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| 1 | Emergency department procedural sedation for primary electrical cardioversion — a comparison with procedural sedations for other reasons显示文摘BACKGROUND: Atrial fibrillation(AF) is the most common arrhythmia treated in the emergency department(ED), with primary electrical cardioversion(PEC) the preferred method of rhythm control. Anecdotally, patients undergoing ED procedural sedation(EDPS) for PEC differ from those requiring EDPS for other procedures: they are at higher risk of adverse events, and require fewer drugs and lower doses. We attempt to verify this using an EDPS registry at a Canadian, tertiary care teaching hospital.METHODS: This is a retrospective review of patients that underwent EDPS for the period of June 2006 to September 2014. We compared demographics, medication use and intra-procedural adverse events between those receiving EDPS for PEC for AF compared to that for other indications. We report the asssociation between AEs and predictors using logistic regression.RESULTS: A total of 4 867 patients were included, 714 for PEC for AF and 4 153 for other indications. PEC patients were more likely male(58.5% vs. 47.1%), older(59.5 years vs. 48.1 years), and less likely to be ASA I(46.6% vs. 69.0%). PEC patients received smaller doses of propofol and less likely to receive adjuvant analgesic therapy(11.5% vs. 78.2%). PEC patients were more likely to experience hypotension(27.6% vs. 16.5%) but respiratory AEs(apnea, hypoxia and airway intervention) were not different.CONCLUSION: EDPS for PEC differs from that conducted for other purposes: patients tend to be less healthy, receive smaller doses of medication and more likely to suffer hypotension without an increase in respiratory AEs. These factors should be considered when performing EDPS. | Michael Butler Patrick Froese Peter Zed George Kovacs Robert Mac Kinley Kirk Magee Mary-Lynn Watson Samuel G.Campbell | 2017 | World Journal of Emergency Medicine2017，8，3： | 6 |
| 2 | Endothelial progenitor cells:Exploring the pleiotropic effects of statins显示文摘Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct and or death after a myocardial infarction,prior to any significant change in lipid profile. Therefore,pleiotropic mechanisms,other than lowering lipid profile alone,must account for this effect. One such proposed pleiotropic mechanism is the ability of statins to augment both number and function of endothelial progenitor cells. The ability to augment repair and maintenance of a functioning endothelium may have profound beneficial effect on vascular repair and potentially a positive impact on clinical outcomes in patients with cardiovascular disease. The following literature review will discuss issues surrounding endothelial progenitor cell(EPC) identification,role in vascular repair,factors affecting EPC numbers,the role of statins in current medical practice and their effects on EPC number. | Kully Sandhu Mamas Mamas Robert Butler | 2017 | World Journal of Cardiology2017，9，1： | 5 |
| 3 | Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies显示文摘 | Michael Elashoff Aleksey V. Matveyenko Belinda Gier Robert Elashoff Peter C. Butler | 2011 | Gastroenterology2011，，1： | 3 |
| 4 | Mechanical behavior predictions of additively manufactured microstructures using functional Gaussian process surrogates显示文摘Relational linkages connecting process,structure,and properties are some of the most sought after goals in additive manufacturing(AM).This is desired especially because the microstructural grain morphologies of AM components can be vastly different than their conventionally manufactured counterparts.Furthermore,data collection at the microscale is costly.Consequently,this work describes and demonstrates a methodology to link microstructure morphology to mechanical properties using functional Gaussian process surrogate models in a directed graphical network capable of achieving near real-time property predictions with single digit error magnitudes when predicting full stress–strain histories of a given microstructure.This methodology is presented and demonstrated using computationally generated microstructures and results from crystal plasticity simulations on those microstructures.The surrogate model uses grain-level microstructural descriptors rather than whole microstructure descriptors so that properties of new,arbitrary microstructures can be predicted.The developed network has the potential to scale to predict mechanical properties of grain structures that would be infeasible to simulate using finite element methods. | Robert Saunders Celia Butler John Michopoulos Dimitris Lagoudas Alaa Elwany Amit Bagchi | 2021 | npj Computational Materials2021，，1： | 3 |
| 5 | Inflammatory mediators as potential ther?apeutic targets in the spine 显示文摘 | Roberts S Butler RC | 2005 | CUff Drug Targets Inflamm Al?lergy2005，4，： | 1 |
| 6 | Telomere shortening in atherosclerosis显示文摘 | Nilesh J Samani Rachel Boultby Robert Butler John R Thompson Alison H Goodall | 2001 | The Lancet2001，，9280： | 1 |
| 7 | Pneumococcal polysaccharide vaccine efficacy :an evaluation of current recommendations显示文摘 | Jay C Butler Robert F Breiman John F Campbell | 1993 | JAMA1993，270，： | 1 |
| 8 | Pilot-scale tests of poly ferric sulfate synthesized using SO2 at Des Moines Water Works显示文摘 | Aron D Butler Maohong Fan Robert C | 2005 | Chemical Engineering and Processing2005，44，： | 1 |
| 9 | Linking international entrepreneurship to uncertainty, opportunity discovery, and cognition显示文摘 | John E. Butler Robert Doktor Frederick A. Lins | 2010 | Journal of International Entrepreneurship2010，，2： | 1 |
| 10 | Absorption of dilute SO2 gas stream with conversion to polymeric ferric sulfate for use in water treatment显示文摘 | Maohong Fan Robert C Brown | 2004 | Chemical Engineering Journal2004，98，： | 1 |
| 11 | Pilot-scale tests of poly ferric sulfate synthesized using SO2 at Des Moines Water Works显示文摘 | Maohong Fan Robert C Brown | 2005 | Chemical Engineering and Processing2005，44，： | 1 |
| 12 | Recognizing Hospitalized Heart Failure as an Entity and Developing New Therapies to Improve Outcomes显示文摘 | Mihai Gheorghiade Ami N. Shah Muthiah Vaduganathan Javed Butler Robert O. Bonow Giuseppe M.C. Rosano Scott Taylor Stuart Kupfer Frank Misselwitz Arjun Sharma Gregg C. Fonarow | 2013 | Heart Failure Clinics2013，，： | 1 |
| 13 | Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure显示文摘 | Alessandra Dei Cas Sadiya S. Khan Javed Butler Robert J. Mentz Robert O. Bonow Angelo Avogaro Diethelm Tschoepe Wolfram Doehner Stephen J. Greene Michele Senni Mihai Gheorghiade Gregg C. Fonarow | 2014 | JACC: Heart Failure2014，，： | 1 |
| 14 | Beta-cell selective K ATP -channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity显示文摘 | Robert A. Ritzel Sajith Jayasinghe John B. Hansen Jeppe Sturis Ralf Langen Peter C. Butler | 2010 | Regulatory Peptides2010，，2： | 1 |
| 15 | A scalable HTTP server:The NCSA prototype显示文摘 | Katz Eric Dean Butler Michelle McGrath Robert E | 1994 | Computer Networks and ISDN Systems1994，，27： | 1 |
| 16 | Phase optimization of antenna array gain with constrained amplitude excitation显示文摘 | Robert G Voges Jerome K Butler | 1972 | IEEE Transactions on Antennas and Propagation1972，20，4： | 1 |
| 17 | Incidence of Dyspnea and Assessment of Cardiac and Pulmonary Function in Patients With Stable Coronary Artery Disease Receiving Ticagrelor, Clopidogrel, or Placebo in the ONSET/OFFSET Study显示文摘 | Robert F. Storey Kevin P. Bliden Shankar B. Patil Arun Karunakaran Rosemary Ecob Kathleen Butler Renli Teng Cheryl Wei Udaya S. Tantry Paul A. Gurbel | 2010 | Journal of the American College of Cardiology2010，，3： | 1 |
| 18 | Long-standing type II diabetes mellitus is not a?risk factor for slow gastric emptying in critically ill patients显示文摘 | Nam Q. Nguyen Marianne Chapman Robert J. Fraser Marc Ritz Laura K. Bryant Ross Butler Geoffrey Davidson Betty Zacharakis Richard H. Holloway | 2006 | Intensive Care Medicine2006，，9： | 1 |
| 19 | Stem design and dislocation after revision total hip arthroplasty: Clinical results and computer modeling显示文摘 | Robert L. Barrack R.Allen Butler Daniel R. Laster Pamela Andrews | 2001 | The Journal of Arthroplasty2001，，8： | 1 |
| 20 | Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies: The RESPOND Study显示文摘 | Paul A. Gurbel Kevin P. Bliden Kathleen Butler Mark J. Antonino Cheryl Wei Renli Teng Lars Rasmussen Robert F. Storey Tonny Nielsen John W. Eikelboom Georges Sabe-Affaki Steen Husted Dean J. Kereiakes David Henderson Dharmendra V. Patel Udaya S. Tantry | 2010 | Circulation2010，，10： | 1 |
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