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| 1 | Increase of beta-amyloid and C-reactive protein in liver transplant recipients with postoperative cognitive dysfunction显示文摘BACKGROUND: Postoperative cognitive dysfunction (POCD) is an adverse condition characterized by declined cognitive functions following surgeries and anesthesia. POCD has been associated with increased hospital stay and mortality. There are histological similarities to Alzheimer's disease. Most early studies were conducted in patients receiving cardiac surgery. Since there is no information about POCD in liver transplant recipients, we measured the incidence of POCD in patients after liver transplantation and examined the correlation between neurological dysfunction and biological markers of dementia- based diseases. METHODS: We studied 25 patients who had a liver transplan- tation between July 2008 and February 2009. Patients with prior encephalopathy or risk factors associated with the development of POCD were excluded from the study. Five validated neuropsychiatric tests were used for diagnosis. The diagnosis was based on one standard deviation decline in two of the five neuropsychiatric tests. The correlation between patient variables and the development of POCD was examined. Serum levels of beta-amyloid and C-reactive protein were measured by standard ELISA and compared between patients with and without POCD. RESULTS: POCD was present in 11 (44%) of the 25 patients. Patients with POCD had significantly higher MELD scores, were more often Child-Pugh class C and received more blood transfusion during surgery. The serum beta-amyloid protein and C-reactive protein concentrations were significantly increased at 24 hours after surgery in the POCD group.CONCLUSIONS: The incidence of POCD in our group of liver transplant patients was greater than that reported in other surgical patients. The increase in the serum biomarkers of dementia in the POCD patients supports the hypothesis that chronic cognitive defects are due to a process similar to that seen in Alzheimer's disease. | Xing Li Da-Xiang Wen Yan-Hong Zhao Yan-Nan Hang M Susan Mandell | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 13 |
| 2 | Using phylogenomics to resolve mega-families: An example from Compositae显示文摘为阐明的下一代的定序和 phylogenomics 抓住伟人诺言在大植物家庭之中的复杂关系。这里,我们执行了在大、多样的被子植物家庭 Compositae (Asteraceae ) 的在 Illumina 站台上的下一代的定序跟随的低拷贝序列的指向的俘获。家庭是 monophyletic 基于形态学和分子的数据,然而,发展史的许多区域有未解决的 polytomies 和解释种系发生的模式是历史上困难的。以便构画出一个方法并且提供一个框架并且为未来在 Compositae 的种系发生的研究,我们从越过关系很好象姐妹家庭 Calyceraceae 的一个成员一样在被建立的家庭定序 23 taxa。我们从 795 产生了原子数据从离开目标俘获的 loci 和装配叶绿体染色体读启用比较原子并且为种系发生的分析的叶绿体染色体。我们也分析了在我们的数据的原子基因在 orthology 察觉期间用一个聚类的方法设置了的多拷贝,并且我们把一条网络途径用于所有相关地点拷贝的这些 clusters—analyzing。用这些数据,我们生产了两个都雇用一个保守人士的种系发生的关系的假设(每指向的地点与一个拷贝限制了为仅仅 loci ) 并且一条 multigene 途径(每指向的地点包括所有拷贝) 。这里介绍的方法和生物信息学工作流为针对象在另外的工厂为 phylogenomic 分析提供一个模型一样在 Compositae 理解基因家庭进化的未来工作提供一个稳固的基础大家庭。 | Jennifer R. Mandel Rebecca B. Dikow Vicki A. Funk | 2015 | Journal of Systematics and Evolution2015，53，5： | 11 |
| 3 | Cardiac evaluation of liver transplant candidates显示文摘Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Cardiomyopathy also occurs in greater frequency. While all patients with advanced cardiac disease have defects in cardiac performance, a larger than expected number of patients have classical findings of dilated, restrictive and hypertropic cardiomyopathy. This may explain why up to 56% of patients suffer from hypoxemia due to pulmonary edema following transplant surgery. There is considerable controversy on how to screen transplant candidates for the presence of heart disease. Questions focus upon, which patients should be screened and what tests should be used. This review examines screening strategies for transplant candidates and details the prognostic value of common tests used to identify ischemic heart disease. We also review the physiological consequences of cardiomyopathy in transplant candidates and explore the specific syndrome of 'cirrhotic cardiomyopathy'. | Mercedes Susan Mandell JoAnn Lindenfeld Mei-Yung Tsou Michael Zimmerman | 2008 | World Journal of Gastroenterology2008，14，22： | 8 |
| 4 | 根据甲状腺癌危险程度分层行放射性碘治疗和选择性靶向治疗显示文摘亲碘是分化型甲状腺癌的典型表现,可用放射性碘对该肿瘤进行有效治疗。在大多数分化型甲状腺癌患者中,常采用放射性碘来清除残留甲状腺组织(简称清甲),对于这类患者主张用最小有效剂量。辅助治疗可降低分化型甲状腺癌复发风险,但相关患者的最佳纳入标准及具体治疗剂量尚不清楚。进展期分化型甲状腺癌患者能从最大放射性碘耐受剂量的治疗中获益。筛选适合清甲的患者及其治疗剂量是近期研究热点之一。近年来研发出一些用于治疗碘抵抗难治性分化型甲状腺癌的靶向药物,其中一种已通过美国食品与药品管理局(FDA)的批准,此外,多个临床试验正在评估单用靶向药物或靶向药物联合放射性碘治疗难治性分化型甲状腺癌的疗效。 | 董萍 李林 Daniel A. Pryma Susan J. Mandel | 2018 | 中华核医学与分子影像杂志2018，38，5： | 7 |
| 5 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 6 | Phylogenomics of the hyperdiverse daisy tribes:Anthemideae,Astereae,Calenduleae,Gnaphalieae,and Senecioneae显示文摘Asteraceae account for 10%of all flowering plant species,and 35%-40%of these are in five closely related tribes that total over 10000 species.These tribes include Anthemideae,Astereae,Calenduleae,Gnaphalieae,and Senecioneae,which form one of two enormous clades within Subfamily Asteroideae.We took a phylogenomics approach to resolve evolutionary relationships among these five tribes.We sampled the nuclear and plastid genomes via HybSeq target enrichment and genome skimming,and recovered 74 plastid genes and nearly 1000 nuclear loci,known as Conserved Orthologous Sequences.We tested for conflicting support in both data sets and used network analyses to assess patterns of reticulation to explain the early evolutionary history of this lineage,which has experienced whole-genome duplications and rapid radiations.We found concordance and conflicting support in both data sets and documented four ancient hybridization events.Due to the timing of the early radiation of this five-tribe lineage,shortly before the Eocene-Oligocene extinction event(34 MYA),early lineages were likely lost,obscuring some details of their early evolutionary history. | Linda E.Watson Carolina M.Siniscalchi Jennifer Mandel | 2020 | Journal of Systematics and Evolution2020，58，6： | 5 |
| 7 | 用酵母双杂交体系筛选与FMRP相作用蛋白的cDNA显示文摘目的采用酵母双杂交体系寻找与脆性X智力低下蛋白(Fragile X men-tal retadation protein,FMRP)相互作用的蛋白,探讨FMRP的生物医学功能。方法以编码FMRP_(Pro327-Thr518)肽段的cDNA序列与pBTM116质粒DNA结合结构域重组作为'钓饵',从小鼠胚胎cDNA文库中筛选与之相互作用蛋白的cDNA。结果筛选出13个与FMRP_(Pro327-Thr518)肽段特异性地相互作用的克隆,其中12个为小鼠泛素转运酶9(UBC9),1个是在GenBank中无高同源序列的未知cDNA序列。结论小鼠UBC9与人UBC9的氨基酸序列完全相同,且FMRP与UBC9蛋白表达的时空特征相似,因此认为人UBC9是与FMRP相互作用的蛋白,其相互作用的生物学意义有待进一步研究。本工作表明酵母双杂交体系是研究蛋白质相互作用的有效方法。 | 陈雨亭 Anne Sittler 余珉 Barbara Bardoni 吴冠芸 Jean Louis Mandel 沈岩 | 1998 | 中国医学科学院学报1998，20，3： | 4 |
| 8 | 动态增强磁共振成像对恶性血液病骨髓肿瘤浸润监测的初步研究显示文摘目的本研究旨在利用动态增强MR成像技术(DCE-MR)检测血液病患者骨髓强化特征变化,研究其与骨髓肿瘤细胞浸润状态的相关性。方法25例血液病经DCE-MR成像及髂嵴穿刺活检,测定骨髓灌注的最大强化率(PER),最大强化斜率值(Slopemax),峰值时间(TTP),平均时间(MT),以及骨髓活检分析肿瘤分数(TF)。结果肿瘤浸润组较缓解期组PER高(临床缓解期为0.252±0.156,肿瘤组为0.592±0.433),统计学上有显著性差异(P<0.05)。肿瘤浸润组较缓解期组的Slopemax高肿瘤组:(0.561±0.634)/s;缓解期组:(0.204±0.105)/s、TTP缩短肿瘤组:(68.12±42.18)s;缓解期组:(81.52±38.49)s,但统计学上无显著性差异(P>0.05),MT值两组差异不明显(P>0.05)。结论动态增强MR成像能够监测血液病骨髓肿瘤细胞浸润状态,为恶性血液病治疗随访提供了一种新的无创性监测手段。 | 张蕾 Catherine Mandel 杨振燕 Qing Yang Richard Nibbs David Westerman Alex G Pitman | 2006 | 中国医学影像技术2006，22，7： | 4 |
| 9 | The Compositae Tree of Life in the age of phylogenomics显示文摘包括超过 25000 种类,葵花家庭(Compositae 或 Asteraceae ) 是 flowering 植物的最大的家庭。许多它的系经历了最近、快速的放射,和家庭有大规模基因复制和 polyploidy 的深、普遍的历史。许多由于对发展史的主要节点的支持的差的分辨率和缺乏关于家庭差异的最重要的进化问题仍然保持未答复。我们的组用包括定序 1000 低拷贝的数字的 Hyb-Seq 采用了一条 phylogenomics 途径原子标记,为大量种类的正部分 plastomes。这里,我们讨论我们的进步标明日期并且介绍包括九个亚科和 25 个部落用的二发展史并置并且基于结合的分析。我们为合并高质量的参考染色体和 transcriptomes 在 Compositae 推进系统、进化的研究讨论未来计划。当我们向为采用 phylogenomics 并且在 Compositae 以内解决关系开发工具做了大迈进时,许多工作留下。最近形成的全球合伙将工作 megafamily 为这解决未答复的进化问题。 | Jennifer R. Mandel Michael S. Barker Randall J. Bayer Rebecca B. Dikow Tian-Gang Gao Katy E. Jones Sterling Keeley Norbert Kilian Hong Ma Carolina M. Siniscalchi Alfonso Susanna Ramhari Thapa Linda Watson Vicki A. Funk | 2017 | Journal of Systematics and Evolution2017，55，4： | 4 |
| 10 | Evidence-based medical oncology and interventional radiology paradigms for liver-dominant colorectal cancer metastases显示文摘Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is(limited) extrahepatic disease. Unfortunately, these patients carry a known risk of recurrence in the liver regardless of initial therapy choice. Therefore, there is a demand for minimally invasive, non-surgical, personalized cancer treatments to preserve quality of life in the induction, consolidation, and maintenance phases of cancer therapy. This report aims to review evidence-based conceptual, pharmacological, and technological paradigm shifts in parenteral and percutaneous treatment strategies as well as forthcoming evidence regarding next-generation systemic, locoregional, and local treatment approaches for this patient population. | Alan Alper Sag Fatih Selcukbiricik Nil Molinas Mandel | 2016 | World Journal of Gastroenterology2016，22，11： | 4 |
| 11 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 12 | Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline显示文摘 | Leslie De Groot Marcos Abalovich Erik K. Alexander Nobuyuki Amino Linda Barbour Rhoda H. Cobin Creswell J. Eastman John H. Lazarus Dominique Luton Susan J. Mandel Jorge Mestman Joanne Rovet Scott Sullivan | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，8： | 2 |
| 13 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 14 | Inflammatory bowel disease course in Crohn's disease:Is the natural history changing?显示文摘Crohn’s disease(CD)is a multifactorial potentially debilitating disease.It has a variable disease course,but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability.Studies on the natural history of CD provide invaluable data on its course and clinical predictors,and may help to identify patient subsets based on clinical phenotype.Most data are available from referral centers,however these outcomes may be different from those in population-based cohorts.New data suggest the possibility of a change in the natural history in Crohn’s disease,with an increasing percentage of patients diagnosed with inflammatory disease behavior.Hospitalization rates remain high,while surgery rates seem to have decreased in the last decade.In addition,mortality rates still exceed that of the general population.The impact of changes in treatment strategy,including increased,earlier use of immunosuppressives,biological therapy,and patient monitoring on the natural history of the disease are still conflictive.In this review article,the authors summarize the available evidence on the natural history,current trends,and predictive factors for evaluating the disease course of CD. | Petra A Golovics Michael D Mandel Barbara D Lovasz Peter L Lakatos | 2014 | World Journal of Gastroenterology2014，20，12： | 2 |
| 15 | Reducing mortality from colorectal cancer by screening for fecal occult blood, minnesota colon cancer study显示文摘 | Mandel JS BONG JH Church TR | 1993 | N engl J med1993，328，： | 2 |
| 16 | 血液病骨髓动态增强MRI特征的初步研究显示文摘目的 探讨血液病患者骨髓动态增强MRI(DCE-MRI)与骨髓细胞构成的关系。方法对25例恶性血液病患者进行DCE-MRI检查,测定骨髓灌注的最大强化率(PER)、最大强化斜率(Slopemax)、峰值时间(哪)和平均时间(MT);30min后进行髂嵴穿刺活检,分析细胞构成。结果 25例血液病患者中,正常细胞数型骨髓20例,细胞数增多型骨髓3例,细胞数减少型骨髓2例。DCE-MRI骨髓时间.信号强度曲线(TIC)B型3例,C型7例,D型13例,E型2例。细胞数增多型骨髓PER、Slopemax均高于正常细胞数型骨髓和细胞数减少型骨髓;细胞数增多型骨髓,TTP短于正常细胞数型骨髓和细胞数减少型骨髓;细胞数减少型骨髓MT短于正常细胞数型骨髓和细胞数增多型骨髓。结论 DCE-MRI可以作为无创、有效监测血液病骨髓细胞构成变化的手段之一。 | 张蕾 Catherine Mandel 杨振燕 王培军 Alex G Pitman | 2007 | 中华肿瘤杂志2007，29，3： | 2 |
| 17 | Colorectal Cancer in Patients Under Close Colonoscopic Surveillance显示文摘 | Douglas J. Robertson E. Robert Greenberg Michael Beach Robert S. Sandler Dennis Ahnen Robert W. Haile Carol A. Burke Dale C. Snover Robert S. Bresalier Gail McKeown-Eyssen Jack S. Mandel John H. Bond Rosalind U. van Stolk Robert W. Summers Richard Rothste | 2005 | Gastroenterology2005，，1： | 2 |
| 18 | Hepatopulmonary syndrome and portopulmonary hypertension: A report of the multicenter liver transplant database显示文摘 | Michael J. Krowka M. Susan Mandell Michael A.E. Ramsay Steve M. Kawut Michael B. Fallon Cosme Manzarbeitia Manuel Pardo Paul Marotta Shinji Uemoto Markus P. Stoffel Joanne T. Benson | 2004 | Liver Transpl2004，，2： | 2 |
| 19 | 罗氏芬治疗下呼吸道感染的多中心前瞻性开放性研究显示文摘在加拿大的14家医院进行前瞻性开放性研究,观察每日一次1g罗氏芬(头孢三嗪)治疗下呼吸道感染的效果。病人用本药至少3天。共观察137例病人,年龄19~95岁,平均68岁。91%病例诊断为不伴菌血症的院外感染性肺炎。82%属中度或重度感染。病人用头孢三嗪平均5天,34例病人同时加用了大环内酯类抗生素或甲硝唑,占25%。在静脉注射头孢三嗪至少3天后,59例(43%)改用口服抗菌药物。92.9%病人的治疗结果顺利;仅7.1%病人治疗失败,包括无效和感染复发。全部观察病例中91%符合评定疗效的研究条件,其中临床治愈占64.6%,好转占28.3%,2例病人复发,占1.8%;6例治疗无效,占5.3%,12例病人死于与治疗研究药物无关的病因,占8.8%,3例出现可能与头孢三嗪有关的不良反应,表现为荨麻疹、腹泻和注射部位静脉炎。加拿大全国性的致病菌,常见的肺炎致病菌体外敏感性监测结果表明,血清中的头孢三嗪浓度,超过90%菌株最低抑菌浓度,从而支持作者采用的头孢三嗪治疗剂量方案,仅肠杆菌属例外。研究结果表明,需要住院的感染性肺炎病人可用头孢三嗪每日一次1g静脉注射作经验性治疗。 | Low DE Mandell LA | 1998 | 上海医药1998，10，3： | 2 |
| 20 | Radical prostatectomy in patients aged 75 years or older:review of the literature显示文摘Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological age.As a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit.As perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be addressed.It is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after treatment.Moreover,elderly patients also demonstrate worse postoperative recovery of continence and erectile function.As the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients. | Philipp Mandel Thenappan Chandrasekar Felix K Chun Hartwig Huland Derya Tilki | 2019 | Asian Journal of Andrology2019，21，1： | 2 |
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