result of a failure to adapt to stress and that inflammatory responses and cytokines are involved in this process.In this review,the interactions of cytokines with the CNS,neuroendocrine system,neurotransmitters,neurodegeneration/neurogenesis,and antidepressants are discussed.The roles of cytokines in the etiology and psychopathology of depression are examined.The use of cytokine inhibitors or anti-inflammatory drugs in depression treatment is explored.Finally,the significance and limitations of the cytokine hypothesis are discussed. | Sang Won Jeon Yong Ku Kim | 2016 | World Journal of Psychiatry2016，6，3： | 16 |
| 8 | Evaluation of global and regional left ventricular systolic function in patients with frequent isolated premature ventricular complexes from the right ventricular outflow tract显示文摘从恰好室的流出道( RVOT-PVCs )的背景经常的早熟的室的建筑群与学习采用了二维的点缀追踪的左室的 dysfunction.This 被联系与这研究包括了的经常的 RVOT-PVCs.Methods 在病人评估全球、地区性的左室的心肌的功能的成像有经常的 RVOT-PVCs 和 30 健康 subjects.Aortic 的 30 个病人收缩速度时间积分( AoVTI )并且心肌层紧张在环绕( CS ),光线( RS ) | Yao Jing Xu Jing Yong Yong-hong Cao Ke-jiang Chen Shao-liang Ku Di | 2012 | Chinese Medical Journal2012，，2： | 15 |
| 9 | Characterization of pancreatic stem cells derived from adult human pancreas ducts by fluorescence activated cell sorting显示文摘瞄准:用没有浆液的、调节媒介从胰管的人的成年纸巾孤立通常认为的胰腺的干细胞(PSC ) 。这些 PSC 的表面显型的描述被流动血细胞计数分析。为胰腺的系和在这些 PSC 的贝它房间区别的能力的潜力也被评估。方法:由使用与必要生长因素补充的没有浆液的媒介,我们试图孤立被报导了表示巢在的通常认为的 PSC 和 pdx-1。Matrigel (TM ) 被采用评估孤立的房间的微分能力。染色的染色的双硫腙,胰岛素内容 / 分泌物测量,和免疫组织化学被用来监视区别。荧光(FACS ) 激活的房间排序被用来检测通常认为的 PSC 的表型的标记。结果:像锭子的房间的单层被栽培。通常认为的 PSC 表示了 pdx-1 和巢在里面。他们也能区分进胰岛素 -- , glucagon- ,和 somatostatin 积极的房间。在 PSC 的表型的标记的光谱被调查;当用人的骨头导出髓的干细胞作为比较级试验时,类似被揭示,例如 CD29, CD44, CD49,半数治愈量, CD51, CD62E, PDGFR-alpha, CD73 (SH2 ) , CD81, CD105 (SH3 ) 。结论:在这研究,我们成功地由使用没有浆液的媒介从成年的人的胰腺的管孤立 PSC。这些 PSC 不仅表示的巢在和 pdx-1 而且对间充质的干细胞可归因的展出标记。尽管工作被需要阐明这些房间的角色,这些 PSC 的申请可能是为糖尿病的治疗学的策略。 | Han-Tso Lin Shih-Hwa Chiou Chung-Lan Kao Yi-Ming Shyr Chien-Jen Hsu Yin-Wen Tarng Larry L-T Ho Ching-Fai Kwok Hung-Hai Ku | 2006 | World Journal of Gastroenterology2006，12，28： | 15 |
| 10 | Environmental Factors Affecting Temporal and Spatial Dynamics of Soil Erosion in Xingguo County, South China显示文摘By using soil erosion maps of four different time periods and a digital elevation model (DEM), in combination withthe remote sensing and GIS technologies, soil erosion dynamics in Xingguo County of Jiangxi Province in South Chinawere analyzed on both temporal and spatial scales in soils of different parent materials, altitudes and slopes. The resultsshowed that from 1958 to 2000 severe soil erosion was coming under control with a decreasing percentage of the land undersevere erosion. It was also found that the soils developed from Quaternary red clay, granite and purple shale were moresusceptible to soil erosion and that areas sitting between 200 to 500 m in altitude with a slope less than 3° or between7° to 20° where human activities were frequent remained to be zones where soil erosion was most likely to occur. Theseareas deserve special attention in monitoring and controlling. | WANG Ku SHI Xue-Zheng YU Dong-Sheng SHI De-Ming CHEN Jing-Ming XU Bin-Bin LIANG Yin LI De-Cheng | 2005 | Pedosphere2005，15，5： | 12 |
| 11 | Vector Magnetograph Observations by the Solar Flare Telescope at Boao显示文摘We report that vector magnetograph (VMG) observations of the solar photosphere are being carride out by the Solar Flare Telescope (SOFT) at BOAO. The VMG uses a narrow band Lyot filter (FWHM=0 125A) for Stokes parameter (I, Q, U, V) observations to obtain longitudinal and transverse fields. We have obtained a filter convolved line profile of Fe I 6302 5 for VMG by changing the central wavelength of the Lyot filter, which is consistent with the Sacremento Peak spectral atlas data. Using the line profile, we have determined calibration coefficients of longitudinal and transverse fields by the line slope method. Then we have compared vector fields of AR8422 observed at BOAO with those at Mitaka. The comparison shows that longitudinal fields are very similar to each other, but transverse fields are a little different. Finally, we present Hα and magnetic observations of AR8419 during its flaring activity (M3 1/1B). | Y. D. Park, Y. J. Moon (Korea Astronomy Observatory, Whaamdong, Yooseong ku, Taejon, 305 348, Korea) H. S. Yun (Department of Astronomy, Seoul National University, Seoul 151 742, Korea) | 1999 | 天文研究与技术1999，，S1： | 12 |
| 12 | Role of electrodes in ambient electrolytic decomposition of hydroxylammonium nitrate (HAN) solutions显示文摘Decomposition of hydroxylammonium nitrate (HAN) solution with electrolytic decomposition method has attracted much attention in recent years due to its efficiencies and practicability.However,the phenomenon has not been well-studied till now. By utilizing mathematical model currently available,the effect of water content and power used for decomposition was studied. Experiment data shows that sacrificial material such as copper or aluminum outperforms inert electrodes in the decomposition of HAN solution. In the case of using copper wire to electrolyse HAN solutions, approximately 10 seconds is required to reach 100℃ regardless of concentration of HAN. In tem of power consumption,100W-300W was found to be the range in which decomposition could be triggered effectively using copper wire as electrodes. | Kai SengKoh Jitkai Chin Tengku F.Wahida Ku Chik | 2013 | Propulsion and Power Research2013，2，3： | 12 |
| 13 | Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits显示文摘瞄准:为了调查超级顺磁的氧化铁(SPIO ) 的生物进程是否把人的间充质的干细胞(hMSCs ) 标记,可以被使用在活体内 non-invasively 监视有在老鼠和兔子的阴茎海绵体的常规 1.5-T 系统考试的磁性的回声(先生) 成像。方法:分别地与普鲁士的蓝色和 Tripan 蓝色检验的标记 SPIO 的 hMSCswere 的标记的效率和生存能力。在标记 SPIO 的 hMSCs 被移植到老鼠和兔子的阴茎海绵体以后,连续 T2 加权的先生图象被拿,组织学的考试在一个 4 星期的时期上被执行。结果:与 SPIOcompared 装载到未标记的房间的 hMSCs 有一个类似的生存能力。为标记 SPIO 的 hMSCs 超过 1 x 10 ~ 5concentration 在试管内,先生图象在信号紧张显示出减少。在在老鼠和兔子阴茎海绵体的标记 SPIO 的 hMSCs 的区域的先生信号紧张局部地减少了并且被限制。在进阴茎海绵体的标记 SPIO 的 hMSCs 的注射以后,先生成像证明 hMSCs 能在注射以后被看见至少 12 个星期。铁的存在被证实,普鲁士的蓝色在组织学的节染色。结论:在老鼠和兔子的阴茎海绵体的标记 SPIO 的 hMSCs 能被分子的先生成像 non-invasively 评估。我们的调查结果建议先生成像有能力在可勃起的机能障碍的背景在动物测试 hMSCs 的长期的治疗学的潜力。 | Yun-Seob Song Ja-Hyeon Ku Eun-Seop Song Jung-Hoon Kim Jin-Suck Jeon Kong-Hee Lee Sook-Ja Kim Hee-Jeong Cheong Ik-Sung Lim Dongho Choi Jong-Ho Won | 2007 | Asian Journal of Andrology2007，9，3： | 11 |
| 14 | Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method显示文摘AIM: To enhance the differentiation of insulin producing cell (IPC) ability from embryonic stem (ES) cells in vitro. METHODS: Four-day embryoid body (EB)-formatted ES cells were dissociated as single cells for the followed plasmid DNA delivery. The use of NucleofectorTM electroporator (Amaxa biosystems, Germany) in combination with medium-contained G418 provided a high efficiency of gene delivery for advanced selection. Neucleofected cells were plated on the top of fibronectincoated Petri dishes. Addition of Ly294002 and raised the glucose in medium at 24 h before examination.The differentiation status of these cells was monitored by semi-quantitative PCR (SQ-PCR) detection of the expression of relative genes, such as oct-4, sox-17, foxa2, mixl1, pdx-1, insulin 1, glucagons and somatostatin. The percentage of IPC population on d 18 of the experiment was investigated by immunohistochemistry (IHC), and the content/secretion of insulin was estimated by ELISA assay. The mice with severe combined immunodeficiency disease (SCID) pretreated with streptozotocin (STZ) were used to eliminate plasma glucose restoration after pax4+ ES implantation. RESULTS: A high efficiency of gene delivery was demonstrated when neucleofection was used in the present study; approximately 70% cells showed DsRed expression 2 d after neucleofection. By selection of medium-contained G418, the percentage of DsRed expressing cells kept high till the end of study. The pancreatic differentiation seemed to be accelerated by pax4 nucleofection. When compared to the group of cells with mock control, foxa2, mixl1, pdx1, higher insulin and somatostatin levels were detected by SQ-PCR 4 d after nucleofection in the group of pax4 expressing plasmid delivery. Approximately 55% of neucleofected cells showed insulin expression 18 d after neucleofection, and only 18% of cells showed insulin expression in mock control. The disturbance was shown by nucleofected pax4 RNAi vector; only 8% of cells expressed insulin 18 d after nucleofection. A higher IPC population was also detected in the insulin content by ELISA assay, and the glucose dependency was demonstrated in insulin secretion level. In the animal model, improvement of average plasma glucose concentration was observed in the group of pax-4 expressed ES of SCID mice pretreated with STZ, but no significant difference was observed in the group of STZ-pretreated SCID mice who were transplanted ES with mock plasmid. CONCLUSION: Enhancement of IPC differentiation from EB-dissociated ES cells can be revealed by simply using pax4 expressing plasmid delivery. Not only more IPCs but also pancreatic differentiation-related genes can be detected by SQ-PCR. Expression of relative genes, such as foxa 2, mixl 1, pdx-1, insulin 1 and somatostatin after nucleofection, suggests that pax4 accelerates the whole differentiation progress. The higher insulin production with glucose dependent modulation suggests that pax4 expression can drive more mature IPCs. Although further determination of the entire mechanism is required, thepotential of pax-4-nucleofected cells in medical treatment is promising. | Han-Tso Lin Chung-Lan Kao Kun-Hsiung Lee Yuh-Lih Chang Shih-Hwa Chiou Fu-Ting Tsai Tung-Hu Tsai Dey-Chyi Sheu Larry LT Ho Hung-Hai Ku | 2007 | World Journal of Gastroenterology2007，13，11： | 10 |
| 15 | Experimental and Numerical Investigation on Impact Performance of Carbon Reinforced Aluminum Laminates显示文摘It is known that fiber metal laminates (FML) as one of hybrid materials with thin metal sheets and fiber/epoxy layers have the characteristics of the excellent damage tolerance, fatigue and impact properties with a relatively low density. Therefore, the mechanical components using FML can contribute the enhanced safety level of the sound construction toward the whole body. In this study, the impact performance of carbon reinforced aluminum laminates (CARAL) is investigated by experiments and numerical simulations. Drop weight tests are carried out with the weight of 4.7 kg at the speed of 1 and 2 m/s, respectively. Dynamic non-linear transient analyses are also accomplished using a finite element analysis software, ABAQUS. The experiment results and numerical results are compared with impact load-time histories. Also, energy-time histories are applied to investigate the impact performance of CARAL. | S.H. Song Y.S. Byun T.W. Ku W.J. Song J. Kim B.S. Kang | 2010 | Journal of Materials Science & Technology2010，26，4： | 10 |
| 16 | Targeting PVR(CD155)and its receptors in anti-tumor therapy显示文摘Poliovirus receptor(PVR,CD155)has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.In contrast to healthy tissues,PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic virotherapy.More intriguingly,PVR participates in a considerable number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors.These functions are often modified in the tumor microenvironment,contributing to tumor immunosuppression.Indeed,increasing evidence supports the rationale for developing strategies targeting these interactions,either in terms of checkpoint therapy(i.e.,targeting inhibitory receptors)or in adoptive cell therapy,which targets PVR as a tumor marker. | Paola Kučan Brlić Tihana Lenac Roviš Guy Cinamon Pini Tsukerman Ofer Mandelboim Stipan Jonjić | 2019 | Cellular & Molecular Immunology2019，16，1： | 10 |
| 17 | Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX显示文摘在 BCL-2 家庭蛋白质之间的相互作用决定房间的命运生活或死。他们怎么与对方一起交往调整 apoptosis,作为一个未解决的中央问题留下。到目前为止, antiapoptotic BCL-2 蛋白质被认为微弱地与 BAX 交往,但是这个相互作用的生理的意义是含糊的。此处,我们证明 recombinant BCL-2 和 BCL-w 与 3 包含域的肽从 BAX 导出的 BCL-2 相同(BH ) potently 交往,分别地展出 15 和 23 nM 的分离常数。为这个强壮的相互作用澄清基础,我们与跨越它的 BH3 领域的 BAX 肽决定了 BCL-2 的建筑群的三维的结构。它表明他们在正规 BH3 领域以外扩大并且包含了三 nonconserved 的相互作用控告了 BAX 的残余。新奇 BAX 变体,包含这三残余的丙氨酸替换,极大地为 BCL-2 和 BCL-w 损害了亲密关系,但是与野类型的 BAX 另外难区分。极其, BAX 变体的 apoptotic 活动不能被 BCL-2 和 BCL-w 制止,指观察紧密的相互作用为调整 BAX 激活是批评的。我们包括地也确定了与三 BCL-2 亚科蛋白质的有约束力的亲密关系。一起,数据表演由于为 BCL-2 , BCL-w 和 A1 的 BAX 的高亲密关系,并且为 BCL-XL , MCL-1 和 A1 的 BAK ,仅仅一个子集BH3仅仅蛋白质,通常包括的 BIM ,出价和美洲狮,能从 antiapoptotic BCL-2 蛋白质被期望到免费 BAX 或 BAK 得到 apoptosis 。 | Bonsu Ku Chengyu Liang Jae U Jung Byung-Ha Oh | 2011 | Cell Research2011，21，4： | 9 |
| 18 | Relationship between vitamin D deficiency and cardiovascular disease显示文摘Epidemiological studies have found that low 25-hydroxyvitamin D levels may be associated with coronary risk factors and adverse cardiovascular outcomes.Additionally,vitamin D deficiency causes an increase in parathyroid hormone,which increases insulin resistance and is associated with diabetes,hypertension,inflammation,and increased cardiovascular risk.In this review,we analyze the association between vitamin D supplementation and the reduction in cardiovascular disease.The role of vitamin D deficiency in cardiovascular morbidity and mortality is still controversial,and larger scale,randomized placebo controlled trials are needed to investigate whether oral vitamin D supplementation can reduce cardiovascular risk.Given the low cost,safety,and demonstrated benefit of higher 25-hydroxyvitamin D levels,vitamin D supplementation should become a public health priority for combating common and costly chronic cardiovascular diseases. | Yan-Chiou Ku Mu-En Liu Chang-Sheng Ku Ta-Yuan Liu Shoa-Lin Lin | 2013 | World Journal of Cardiology2013，5，9： | 8 |
| 19 | Paleotemperature changes over the past 3000 years in eastern Beijing, China: A reconstraction based on Mg/Sr records in a stalagmite显示文摘The Mg/Sr ratio in a stalagmite, which is di-rectly proportional to DMg/Ca, the solid-liquid distribution coefficient of Mg, is proposed as a geochemical thermometer to estimate paleotemperature changes. The paleotempera-ture change in eastern Beijing over the past 3000 years has been reconstructed by using this thermometer in the stalag-mite ZFFS-1 from Jingdong Cave. The records can be di-vided into two periods: 3000—2000 aBP, cool and wet, the air temperature averaging 9.8℃; and 2000 aBP—present, hot and dry, the air temperature being 1℃ higher than the mean value (11.7℃) of the past 3000 years. During 500—200 aBP, the air temperature was about 1.2℃ lower than that of the present, corresponding to the Little Ice Age in Europe. Like d 18O and d 13C, Mg/Sr (or DMg/Ca) reflects an obviously warming trend of the past 200 years. These results are sup-ported by historic records. | MA Zhibang1, LI Hongchun2, XIA Ming1, KU Tehlung2, PENG Zicheng3, CHEN Yushu4 & ZHANG Zhaofeng3 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth Sciences, University of Southern California, Los Angeles, CA90089-0740, USA 3. Department of Earth and Space Science, University of Science and Technology of China, Hefei 230026, China 4. Beijing Foshan Tourist Service Centre, Beijing 101201, China | 2003 | Chinese Science Bulletin2003，48，4： | 8 |
| 20 | 世界卫生组织听力障碍防治规划显示文摘根据世界卫生组织(World Health Organization,WHO)的估计,2005年全球至少有2.78亿人有致残性听力损害(WHO关于致残性听力损害的标准是听力较好耳有中度以上听力损失),其中80%的听力障碍人士生活在中低收入国家。据调查50%的耳聋和听力障碍通过预防、早期诊断和处理是可避免的。因此,WHO听力障碍防治规划任重而道远。 | Young-Ah Ku 冯定香 苏俊 | 2009 | 中国医学文摘(耳鼻咽喉科学)2009，24，1： | 8 |
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