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| 1 | Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients显示文摘AIM: To investigate the expression of fragile histidine triad (FHIT) protein, and the possible relationship between FHIT expression and clinicopathological indices in gastric carcinoma.METHODS: FHIT protein expression was examined in 76 cases of gastric carcinoma, 58 cases of intraepithelial neoplasia, and 76 cases of corresponding normal mucosae by immunohistochemical method to analyze its relationship to histological grade, clinical stage, metastatic status and prognosis.RESULTS: The FHIT protein expression was positive in 28/76 (36.8%) cases of adenocarcinoma tissue, 22/58(37.9%) cases of adjacent dysplastic tissue and 76/76(100%) cases of distal normal gastric mucosa. There was a significant difference in the expression of FHIT protein between cancer or adjacent intraepithelial neoplasia and normal gastric mucosa (P = 0.000). FHIT protein expression was found in 64.3% (18/28) of grades Ⅰ and Ⅱ cancers,and 20.8% (10/48) of grade Ⅲ cancers (P = 0.000), in 56.3% (18/32) of stages Ⅰ and Ⅱ cancers and 22.7%(10/44) of stages Ⅲ and Ⅳ cancers (P = 0.004), and in 63.6% (14/22) of cancers without metastasis but only 25.9% (14/54) of those with metastasis (P = 0.003). The significant difference in the expression of FHIT was found between histological grade, clinical stage and metastatic status of cancer. Follow-up data showed that there was a significant difference in median survival time between cancer patients with expression of FHIT (71 mo) and those without (33 mo, log rank = 20.78, P = 0.000).CONCLUSION: FHIT protein is an important tumor suppressor protein. Loss of FHIT protein expression may be associated with carcinogenesis, invasion, metastasis and prognosis of gastric adenocarcinoma. | Po Zhao Wu Liu Ya-Li Lu | 2005 | World Journal of Gastroenterology2005，11，36： | 30 |
| 2 | Loss of fragile histidine triad protein in human hepatocellular carcinoma显示文摘AIM: To investigate the expression of fragile histidine triad (FHIT) gene protein, Fhit, which is recently thought to be a candidate tumor suppressor. Abnormal expression of fragile histidine triad has been found in a variety of human cancers,but little is known about its expression in human hepatocellular carcinogenesis and evolution.METHODS: Sections of 83 primary human hepatocellular carcionoma with corresponding para-neoplastic liver tissue and 10 normal liver tissue were evaluated immunohistochemically for Fhit protein expression.RESULTS: All normal liver tissue and para-neoplastic liver tissue showed a strong expression of Fhit, whereas 50 of 83(65.0 %) carcinomas showed a marked loss or absence of Fhit expression. The differences of Fhit expression between carcinoma and normal or para-neoplastic liver tissue werehighly significant (P=0.000). The proportion of carcinomas with reduced Fhit expression showed an increasing trend (a) with decreasing differentiation or higher histological grade (P=0.219); (b) in tumors with higher clinical stage Ⅲ and ⅣV (91.3 %, P=0.000), compared with tumors with lower stage Ⅰ and Ⅱ (27.6 %); and (c) in cancers with bigger tumor size (>50 mm) (75.0 %, P=0.017), compared withsmaller tumor size (≤ 50 mm).
CONCLUSION: FHIT inactivation seems to be both an earlyand a later event, associated with carcinogenesis andprogression to more aggressive hepatocellular carcinomas.Thus, evaluation of Fhit expression by immunohistochemistryin hepatocellular carcinoma may provide important diagnosticand prognostic information in clinical application. | Po Zhao Xin Song Yuan-Yuan Nin Ya-Li Lu Xiang-Hong Li Department of Pathology,Chinese PLA General Hospital,Beijing 100853,China | 2003 | World Journal of Gastroenterology2003，9，6： | 28 |
| 3 | A low-carbon oriented probabilistic approach for transmission expansion planning显示文摘Following the deregulation of the power industry,transmission expansion planning(TEP)has become more complicated due to the presence of uncertainties and conflicting objectives in a market environment.Also,the growing concern on global warming highlights the importance of considering carbon pricing policies during TEP.In this paper,a probabilistic TEP approach is proposed with the integration of a chance constrained load curtailment index.The formulated dynamic programming problem is solved by a hybrid solution algorithm in an iterative process.The performance of our approach is demonstrated by case studies on a modified IEEE 14-bus system.Simulation results prove that our approach can provide network planners with comprehensive information regarding effects of uncertainties on TEP schemes,allowing them to adjust planning strategies based on their risk aversion levels or financial constraints. | Jing QIU Zhaoyang DONG Junhua ZHAO Ke MENG Fengji LUO Kit Po WONG Chao LU | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 8 |
| 4 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 5 | Metal halide perovskite nanocrystals and their applications in optoelectronic devices显示文摘In recent years, metal halide perovskite nanocrystals (NCs) have been favored by manyresearchers due to their unique properties including long carrier diffusion length, highcarrier mobility, tunable emission wavelength, and narrow full width at half maximum,making them great application potentials in optoelectronic devices. The photoluminescencequantum yields of perovskite NCs are nearly 100%, and the device efficiencyof perovskite NC-based light-emitting diodes (LEDs) has been improvedsignificantly from below 0.1% to over 20%. In addition, perovskite NC-based solarcells and photodetectors have also developed rapidly in recent years. Here, we summarizethe synthesis and the basic optoelectronic properties of metal halide perovskiteNCs and introduce their applications in LEDs, solar cells, and photodetectors. | Po Lu Min Lu Hua Wang Ning Sui Zhifeng Shi William W.Yu Yu Zhang | 2019 | InfoMat2019，1，4： | 7 |
| 6 | Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants显示文摘这当前的代表性的研究 40 年并且在上面在 euthyroid 汉语人口之中调查在甲状腺荷尔蒙和外部动脉疾病(垫) 之间的关系。浆液免费 triiodothyronine (FT3 ) ,免费甲状腺素(FT4 ) ,刺激甲状腺的荷尔蒙(TSH ) ,和甲状腺抗体被测量。垫被定义为脚关节臂的索引(ABI )< 0.9。有 91 (2.9%) 在 3,148 euthyroid 之中的垫案例学习参加者。参加者在有的 FT3 和 free-triiodothyronine-to-free-thyroxin (FT3/FT4 比率) 最高方照流行的垫的减少的风险(调整 multivariate 的机会比率, 95% 信心间隔:0.32, 0.15-0.62,为趋势 = 的 P 0.01 和 0.31, 0.13-0.66,为趋势 = 的 P 0.004,分别地) 与那些相比在里面最低方照。得出结论, FT3 层次和 FT3/FT4 比率相反地 40 年并且在上面在 euthyroid 汉语人口与流行的垫被联系。 | WANG Po DU Rui LIN Lin DING Lin PENG Kui XU Yu XU Min BI Yu Fang WANG Wei Qing NING Guang LU Jie Li | 2017 | Biomedical and Environmental Sciences2017，30，2： | 5 |
| 7 | Emphysematous pyelonephritis: Clinical characteristics and prognostic factors显示文摘 | Yu‐Chuan Lu Bing‐Juin Chiang Yuan‐Hung Pong Chung‐Hsin Chen Yeong‐Shiau Pu Po‐Ren Hsueh Chao‐Yuan Huang | 2014 | Int J Urol2014，，3： | 1 |
| 8 | Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi显示文摘 | Lu Z Scherlag B J Po SS | 2009 | Cardiovasc Res2009，84，2： | 1 |
| 9 | Intelli- gent agent- based systems for personalized recommenda- tions in Internet commerce显示文摘 | Wei - Po Lee Chih - Hung Liu Cheng - Che Lu | | 0，，02： | 1 |
| 10 | Comparison of atrial fibrillation inducibility by electrical stimulation of either the extrinsic or the intrinsic autonomic nervous systems显示文摘 | Yuan Zhang Benjamin J. Scherlag Zhibing Lu Guo-Dong Niu William S. Yamanashi Cameron Hogan Jerad Fields Muhammad Ghias Ralph Lazzara Warren M. Jackman Sunny Po | 2009 | Journal of Interventional Cardiac Electrophysiology2009，，1： | 1 |
| 11 | Atrial Fibrillation Begets Atrial Fibrillation: Autonomic Mechanism for Atrial Electrical Remodeling Induced by Short-Term Rapid Atrial Pacing显示文摘 | Zhibing Lu Benjamin J. Scherlag Jiaxiong Lin Guodong Niu Kar-Ming Fung Lichao Zhao Muhammad Ghias Warren M. Jackman Ralph Lazzara Hong Jiang Sunny S. Po | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，： | 1 |
| 12 | Chinese-Language Montreal Cognitive Assessment for Cantonese or Mandarin Speakers: Age, Education, and Gender Effects显示文摘 | Ling Zheng Evelyn L. Teng Rohit Varma Wendy J. Mack Dan Mungas Po H. Lu Helena C. Chui Hiroko H. Dodge | 2012 | International Journal of Alzheimer’s Disease2012，，： | 1 |
| 13 | Severe vitreous hemorrhage associated with closed-globe injury显示文摘 | Ling Yeung Tun Lu Chen Ya Hui Kuo An Ning Chao Wei Chi Wu Kuan Jen Chen Yih Shiou Hwang Yen Po Chen Chi Chun Lai | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，1： | 1 |
| 14 | Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial显示文摘 | Masatoshi Kudo Guohong Han Richard S. Finn Ronnie T.P. Poon Jean‐Frederic Blanc Lunan Yan Jijin Yang Ligong Lu Won‐Young Tak Xiaoping Yu Joon‐Hyeok Lee Shi‐Ming Lin Changping Wu Tawesak Tanwandee Guoliang Shao Ian B. Walters Christine Dela Cruz Valerie Po | 2014 | Hepatology2014，，5： | 1 |
| 15 | Neuropsychological functions in Han Chinese patients in Taiwan with bipolar II disorder comorbid and not comorbid with alcohol abuse/alcohol dependence disorder显示文摘 | Cindy Shan Sheng-Yu Lee Yun-Hsuan Chang Jo Yung-Wei Wu Shiou-Lan Chen Shih-Heng Chen Yih-Lynn Hsiao Hsin-Fen Yang I. Hui Lee Po See Chen Tzung Lieh Yeh Yen Kuang Yang Ru-Band Lu | 2010 | Progress in Neuropsychopharmacology & Biological Psychiatry2010，，1： | 1 |
| 16 | Finite Element Formulation and Shaking Table Tests of Direction Optimized Friction Pendulum System 显示文摘 | Tsai C S Lu Po Ching Wen Shin Chen | 2008 | Engineering Structures2008，30，9： | 1 |
| 17 | 老年痴呆患者精神状态和神经心理测评进展显示文摘尽管神经影像技术取得突飞猛进的发展,但仍无法直接检测大脑的整合功能。神经科学专家和临床医师仍必须依赖于其他许多间接检查方法,特别是广泛的行为学研究,以了解患者目前脑功能的状态。精神状况检查和神经心理测评的本质就是研究脑功能的行为表现,是提高痴呆诊断准确率,制定患者治疗、照料、康复计划,评估治疗效果以及进行临床研究的关键。事实上,美国神经病学学会在痴呆早期诊断的操作原则中明确指出,各种神经心理测评量表是有用的工具,可用于识别痴呆患者。特别对认知功能障碍危险增大的患者。 | Po H. Lu 任汝静(翻译) 王刚(审校) 陈生弟(审校) | 2009 | 诊断学理论与实践2009，，4： | 1 |
| 18 | Normative data for healthy older adults and an abbreviated version of the Stroop test显示文摘 | Kang Christinel Lee GraceJ Yi Dahyun McPherson Susan Rogers Steven Tingus Kathleen Lu Po H | | 0，，02： | 1 |
| 19 | Separation of micro- Doppler signals based on time frequency filter and Viterbi algorithm 显示文摘 | Li Po Wang Dechun Wang Lu | 2013 | Signal Image and Video Processin g2013，7，3： | 1 |
| 20 | Degradation and environ-mental fate of 1-(2,6-difluoro benzoyl)-3-(4-chlorophenol) urea显示文摘 | Metcalf R L Lu Po yung Bowlus S | 1975 | Agric Food Chem1975，，3： | 1 |
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