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| 1 | 尖锐心肌的梗塞: 在在新加坡的年轻成年人的临床的特征和结果显示文摘 AIM: To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS: Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS: The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6±1.2 mmol/L, 3.8±1.1 mmol/L and 0.93±0.25 mmol/L respectively. The mean left ventricular function was 44%±10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION: Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI. | Chun Pong Wong Seet Yoong Loh Kwok Kong Loh Paul Jau Lueng Ong David Foo Hee Hwa Ho | 2012 | World Journal of Cardiology2012，4，6： | 13 |
| 2 | Pancreatic cancer with a high serum IgG4 concentration显示文摘Differentiation between autoimmune pancreatitis and pancreatic cancer is sometimes difficult. It has been reported that serum IgG4 concentrations are significantly elevated and particularly high (>135 mg/dL) in autoimmune pancreatitis. Measurement of serum IgG4 has become a useful tool for differentiating between autoimmune pancreatitis and pancreatic cancer. However, we present a 74-year-old female with a markedly elevated serum IgG4 (433 mg/dL) who underwent pancreaticoduodenectomy for pancreatic cancer. Elevated serum IgG4 levels continued after the resection. On histology, adenocarcinoma of the pancreas accompanied with moderate lymphoplasmacytic infiltration infiltrated the lower bile duct and duodenum, but there were no findings of autoimmune pancreatitis. Although a small metastasis was detected in one parapancreatic lymph node, regional lymph nodes were swollen. Abundant IgG4-positive plasma cells infiltrated the cancerous areas of the pancreas, but only a few IgG4-positive plasma cells were detected in the noncancerous areas. Pancreatic cancer cells were not immunoreactive for IgG4. An abundant infiltration of IgG4-positive plasma cells was detected in the swollen regional lymph nodes and in the duodenal mucosa. We believe that the serum IgG4 level was elevated in this patient with pancreatic cancer as the result of an IgG4-related systemic disease that had no clinical manifestations other than lymphadenopathy. | Terumi Kamisawa Pong Yui Chen Yuyang Tu Hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake Okamoto Tsunekazu Hishima | 2006 | World Journal of Gastroenterology2006，12，38： | 10 |
| 3 | Autoimmune pancreatitis metachronously associated with retroperitoneal fibrosis with IgG4-positive plasma cell infiltration显示文摘腹膜后纤维变性是纤维组织的稠密的匾的形成在制动火箭腹膜描绘的不平常的混乱,并且它的病原学仍然保持未知。自体免疫的胰腺炎是纤维变性在胰与 IgG4 积极的血浆房间和淋巴细胞和 obliterative 静脉炎的丰富的渗入描绘的慢性胰炎的一种稀罕类型。我们在场在制动火箭的出现以后开发了 10 瞬间的自体免疫的胰腺炎的一个盒子腹纤维变性。resected 制动火箭腹团的组织检查所见是有 IgG4 积极的血浆房间和淋巴细胞和 obliterative 静脉炎的丰富的渗入的显著 periureteral 纤维变性。这些调查结果在这种情况中为制动火箭腹纤维变性和自体免疫的胰腺炎建议普通 pathophysiological 机制。制动火箭腹纤维变性力量的一些盒子是 IgG4 相关的致硬化的疾病的制动火箭腹损害。 | Terumi Kamisawa Pong Yui Chen Hitoshi Nakajima Naoto Egawa | 2006 | World Journal of Gastroenterology2006，12，18： | 8 |
| 4 | Mitochondrial Composition,Function and Stress Response in Plants显示文摘The primary function of mitochondria is respiration,where catabolism of substrates is coupled to ATP synthesis via oxidative phosphorylation.In plants,mitochondrial composition is relatively complex and flexible and has specific pathways to support photosynthetic processes in illuminated leaves.This review begins with outlining current models of mitochondrial composition in plant cells,with an emphasis upon the assembly of the complexes of the classical electron transport chain (ETC).Next,we focus upon the comparative analysis of mitochondrial function from different tissue types.A prominent theme in the plant mitochondrial literature involves linking mitochondrial composition to environmental stressresponses,and this review then gives a detailed outline of how oxidative stress impacts upon the plant mitochondrial proteome with particular attention to the role of transition metals.This is followed by an analysis of the signaling capacity of mitochondrial reactive oxygen species,which studies the transcriptional changes of stress responsive genes as a framework to define specific signals emanating from the mitochondrion.Finally,specific mitochondrial roles during exposure to harsh environments are outlined,with attention paid to mitochondrial delivery of energy and intermediates,mitochondrial support for photosynthesis,and mitochondrial processes operating within root cells that mediate tolerance to anoxia and unfavorable soil chemistries. | Richard P. Jacoby Lei Li Shaobai Huang Chun Pong Lee A. Harvey Millar Nicolas L. Taylor | 2012 | Journal of Integrative Plant Biology2012，54，11： | 7 |
| 5 | A comparative study of seismic provisions between International Building Code 2003 and Uniform Building Code 1997显示文摘This study focuses on the comparison of the Uniform Building Code (UBC) 1997 and International Building Code (IBC) 2003 in relation to the seismic design and analysis of special steel moment resisting frame buildings (SMRF). This paper formulates a numerical study of a steel SMRF building, studied in four different situations, namely: as an office building in San Francisco; as an office building in Sacramento; as an essential facility in San Francisco, and as an essential facility in Sacramento. The analytical results of the model buildings are then compared and analyzed taking note of any significant differences. This case study explores variations in the results obtained using the two codes, particularly the design base shear and drift ratios as they relate to different locations and occupancy use. This study also proves that IBC 2003 is more stringent for the redundancy factor under design category E for the SMRF building, and drift limits for essential facilities. | Wenshen Pong Zu-Hsu Lee Anson Lee | 2006 | Earthquake Engineering and Engineering Vibration2006，5，1： | 6 |
| 6 | 亚太地区的基层医疗:挑战与解决方案显示文摘1区域多样性
亚太地区地域广大,人口众多,其文化、语言、经济状况和人口情况等多样性程度高。许多国家都面临着诸如老龄化、疾病复杂化、劳动力不足、急需技术以及成本上涨等问题。一些国家的中产阶级开始壮大,这成为其提高医疗服务质量的主要动力。还有些国家仍在与高儿童死亡率和流行病做斗争,特别是疟疾和登革热。虽然有些国家经济增长势头明显,但仍有不少国家还存在贫穷问题,其中一些是由内战或恐怖主义造成的。这些国家的健康卫生问题由不同的卫生系统负责,其基层医疗、二级医疗和三级医疗所占的比例各不相同,就医难度和经费来源也不尽相同。亚太地区与世界其他地区一样,面临着如何分配医疗卫生资源,切实提高医疗服务质量的问题。在某种意义上,这一地区可以成为一个很好的试验场,用于研究如何应对这些挑战。 | Richard Hays Lam Tai Pong Zorayda Leopando | 2014 | 中国全科医学2014，17，10： | 5 |
| 7 | 开关电源近场干扰的研究显示文摘在开关电源中,由于近场干扰的影响,会在印刷电路板( P C B) 布线之间造成电磁干扰( E M I) 噪声。通过反馈变换器实验证实了这一影响的严重性。进一步的实验和现场测试证明,优化 P C B 布线可以有效地抑制电场干扰引起的 E M I。 | 吴昕 Pong M.H. Lee C.M 钱照明 | 1999 | 电力电子技术1999，33，4： | 5 |
| 8 | Utilization of the Accident & Emergency Departments by Chinese elderly in Hong Kong显示文摘BACKGROUND: The epidemiological data on elderly patients attending Accident and Emergency Departments(AEDs) in Hong Kong is lacking. The study aimed to examine the epidemiology of geriatric patient visits to AEDs in Hong Kong, including demographic data and predictors of life-saving interventions(LSI) and admission.METHODS: A retrospective cross-sectional study of geriatric patients older than 64 years old attending three AEDs during the year 2012, with a sample of 1 200 patient visits recruited. The data were retrieved from the medical records of the respective hospitals. Descriptive characteristics of the visits were provided. Multivariate logistic regression was performed to evaluate the predictors of LSI and hospital admission.RESULTS: The mean age of the patients was 79.1 years. Totally 49.7% of the patients were male. 'Diseases of the respiratory system' was the commonest diagnosis in AEDs as well as that required admission. The admission rate was 56.8%. Logistic regression demonstrated that dependent activity of daily living(ADL), arrival by ambulance, and the higher number of co-morbidities were predictors of LSI, while advanced age, dependent ADL, institutionalized patients, arrival by ambulance, and higher number of co-morbidities were predictors of hospital admission.CONCLUSIONS: Ageing population is creating an imminent burden on the emergency service in Hong Kong. Previously unavailable epidemiological information about geriatric attendance to AEDs was described. This forms the basis for development of future studies concerning the medical services on this specific group of patients. | Wai Lam Yip Kit Ling Fan Chun Tat Lui Ling Pong Leung Fu Ng Kwok Leung Tsui | 2015 | World Journal of Emergency Medicine2015，6，4： | 3 |
| 9 | Effect of volume fraction and mechanical stability of austenite on ductility of medium Mn steel显示文摘A hot-rolled medium Mn(0.2C5Mn)steel is annealed at 650℃ to produce an ultrafine-grained duplex microstructure with different austenite volume fractions by austenite reverted transformation(ART)annealing,and the orientation relationship strictly obeys K-S orientation relationship before deformation.Tensile tests are carried out in a temperature range from-196 to 400℃ to examine the effects of the austenite volume fraction and the deformation temperature on the tensile properties and the austenite stability.Microstructural observations reveal that the metastable austenite gradually transformed into a-martensite,which is controlled by the deformation strain,the temperature and the austenite volume fraction.Both strain hardening behavior and ductility of the studied steel are dependent on austenite volume fraction and deformation temperature significantly.The stress-strain curves of ART-annealed 0.2C5Mn steel assume an S shape and a very large work hardening rate of about 10 GPa is obtained at liquid nitrogen deformation temperature.Based on the experimental data,a quantitative relation is proposed to describe the ductility dependence on both the austenite volume fraction and its mechanical stability. | Si-lian Che Zhao-xi Cao Chang Wang Chong-xiang Huang Dirk Ponge Wen-quan Cao | 2019 | Journal of Iron and Steel Research(International)2019，26，11： | 3 |
| 10 | Stereocompfexed Poiy(iactide) Composites toward Engineering Plastics with Superior Toughness, Heat Resistance and Anti-hydrolysis显示文摘Polyl(lactide),PLA,suffers from bitleness and low heat deflection temperature(HDT),which limits its application as an engineering plastic.In this work,poly(L-lactide)/poly(D-lactide)/ethylene-vinyl acetate glycidyl methacrylate random copolymer(PLLA/PDL A/EVM-GMA=1/1/x)composites were prepared by melt blending,and the in situ formed EVM-g PLA copolymers improved the compatibility between PLA and EVM-GMA.Subsequently,the blends were subjected to a two-step annealing process during compression molding,i.e.first annealing at 120℃ to rapidly form a certain amount of stereocomplex(sc)crystallites as nucleation sites,and then annealing at 200℃ to guide the formation of new sccrystallites.Both differential scanning calorimetry(DSC)and wide angle X-ray dffrction(WAXD)measurements confirmed the formation of highly stereocomplexed PLA products.Mechanical results showed that the PLLA/PDLA blend with 20 wt%of EVM-GMA had a notched impact strength up to 65 kJ/m2 and an elongation at break of 48%,while maintaining a tensile strength of 40 MPa.Meanwhile,dynamic mechanical analysis(DMA)and heat deflection tests showed that the PLA composite had an HDT up to 142℃ which is 90℃ higher than that of normal PLA products.Scanning electron microscopy(SEM)confirmed the fine dispersion of EVM-GMA particles,which facilitated to understand the toughening mechanism.Furthermore,the highly stereocomplexed PLA composites simultaneously exhibited excellent chemical and hydrolysis resistance.Therefore,these fascinating properties may extend the application range of sc PLA material as an engineering bioplastic. | Bao-Gou Wu WeiJun Yang De-Yu Niu WeiFu Pong Ming-Qing Chen Tian-Xi Liu Ming-Liang Du Pi-Ming Ma | 2020 | Chinese Journal of Polymer Science2020，38，10： | 3 |
| 11 | Synthesis and antitussive evaluation of verticinone-cholic acid salt,a novel and potential cough therapeutic agent显示文摘瞄准:基于 Shedan-Chuanbei 粉末寻求新奇、有势力的能止咳的药,为咳嗽的繁体中文药准备的建筑群治疗。方法:Verticinone 胆酸酸(Ver-CA ) 盐,一篇小说, verticinone 和胆酸的 salifying 衍生物,哪个是在 Shedan-Chuanbei 粉末的主要简历有功成分,被综合。我们然后评估了能止咳的活动和盐的尖锐毒性。结果:与水里的好溶解度,新混合物有与一样比较的能止咳的活动单个 verticinone 和单个胆酸开的更多有势力。管理 Ver-CA 的 3 mg/kg 能导致柠檬性的导致酸的咳嗽的超过 50% 减小。有 naloxone 的预告的处理(0.8 mg/kg, ip ) 能仅仅部分反对它的能止咳的效果。在另一方面, glybenclamide (3 mg/kg, ip ) , ATP 敏感的 K+ 隧道 blocker,能显著地也减少 Ver-CA 的能止咳的效果。进一步尖锐的毒性研究证明 Ver-CA 的 LD (50 ) 价值是乘 verticinone 的的 3。结论:基于药理学和尖锐毒性的研究,盐与单个 verticinone 和胆酸相比有协作、稀释的毒性。而且,现在的学习也建议那 Ver-CA,一个潜在的新奇能止咳的代理人,可以经由两个施加它的能止咳的效果外设(由 ATP 敏感的 K+ 隧道调制了) 并且中央机制(由 opioid 受体调制了) 。 | Fang-zhou XU Chang CHEN Yong-hui ZHANG Han-li RUAN Hui-fang PI Pong ZHANG Ji-zhou WU | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 12 | Segregation-assisted spinodal and transient spinodal phase separation at grain boundaries显示文摘Segregation to grain boundaries affects their cohesion,corrosion,and embrittlement and plays a critical role in heterogeneous nucleation.In order to quantitatively study segregation and low-dimensional phase separation at grain boundaries,here,we apply a density-based phase-field model.The current model describes the grain-boundary thermodynamic properties based on available bulk thermodynamic data,while the grain-boundary-density profile is obtained using atomistic simulations.To benchmark the performance of the model,Mn grain-boundary segregation in the Fe–Mn system is studied.3D simulation results are compared against atom probe tomography measurements conducted for three alloy compositions.We show that a continuous increase in the alloy composition results in a discontinuous jump in the segregation isotherm.The jump corresponds to a spinodal phase separation at grain boundary.For alloy compositions above the jump,we reveal an interfacial transient spinodal phase separation.The transient spinodal phenomenon opens opportunities for knowledge-based microstructure design through the chemical manipulation of grain boundaries.The proposed density-based model provides a powerful tool to study thermodynamics and kinetics of segregation and phase changes at grain boundaries. | Reza Darvishi Kamachali Alisson Kwiatkowski da Silva Eunan McEniry Dirk Ponge Baptiste Gault Jörg Neugebauer Dierk Raabe | 2020 | npj Computational Materials2020，，1： | 2 |
| 13 | Interactive Behavior of Structures with Multiple Friction Pendulum Isolation System and Unbounded Foundations显示文摘 | C. S. Tsai Bo-Jen Chen W. S. Pong Tsu-Cheng Chiang | 2009 | Advances in Structural Engineering2009，，6： | 2 |
| 14 | 最新无模型深度强化学习研究:从零开始训练机器人“玩乐高”显示文摘伯克利最新提出无模型深度强化学习方法——soft Q-learning(SQL)算法,该算法可以对模拟和现实世界的任务执行组合性,同时在该算法基础上提出了一种使用具有表达性的神经网络策略学习机器人操作技能的学习框架。 | Tuomas Haarnoja Vitchyr Pong Aurick Zhou Murtaza Dalal Pieter Abbeel Sergey Levine | 2018 | 机器人产业2018，，3： | 2 |
| 15 | Diagnostic accuracy of Focused Abdominal Sonography for Trauma in blunt abdominal trauma patients in a trauma centre of Hong Kong显示文摘为损伤的 ObjectiveFocused 腹的 Sonography (快) 广泛地为 intraperitoneal 的察觉被使用在受不了钝腹的损伤(蝙蝠) 的病人的免费液体。针对在指明的损伤 centre.MethodsThis 估计这调查的诊断精确性的这研究是在在香港在一个损伤中心看见的 6 年时期上的蝙蝠病人的回顾的研究。快调查结果与剖腹术,腹的计算断层摄影术或尸体调查结果相比,它为 intraperi-toneal 的存在用作标准答案免费液体。没快有的病人或确定的测试执行了,有先存在的腹液体,在复活死了或有快调查结果的 imcomplete 文档的标准答案被排除。性能当敏感,特性,预兆的值(PV ) ,可能性的比率(LR ) 和 accuracy.ResultsFAST 在 302 个病人被执行,他们中的 153 个在这分析被包括,快被表示。敏感,特性,积极 PV,否定 PV,积极 LR,否定 LR 和精确性为快分别地 50.0% , 97.3% , 87.0% , 84.6% , 18.8, 0.5 和 85.0% 。快被发现在不太严重地受伤的病人和在更严重地受伤的 patients.ConclusionFAST 特定的更多更敏感是在对蝙蝠病人的起始的评价的可靠调查。诊断价值能被损害的严厉快影响,职员训练被需要进一步提高它的有效使用。 | Cheung Kent Shek Wong Hay Tai Leung Ling Pong Tsang Tat Chi Leung Gilberto Ka Kit | 2012 | Chinese Journal of Traumatology2012，15，5： | 2 |
| 16 | Spontaneous subconjunctival haemorrhage secondary to carotid-cavernous fistula显示文摘 | Pong JC Lam DK Lai JS | 2008 | Clin Experiment Ophthalmol2008，36，： | 1 |
| 17 | Critical challenges for picoTesla magnetic-tunnel-junction sensors 显示文摘 | Egelhoff Jr W F Pong P W T Unguris J | 2009 | J Sensors and Actualtors A2009，，： | 1 |
| 18 | Surrogate marker for predicting the virus binding of urogenital cancer cells during adenovirus-based gene therapy 显示文摘 | Lai YJ Pong RC McConnell JD | 2003 | Biotechniques2003，35，1： | 1 |
| 19 | Emphysematous pyelonephritis: Clinical characteristics and prognostic factors显示文摘 | Yu‐Chuan Lu Bing‐Juin Chiang Yuan‐Hung Pong Chung‐Hsin Chen Yeong‐Shiau Pu Po‐Ren Hsueh Chao‐Yuan Huang | 2014 | Int J Urol2014，，3： | 1 |
| 20 | Overview of processing, microstructure and mechanical properties of ultrafine grained bcc steels显示文摘 | Song R Ponge D Raabe D | 2006 | Materials Science and Engineering2006，441，1： | 1 |
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