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| 1 | Progress involving new techniques for liposome preparation显示文摘The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were examined.In addition to the theories,characteristics and problems associated with traditional methods,the advantages and drawbacks of the latest techniques were reviewed.In the light of developments in many relevant areas,a variety of new techniques are being used for liposome preparation and each of these new technique has particular advantages over conventional preparation methods.However,there are still some problems associated with these new techniques that could hinder their applications and further improvements are needed.Generally speaking,due to the introduction of these latest techniques,liposome preparation is now an improved procedure.These applications promote not only advances in liposome research but also the methods for their production on an industrial scale. | Zhenjun Huang Xuan Li Ting Zhang Yanzhi Song Zhennan She Jing Li Yihui Deng | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 7 |
| 2 | Application of sialic acid/polysialic acid in the drug delivery systems显示文摘The properties of modified biomaterial are gaining more and more importance in drug delivery systems.Sialic acid(SA)and polysialic acid(PSA)serve as endogenous substances,which are non-immunogenic and biodegradable.At the same time,SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain;PSA modifi-cation can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood,thus achieving active targeting effect.These properties offer a variety of opportunities for applications in drug delivery systems.This article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs,proteins and carriers in drug delivery systems. | Ting Zhang Zhennan She Zhenjun Huang Jing Li Xiang Luo Yihui Deng | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，2： | 4 |
| 3 | Characterization and Properties of Duplex a-C:H/MAO Coatings on Magnesium Alloy using Combined Microarc Oxidation and Hybrid Magnetron Sputtering显示文摘The combined microarc oxidation(MAO) and magnetron sputtering deposition process was used to deposit duplex a-C:H/MAO and Ti-a-C:H/MAO coatings on AM80 magnesium alloy. The microstructure, mechanical properties and tribological behavior of the two duplex coatings were investigated. The experimental results showed that the a-C:H and Ti-a-C:H top films on Si substrates were dense and had a low G peak position and ID/IG ratio, compared with the hydrogen-free amorphous carbon films. Numerous micropores were found on the duplex a-C:H/MAO and Ti-a-C:H/MAO coatings together with low values of hardness(H) and elastic modulus(E), which also showed good binding strength with the Mg alloy substrates. Compared to MAO treated substrate used for the protection of the Mg alloy, the duplex a-C:H/MAO and Ti-aC:H/MAO coatings still had stable and low value of friction coefficient, even though the surface of the duplex coatings was rough and porous. Furthermore, the mechanism of friction reduction of the two duplex coatings on the Mg alloy substrates was discussed. | 杨巍 DENG Zhennan YANG Zhong LI Jianping 汪爱英 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，4： | 3 |
| 4 | The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid-octadecylamine conjugate显示文摘 | Zhennan She Ting Zhang Xuling Wang Xuan Li Yanzhi Song Xiaobo Cheng Zhenjun Huang Yihui Deng | 2014 | Biomaterials2014，，： | 2 |
| 5 | Microstructure and Tribological Behavior of Self-lubricating(Si:N)-DLC/MAO Coatings on AZ80 Magnesium Substrate显示文摘The combined micro arc oxidation(MAO)and a hybrid beam deposition process was used to deposit duplex(Si:N)-DLC/MAO coatings on AZ80 magnesium alloy.The microstructure and composition of the duplex coatings were analyzed by Raman spectroscopy,X-ray photoelectron spectroscope(XPS),scanning electron microscope(SEM)and atomic force microscopy(AFM).Tribological behaviors of the coatings were studied by ball-on-disk friction test.It was found that the ID/IG ratio of the(Si:N)-DLC(diamond-like carbon)top films increases with decreasing C2H2/N2ratio.The(Si:N)-DLC top film with Si3N4was formed on the MAO coated sample as the C2H2/N2ratio was 10sccm:5sccm,which showed an increasing critical load compared with the pure DLC directly deposited on the Mg alloy substrate.As a result,the(Si:N)-DLC/MAO coating exhibited an advanced wear protection for the substrate. | Wei YANG Zhennan DENG Dong ZHANG Peiling KE Aiying WANG | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，6： | 2 |
| 6 | Multiplexed cytokine profiling of serum for detection of colorectal cancer显示文摘 | Zhang Pengjun Wen Xinyu Gu Feng Deng Xinxin Liu Yulan Li Juan Jia Xingwang Dong Zhennan Tian Yaping | 2013 | Future Oncol2013，，7： | 2 |
| 7 | High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway显示文摘The excessive accumulation of reactive oxygen species(ROS)under osteoporosis precipitates a microenvironment with high levels of oxidative stress(OS).This could significantly interfere with the bioactivity of conventional titanium implants,impeding their early osseointegration with bone.We have prepared a series of strontium(Sr)-doped titanium implants via micro-arc oxidation(MAO)to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic(high OS levels)conditions.Apart from the chemical composition,all groups exhibited similar physicochemical properties(morphology,roughness,crystal structure,and wettability).Among the groups,the low Sr group(Sr25%)was more conducive to osteogenesis under normal conditions.In contrast,by increasing the catalase(CAT)/superoxide dismutase(SOD)activity and decreasing ROS levels,the high Sr-doped samples(Sr75% and Sr100%)were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells,thus enhancing early osseointegration.Furthermore,the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples(especially Sr100%)had positive effects on osteoimmunomodulation under the OS microenvironment.Ultimately,the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations. | Xinkun Shen Kai Fang Kendrick Hii Ru Yie Zixin Zhou Yiding Shen Shuyi Wu Yue Zhu Zhennan Deng Pingping Ma Jianfeng Ma Jinsong Liu | 2022 | Bioactive Materials2022，7，4： | 2 |
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