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| 1 | Production of bioactive ginsenoside compound K in metabolically engineered yeast显示文摘 | Xing Yan Yun Fan Wei Wei Pingping Wang Qunfang Liu Yongjun Wei Lei Zhang Guoping Zhao Jianmin Yue Zhihua Zhou | 2014 | Cell Research2014，24，6： | 81 |
| 2 | Two stages of immiscible liquid separation in the formation of Panzhihua-type Fe-Ti-V oxide deposits,SW China显示文摘在 260 妈 Emeishan 大火的省(ELIP ) 的 Magmatic 氧化物沉积物, SW 中国和北越南,是 Fe, Ti 和 V 的重要来源。一些巨大的 magmatic Fe-Ti-V 氧化物沉积物例如 Panzhihua, Hongge,和 Baima 沉积物,很好在文学被描述并且在 Panxi 区域在分层的 mafic-ultramafic 侵入被招待,中央 ELIP。ELIP 相关的沉积物的一样的类型也远发生到南方并且在红河差错地区包括 Anyi 沉积物, Panzhihua 的大约 130 km 南方,和 Mianhuadi 沉积物。Anyi 沉积物是相对小的,但是同样在分层的 mafic 侵入被招待。Mianhuadi 沉积物有 260 妈的锆石 U-Pb 年龄并且与 ELIP 因此是同时期的。这存款易变地在指责的 Indosinian 造山运动和红河期间被变形。组合地, Mianhuadi 存款的磁铁矿比另外的存款的包含 Ti 和 V 的更小的数量,对以后的变态可能可归因。氧化物矿石存款的分发不与 ELIP 的 domal 结构有关。在 ELIP 的所有氧化物存款的一个主要特征是忍受氧化物的 gabbroic 侵入,黑花岗石 plutons 和 high-Ti 洪水暗岩的空间协会。因此,我们建议从一根披风羽毛的岩浆是进他们被发展进液体 immiscibility 的域形成二硅酸盐液体的一个浅岩浆房间的 emplaced,与一极其 Fe-Ti-rich gabbroic 作文和另外的黑花岗石。不能混合的 Fe-Ti-(P) 氧化物融化然后可以与 mafic 岩浆分开形成氧化物存款。这些存款从形成了的父母岩浆是在作文的可能的 Fe-Ti-rich picritic 并且比生产了 ELIP 的忍受硫化物的侵入的岩浆在更大的深度从充实的 asthenospheric 披风被导出。 | Mei-Fu Zhou Wei Terry Chen Christina Yan Wang Stephen A.Prevec Patricia Pingping Liu Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 35 |
| 3 | Characterization of Panax ginseng UDP- Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rhl in Metabolically Engineered Yeasts显示文摘人参皂甙,在人参(人参属人参) 的主要 pharmacologically 活跃的自然混合物,主要是 protopanaxadiol (PPD ) 和 protopanaxatriol (PPT ) 的 glycosylated 产品。uridine diphosphate glycosyltransferase (UGT ) 催化 PPT 生产 PPT 类型人参皂甙,还都没被报导。这里,我们显示出那 UGTPg1,它 regio 明确地被表明了到 glycosylate C20 -- PPD 的 OH,另外明确地 glycosylates C20 -- PPT 到的 OH 生产 bioactive 人参皂甙 F1。我们报导四新奇 UGT 基因从 P.ginseng 孤立的 characterizationof,分享高推出的氨基酸身份(>84%) 与 UGTPg1。我们明确地表明那 UGTPg100 glycosylates C6 -- PPT 的 OH 催化 PPT 生产 bioactive 人参皂甙 Rh1,和 UGTPg101 生产 F1,从 F1 由人参皂甙 Rg1 的产生列在后面。然而, UGTPg102 和 UGTPg103 被发现不在 PPT 上举办可检测的活动。通过结构的建模和指导地点的 mutagenesis,我们识别了可以在决定他们的活动和底层 regio 特性起重要作用的这些 UGT 的几关键氨基酸。而且,我们由介绍遗传上设计的生产 PPT 小径和 UGTPg1 或 UGTPg100 构造了酵母 recombinants 到 biosynthesize F1 和 Rh1。我们的学习经由合成生物学策略在酵母为 bioactive PPT 类型人参皂甙在人参属工厂,和 providesa 声音生产途径揭示 PPT 类型人参皂甙的可能的 biosynthetic 小径。 | Wei Wei Pingping Wang Yongjun Wei Qunfang Liu Chengshuai Yang Guoping Zhao Jianmin Yue Xing Yan Zhihua Zhou | 2015 | Molecular Plant2015，8，9： | 37 |
| 4 | 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation显示文摘Vitamin D_3 has been found to produce therapeutic effects on obesity-associated insulin resistance and dyslipidemia through its potent anti-inflammatory activity, but the precise immunomodulatory mechanism remains poorly understood. In the present study we found that 1,25-dihydroxyvitamin D_3[1,25(OH)_2D_3], the biologically active form of vitamin D_3, significantly attenuated monosodium glutamate(MSG)-induced obesity and insulin resistance as indicated by body weight reduction, oral glucose tolerance improvement, and a glucose infusion rate increase as detected with hyperinsulinemiceuglycemic clamp. Moreover, 1,25(OH)_2D_3 not only restored pancreatic islet functions but also improved lipid metabolism in insulin-targeted tissues. The protective effects of 1,25(OH)_2D_3 on glycolipid metabolism were attributed to its ability to inhibit an obesity-activated inflammatory response in insulin secretory and targeted tissues, as indicated by reduced infiltration of macrophages in pancreas islets and adipose tissue while enhancing the expression of Tgf-β1 in liver tissue, which was accompanied byincreased infiltration of Treg cells in immune organs such as spleen and lymph node as well as in insulintargeted tissues such as liver, adipose, and muscle. Together, our findings suggest that 1,25(OH)_2D_3 serves as a beneficial immunomodulator for the prevention and treatment of obesity or metabolic syndrome through its anti-inflammatory effects. | Wen Jin Bing Cui Pingping Li Fang Hua Xiaoxi Lv Jichao Zhou Zhuowei Hu Xiaowei Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 9 |
| 5 | Systematic optimization of the yeast cell factory for sustainable and high efficiency production of bioactive ginsenoside compound K显示文摘Ginsenoside Compound K(CK)has been recognized as a major functional component that is absorbed into the systemic circulation after oral administration of ginseng.CK demonstrates diverse bioactivities.A phase I clinical study indicated that CK was a potential candidate for arthritis therapy.However,a phase II clinical study was suspended because of the high cost associated with the present CK manufacturing approach,which is based on the traditional planting-extracting-biotransforming process.We previously elucidated the complete CK biosynthetic pathway and realized for the first time de novo biosynthesis of CK from glucose by engineered yeast.However,CK production was not sufficient for industrial application.Here,we systematically engineered Saccharomyces cerevisiae to achieve high titer production of CK from glucose using a previously constructed protopanaxadiol(PPD)-producing chassis,optimizing UGTPg1 expression,improving UDP-glucose biosynthesis,and tuning down UDP-glucose consumption.Our final engineered yeast strain produced CK with a titer of 5.74 g/L in fed-batch fermentation,which represents the highest CK production in microbes reported to date.Once scaled-up,this high titer de novo microbial biosynthesis platform will enable a robust and stable supply of CK,thus facilitating study and medical application of CK. | Pingping Wang Jiali Wang Guoping Zhao Xing Yan Zhihua Zhou | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 7 |
| 6 | Effect of monovalent anions on cationic Gemini micro-emulsion显示文摘Micro-emulsion usually consists of water, oil, surfactants and co-surfactants, and each component has an effect on the phase behavior and solubilization of the micro-emulsion. When the surfactant in the micro-emulsion system is quaternary ammonium cationic Gemini surfactant, the surfactant mainly combines with the anions in the salt. With the increase of salt concentration, the phase transformation of Winsor I → Winsor III → Winsor II occurred, but the optimum salinity and salt width are different because of the type of salt. The effects of 5 different kinds of monovalent anions, including C_6H_5SO_3^-, I-, Br-, NO_3^- and Cl-, on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are researched by Winsor phase diagram. It is found that the effects of organic anions C_6H_5SO_3-and I-on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are most significant, and the effects of Br-, NO_3^- and Cl-are less significant. Meanwhile, when the optimum solubilization is achieved, the amount of sodium benzoate is the least, indicating that the organic anion has stronger self-organization behavior with quaternary ammonium cationic Gemini surfactants. | Yinglu Gu Shuang Chen Hui'e Liu Yubin Wang Pingping Zhou | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 6 |
| 7 | Powder metallurgy processed metal-matrix friction materials for space applications显示文摘Owing to the increasing demand for tribological brakes for space applications, the development of novel materials and advanced technologies is necessary. This paper presents the design, characterization, and realization of powder metallurgy processed metal-matrix friction materials intended for the above-mentioned tribological brakes. Selecting appropriate ingredients, which provides an effective way to tailor the properties of the friction material, is evolving as a strategy to meet the design requirements. The tribological behaviors of the friction material are experimentally investigated under different conditions, and special attention is focused on the vacuum tribology. Examinations and analyses of the friction surface and subsurface corroborate the wear mechanism. In addition, the erosion resistances of the friction material are evaluated by exposure tests of ultraviolet irradiation and atomic oxygen. Finally, present and potential space applications of the friction material are also introduced based on experimental studies. | Yelong XIAO Pingping YAO Kunyang FAN Haibin ZHOU Minwen DENG Zongxiang JIN | 2018 | Friction2018，6，2： | 2 |
| 8 | DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice显示文摘Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility. | Dan Zhou Ting Zou Kaixuan Zhang Pingping Xiong Fuxing Zhou Hao Chen Gongwen Li Kaiyou Zheng Yuhao Han Kun Peng Xu Zhang Shangyu Yang Qiming Deng Shiquan Wang Jun Zhu Yueyang Liang Changhui Sun Xiumei Yu Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 9 | Modulating a Local Shape Descriptor through Biologically Inspired Color Feature显示文摘 | Hongwei Zhao Baoyu Zhou Pingping Liu Tianjiao Zhao | 2014 | Journal of Bionic Engineering2014，11，2： | 2 |
| 10 | High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway显示文摘The excessive accumulation of reactive oxygen species(ROS)under osteoporosis precipitates a microenvironment with high levels of oxidative stress(OS).This could significantly interfere with the bioactivity of conventional titanium implants,impeding their early osseointegration with bone.We have prepared a series of strontium(Sr)-doped titanium implants via micro-arc oxidation(MAO)to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic(high OS levels)conditions.Apart from the chemical composition,all groups exhibited similar physicochemical properties(morphology,roughness,crystal structure,and wettability).Among the groups,the low Sr group(Sr25%)was more conducive to osteogenesis under normal conditions.In contrast,by increasing the catalase(CAT)/superoxide dismutase(SOD)activity and decreasing ROS levels,the high Sr-doped samples(Sr75% and Sr100%)were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells,thus enhancing early osseointegration.Furthermore,the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples(especially Sr100%)had positive effects on osteoimmunomodulation under the OS microenvironment.Ultimately,the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations. | Xinkun Shen Kai Fang Kendrick Hii Ru Yie Zixin Zhou Yiding Shen Shuyi Wu Yue Zhu Zhennan Deng Pingping Ma Jianfeng Ma Jinsong Liu | 2022 | Bioactive Materials2022，7，4： | 2 |
| 11 | Image encryption based on a reality-preserving fractional discrete cosine transform and a chaos-based generating sequence显示文摘 | Jianhua Wu Fangfang Guo Pingping Zeng Nanrun Zhou | 2013 | Journal of Modern Optics2013，，20： | 1 |
| 12 | Data communication mechanism for greenhouse environment monitoring and control:An agent-based IoT system显示文摘Internet of things(IoT)technology has been constantly applied in greenhouse environmental monitoring and control in recent years.The acquisition and control parameters,network protocols are different for the various purposes of the greenhouse.These factors are the keys to the abilities to effectively communicate and transfer meaningful data in IoT infrastructures.To achieve the adaptive matching of data communication between the gateway and server in a greenhouse IoT system,a data encapsulation method based on XML was designed to enable data interoperability in a distributed greenhouse IoT system.Furthermore,the behaviour of the Multi-Agent System(MAS)was used to merge the heterogeneous information and the responses for data synchronization in the greenhouse IoT system.The data communication mechanism for real-time and cumulative data synchronization between the gateway and server based on JADE was tested in a specific greenhouse.The results showed that the data loss rate between the data acquisition unit and the gateway was 1.52%,and the data loss rate was 0.4%between the gateway and the server;therefore,the mechanism could be feasibly applied to the data communication for a greenhouse IoT system. | Jizhang Wang Meizheng Chen Jinsheng Zhou Pingping Li | 2020 | Information Processing in Agriculture2020，7，3： | 1 |
| 13 | Synthesis,structure and nonlinear optical properties of two novel two-photon absorption chromophores显示文摘Two triphenylamine-based derivatives that can be used as two-photon absorption chromophore,tris{4-[4-(3-trifluoromethyl-3-oxopanoyl)]phenyl}amine (1) and tris{4-[4-(3-phenyl-3-oxopanoyl)] phenyl} amine (2) were successfully synthesized and fully characterized by elemental analysis,IR,1H NMR and MS. The single crystal X-ray diffraction analysis showed that the molecules possess D-(π-A)3 structures. One-and two-photon absorption and fluorescence in various solvents were experimentally investigated. A data recording experiment proved the potential application of these chromophores. | CHENG LeHua LI Lin SUN PingPing ZHOU HongPing TIAN YuPeng TANG HuoHong | 2009 | Science China Chemistry2009，52，4： | 1 |
| 14 | Chemical composition and antioxidative and anti-inflammatory properties of ten commercial mung bean samples显示文摘 | Xiaowei Zhang Pingping Shang Fang Qin Qin Zhou Boyan Gao Haiqiu Huang Haisha Yang Haiming Shi Liangli (Lucy) Yu | 2013 | LWT - Food Science and Technology2013，，1： | 1 |
| 15 | Transmission Probability Method Based on Triangle Meshes for Solving Unstructured Geometry Neutron- Transport Problem显示文摘 | Wu Hongchun Liu Pingping Zhou Yongqiang | 2007 | Nucl Eng Des2007，237，1： | 1 |
| 16 | Manage system for internet of things of greenhouse based on GWT显示文摘In order to fit the different demands for the internet of things system of greenhouse environment monitoring and control,the greenhouse environment monitoring and control management system based on Google Web Toolkit(GWT)was developed.Using remote method call(RPC)AJAX as the communication method between browser and web server,the system realized the functions such as:configuration of acquisition and control parameters,the adaptive match of database between gateway and server,the adaptive diagnosis of monitoring parameters,the warning of monitoring parameters,the adaptive generation of interface,and so on.The functions of the system was tested the results shows that the WEB browser application and Android App can adaptively realize the greenhouse environment monitoring and control according to the information configuration. | Jizhang Wang Jinsheng Zhou Rongrong Gu Meizheng Chen Pingping Li | 2018 | Information Processing in Agriculture2018，5，2： | 1 |
| 17 | NF-kappaB and its regulation on the immune system显示文摘 | LIANG Yan ZHOU Yang SHEN Pingping | 2004 | Cell Mol Immu- nol2004，1，5： | 1 |
| 18 | Using Multiphase Solid Inclusions to Constrain the Origin of the Baima Fe-Ti-(Ⅴ) Oxide Deposit, SW China显示文摘Multiphase solid inclusions within cumulus silicates,particularly olivine,in Fe-Ti oxide ores from the Lower Zone of the Baima intrusion,Emeishan large igneous province,SW China,have been identified for the first time using 2-D scanning electron microscope and 3-D highresolution X-ray computed tomography.These inclusions are spherical to subspherical and range from 100 to | LIU Pingping ZHOU Meifu CHEN Weiterry BOONE Marijn CNUDDE Veerle | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 1 |
| 19 | Dietary exposure to persistent organochlorine pesticides in 2007 Chinese total diet study显示文摘 | Pingping Zhou Yunfeng Zhao Jingguang Li Guohua Wu Lei Zhang Qing Liu Sai Fan Xin Yang Xiaowei Li Yongning Wu | 2011 | Environment International2011，，： | 1 |
| 20 | The Roles of p38 MAPK/MSK1 Signaling Pathway in the Neuroprotection of Hypoxic Postconditioning Against Transient Global Cerebral Ischemia in Adult Rats显示文摘 | Pingping Zhu Lixuan Zhan Tingna Zhu Donghai Liang Jiaoyue Hu Weiwen Sun Qinghua Hou Huarong Zhou Baoxing Wu Yanmei Wang En Xu | 2014 | Molecular Neurobiology2014，，3： | 1 |
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