|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Locking plate fixation combined with iliac crest bone autologous graft for proximal humerus comminuted fracture显示文摘 | Zhu Lian Liu Yueju Yang Zongyou Li Han Wang Juan Zhao Changping Chen Xiao Zhang Yingze | 2014 | Chinese Medical Journal2014，，9： | 40 |
| 2 | Analysis of the Fungal Community in Apple Replanted Soil Around Bohai Gulf显示文摘Apple replant disease(ARD) is a frequently occurring plant disease in replanted orchards around Bohai Gulf, which causes growth inhibition and even death of plants. The aim of this study was to investigate the etiology of ARD around Bohai Gulf. In this study, the primary growth inhibition of apple seedlings was evaluated in ten replanted soils, sampled around Bohai Gulf. A fungal clone library was used to identify changes in the structure and composition of the soil fungal community. The results revealed that the Simpson diversity indices of Laizhou and Pulandian orchards were higher than others, presenting severe ARD. Ascomycota dominated around Bohai Gulf at the phyla level. Fusarium and Saccharomyces were abundant in all replanted soils. In addition, correlations between the relative abundance of fungal genera in soils and the severity of ARD were analyzed. The results showed that Fusarium was correlated positively with the severity of ARD, but Mortierella was negatively correlated. Furthermore, the quantitative PCR of Fusarium oxysporum, which was regarded as a factor of ARD, was performed. Overall, this study demonstrated that ARD was strongly associated with an unbalanced microbial ecosystem with more pathogenic fungi, while Fusarium in the apple replanted soil was the key factor for ARD around Bohai Gulf. | WANG Gongshuai YIN Chengmiao PAN Fengbing WANG Xiaobao XIANG Li WANG Yanfang WANG Jinzheng TIAN Changping CHEN Jie MAO Zhiquan | 2018 | Horticultural Plant Journal2018，4，5： | 21 |
| 3 | Long-term changes of phytoplankton community in Xiagu waters of Xiamen,China显示文摘Long-term changes of phytoplankton community by water sampling method in Xiagu Sea waters of Xiamen,China,were investigated in this study.Species composition of the phytoplankton community in these waters changed greatly since the 1950s.The numbers of Dinophyta species increased significantly,although Bacillariophyta species are generally dominant.The succession of dominant species in phytoplankton community is obvious: large-size dominant species such as Biddulphia sinensis of the 1950s were gradually replaced by small-size ones such as Cyclotella striata and Nitzschia closterium,and species that still maintain dominant such as Skeletonema costatum are also small ones,leading the whole phytoplankton community of smaller size.Cell density of phytoplankton community increased greatly,among which cell density of the most dominant species Skeletonema costatum have been increasing in exponent function.Margalef index of phytoplankton community decreased,indicating decline of biodiversity of the community,and dominant character of Skeletonema costatum increased.Generally,the structure of the entire phytoplankton community is becoming more and more singular and unstable,which makes the occurrence of red tides more frequent.The succession in the phytoplankton community is related to the long-term changes in marine environment,influenced by human activities and global climate changes,especially the increases of nutrient content. | CHEN Baohong XU Zhuhua ZHOU Qiulin CHEN Changping GAO Yahui YANG Shengyun JI Weidong | 2010 | Acta Oceanologica Sinica2010，29，6： | 14 |
| 4 | Relationship between structure and function of JWA in the modulation of cell differentiation显示文摘To elucidate the structure characteristic, regulation of expression and the potential function of JWA——anovel rctinoic acid responsible and cytoskeleton associate gene, a rat JWA homologue gene and a 621-bp JWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR), JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter of JWA at -437 to -443 bp; rat JWA homologue gene showed that there are four nucleotides different from human JWA within coding region. After treatment with TPA, an uneven pattern of JWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in | XIA Wei ZHOU Jianwei CAO Haixia ZOU Changping WANG Chengya SHEN Qun LU Hua | 2001 | Chinese Science Bulletin2001，46，24： | 11 |
| 5 | Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide显示文摘JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ | CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping ZHOU Jianwei | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 6 | High-voltage Ride Through Strategy for DFIG Considering Converter Blocking of HVDC System显示文摘This paper presents a P-Q coordination based highvoltage ride through(HVRT) control strategy for doubly fed induction generators(DFIGs) based on a combined Q-V control and P-V de-loading control. The active/reactive power injection effect of DFIG on transient overvoltage is firstly analyzed and the reactive power capacity evaluation of DFIG considering its de-loading operation is then conducted. In the proposed strategy, the reactive power limit of DFIG can be flexibly extended during the transient process in coordination with its active power adjustment. As a result, the transient overvoltage caused by DC bipolar block can be effectively suppressed. Moreover, key outer loop parameters such as Q-V control coefficient and deloading coefficient can be determined based on the voltage level of point of common coupling(PCC) and the available power capacity of DFIG. Finally, case studies based on MATLAB/Simulink simulation are used to verify the effectiveness of the proposed control strategy. | Changping Zhou Zhen Wang Ping Ju Deqiang Gan | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 7 | Side Effects during Treatment of Advanced Gastric Carcinoma by Chemotherapy Combined with CIK-cell Transfusion in Elderly People显示文摘OBJECTIVE To study the side effects and therapeutic results of autologous cytokine-induced killer(CIK)cell treatment in elderly patients with advanced gastric cancer. METHODS CIK cells were induced and cultured using biotechnics in vitro,and then the cells were infused back into the patients.Sixty elderly gastric cancer patients treated by chemotherapy(FOLFOX4 protocol)were followed-up.Among them,29 patients were treated with CIK cells during application of chemotherapy.Short-term curative effects and adverse events from the CIK transfusion and chemotherapy were observed. RESULTS Eight cases developed partial remission(PR),9 cases moderate remission(MR),7 cases stable disease(SD)and 5 cases progressive disease(PD).Out of a total of 29 patients who received chemotherapy combined with autologous CIK therapy, the total remission rate(PR+MR)was 58.6%.The total remission rate following chemotherapy alone was 45.2%,including 5 PR cases,9 MR cases,7 SD cases,and 10 PD cases.There was a relatively lower rate of severe chemotherapic toxicities in the CIK- cell transfusion group.Side e?ects of autologous CIK transfusion included chills(13 cases),fever(9 cases),nausea and vomiting (1 case)and general malaise(3 cases).Side effects were treated with conventional therapy resulting in their amelioration.No patients developed shock,blood capillary leakage syndrome,or abnormalities in routine blood,urine,liver and renal function tests. CONCLUSION Adoptive immunotherapy with autologous CIK cells may decrease the clinical signs and symptoms of elderly patients who suffer from advanced gastric cancer.Adverse reactions of patients can be alleviated by conventional therapy. Autologous CIK-cell transfusion may improve endurance to chemotherapy. | Jingting Jiang Changping Wu Liangrong Shi Ning Xu Haifeng Deng Mingyang Lu Mei Ji Hbei Zhu Xueguang Zhang | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 10 |
| 8 | Classification of hypersurfaces with constant Laguerre eigenvalues in R^n显示文摘Let x:M → Rn be an umbilical free hypersurface with non-zero principal curvatures.Then x is associated with a Laguerre metric g,a Laguerre tensor L,a Laguerre form C,and a Laguerre second fundamental form B,which are invariants of x under Laguerre transformation group.An eigenvalue of Laguerre tensor L of x is called a Laguerre eigenvalue of x.In this paper,we classify all oriented hypersurfaces with constant Laguerre eigenvalues and vanishing Laguerre form. | LI TongZhu LI HaiZhong WANG ChangPing | 2011 | Science China Mathematics2011，54，6： | 10 |
| 9 | Time-frequency characteristics of blasting vibration signals measured in milliseconds显示文摘In order to study the time-frequency characteristics of blasting vibration signals, measured in milliseconds, we carried out site blasting vibration tests at an open pit of the Jinduicheng Mine. Based on recorded field data and applying a combination of RSPWVD and wavelet, we analyzed the time-frequency characteristics of recorded field data, summarized the time-frequency characteristics of blasting vibration signals in different frequency bands and present detailed information of blasting vibration signals in milliseconds of high time-frequency resolutions. Because RSPWVD can be seen as of definite physical significance to signal energy distribution in time and frequency domains, we studied the energy distribution of blasting vibration signals for various milliseconds intervals from a perspective of energy distribution. The results indicate that the effect of milliseconds intervals on time-frequency characteristics of blasting vibration signals is significant; the length of delay time directly affects the energy distribution of blasting vibration signals as well as the duration of energy in frequency bands. | Zhao Mingsheng ZhangJianhua Yi Changping | 2011 | Mining Science and Technology2011，21，3： | 9 |
| 10 | Seasonal variations in the Sr-Nd isotopic compositions of suspended particulate matter in the lower Changjiang River:Provenance and erosion constraints显示文摘Suspended particulate matter samples were collected monthly for more than 2 years in Nanjing,China to examine seasonal changes in the Sr-Nd isotopic compositions of the lower Changjiang River(CR).The results indicate that the 87Sr/86Sr ratios of the samples ranges from 0.725352 to 0.738128,and the values ofεNd(0)ranges from-10.55 to-12.29.The Sr-Nd isotopic compositions show distinct seasonal variations.The samples had lower 87Sr/86Sr ratios and higherε Nd(0)values during the flood season than the dry seasons.The seasonal variations primarily reflect the controls of provenance rocks and erosion in different sub-catchments.The relative decrease in 87Sr/86Sr ratios and the increase inε Nd(0)values during the flood season may reflect an increasing in the mechanical erosion rate in the upper basin and the contribution of more sediment from the upper reaches.The end member values of 87Sr/86Sr andε Nd(0)of the samples were 0.728254 and?11.26,respectively. | MAO ChangPing CHEN Jun YUAN XuYin YANG ZhongFang JI JunFeng | 2011 | Chinese Science Bulletin2011，56，22： | 7 |
| 11 | Sonochemical effect of a bifrequency irradiation显示文摘The sonochemical effect of a bifrequency orthogonal ultrasonic irradiation has been studied by using two different detecting methods. It has been shown that the sonochemical yield produced by the bifrequency irradiation appears to be much more than the sum of the yields produced separately by the two irradiations. The bifrequency irradiation, therefore, can be expected to exert a great influence on the development of sonohemical | ZHU Changping, FENG Ruo & ZHAO Yiyun Department of Physics. Jingzhou Normal College, Jingzhou 434100, China State Key Laboratory of Modern Acoustics, Nanjing University, Nanjing 210093, China Chemistry Department of Yunnan University, Kunming 650091, Ch | 2000 | Chinese Science Bulletin2000，45，2： | 7 |
| 12 | ^(14)C measurement of forest soils in Dinghushan Biosphere Reserve显示文摘Organic carbon in forest soils of Qingyunsi and Wukesong profiles can be divided into fast and slow components. Δ14C values of these profiles decrease with increasing of depth. The Δ14C values in 30—40 cm depth interval of Wukesong profile are decreasing sharply until a very low value,showing that a strong geological environment change occurred about 1 560 years ago. The 14C apparent ages of Wukesong profile show that the coniferous and broad-leaf mixed forests around Wukesong profile have been developing since 425 a BP, which is consistent with historical documents. The penetrating depths of 'bomb 14C' in Qingyunsi and Wukesong profiles are 10 and 20 cm, respectively. | SHEN Chengde , LIU Dongsheng (LIU Tungsheng) , PENG Shaolin, SUN Yanmin , JIANG Mantao , Yl Weixi , XING Changping , GAO Quanzhou , LI Zhi’an and ZHOU Guoyi Guangzhou Institute of Geochemisry, Chinese Academy of Sciences, Guangzhou 510640, China Institute of Geology, Chinese Academy of Sciences , Beijing 100029, China South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650, China | 1999 | Chinese Science Bulletin1999，44，3： | 7 |
| 13 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 14 | Detrital Zircon Geochronology of the Radial Sand Ridge System of Jiangsu Coast, East China: Implication for Sediment Provenance显示文摘The radial sand ridge system(RSRS) located at Jiangsu coast of China attracts much attention on its origin and mechanic of formation for its special structure and potential land resource. Due to complicated hydrodynamic condition, the Jiangsu RSRS is a hot debated on its potential sources, Yangtze River or Yellow River? We collected ten sand samples from surface sediments along the west coast of Bohai Sea and Yellow Sea from the modern Yellow River estuary to Yangtze River estuary in summer, 2013. The samples are analyzed by method of detrital zircon age for source identification of the RSRS sediments. The U-Pb age spectra of detrital zircon grains of the samples show a wide range from Cenozoic to Late Archean with several age peaks. Comparing the age spectra between the Yangtze River and the Yellow River, the detrital zircons have younger age(<100 Ma) group in the Yangtze River. These age distribution of the Jiangsu coastal RSRS sediments are similar to that of the Yangtze River, but different from the Yellow River. The samples located adjacent to the old Yellow River Delta show more wide-range age distribution, implying a compounded origination from the both rivers. Based on these findings it is proposed that, contrary to common opinion, the main sediment source of the Jiangsu RSRS is the Yangtze River, rather than the Yellow River. By implication, there should be evidence of hydrodynamic mechanics of oceanic currents and tidal motion. This aspect awaits confirmation in future research. | Jinbao Su Wenbo Rao Yigang Wang Changping Mao | 2018 | Journal of Earth Science2018，29，1： | 6 |
| 15 | SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza显示文摘MYB transcription factors play vital roles in plant growth and metabolism.The phytohormone methyl jasmonate(MeJA)promotes phenolic acid accumulation in the medicinal herb Salvia miltiorrhiza,but the regulatory mechanism is poorly understood.Here,we identified the MeJA-responsive R2R3-MYB transcription factor gene 5mMYB2 from a transcriptome library produced from MeJAtreated S.mi'/horr/ifza hairy roots.Sm/VIYB2 expression was tightly correlated with the expression of key salvianolic acid biosynthetic genes including CYP^8Ai^.5mMYB2 was highly expressed in the periderm of S.miltiorrhiza and SmMYB2 localized to the nucleus.Overexpressing Sml\AYB2 in S.miltiorrhiza hairy roots significantly increased the levels of salvianolic acids(including rosmarinic acid and salvianolic acid B)by upregulating salvianolic acid biosynthetic genes such as CYP98A14.SmMYB2 binds to the MYB-binding motifs in the promoter of CYP98A14,as confirmed by a dual-luciferase assay and electrophoretic mobility shift assays.Anthocyanin contents were significantly higher in Sm/ViyB2-overexpressing hairy root lines than the control,primarily due to the increased expression of CHI,DFR,and ANS.These findings reveal the novel regulatory role of SmMYB2 in MeJA-mediated phenolic acid biosynthesis,providing a useful target gene for metabolic engineering and shedding light on the salvianolic acid regulatory network. | Changping Deng Yao Wang Fenfen Huang Sunjie Lu Limei Zhao Xingyuan Ma Guoyin Kai | 2020 | Journal of Integrative Plant Biology2020，62，11： | 6 |
| 16 | Conformation-activity studies on the interaction of berberine with acetylcholinesterase:Physical chemistry approach显示文摘Berberine has been reported as an acetylcholinesterase(AChE) inhibitor.With significantly low cytotoxicity,berberine will be developed for the clinical treatment of Alzheimer disease(AD) with higher efficacy and fewer side effects.This work investigated the structure change events of AChE that occur during the interaction with berberine by isothermal titration calorimetry(ITC),fluorescence titration, and circular dichroism(CD).The results show that the binding of berberine to AChE is mainly driven by a favorable entropy increase with a less weak affinity.Berberine causes a loss in enzymatic activity at a concentration much below the concentration which gradually exposed the tryptophan residues to a more hydrophilic environment and unfolded the protein,which indicates that the inhibition of AChE with berberine includes the main contributions of interaction and minor conformation change of the protein induced by the alkaloid. | Jin Xiang Changping Yu Fang Yang Ling Yang Hong Ding | 2009 | Progress in Natural Science:Materials International2009，19，12： | 4 |
| 17 | Conformal CMC-Surfaces in Lorentzian Space Forms显示文摘让 Q^3 是 Lorentzianspace 形式 R_1~3, S_1~3 和 H_1~3 的普通保角的 compactification 空间。我们在 Q^3.It 学习像空间的表面的保角的几何学被看在 Q^3 的保角的 CMC 表面必须是的那个任何东西正式等价于一个常数的反对在 R_1~3, S_1~3 或 H_1~3 的平均数弯曲表面。我们也看那是否 x: M → Q^3 是 g 其保角的度量标准有经常的弯曲 K 的 space-likeWillmore 表面,然后任何一个 K = -1 和 isconformally 等价于在 R_1~3 的最小的表面的 x ,或 K = 0 并且 x 正式是反对等价于表面 H^1 (1/( 2 ^( 1/2 )))在 H_1~3 的 x H^1 (1/( 2 ^( 1/2 )))。 | Changxiong NIE Xiang MA Changping WANG | 2007 | Chinese Annals of Mathematics,Series B2007，28，3： | 4 |
| 18 | Controlling the coal dust at transshipment point: A study of the foam-sol foaming device显示文摘In order to effectively control the dust at the transshipment point with foam-sol, this paper attempted to study the characteristics of dust diffusion at transshipment point and the foam-sol foaming device with diffusion outlet was also designed in this paper. To study the diffusion rules of coal dust, fluent discrete phase model was utilized in the numerical simulation, as the coal dust was thrown down at a horizontal velocity of 2.5 m/s. A foam-sol foaming device was designed, through which foaming agent could be automatically sucked into the Venturi by the negative pressure. The automatic controller was also equipped,which could transform the energy of the compressed air into the constant pressure difference so that the gelling agent could be qualitatively added into the gel container. The diffusion outlet that could spray out foam-sol in a continuous, conical and 3D manner was also designed. Moreover, this paper also carried out the contrast experiments on dust removal efficiency among water, aqueous foam and foam-sol. The results clearly show that the symmetrical whirlpools appeared below the inlet where the largest whirlpool diameter was 0.52 m, and the horizontal distance from swirl range to the inlet was approximately0.69 m. By using the self-designed foaming device, the foaming was multiplied by 30 times and the volume ratio with water and foaming agent reached 95%:5%. In this context, the gas pressure was controlled at 0.3 MPa, with gas flow at 15 m3/h and water flow at 0.5 m3/h, with water pressure controlled between0.34 and 0.36 MPa. The foam-sol has the highest dust removal efficiency than other agents. | Xi Zhilin Jiang Manman Sun Changping Tu Xian | 2014 | International Journal of Mining Science and Technology2014，24，5： | 4 |
| 19 | Investigation into the flotation response of refractory molybdenum ore to depressant mixtures:A case study显示文摘In this paper, bulk flotation followed by separation was investigated to concentrate purified molybdenite product from Jinduicheng molybdenum ores(Shanxi province, China). The bench scale tests mainly focussed on separation of molybdenite from other sulfide minerals using the new type of depressants.The effect of each single depressant, including organic depressant-modified dextrin(MD), P-Nokes reagent(PN) and sodium trithiocarbonate(ST), and their mixtures on galena, chalcopyrite and other sulfide ores, was examined in turn by changing the concentrations used in cleaner flotation tests. Closed circuit experiments were carried out under the optimal condition and satisfying recovery and grade of molybdenite concentrate could be achieved(86.294% and 53.157%, respectively). A potential reagent regime was developed, with more environmental friendly and more economical advantages due to the introduction of modified dextrin. | Yin Zhigang Sun Wei Liu Jiandong Hu Yuehua Guan Qingjun Zhang Chenhu Tang Honghu Guan Changping | 2016 | International Journal of Mining Science and Technology2016，26，6： | 4 |
| 20 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员