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| 1 | Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma显示文摘AIM: To evaluate the relationship between glycemic control [assessed by glycated hemoglobin (HbA1c)], antidiabetic therapies and the risk of hepatocellular carcinoma (HCC).METHODS: We recruited 465 patients with HCC, 618 cases with liver cirrhosis and 490 controls with no liver disease. Among subjects with type 2 diabetes mellitus (DM2), the associations between the antidiabetic strategies and HbA1c level with HCC were determined through 2 series of multivariate logistic regression models using cirrhotic patients and controls as comparison groups. RESULTS: DM2 prevalence was 31.2% in patients with HCC, 23.2% in cirrhotic patients and 12.6% in controls (P < 0.0001). In 86% of study subjects, DM2 had been diagnosed for more than 1 year before the HCC diagnosis. HCC patients with DM2 had a 1.52.5fold increased risk of liver cancer. The HbA1c mean levels were signif icantly higher in DM2 patients with HCC than in cirrhoticand control DM2 patients. Antidiabetic treatment with metformin was more common among cirrhotic and control DM2 subjects than among cases with HCC. In both series of multivariate analyses, treatment with metformin signif icantly reduced the risk of HCC by more than 80% compared with sulphonylureas and insulin therapy. No signif icant differences were seen between sulphonylureas and insulin treatment. Elevated HbA1c levels were positively related to the risk for HCC in diabetic patients, with a 26%50% increase in risk for each 1% increase in HbA1c values.CONCLUSION: In patients with preexisting DM2, the risk of HCC is positively associated with poor chronic glycemic control and significantly decreased by metformin therapy. | Valter Donadon Massimiliano Balbi Francesca Valent Angelo Avogaro | 2010 | World Journal of Gastroenterology2010，16，24： | 15 |
| 2 | Potential manipulation of endothelial progenitor cells in diabetes and its complications显示文摘 | FADINI G P AVOGARO A | 2010 | Diabetes Obes Metab2010，12，7： | 1 |
| 3 | Incidence and risk factors for stroke in type 2 diabetic patients: the DAI study 显示文摘 | GIORDA C B AVOGARO A MAGGINI M eta| | 2007 | Stroke2007，38，4： | 1 |
| 4 | The good and the bad in the link between insulin resistance and vascular calcification 显示文摘 | Fadini GP Pauletto P Avogaro A | 2007 | Atherosclero- sis2007，193，2： | 1 |
| 5 | In situ protein Kinase C activity is increased in cultured fibroblasts from Type 1 diabetic patients with nephropathy显示文摘 | E. Iori M. C. Marescotti M. Vedovato G. Ceolotto A. Avogaro A. Tiengo S. Del Prato R. Trevisan Dr | 2003 | Diabetologia2003，，4： | 1 |
| 6 | Moderate alcohol consamption, glucose metabolism and lipolysis: the effect on adiponectin and tumor necrosis factor alpha显示文摘 | Sambataro M Marangoni A Pianta A Vettor R Pagano C | 2003 | J Endocrinol Invest2003，26，12： | 1 |
| 7 | Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocrdial dysfuntion in type 2 diabetes 显示文摘 | Scognamiglio R Avogaro A De Kreutzenberg S V | 2002 | Diabetes2002，51，3： | 1 |
| 8 | Cerebrovas- cular disease in diabetes mellitus : The role of carotid inti- ma - media thickness 显示文摘 | De Kreutzenberg S V Tiengo A Avogaro A | 2009 | Nutrition Metabolism and Car- diovascular Disease2009，19，： | 1 |
| 9 | Endothelial dysfunction in type 2 diabetesmellitus显示文摘 | Avogaro A Fadini GP Gallo A | 2006 | Nutrmetab Cardiovasc Dis2006，161，： | 1 |
| 10 | Diabetes Induces p66shc Gene Expression in Human Peripheral Blood Mononuclear Cells: Relationship to Oxidative Stress显示文摘 | Elisa Pagnin Gianpaolo Fadini Renzo de Toni Antonio Tiengo Lorenzo Calò Angelo Avogaro | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，2： | 1 |
| 11 | The janus face of nicotinic angiogenesis显示文摘 | Avogaro A Fadini GP | 2006 | J Am Coll Cardiol2006，48，12： | 1 |
| 12 | Myocardial dysfunction and adrenergic cardiac innervation in patients with insulin-dependent diabetes mellitus显示文摘 | Scognamiglio R Avogaro A Casara D | 1998 | J Am Coll Cardiol1998，31，2： | 1 |
| 13 | Cerebrovascular disease in diabetes mellitus:the role of carotid intima-media thickness显示文摘 | Vigili de Kreutzenberg S Tiengo A Avogaro A | | 0，，09： | 1 |
| 14 | Moderate alcohol use and health: A consensus document显示文摘 | A. Poli F. Marangoni A. Avogaro G. Barba S. Bellentani M. Bucci R. Cambieri A.L. Catapano S. Costanzo C. Cricelli G. de Gaetano A. Di Castelnuovo P. Faggiano F. Fattirolli L. Fontana G. Forlani S. Frattini R. Giacco C. La Vecchia L. Lazzaretto L. Loffredo | 2013 | Nutrition, Metabolism and Cardiovascular Diseases2013，，6： | 1 |
| 15 | Are apolipoproteins better discrimi- nators than lipids for atherosclerosis? 显示文摘 | Avogaro P Bon GB Gazzolato G | 1979 | Lancet1979，1，8122： | 1 |
| 16 | Endothelial dysfunction in type 2 diabetes mellitus显示文摘 | Avogaro A Fadini GP Gallo A | 2006 | Nutr Metab Cardiovasc Dis2006，16，1： | 1 |
| 17 | Incidence and risk factors for stroke in type 2 diabetic patients:The DAI Study显示文摘 | Giorda CB Avogaro A Maggini M | 2007 | Stroke2007，38，： | 1 |
| 18 | Moderate alcohol consumption, glucose metabolism and lipolysis: the effect on adiponeefin and tumor Beemsis factor alpha显示文摘 | Avogaro A Samhataro M Mmangoni A | 2003 | J Endocrinol In- vest2003，26，12： | 1 |
| 19 | Towards evidence - based medicine ; large - scale intervention trials with dipeptidyl peptidase - 4 inhibitors显示文摘 | Avogaro A | 2012 | G Ital Cardiol2012，13，12： | 1 |
| 20 | Lipoprotein(a) and the risk for myocardial infarction显示文摘 | AVOGARO P CAZZOLATO G | 1981 | Atherosclerosis1981，38，： | 1 |
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