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| 1 | Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update显示文摘More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding,the transjugular intrahepatic portosystemic shunt(TIPS)procedure continues to remain a focus of intense clinical and biomedical research.By the impressive reduction in portal pressure achieved by this intervention,coupled with its minimally invasive nature,TIPS has gained increasing acceptance in the treatment of complications of portal hypertension.The early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic encephalopathy.Moreover,the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions,which was occasionally severe.While the incidence of shunt dysfunction has markedly reduced with the advent of covered stents,hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after TIPS.It has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after TIPS.The past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax,portal hypertensive gastropathy,ectopic varices,hepatorenal and hepatopulmonary syndromes,non-tumoral portal vein thrombosis and chylous ascites.It has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and mortality.The current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis. | Sasidharan Rajesh Tom George Cyriac Abby Philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan Philip Augustine | 2020 | World Journal of Gastroenterology2020，26，37： | 26 |
| 2 | Epidural anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and biliary calculi显示文摘AIM: To evaluate the efficacy of thoracic epidural analgesia for extracorporeal shock wave lithotripsy (ESWL). METHODS: ESWL is an effective, non-invasive technique for the treatment of difficult pancreatic and large bile duct calculi. The procedure is often painful and requires large doses of analgesics. Many different anesthetic techniques have been used. Patients with either large bile duct calculi or pancreatic duct calculi which could not be extracted by routine endoscopic methods were selected. Thoracic epidural anesthesia (TEA) was routinely used in all the subjects unless contraindicated. Bupivacaine 0.25% with or without clonidine was used to block the segments D6 to D12. The dose was calculated depending on the age, height and weight of the patient. It was usually 1-2 mL per segment blocked.RESULTS: Ninety eight percent of the 1509 patients underwent ESWL under TEA. The subjects selected were within American Society of Anesthesiologists grade Ⅰ to Ⅲ. ESWL using EA permitted successful elimination of bile duct or pancreatic calculi with minimal morbidity. The procedure time was shorter in patients with TEA than in those who underwent ESWL under total intravenous anesthesia. CONCLUSION: Almost all patients undergoing ESWL with EA had effective blocks with a single catheter insertion and local anesthetic injection. | Santosh Darisetty Manu Tandan Duvvuru Nageshwar Reddy Rama Kotla Rajesh Gupta Mohan Ramchandani Sandeep Lakhtakia Guduru Venkat Rao Rupa Banerjee | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 13 |
| 3 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 4 | 柚皮苷改善束缚性应激引起的小鼠生化指标及行为变化的一氧化氮调节机制(英文)显示文摘目的:研究柚皮苷对束缚性应激引起的小鼠生化指标改变、行为变化及线粒体功能紊乱的影响。方法:将小鼠按照体质量随机分组,分别给予不同药物治疗14 d。在第15天让所有小鼠接受束缚性应激刺激6 h,然后在接受各种不同的行为测试后处死。取小鼠的大脑匀浆进行各种生化指标测量和线粒体功能分析。结果:6 h的急性束缚性应激刺激能显著改变小鼠的行为(焦虑和记忆),引起生化指标变化和线粒体功能紊乱。用柚皮苷预处理(50或100 mg/kg口服)14 d则能显著减轻急性束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱(P<0.05);而使用一氧化氮的前体左旋精氨酸预处理(50 mg/kg腹腔注射)可以拮抗柚皮苷的保护效应(P<0.05)。此外,采用左旋精氨酸甲酯预处理(5 mg/kg腹腔注射)则导致柚皮苷的保护效应增强。结论:柚皮苷对束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱的保护作用与氮能神经通路有关。 | Gollapalle L.Viswanatha Hanumanthappa Shylaja K.Sadashiva Sandeep Rao Yathiraj Ashwini V.Ramaiah Santhosh Kumar C.Gangadharaiah Mohan Venkate Gowda Sunil M.Venkateshappa Sarvesh Kumar Subbanna Rajesh | 2011 | 中西医结合学报2011，9，11： | 3 |
| 5 | Endoscopic radiofrequency ablation of cholangiocarcinoma: new palliative treatment modality (with videos)显示文摘 | Amitabh Monga Rajesh Gupta Mohan Ramchandani Guduru V. Rao Darisetty Santosh D. Nageshwar Reddy | 2011 | Gastrointestinal Endoscopy2011，，4： | 2 |
| 6 | Laparoscopic Appendicectomy for Complicated Appendicitis: Is it Safe and Justified?: A Retrospective Analysis显示文摘 | Lakshman S. Khiria Ramesh Ardhnari Narshimhan Mohan Palaniappan Kumar Rajesh Nambiar | 2011 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2011，，3： | 1 |
| 7 | Comparison of the Clinical Profile and Outcome for Squamous Cell Carcinoma and Adenocarcinoma of the Distal Esophagus and Cardia in India显示文摘 | Narendar Mohan Gupta Ravul Jindal Om Prakash Rajesh Gupta Deepak Kumar Bhasin | 2001 | Surgery Today2001，，5： | 1 |
| 8 | Endoscopic radiofrequency ablation of cholangiocarcinoma: new palliative treatment modality (with videos)显示文摘 | Amitabh Monga Rajesh Gupta Mohan Ramchandani Guduru V. Rao Darisetty Santosh D. Nageshwar Reddy | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 9 | A new BIS-Andrographolide Ether from Andrographis paniculata Nees and evaluation of anti-HIV activity显示文摘 | V.L. Niranjan Reddy S. Malla Reddy V. Ravikanth P. Krishnaiah T. Venkateshwar Goud T. P. Rao T. Siva Ram Rajesh G. Gonnade Mohan Bhadbhade Y. Venkateswarlu | 2005 | Natural Product Research2005，，3： | 1 |
| 10 | Maxillary lateral incisors with two canals and two separate curved roots 显示文摘 | Mohan AG Rajesh EA George L | 2012 | Contemp Clin Dent2012，3，4： | 1 |
| 11 | Clinical evaluation of a prototype multi‐bending peroral direct cholangioscope显示文摘 | Takao Itoi D Nageshwar Reddy Atsushi Sofuni Mohan Ramchandani Fumihide Itokawa Rajesh Gupta Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Nobuhito Ikeuchi Fuminori Moriyasu Jong Ho Moon | 2014 | Digestive Endoscopy2014，，1： | 1 |
| 12 | Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells显示文摘 | Sarumathi Mohan Sivanandhan Dhanalakshmi G.U Mallikarjuna Rana P Singh Rajesh Agarwal | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 13 | Development of an ergonomic evaluation facility for Indian tractors显示文摘 | Rajesh Patel Adarsh Kumar Dinesh Mohan | 2000 | Applied Ergonomics2000，31，3： | 1 |
| 14 | EUS-guided radiofrequency ablation for management of pancreatic insulinoma by using a novel needle electrode (with videos)显示文摘 | Sundeep Lakhtakia Mohan Ramchandani Domenico Galasso Rajesh Gupta Sushma Venugopal Rakesh Kalpala D. Nageshwar Reddy | 2015 | Gastrointestinal Endoscopy2015，，： | 1 |
| 15 | Longterm clinical outcomes of extracorporeal shock wave lithotripsy in painful chronic calcific pancreatitis显示文摘 | Manu Tandan D Nageshwar Reddy Rupjyoti Talukdar K. Vinod D. Santosh Sundeep Lakhtakia Rajesh Gupta Mohan J. Ramchandani Rupa Banerjee K. Rakesh G. Varadaraj G. Venkat Rao | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 16 | Preparation, Character- ization, and Performance Evaluation of Poly( Ether- imide) Incor- porated Cellulose Acetate Ultrafiltration Membrane for Hemodialysis 显示文摘 | Senthilkumar S Rajesh S Mohan D | 2013 | Separation Science and Technology2013，48，15： | 1 |
| 17 | Longterm clinical outcomes of extracorporeal shock wave lithotripsy in painful chronic calcific pancreatitis显示文摘 | Manu Tandan D Nageshwar Reddy Rupjyoti Talukdar K. Vinod D. Santosh Sundeep Lakhtakia Rajesh Gupta Mohan J. Ramchandani Rupa Banerjee K. Rakesh G. Varadaraj G. Venkat Rao | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 18 | Diagnostic yield and therapeutic impact of single-balloon enteroscopy:Series of 106 ca- ses 显示文摘 | Mohan Ramchandani Reddy DN Rajesh Gupta | 2009 | Journal of Gastroenterology and Hepatology2009，24，： | 1 |
| 19 | Retrospective analysis of anti-inflammatory therapies during the first wave of COVID-19 at a community hospital显示文摘BACKGROUND Our understanding of the severe acute respiratory syndrome coronavirus 2 has evolved since the first reported cases in December 2019,and a greater emphasis has been placed on the hyper-inflammatory response in severely ill patients.The purpose of this study was to determine risk factors for mortality and the impact of anti-inflammatory therapies on survival.AIM To determine the impact of various therapies on outcomes in severe coronavirus disease 2019 patients with a focus on anti-inflammatory and immune-modulating agents.METHODS A retrospective analysis was conducted on 261 patients admitted or transferred to the intensive care unit in two community hospitals between March 12,2020 and June 17,2020.Totally 167 patients received glucocorticoid(GC)therapy.Seventythree patients received GC alone,94 received GC and tocilizumab,28 received tocilizumab monotherapy,and 66 received no anti-inflammatory therapy.RESULTS Patient survival was associated with GC use,either alone or with tocilizumab,and decreased vasopressor requirements.Delayed administration of GC was found to decrease the survival benefit of GC therapy.No difference in survival was found with varying anticoagulant doses,convalescent plasma,tocilizumab monotherapy;prone ventilation,hydroxychloroquine,azithromycin,or intravenous ascorbic acid use.CONCLUSION This analysis demonstrated the survival benefit associated with anti-inflammatory therapy of GC,with or without tocilizumab,with the combination providing the most benefit.More studies are needed to assess the optimal timing of anti-inflammatory therapy initiation. | Jose I Iglesias Andrew V Vassallo Jesse B Sullivan Yasmine Elbaga Vishal V Patel Nikunjkumar Patel Lydia Ayad Payam Benson Marina Pittiglio Emad Gobran Alexander Clark Wajahat Khan Kaliope Damalas Rajesh Mohan Satyendra P Singh | 2021 | World Journal of Critical Care Medicine2021，10，5： | 0 |
| 20 | One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease显示文摘Since the appearance of the novel coronavirus(severe acute respiratory syndrome-coronavirus-2)and related coronavirus disease 2019(COVID-19)in China in December 2019,a very high number of small and large patient series have been published in literature from around the world.Even though the classical presentation of COVID-19 is one with respiratory symptoms with or without pneumonia that can be self-limiting or evolve into severe respiratory distress syndrome with multiple organ failure,and secondary bacterial sepsis,a large body of evidence suggests a plethora of other types of clinical presentation.In this exhaustive review,we reviewed all of the published literature on COVID-19 to identify different types of clinical presentations affecting various organ systems,to provide an in-depth analysis that may prove useful for clinicians and health-workers on the frontline,battling the severe pandemic. | Cyriac Abby Philips Narain Mohan Rizwan Ahamed Sandeep Kumbar Sasidharan Rajesh Tom George Meera Mohanan Philip Augustine | 2020 | World Journal of Clinical Cases2020，8，18： | 0 |
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