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| 1 | Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update显示文摘More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding,the transjugular intrahepatic portosystemic shunt(TIPS)procedure continues to remain a focus of intense clinical and biomedical research.By the impressive reduction in portal pressure achieved by this intervention,coupled with its minimally invasive nature,TIPS has gained increasing acceptance in the treatment of complications of portal hypertension.The early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic encephalopathy.Moreover,the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions,which was occasionally severe.While the incidence of shunt dysfunction has markedly reduced with the advent of covered stents,hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after TIPS.It has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after TIPS.The past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax,portal hypertensive gastropathy,ectopic varices,hepatorenal and hepatopulmonary syndromes,non-tumoral portal vein thrombosis and chylous ascites.It has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and mortality.The current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis. | Sasidharan Rajesh Tom George Cyriac Abby Philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan Philip Augustine | 2020 | World Journal of Gastroenterology2020，26，37： | 26 |
| 2 | Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis显示文摘AIM To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis(CHP).METHODS Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters(plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin(HbA1c), fasting lipid profile, and fasting blood glucose]. The case group received non-surgical periodontal therapy. Subjects were re-evaluated for periodontal and systemic parameters after three months.RESULTS Both groups were comparable at baseline. Three months after non surgical periodontal therapy(NSPT), there was significant improvement in periodontal parameters in case group. The mean difference in systemic parameters like HbA1c and fasting plasma glucose from baseline to fourth month for case group was 0.22 ± 0.11 and 3.90 ± 8.48 respectively and control group was-0.056 ± 0.10 and-1.66 ± 6.04 respectively, which was significant between case and control group(P < 0.05). In the case group there was a significant decrease in HbA1c from baseline to three months following NSPT(P < 0.05).CONCLUSION This study showed that periodontal inflammation could affect the glycemic control in otherwise systemically healthy individuals. Periodontal therapy improved periodontal health status and decreased glycosylated haemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP. | Rosamma Joseph Meera Sasikumar Jerry Mammen M G Joseraj Chandni Radhakrishnan | 2017 | World Journal of Diabetes2017，8，5： | 7 |
| 3 | Scientific Validation of the Ethnomedicinal Properties of the Ayurvedic Drug Triphala:A Review显示文摘Triphala,一个草药的公式 Terminalia chebula Retz 的三水果创作了。( Haritaki,家庭:Combretaceae ) , Terminalia bellirica Roxb。( Bibhitaki,家庭:Combretaceae ) 并且 Phyllanthus emblica 悬崖。或 Emblica officinalis Gaertn。( Amalaki 或印度醋栗,家庭:Euphorbiaceae ) 被认为是在药的传统的印度系统的通用灵丹妙药 Ayurveda。它在 Ayurveda 文章被描述了为 Rasayana 并且到 rejuvenat 削弱的机关。Ayurvedic 医生使用 Triphala 让许多疾病对待各种各样的胃肠的混乱。在过去的二十年执行的科学研究 ethnomedicinal 主张验证了许多,研究显示了 Triphala 拥有免费激进的清除,抗氧化剂, antiinflammatory ,退热,止痛,抗菌剂, antimutagenic ,愈合弯屈, anticariogenic , antistress , adaptogenic , hypoglycaemic , anticancer , chemoprotective ,避免受辐射影响并且 chemopreventive 效果。临床的研究也证明了 Triphala 被发现有好缓泻的性质,到改进胃口并且减少胃的胃酸过多症。研究也证明了 Triphala 在阻止牙齿的龋是有效的并且这效果等于 chlorhexidine 的。当前的评论探讨 Triphala 的验证药理学性质并且也在方面上强调需要为它的未来诊所申请推进调查。 | Manjeshwar Shrinath Baliga Sharake Meera Benson Mathai Manoj Ponadka Rai Vikas Pawar Princy Louis Palatty | 2012 | Chinese Journal of Integrative Medicine2012，18，12： | 5 |
| 4 | 小反刍兽疫病毒H蛋白抗体化学发光免疫分析检测方法的建立显示文摘本研究旨在建立小反刍兽疫病毒H蛋白抗体的化学发光免疫分析检测方法。以H蛋白4个反应原性较好的B细胞表位串联后为检测抗原,在确定抗原包被量和血清稀释度,优化血清和酶标二抗反应时间的基础上,用ROC曲线分析确定检测临界值,建立了小反刍兽疫病毒H蛋白抗体化学发光免疫分析检测方法,然后对该方法进行敏感性、特异性和重复性评价。结果显示,建立的小反刍兽疫病毒H蛋白抗体化学发光免疫分析检测方法最佳抗原包被浓度为1.5×10^(-6)μg/孔,待检血清最佳稀释度为1∶100;血清及酶标二抗孵育时间均为10 min,检测方法的临界值为S/P=9.77%,批内及批间变异系数均小于10%;与口蹄疫、羊痘、蓝舌病及山羊传染性胸膜肺炎阳性血清不发生交叉反应;用建立的化学发光法和市售小反刍兽疫抗体cELISA试剂盒平行检测247份田间血清,两者相对符合率为94.33%,但化学发光法敏感性更高。研究结果表明,建立的小反刍兽疫病毒H蛋白抗体化学发光免疫分析方法灵敏、特异、稳定,可用于田间血清样品小反刍兽疫抗体检测。 | 钱榜 刘振东 赵印 李静 PRAJAPATI Meera 李彦敏 孙跃峰 窦永喜 | 2023 | 生物技术通报2023，39，5： | 4 |
| 5 | Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses显示文摘Peste des petits ruminants(PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus(PPRV)pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals,establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV. | Alfred Niyokwishimira Yongxi Dou Bang Qian Prajapati Meera Zhidong Zhang | 2018 | Virologica Sinica2018，33，6： | 3 |
| 6 | Update on diagnosis and management of sepsis in cirrhosis: Current advances显示文摘Sepsis and septic shock are catastrophic disease entities that portend high mortality in patients with cirrhosis.In cirrhosis,hemodynamic perturbations,immune dysregulation,and persistent systemic inflammation with altered gut microbiota in the background of portal hypertension enhance the risk of infections and resistance to antimicrobials.Patients with cirrhosis develop recurrent lifethreatening infections that progress to multiple organ failure.The definition,pathophysiology,and treatment options for sepsis have been ever evolving.In this exhaustive review,we discuss novel advances in the understanding of sepsis,describe current and future biomarkers and scoring systems for sepsis,and delineate newer modalities and adjuvant therapies for the treatment of sepsis from existing literature to extrapolate the same concerning the management of sepsis in cirrhosis.We also provide insights into the role of gut microbiota in initiation and progression of sepsis and finally,propose a treatment algorithm for management of sepsis in patients with cirrhosis. | Cyriac Abby Philips Rizwan Ahamed Sasidharan Rajesh Tom George Meera Mohanan Philip Augustine | 2020 | World Journal of Hepatology2020，12，8： | 2 |
| 7 | Effects of Exogenous VEGF_(165)b on Invasion and Migration of Human Lung Adenocarcinoma A549 Cells显示文摘Vascular endothelial growth factor 165 (VEGF165)-mediated autocrine stimulation of tumor cells enhances the progression to a malignant phenotype. VEGF165b competes with VEGF165 and binds to vascular endothelial growth factor receptor (VEGFR), resulting in inhibition of downstream signal transduction pathways. This study was designed to investigate the role of VEGF165b in the migration and invasion of human lung adenocarcinoma A549 cells. The full-length of VEGF165b was constructed and cloned into an expression plasmid (pVEGF165b), and then transfected into A549 cells. Dimethylthiazolyl-2, 5-diphenyltetrazolium bromide (MTT) assay was used to detect the effect of VEGF165b on proliferation of transfected cells. Reverse transcription polymerase chain reaction (RT-PCR) was employed to examine the effect of VEGF165b on the expression of VEGF165 in transfected cells. Wound-healing assays were used to investigate the effect of VEGF165b on migration of transfected cells. Matrix metalloproteinase (MMPs) activity assay and in vitro invasion assay were used to determine the role of VEGF165b in invasion of transfected cells. There was no significant change in proliferation of A549 cells after transfection of pVEGF165b, but the expression of VEGF165, migration and invasion in A549 cells were inhibited. Furthermore, exogenous VEGF165b inhibited the activity of MMP9 in the supernatant of A549 cells and the subsequent invasion capacity of those cells. We therefore conclude that exogenous VEGF165b can inhibit the expression of VEGF165, as well as the migration and invasion of A549 cells, but has no effect on the proliferation of A549 cells. | 陈静 李振宇 张盛 张瑞光 Meera Dassarath 伍钢 | 2011 | Journal of Huazhong University of Science and Technology(Medical Sciences)2011，31，5： | 2 |
| 8 | Reactive power control and optimisation of hybrid off shore tidal turbine with system uncertainties显示文摘This paper projects an isolated hybrid model of Offshore wind-diesel-tidal turbine and discusses the stability and reactive power management issue of the whole system.The hybrid system often loses its stability as it becomes prone to uncertain load and input parameters and therefore the necessity of Reactive power management becomes necessary.The overall stability of the hybrid offshore wind-diesel-tidal turbine is made possible by the management of reactive power in the hybrid system through the application of FACTS devices.And therefore the dynamic hybrid model of the DFIG and DDPMSG based offshore wind-diesel-tidal turbine is analysed for stability with different input parameters like wind and tidal energies.For detailed modelling and simulation,a small signal model of the whole hybrid system is designed and reactive power management of the system is achieved by the incorporation of a STATCOM controller.For improvement of stability and reactive power compensation of the hybrid system,GA and PSO optimised STATCOM controller is used. | Asit Mohanty Meera Viswavandya Prakash K Ray Sthitapragyan Mohanty | 2016 | Journal of Ocean Engineering and Science2016，1，4： | 2 |
| 9 | Gallbladder adenocarcinoma and paraneoplastic parathyroid hormone mediated hypercalcemia显示文摘Parathyroid hormone mediated hypercalcemia is not always exclusively primary hyperparathyroidism and rarely could be due to ectopic parathyroid hormone secretion from tumor cells.We present a case of 86-yearold female with metastatic gall bladder adenocarcinoma diagnosed eight months back who presented with generalized fatigue and poor oral intake and was found to be hypercalcemic with elevated parathyroid hormone levels.Imaging with technetium 99 m sestamibi scintigraphy with dual phase,subtraction thyroid scan(dual isotope scintigraphy),magnetic resonance imaging and ultrasonography did not demonstrate any parathyroid lesion in normal or ectopic sites.We believe that the tumor cells were the source of ectopic parathyroid hormone secretion as we had excluded all the other possibilities with extensive combined imaging thereby increasing the sensitivity of our testing.We report the first case of metastatic gall bladder adenocarcinoma with paraneoplastic ectopic parathyroid hormone secretion. | Meera Yogarajah Bhradeev Sivasambu Zewge Shiferaw-Deribe | 2016 | World Journal of Clinical Oncology2016，7，2： | 2 |
| 10 | 炭化米糠经臭氧活化制备活性炭及其去除Cr(Ⅵ)离子显示文摘以臭氧为活化剂,炭化的米糠为原料制备出活性炭。采用氮吸附、SEM-EDAX和FT-IR对样品进行表征。活性炭的比表面积由活化前的20 m2/g增加到380 m2/g。在臭氧活化过程中,吸附在炭材料上的二氧化硅变疏松,从而导致碳逸出。臭氧同时以氧分子和原子形式存在于炭表面。氧原子,作为强氧化剂,将炭表面氧化成酸性官能团如羧基、酮基和酚基。采用该活性炭吸附Cr(VI)离子,Cr(VI)离子的最大去除率(94%)的条件为:p H值2.0、浓度100 mg/L、吸附量0.2 g,时间2.5 h及转速300 r/min。采用吸附平衡和动力学模型探讨吸附机理,结果表明,吸附等温线符合Freundlich方程,吸附速率符合准二级动力学方程。吸附是自发的放热反应,可能与Na OH脱落而恢复Cr和碳有关。 | Sivaraju Sugashini Kadhar Mohamed Meera Sheriffa Begum | 2015 | 新型炭材料2015，30，3： | 2 |
| 11 | Erythropoietin in cardiovascular diseases 显示文摘 | Van der Meera P Voors AA Lipsie E | 2004 | Europ Heart J2004，25，： | 1 |
| 12 | A Contemporary Method to Enhance the Metastable Zone Width for Crystal Growth from Solution 显示文摘 | Srinivasan K Meera K Ramasamy P | 2001 | Materials Science and Engineering2001，84，3： | 1 |
| 13 | Separation identification and characterization of microorganisms by capillary electrophoresis显示文摘 | Meera J esai Daniel W Armstrong | 2003 | Microbiology and Molecularbiology Reviews2003，67，： | 1 |
| 14 | Noninvasive Identification of the Unstable Carotid Plaque显示文摘 | Brajesh K. Lal Robert W. Hobson Meera Hameed Peter J. Pappas Frank T. Padberg Zafar Jamil Walter N. Durán | 2006 | Annals of Vascular Surgery2006，，2： | 1 |
| 15 | Skeletal Muscle Lipid Peroxidation and Insulin Resistance in Humans显示文摘 | Katherine H. Ingram Helliner Hill Douglas R. Moellering Bradford G. Hill Cristina Lara-Castro Bradley Newcomer L. Jerome Brandon Christopher P. Ingalls Meera Penumetcha Jeffrey C. Rupp W. Timothy Garvey | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，7： | 1 |
| 16 | Medication adherence and associated barriers in hypertension management in India显示文摘 | Thomas Dennis N.K. Meera K. Binny M. Sonal Sekhar Githa Kishore Salini Sasidharan | 2010 | CVD Prevention and Control2010，，： | 1 |
| 17 | Characterization of alkaline protease from Vibrio fluvialis strain VM10 isolated from a mangrove sediment sample and its application as a laundry detergent additive 显示文摘 | Meera Venugopal Saramma A V | 2006 | Process Biochemistry2006，41，： | 1 |
| 18 | Morphological and immunological characteristics of nanobacteria from human renal stones of a north Indian population显示文摘 | Madhu Khullar S. K. Sharma S. K. Singh Pratibha Bajwa Farooq A. Sheikh Vandana Relan Meera Sharma | 2004 | Urological Research2004，，3： | 1 |
| 19 | Maxi-K (Ca), a unique member of the voltage-gated K channel superfamily显示文摘 | Toro L Wallner M Meera P | 1998 | News Physiol Sci1998，，13： | 1 |
| 20 | Effect of EDTA on the metastable zone width of ADP显示文摘 | Meera K | 2000 | Journal of Crystal Growth2000，213，： | 1 |
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