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| 1 | Creative Industries Agglomeration,Regional Innovation and Productivity Growth in China显示文摘This paper falls into the broad area of economic geography and economics of creativity,and it presents an alternative approach to explain why total factor productivity(TFP)growth is different across China′s regions.It establishes an empirical model to estimate the spatial agglomeration effects of creative industries on regional TFP growth,using China′s provincial panel data during the period of 2003 to 2010.We found that the creative industries agglomeration(CIA)has significant and positive impact on regional TFP growth.The result also implies that the CIA can facilitate regional TFP growth through promoting regional innovation instead of improving regional efficiency.Therefore,we argue that policy makers should take some measures to retain and establish more creative zones. | HONG Jin YU Wentao GUO Xiumei ZHAO Dingtao | 2014 | Chinese Geographical Science2014，24，2： | 18 |
| 2 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 3 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 4 | A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction显示文摘Regeneration of Intervertebral disc(IVD)is a scientific challenge because of the complex structure and composition of tissue,as well as the difficulty in achieving bionic function.Here,an anatomically correct IVD scaffold composed of biomaterials,cells,and growth factors were fabricated via three-dimensional(3D)bioprinting technology.Connective tissue growth factor(CTGF)and transforming growth factor-β3(TGF-β3)were loaded onto polydopamine nanoparticles,which were mixed with bone marrow mesenchymal stem cells(BMSCs)for regenerating and simulating the structure and function of the nucleus pulposus and annular fibrosus.In vitro experiments confirmed that CTGF and TGF-β3 could be released from the IVD scaffold in a spatially controlled manner,and induced the corresponding BMSCs to differentiate into nucleus pulposus like cells and annulus fibrosus like cells.Next,the fabricated IVD scaffold was implanted into the dorsum subcutaneous of nude mice.The reconstructed IVD exhibited a zone-specific matrix that displayed the corresponding histological and immunological phenotypes:primarily type II collagen and glycosaminoglycan in the core zone,and type I collagen in the surrounding zone.The testing results demonstrated that it exhibited good biomechanical function of the reconstructed IVD.The results presented herein reveal the clinical application potential of the dual growth factors-releasing IVD scaffold fabricated via 3D bioprinting.However,the evaluation in large mammal animal models needs to be further studied. | Binbin Sun Meifei Lian Yu Han Xiumei Mo Wenbo Jiang Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，1： | 5 |
| 5 | Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice显示文摘 | Jizheng Chen Yang Zhao Chao Zhang Hairong Chen Jin Feng Xiumei Chi Yu Pan Jun Du Min Guo Huang Cao Honghe Chen Zilong Wang Rongjuan Pei Qian Wang Lei Pan Junqi Niu Xinwen Chen Hong Tang | 2014 | Cell Research2014，24，9： | 5 |
| 6 | Histological Study on the Digestive System Development of Takifugu rubripes Larvae and Juvenile显示文摘Takifugu 的消化道在早年生活舞台期间磨擦 ripes 与光被学习显微镜学。在孵化的开始,消化道被一个简单、无差别的直试管代表并且不与外表交流,因为嘴和肛门还不是开的。在在孵化以后的 2d,在将成为 intestino 直肠的阀门的肠和直肠之间的收缩是可见的。在内长的喂阶段期间,蛋黄囊被再吞,消化道变得功能、区分。肝和胰在这时候也变得明显。在外长的喂的发作(在孵化以后的 3d ) ,蛋黄囊 resesvesare 不完全弄空,建议混合营养的经期。消化道充分区分进 buccopharynx,食管,胃,肠和直肠。在在孵化以后的 9 d,蛋黄囊储备完全被弄空。从 5to 发生的最显著的事件在孵化以后的 17 d 是 epithelia 类型,灵魂囊的区别,上皮的房间,内脏卷绕旋转, mucosal 褶层增加,和肝和胰的生长的转变。从在孵化以后的 18 ~ 27 d,肠褶层和粘液房间的数字日益增多地增加。从那时起,消化特征的词法变化几乎被完成。在在孵化以后的 27 d,消化系统的形态学和函数类似于成年人的。 | WAN Zhenzhen GAO Tianxiang ZHANG Xiumei CHEN Chao YU Changhong | 2006 | Journal of Ocean University of China2006，5，1： | 5 |
| 7 | Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior显示文摘The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system.In this study,two kind of aqueous model drugs with different molecule weight,Congo red and albumin from bovine serum(BSA)were nanoencapsulated in poly(DL-lactic-co-glycolic acid)(PLGA)microspheres by emulsion electrospray.In the preparation process,the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution.The emulsion was then electrosprayed to fabricate drugnanoencapsulated PLGA microspheres.The morphology of the PLGA microspheres was affected by the volume ratio of aqueous drug phase and organic PLGA phase(V_(w)/V_(o))and the molecule weight of model drugs.Confocal laser scanning microcopy showed the nanodroplets of drug phase were scattered in the PLGA microspheres homogenously with different distribution patterns related to V_(w)/V_(o).With the increase of the volume ratio of aqueous drug phase,the number of nanodroplets increased forming continuous phase gradually that could accelerate drug release rate.Moreover,BSA showed a slower release rate from PLGA microspheres comparing to Congo red,which indicated the drug release rate could be affected by not only V_(w)/V_(o)but also the molecule weight of model drug.In brief,the PLGA microspheres prepared using emulsion electrospray provided an efficient and simple systemto achieve controlled drug release at a desired rate satisfying the need of the practices. | Shenglian Yao Huiying Liu Shukui Yu Yuanyuan Li Xiumei Wang Luning Wang | 2016 | Regenerative Biomaterials2016，3，5： | 5 |
| 8 | A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocelluar carcinoma显示文摘 | Xiaozhou Yu Hua Zhao Liang Liu Shui Cao Baozhu Ren Naining Zhang Xiumei An Jinpu Yu Hui Li Xiubao Ren | 2014 | Journal of Clinical Immunology2014，，2： | 5 |
| 9 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 10 | Gene expression profiling and mechanism study of neural stem cells response to surface chemistry显示文摘To declare the mechanisms of neural stem cells(NSCs)in response to material surface chemistry,NSCs were exposed to the self-assemble monolayers of alkanethiolates on gold surfaces terminated with amine(NH2),hydroxyl(OH)and methyl(CH3)for analysis.The morphological responses of NSCs were recorded;the gene expression profilings were detected by genechips;the gene expressions data of NSCs responded to different chemical groups were declared through the gene ontology term and pathway analyses.It showed that cells behaved dissimilar on the three chemical groups,the adhesion,proliferation and migration were easier on the NH2 and OH groups;the gene expressions of NSCs were induced differently,either,involved in several functional processes and signaling pathways.CH3 group induced genes enriched much in chemistry reactions and death processes,whereas many genes of cellular nucleotide metabolism were down-regulated.NH2 group induced NSCs to express many genes of receptors on membrane,and participated in cellular signal transduction of cell adhesion and interactions,or associated with axon growth.OH group was similar to NH2 group to induce the membrane response,but it also down regulated metabolism of cells.Therefore,it declared the chemical groups affected NSCs through inner way and the NH2,OH and CH3 groups triggered the cellular gene expression in different signaling pathways. | Ying Wang Shenglian Yao Qingyuan Meng Xiaolong Yu Xiumei Wang Fuzhai Cui | 2014 | Regenerative Biomaterials2014，1，1： | 4 |
| 11 | Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound显示文摘Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation.Electrospun nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner.Herein,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive agents.Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities.Furthermore,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation.The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin��6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW. | Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi Zhao Jinzhong Xiumei Mo | 2021 | Bioactive Materials2021，6，9： | 3 |
| 12 | Synthesis and crystal structure of hydroquinone-β-cyclo-dextrin complex显示文摘The title inclusion complex with the formula [(C42H70O35)2 · (C6O2H6)3 · (H2O)21.2(CH3OH)2] has been crystallized and characterized by single crystal X-ray analysis. The complex crystallizes in the triclinic system, space group P1, with a =1.5500 (1), b =1.5536(1), c = 1.8246(1) nm, α = 113.17(2), β = 99.12(2), γ=103.37(3)? V = 3.7739(4) nm3, Z = 1; Dc =1.343 g/cm3, μ = 0.124 mm-1, F(000) = 1594, R = 0.0795 and S = 0.9639. Two independent molecules of β-cyclodextrin (β-CD) form a 'head-to-head' dimer. The fairly important factor of the position and stability of the guest in the host cavity is the solvation of the polar group of the guest. | Shikun Ma Jinling Wang Aixiu Li Ming Yu Ming Sun Xiumei Su Fangming Miao | 2001 | Chinese Science Bulletin2001，46，5： | 3 |
| 13 | Inter-Operator Interference Coordination for CoPrimary Spectrum Sharing in UDN显示文摘Co-primary spectrum sharing for multiple operators has been utilized to fully explore the spectrum resources and thus improve the spectrum efficiency. The inter-operator interference(IOI) problem should be seriously considered in order to achieve the mentioned target, especially under the scenario of the ultradense network(UDN) in the fifth generation(5G) wireless systems. To solve this problem, we propose an asymmetrical power levels based soft IOI coordination mechanism. The shared spectrum pool is consisted of three separated parts, where each part can be dynamically adjusted according to the minimal spectrum demand from each operator. Furthermore, different power masks are configured to different parts for each operator. The simulation results show that the proposed mechanism can improve the network spectrum efficiency significantly. | YU Qiaoling WANG Jiang YANG Xiumei ZHU Yuanping TENG Yong Horneman Kari | 2015 | China Communications2015，12，S1： | 3 |
| 14 | Progress on Li3VO4 as a Promising Anode Material for Li-ion Batteries显示文摘 | Jun Mo Xiumei Zhang Junjie Liu Jingang Yu Zhian Wang Zaichun Liu Xinhai Yuan Chunjiao Zhou Ruilian Li Xiongwei Wu Yuping Wu | 2017 | Chinese Journal of Chemistry2017，35，12： | 3 |
| 15 | LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice显示文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity. | Li Yu Lina Wang Wufan Tao Wenxiang Zhang Shuanghao Yang Jian Wang Jia Fei Rui Peng Yiming Wu Xiumei Zhen Hong Shao Weiyue Gu Rong Li Bai-Lin Wu Hongyan Wang | 2021 | Journal of Genetics and Genomics2021，48，5： | 3 |
| 16 | UNIFORMIZATION OF MULTIGRANULAR LINGUISTIC LABELS AND THEIR APPLICATION TO GROUP DECISION MAKING显示文摘In multiple attribute group decision making(MAGDM) problems based on linguistic information,the granularities of linguistic label sets are usually different due to the differences of thinking modes and habits among decision makers.In order to deal with this inconvenience,the transformation relationships among multigranular linguistic labels(TRMLLs),which are applied to unify linguistic labels with different granularities into a certain linguistic label set with fixed granularity,are presented in this paper.Furthermore,the reference tables are made according to TRMLLs so that the interrelated calculation will be less complicated,and the method of how to use them is explained in detail.At length,the TRMLLs are illustrated through an application example. | Xiaohan YU Zeshui XU Xiumei ZHANG | 2010 | Journal of Systems Science and Systems Engineering2010，19，3： | 3 |
| 17 | Stem cell homing-based tissue engineering using bioactive materials显示文摘 | Yinxian YU Binbin SUN Chengqing YI Xiumei MO | 2017 | Frontiers of Materials Science2017，11，2： | 2 |
| 18 | DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice显示文摘Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility. | Dan Zhou Ting Zou Kaixuan Zhang Pingping Xiong Fuxing Zhou Hao Chen Gongwen Li Kaiyou Zheng Yuhao Han Kun Peng Xu Zhang Shangyu Yang Qiming Deng Shiquan Wang Jun Zhu Yueyang Liang Changhui Sun Xiumei Yu Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 19 | In situ TEM revealing the effects of dislocations on lithium-ion migration in transition metal dichalcogenides显示文摘The two-dimensional (2D) structure of layered transition metal dichalcogenides (TMDs) provides unusual physical properties [1,2]and chemical reactivity [3,4], which can be influenced by defects such as dislocations [5,6]. For example, dislocations can act as nucleation sites for the onset of deformation when subjected to stress [7]. | Ruiwen Shao Chengkai Yang Chen Yang Shulin Chen Weikang Dong Bairong Li Xiumei Ma Jing Lu Lixin Dong Peng Gao Dapeng Yu | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 20 | Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride显示文摘 | Taoguang Huo Shuang Cai Xiumei Lu Yi Sha Mingyang Yu Famei Li | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，4： | 1 |
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