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| 1 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 2 | Synthesis,optimization and characterization of biochar based catalyst from sawdust for simultaneous esterification and transesterification显示文摘The development of a benign environmental catalyst for the generation of biodiesel is an area of importance to reduce the overall usage of fossil fuels. In the current work, biochar was produced by slow pyrolysis of Irul wood sawdust. The optimization for biochar generation was carried out for different reaction temperatures and heating durations. The biochar was used to prepare solid acid catalysts by sulfonation process. The characterization of biochar and the sulfonated catalyst were carried out using Elemental analysis, Fourier Transform Infrared spectroscopy(FTIR), Powder X-ray Diffraction(XRD), Thermo Gravimetric Analysis(TGA), Scanning Electron Microscopy(SEM) and Surface area analyzer(BET). The characterization results showed that sulfonation of biochar resulted in biochar based solid acid catalyst containing various functional acidic groups like weak acidic\\OH groups, strong acidic\\COOH and SO3 H groups. The total acid density and sulfonic acid group density of catalyst were estimated and showed excellent acidic sites concentration which gives a good catalytic activity for biodiesel production through simultaneous esterification and transesterification. The enhanced catalytic activity is due to the high acid density of SO3 H groups and the reactant accessibility towards acidic sites as well as the strong affinity between the hydrophilic reactants and the neutral OH groups which are bonded with the polycyclic aromatic carbon rings. The performance of biochar catalyst for the production of biodiesel was evaluated by comparing the yield obtained. The FTIR and Gas Chromatography–Mass Spectroscopy(GC–MS) were also carried out for the analysis of biodiesel produced. | Suchith Chellappan Vaishakh Nair Sajith V. Aparna K. | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 3 |
| 3 | Genetic characterization of 2006–2008 isolates of Chikungunya virus from Kerala, South India, by whole genome sequence analysis显示文摘 | E. Sreekumar Aneesh Issac Sajith Nair Ramkumar Hariharan M. B. Janki D. S. Arathy R. Regu Thomas Mathew M. Anoop K. P. Niyas M. R. Pillai | 2010 | Virus Genes2010，，1： | 2 |
| 4 | Room-temperature ferromagnetism of Fe-doped TiO 2 nanoparticles driven by oxygen vacancy显示文摘 | Sandeep K.S. Patel Sajith Kurian Namdeo S. Gajbhiye | 2013 | Materials Research Bulletin2013，，2： | 1 |
| 5 | Barium rare-earth zirconates:synthesis,characterization and their possible application as substrates for YBa2Cu3O7-δ superconduction显示文摘 | Koshy J Sajith P K Kurian J | 1995 | Mater Res Bull1995，30，11： | 1 |
| 6 | Prophylactic Dexamethasone for Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Dose Ranging and Safety Evaluation Study显示文摘 | Rashmi Madan Anuj Bhatia Sajith Chakithandy Rajeshwari Subramaniam Gurram Rammohan Shrinivas Deshpande Manorama Singh H L. Kaul | 2005 | Anesthesia & Analgesia2005，，6： | 1 |
| 7 | 显示文摘 | Koshy J Sajith P K Kurian J | 1995 | Materials Research Bulletin1995，30，11： | 1 |
| 8 | Extrapontine myelinolysis presenting as acute parkinsonism显示文摘 | Sajith J Ditchfield A Katifi HA | 2006 | BMC Neurol2006，6，： | 1 |
| 9 | Study on seismic performance enhancement in bridges based on factorial analysis显示文摘The seismic performance of bridges depends on the ductile behavior of its column, as the deck and other substructural components except pile foundations are normally designed to be elastic to facilitate bridge retrofitting.Codes such as AASHTO, Caltrans, IRC: 112 etc.give guidelines for the seismic performance enhancement of columns through ductile detailing.In the present study, a methodology for the seismic performance enhancement of bridges is discussed by using a 'Parameter-Based Influence Factor'(PIF) developed from factorial analysis.The parameters considered in the factorial analysis are: percentage of longitudinal reinforcement(P_t), compressive strength of concrete(f'_c), yield strength of steel(f_y), spacing of lateral ties(S) and column height(H).The influence of each parameter and their combination on the limit states considered is estimated.Pushover analysis is used to evaluate the capacity of columns, considering shear failure criteria.A total of 243(3~5 combinations) analysis results are compiled to develop ‘PIF’ used in the performance enhancement process.The study also encompasses other sub-objectives such as evaluating the discrepancies in using the Importance Factor(I) in designing bridges of varied functional importance; and estimating the aspect ratio and slenderness ratio values of bridge columns for its initial sizing. | Abey ET Somasundaran TP Sajith AS | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 1 |
| 10 | Melatonin and sleep disorders associated with intellectual disability显示文摘 | Sajith SG Clarke D | 2007 | J Intellect Disabil Res2007，51，1： | 1 |
| 11 | Application of TiO 2 nanoparticles as a lubricant-additive for vapor compression refrigeration systems – An experimental investigation显示文摘 | R. Krishna Sabareesh N. Gobinath V. Sajith Sumitesh Das C.B. Sobhan | 2012 | International Journal of Refrigeration2012，，7： | 1 |
| 12 | An Investigation of flashing-driven natural circulation显示文摘 | SAJITH P P VEDULA R P MITRA S K | 2006 | International jour- nal of green energy2006，3，4： | 1 |
| 13 | Beta-cell selective K ATP -channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity显示文摘 | Robert A. Ritzel Sajith Jayasinghe John B. Hansen Jeppe Sturis Ralf Langen Peter C. Butler | 2010 | Regulatory Peptides2010，，2： | 1 |
| 14 | Semi-analytical model for pool boiling of nanofluids 显示文摘 | Ganapathy H Sajith V | 2013 | International Journal of Heat and Mass Transfer2013，57，1： | 1 |
| 15 | Application of TiO2 nanoparticles as a lubricant-additive for vapor compressionrefrigeration systems--an experimental investigation显示文摘 | SABAREESH R K GOBINATH N SAJITH V | 2012 | International JoumalofRefrigeration2012，35，7： | 1 |
| 16 | Application of TiO2 nanoparticles as a lubricant-additive for vapor compression refrigeration systems:An experimental investigation显示文摘 | Sabareesh R Krishna Gobinath N Sajith V | 2012 | International Journal of Refrigeration2012，35，7： | 1 |
| 17 | Folding Amphipathic Helices Into Membranes: Amphiphilicity Trumps Hydrophobicity显示文摘 | Mónica Fernández-Vidal Sajith Jayasinghe Alexey S. Ladokhin Stephen H. White | 2007 | Journal of Molecular Biology2007，，3： | 1 |
| 18 | Experimental investigations on the effects of cerium oxide nanoparticle fuel additives on biodiesel显示文摘 | Sajith V Sobhan C B Peterson G P | 2009 | Advances in Mechanical Engineering2009，6，10： | 1 |
| 19 | Thermal Analysis and Nanoindentaion Studies on Nanocrystalline AlCrNiFeZn High Entropy Alloy显示文摘 | C. Sajith Babu N.T.B.N. Koundinya K. Sivaprasad Jerzy A. Szpunar | 2014 | Procedia Materials Science2014，，： | 1 |
| 20 | Advanced glycation end products induce crosslinking of collagen in vitro显示文摘 | Sajithal GB Chithra P Chandrakasan G | 1998 | Biochem Biophys Acta1998，1407，3： | 1 |
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