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| 1 | Zika threatens to become a huge worldwide pandemic显示文摘The Aedes aegypti mosquito which transmits Zika virus(as well as dengue, chikungunya and yellow fever) represents a high risk for global transmission. This virus comes from Africa, the Zika forest in Uganda, where it was discovered in 1947 in a rhesus monkey. In May 2015, the first local cases were recorded in Brazil, surpassing 1.5 million cases in December of the same year. By March 2016, local transmission of Zika was recognized in 34 countries. Its clinical condition is similar to dengue febrile illness, although milder.The final geographical distribution area is constantly expanding. Recently, it has been associated with cases of Guillain-Barre′ syndrome in Brazil, Colombia, El Salvador,Venezuela and Suriname. Microcephaly was documented in Brazil. This article discusses some factors that contributed to the spread of Zika virus in South America. Climate change associated with the events of the phenomenon of 'El Ni?o' is also analyzed. The biggest concern is how quickly Zika is spreading around the world and that it could be far more dangerous than previously thought. Zika virus infection, by its explosive potential,has every chance of becoming a global pandemic. | Alcides Troncoso | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 1 |
| 2 | Current perspectives on dengue episode in Malaysia显示文摘To Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per annum.Urban encroachment,ecological disruption and poor sanitation are all contributory factors of increased epidemiology.Complication however arises from the fact that dengue virus inherently exists as four different serotypes.Secondary infection is often manifested in the more severe form,such that antibody-dependent enhancement(ADE) could aggravate ailment by allowing pre-existing antibodies to form complexes with infecting viruses as means of intrusion.Consequently,increased viraemic litter and suppression of antiviral response are observed.Deep concerns are thus expressed in regards to escalating trend of hospitalisation and mortality rates.In Malaysia,situation is exacerbated by improper clinical management and pending vector control operations.As a preparedness strategy against the potential deadly dengue pandemic,the call for development of a durable and costeffective dengue vaccine against all infecting serotypes is intensified.Even though several vaccine candidates are currently being evaluated in clinical trials,uncertainties in regards to serotypes interference,incomplete protection and dose adequacy have been raised.Instead of sole reliance on outsourcing,production of local vaccine should be considered in coherent to government's efforts to combat against dengue. | Ee Leen Pang Hwei-San Loh | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 0 |
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