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| 1 | Improving sessile serrated adenoma detection rates with high definition colonoscopy:A retrospective study显示文摘BACKGROUND Sessile serrated adenomas(SSAs)are important premalignant lesions that are difficult to detect during colonoscopy due to poor definition,concealment by mucous caps,and flat appearance.High definition(HD)colonoscopy may uniquely aid in the detection of these inconspicuous lesions compared to standard definition(SD)colonoscopes.In the absence of existing clinical guidelines to obligate the use of HD colonoscopy for colorectal cancer screening in average-risk patients,demonstrating the benefit of HD colonoscopy on SSA detection rate(SSADR)may help strengthen the evidence to recommend its use in all settings.AIM To evaluate the benefit of HD colonoscopy compared to SD colonoscopy on SSADR in average-risk patients undergoing screening colonoscopy.METHODS Data from screening colonoscopies for patients aged 50-76 years two years before and two years after the transition from SD colonoscopy to HD colonoscopy at our large,academic teaching center were collected.Patients with symptoms of colorectal disease,positive occult blood test,history of colon polyps,cancer,polyposis syndrome,inflammatory bowel disease or family history of colon cancer or polyps were excluded.Patients whose endoscopists did not perform colonoscopies both before and after scope definition change were also excluded.Differences in individual endoscopist SSADR,average SSADR,and overall SSADR with SD colonoscopy vs HD colonoscopy were also evaluated for significance.RESULTS A total of 3657 colonoscopies met eligibility criteria with 2012 colonoscopies from the SD colonoscopy period and 1645 colonoscopies from the HD colonoscopy period from a pool of 11 endoscopists.Statistically significant improvements of 2.30%in mean SSADR and 2.53%in overall SSADR were noted with HD colonoscopy(P=0.00028 and P=0.00849,respectively).On the individual level,three endoscopists experienced statistically significant benefit with HD colonoscopy(+5.74%,P=0.0056;+4.50%,P=0.0278;+4.84%,P=0.03486).CONCLUSION Our study suggests that HD colonoscopy statistically significantly improves sessile serrated adenoma detection rate in the screening of average risk patients during screening colonoscopy.By improving the detection and removal of these lesions,adoption of HD colonoscopy may reduce the significant premalignant burden of sessile serrated adenomas. | Abhinav Sehgal Soorya Aggarwal Rohan Mandaliya Thomas Loughney Mark C Mattar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 2 | Adipokines Linking Obesity with Colorectal Cancer Risk in Postmenopausal Women显示文摘 | Gloria Y.F. Ho Tao Wang Marc J. Gunter Howard D. Strickler Mary Cushman Robert C. Kaplan Sylvia Wassertheil-Smoller Xiaonan Xue Swapnil N. Rajpathak Rowan T. Chlebowski Mara Z. Vitolins Philipp E. Scherer Thomas E. Rohan | 2012 | Cancer Research2012，，12： | 2 |
| 3 | Serum Lipid Profiles and Cancer Risk in the Context of Obesity: Four Meta-Analyses显示文摘 | Jennifer C. Melvin Lars Holmberg Sabine Rohrmann Massimo Loda Mieke Van Hemelrijck Thomas E. Rohan | 2013 | Journal of Cancer Epidemiology2013，，： | 2 |
| 4 | Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression显示文摘 | Herbert Yu Thomas Rohan | 2000 | J Natl Cancer I2000，92，18： | 1 |
| 5 | Hepatocyte Growth Factor and the Risk of Ischemic Stroke Developing Among Postmenopausal Women: Results From the Women?s Health Initiative显示文摘 | Swapnil N. Rajpathak Tao Wang Sylvia Wassertheil-Smoller Howard D. Strickler Robert C. Kaplan Aileen P. McGinn Rachel P. Wildman Daniel Rosenbaum Thomas E. Rohan Philipp E. Scherer Mary Cushman Gloria Y.F. Ho | 2010 | Stroke2010，，5： | 1 |
| 6 | 14th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends显示文摘 | Doruk Erkan Cassyanne L. Aguiar Danieli Andrade Hannah Cohen Maria J. Cuadrado Adriana Danowski Roger A. Levy Thomas L. Ortel Anisur Rahman Jane E. Salmon Maria G. Tektonidou Rohan Willis Michael D. Lockshin | 2014 | Autoimmunity Reviews2014，，： | 1 |
| 7 | Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada显示文摘 | Thomas E. Rohan Geoffrey R. Howe J. David Burch Meera Jain | 1995 | Cancer Causes and Control1995，，2： | 1 |
| 8 | Energy balance and breast cancer risk: a prospective cohort study显示文摘 | Stephanie A. Navarro Silvera Meera Jain Geoffrey R. Howe Anthony B. Miller Thomas E. Rohan | 2006 | Breast Cancer Research and Treatment2006，，1： | 1 |
| 9 | Cigarette smoking and risk of glioma:A prospective cohort study显示文摘 | Silvera SA Miller Anthony Rohan Thomas | 2006 | Int J Cancer2006，118，7： | 1 |
| 10 | Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression显示文摘 | Herbert Yu Thomas Rohan | 2000 | J Natl Cancer Inst2000，92，： | 1 |
| 11 | Trace elements and cancer risk: a review of the epidemiologic evidence显示文摘 | Stephanie A. Navarro Silvera Thomas E. Rohan | 2007 | Cancer Causes & Control2007，，1： | 1 |
| 12 | Applicability of equations of state for modeling helium systems 显示文摘 | Rijo Jacob Thomas Rohan Dutta Parthasarathi Ghosh | 2012 | Cryogenics2012，5279，： | 1 |
| 13 | Cigarette smoking and risk of glioma: A prospective cohort study显示文摘 | Silvera S A Miller Anthony Rohan Thomas | 2006 | Int J Cancer2006，118，7： | 1 |
| 14 | Smoking and alcohol consumption in relation to risk of thyroid cancer in postmenopausal women显示文摘 | Geoffrey C. Kabat Mimi Y. Kim Jean Wactawski-Wende Thomas E. Rohan | 2012 | Cancer Epidemiology2012，，4： | 1 |
| 15 | Body fat and risk of colorectal cancer among postmenopausal women显示文摘 | Geoffrey C. Kabat Moonseong Heo Jean Wactawski-Wende Catherine Messina Cynthia A. Thomson Sylvia Wassertheil-Smoller Thomas E. Rohan | 2013 | Cancer Causes & Control2013，，6： | 1 |
| 16 | THE STUDY ON RISK FACTORS ASSOCIATED WITH BREAST CANCER AMONG WOMEN IN TIANJIN, CHINA AND ADELAIDE, AUSTRALIA显示文摘To explore the possible explanation of the marked difference in the incidence of breast cancer between Chinese and Australian women, the authors have compared and analysed the results of two case-control studies completed recently in Tianjin, China and Adelaide, Australia. Of 10 known risk factors for breast cancer 9 were significantly higher in level in Adelaide women than in Tianjin women, i.e., women in Adelaide were much taller, heavier, more obese, earlier at menarche, later at first full-term pregnancy, more nulliparous, less parity, more in history of breast cancer in first degree relatives, more educated. From the 7 risk factors analysed by use of logistic regression model 5 factors, i.e., earlier age at menarche, later age at first full-term pregnancy, less parity, history of benign disease, and history of breast cancer in first degree relatives, were associated significantly with the increased risk for breast cancer in the Tianjin study, but not in Adelaide study. These factors being not | 张安玉 Thomas E Rohan 武光林 | 1989 | Chinese Journal of Cancer Research1989，1，4： | 0 |
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