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| 1 | Endoscopic ultrasound-guided choledochoduodenostomy in patients with failed endoscopic retrograde cholangiopancreatography显示文摘Endoscopic ultrasonography (EUS)-guided biliary drainage was performed for treatment of patients who have obstructive jaundice in cases of failed endoscopic retrograde cholangiopancreatography (ERCP). In the present study,we introduced the feasibility and outcome of EUS-guided choledochoduodenostomy in four patients who failed in ERCP. We performed the procedure in 2 papilla of Vater,including one resectable case,and 2 cases of cancer of the head of pancreas. Using a curved linear array echoendoscope,a 19 G needle or a needle knife was punctured transduodenally into the bile duct under EUS visualization. Using a biliary catheter for dilation,or papillary balloon dilator,a 7-Fr plastic stent was inserted through the choledochoduodenostomy site into the extrahepatic bile duct. In 3 (75%) of 4 cases,an indwelling plastic stent was placed,and in one case in which the stent could not be advanced into the bile duct,a naso-biliary drainage tube was placed instead. In all cases,the obstructive jaundice rapidly improved after the procedure. Focal peritonitis and bleeding not requiring blood transfusion was seen in one case. In this case,pancreatoduodenectomy was performed and the surgical findings revealed severe adhesion around the choledochoduodenostomy site. Although further studies and development of devices are mandatory,EUS-guided choledochoduodenostomy appears to be an effective alternative to ERCP in selected cases. | Takao Itoi Fumihide Itokawa Atsushi Sofuni Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Shujiro Tsuji Nobuhito Ikeuchi Fuminori Moriyasu | 2008 | World Journal of Gastroenterology2008，14，39： | 13 |
| 2 | Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer显示文摘AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy.Informed consent was obtained.This study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at pre-therapy.There were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,4.Treatment after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care treatments.Adverse events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in 1.However,no severe adverse events occurred in this study.CONCLUSION:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC. | Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 3 | Endoscopic resection of carcinoid of the minor duodenalpapilla显示文摘We encountered a 65-year-old man with a carcinoid tumor of the minor duodenal papilla. Since he had liver cirrhosis and completely refused surgery, we performed an endoscopic snare papillectomy. The papillectomy was performed successfully without procedure-related complication. The specimens revealed a carcinoid tumor showing that the margin of the tumor was positive. One week later, upper GI endoscopy was performed and the biopsy specimens obtained from base of ulcer showed no neoplastic cells. We performed a duodenoscopy and CT 3, 6 and 18 mo later, and there was no macroscopic or microscopic evidence of tumor recurrence after more than 4 years. | Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Fuminori Moriyasu | 2007 | World Journal of Gastroenterology2007，13，27： | 6 |
| 4 | Temporary pancreatic stent to prevent post endoscopic retrograde cholangiopancreatography pancreatitis: a preliminary, single-center, randomized controlled trial显示文摘 | Takayoshi Tsuchiya Takao Itoi Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Kentaro Ishii Syujiro Tsuji Takashi Kawai Fuminori Moriyasu | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，3： | 4 |
| 5 | Prognosis of cancer with branch duct type IPMN of the pancreas显示文摘AIM:To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).METHODS: We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intraor extra-pancreatic carcinoma and the outcome of IPMN.RESULTS: The mean observation period was 55.9 ± 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pan-creatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%,pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the patients.CONCLUSION: The prognosis for IPMN depends not on the IPMN per se, but on the presence of intraor extra-pancreatic cancer. | Nobuhito Ikeuchi Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Shujiro Tsuji Junko Umeda Fuminori Moriyasu Akihiko Tsuchida Kazuhiko Kasuya | 2010 | World Journal of Gastroenterology2010，16，15： | 3 |
| 6 | Usefulness of contrast-enhanced ultrasonography in determining treatment efficacy and outcome after pancreatic cancer chemotherapy显示文摘AIM:To investigate if contrast-enhanced ultrasonography(CE-US) is useful for determining treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy by assessing changes in intratumor hemodynamics using CE-US with a contrast agent.METHODS:The subjects were 34 patients with unresectable advanced pancreatic cancer treated by chemotherapy.CE-US was assessed after every treatment(course) completion under the same conditions,and patients were divided into two groups according to the intratumor enhancement pattern:Vascular rich(R) group and vascular poor(P) group.RESULTS:After the second course of treatment,R group in intratumor hemodynamics had 18 patients,and P group had 16 patients.The reduction rates of serum CA19-9 level after chemotherapy which decreased to half or less of the baseline level were 2/15(0.1%) in P group,but 11/16(69%) in R group(P = 0.006).When the mean number of courses of chemotherapy and outcome were compared,P group had a mean number of courses of 4.9(R group,10.2) and mean survival time(MST) of 246 d(R group,402 d),showing that outcome was significantly better in R group(P=0.006).CONCLUSION:CE-US revealed that the change in intratumor blood flow correlated with both serum CA19-9 level and outcome.Patients with serum CA19-9 that decreased to less than half the baseline level,and patients with an abundant intratumor blood flow,had a significantly better outcome.Thus,CE-US is potentially useful for evaluating treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy. | Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Fuminori Moriyasu | 2008 | World Journal of Gastroenterology2008，14，47： | 3 |
| 7 | Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver显示文摘 | Takao Itoi Hiroyuki Isayama Atsushi Sofuni Fumihide Itokawa Miho Tamura Yusuke Watanabe Fuminori Moriyasu Michel Kahaleh Nagy Habib Toshitaka Nagao Tomohisa Yokoyama Kazuhiko Kasuya Hiroshi Kawakami | 2012 | Journal of Hepato-Biliary-Pancreatic Sciences2012，，5： | 3 |
| 8 | Clinical evaluation of a novel lumen-apposing metal stent for endosonography-guided pancreatic pseudocyst and gallbladder drainage (with videos)显示文摘 | Takao Itoi Kenneth F. Binmoeller Janak Shah Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Shujiro Tsuji Nobuhito Ikeuchi Fuminori Moriyasu | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 9 | Endoscopic double stenting for the treatment of malignant biliary and duodenal obstruction due to pancreatic cancer显示文摘 | Ryosuke Tonozuka Takao Itoi Atsushi Sofuni Fumihide Itokawa Fuminori Moriyasu | 2013 | Digestive Endoscopy2013，，： | 2 |
| 10 | Endoscopic ultrasonography-guided biliary drainage显示文摘 | Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Shujiro Tsuji Nobuhito Ikeuchi Junko Umeda Fuminori Moriyasu Akihiko Tsuchida | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，5： | 2 |
| 11 | New large-diameter balloon-equipped sphincterotome for removal of large bile duct stones (with videos)显示文摘 | Takao Itoi Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Shujiro Tsuji Nobuhito Ikeuchi Junko Umeda Fuminori Moriyasu | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 12 | Japanese guidelines for mutagenicity testing显示文摘 | Sofuni T | 1993 | Environ Mole Mutagen1993，21，1： | 1 |
| 13 | EUS-guided rendezvous with single-balloon enteroscopy for treatment of stenotic pancreaticojejunal anastomosis in post-Whipple patients (with video)显示文摘 | Takao Itoi Masataka Kikuyama Kentaro Ishii Kazuyoshi Matsumura Atsushi Sofuni Fumihide Itokawa | 2011 | Gastrointestinal Endoscopy2011，，2： | 1 |
| 14 | The induction of mieronu- clei and gene mutatuons in L5178Y mouse lymphoma cells by hydroquinone and diethylstilbestrol: a comparison of short-and long- term treatments显示文摘 | Zhang LS Honma M Sofuni T | 1996 | MMS commun1996，4，2： | 1 |
| 15 | Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas显示文摘 | Sofuni A Fukushima N | 2007 | J Gastroenterol2007，42，5： | 1 |
| 16 | Initial experience of peroral pancreatoseopy combined with narrow-band imaging in the diagnosis of intraductal papillary mutinous neoplasms of the pancreas 显示文摘 | Itoi T Sofuni A Itokawa F | 2007 | Gastrointest Endosc2007，66，4： | 1 |
| 17 | A procedure for data analysis of the rodent micronueleus test involving a historical control 显示文摘 | HAYASHI M YOSHIMURA I SOFUNI T | 1989 | Environ Mol Mutagen1989，13，4： | 1 |
| 18 | Differential diagnosis Of pancreatic tumors using ultrasound contrast imaging显示文摘 | Sofuni A Iima H Moriyasu F | 2005 | Gastroenterology2005，40，： | 1 |
| 19 | An application of Acridine Orange fluorescent staining to the micronucleus test显示文摘 | Hayashi M Sofuni T Ishidate M Jr | 1983 | Mutat Res1983，120，4： | 1 |
| 20 | Contrast-enhanced ul- trasonography in the diagnosis of gallbladder disease 显示文摘 | Tsuji S Sofuni A Moriyasu F | 2010 | Hepatogastroenterology2010，13，5： | 1 |
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