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| 1 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 2 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 2 |
| 3 | Nuclear factor-kappa B and glucocorticoid receptor alpha-mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and a- cute respiratory distress syndrome: evidence for inflammation-induced target tissue resistance to glucocorticoids 显示文摘 | Meduri GU Muthiah PM Pierluigi C | 2005 | Neuroimmunomedulation2005，12，7： | 1 |
| 4 | Preliminary study on the antimicrobial activity of Enicostemma littorale using different solvents显示文摘Objective:To study the antimicrobial activity of Enicostemma littorale(E.littorale) using different solvents.Methods:Chloroform,methanol and acetone extracts of different parts of E.littorale(leaf,stem and root) were evaluated for antimicrobial activity using disc diffusion method against some gram-negative species such as Escherichia coli,Klebsiella pnemoniae, Pseudomonas aeruginosa,Salmonella typhi and gram-positive species Staphylococcus aureus, Bacillus cereus,Bacillus subtilis and two fugal species viz.,Aspergillus fumigates and Aspergillus flavus.Results:The chloroform extracts showed the highest antibacterial activity.Among leaf, stem and root extracts,the stem extracts showed maximum antibacterial activity.All of the used extracts had no significant antifungal activity against Aspergillus fumigates and Aspergillus flavus.The chloroform stem extract showed highest activity(about 20 mm inhibition zone) against Bacillus subtilis(at 500 tng/mL) followed by the methanolic stem extract which showed highest activity against the same organism.The lowest antibacterial activity was observed by the acetone leaf extract(about 8 mm inhibition zone) against Escherichia coli.Conclusions:The findings of the study indicate littorale could also be a new source for antibiotics discovery. | Pitchamuthu Abirami Muthiah Gomathinayagam Rajaram Panneerselvam | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 1 |
| 5 | NF -kappaB protects lung epithelium against hyperoxia - induced nonapoptotic cell death - oncosis 显示文摘 | Sinha A Muthiah K Jiang W | 2004 | Free Radical Biol Med2004，37，10： | 1 |
| 6 | Potential role ofleukotriene modifiers in the treatment of chronic obstructivepulmonary disease 显示文摘 | Usery JB Self TH Muthiah MP | 2008 | Pharmacotherapy2008，28，9： | 1 |
| 7 | Acute retinal necrosis: a national population-based study to assess the incidence, methods of diagnosis, treatment strategies and outcomes in the UK显示文摘 | Muthiah MN Michaelides M Child CS | 2007 | Br J Ophthalmol2007，91，11： | 1 |
| 8 | Acquired platelet dysfunction with eosinophilia 显示文摘 | Muthiah MM Mitchell TR Thorn CT | 1984 | Br Med J (Clin Res Ed)1984，289，6451： | 1 |
| 9 | Pectin/carboxymethylcellulose/microfibrillated cellulose composite scaffolds for tissueengineering显示文摘 | Ninan N Muthiah M park I K | 2013 | Carbohydr Polym2013，98，1： | 1 |
| 10 | Overall throughput ef- fectiveness (OTE)metric for factory-level performance moni- toring and bottleneck detection显示文摘 | MUTHIAH K M N HUANG S H | 2007 | International Journal of Production Research2007，45，20： | 1 |
| 11 | Early Experience With Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer显示文摘 | Peter M. Y. Goh Ameer Z. Khan Jimmy B. Y. So David Lomanto Wei-Keat Cheah Rajah Muthiah Anil Gandhi | 2001 | Surgical Laparoscopy, Endoscopy & Percutaneous Te2001，，2： | 1 |
| 12 | Pipeline leak detection system for oil and gas flowlines显示文摘 | Rajtar J Muthiah R | 1997 | Journal of manufacturing science and engineering1997，10，2： | 1 |
| 13 | Mononu- clear iron (11)dicarbonyls derived from NNS ligands- structural models related to a'Pre-Acyl' active site of mono-iron ( Hmd ) hydrogenase 显示文摘 | Muthiah K A T Durgaprasad G Xie Z L | 2015 | Eur J Inorg Chem2015，10，： | 1 |
| 14 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 1 |
| 15 | Rheology of HTPB propellant:Effect of mixing speed and mixing time显示文摘 | Muthiah Rm Manjari R Krishnamurthy V N | 1993 | Defence Science Journal1993，43，16： | 1 |
| 16 | Pectin/ carboxymethyl cellulose/microfibrillated cellulose composite scaffolds for tissue engineering 显示文摘 | NINAN N MUTHIAH M PARK I K | 2013 | Carbohydrate Polymers2013，98，1： | 1 |
| 17 | Triadimefon induced salt stress tolerance in Withania sonmifera and its relationship to antioxidant defense system显示文摘 | Cheruth A J Muthiah G Rajaram P | 2008 | South African Journal of Botany2008，，74： | 1 |
| 18 | Effects of single and combined microalgae on larval growth,development and survival of the commercial sea cucumber holothuria spinifera theel显示文摘 | Asha P S Muthiah P | 2006 | Aquaculture Research2006，37，2： | 1 |
| 19 | Recognizing Hospitalized Heart Failure as an Entity and Developing New Therapies to Improve Outcomes显示文摘 | Mihai Gheorghiade Ami N. Shah Muthiah Vaduganathan Javed Butler Robert O. Bonow Giuseppe M.C. Rosano Scott Taylor Stuart Kupfer Frank Misselwitz Arjun Sharma Gregg C. Fonarow | 2013 | Heart Failure Clinics2013，，： | 1 |
| 20 | Role of Reticulated Platelets and Platelet Size Heterogeneity on Platelet Activity After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease显示文摘 | Sasidhar Guthikonda Carlos L. Alviar Muthiah Vaduganathan Mehmet Arikan Armando Tellez Timothy DeLao Juan F. Granada Jing-Fei Dong Neal S. Kleiman Eli I. Lev | 2008 | Journal of the American College of Cardiology2008，，： | 1 |
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