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| 1 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 2 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 3 |
| 3 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9ehoukf5x9nb0qu6on0.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 4 | Dynamic cooperative advertising in a channel显示文摘 | Steffen J?rgensen Simon Pierre Sigué Georges Zaccour | 2000 | Journal of Retailing2000，，1： | 2 |
| 5 | Identification of an alternative CD20 transcript variant in B cell malignancies coding for a novel pro- tein associated to rituximab resistance 显示文摘 | Carole H Marina D Pierre - Simon R | 2010 | Blood2010，115，12： | 1 |
| 6 | Metallurgical Aspects of Ultra Fast Cooling in Front of the Down-Coiler显示文摘 | Aurélie Lucas Pierre Simon Guillaume Bourdon | 2004 | Steel Research2004，75，2： | 1 |
| 7 | Consumer and Retailer Promotions: Who is Better Off?显示文摘 | Simon Pierre Sigué | 2008 | Journal of Retailing2008，，4： | 1 |
| 8 | Dynamic cooperative advertising in a channel显示文摘 | Jorgensen Steffen Sigue Simon Pierre Zaccour Georges | 2000 | J of Retailing2000，76，1： | 1 |
| 9 | Supply chain management : an analytical framework for critical literature review显示文摘 | Simon Croom Pierre Romano Mihalis Giannakis | 2000 | European Journal of Purchasing & Supply Management2000，，6： | 1 |
| 10 | Two expedient methods for the preparation of ehiral diamines 显示文摘 | Simon E de Sousa Peter O' Brien Pierre Poumelleem | 1998 | J Chem Soe Perkin Trans 11998，，9： | 1 |
| 11 | Impairment of tapetum and mitochondria in engineered male-sterile tobacco plants显示文摘 | Michel Hernould S. Suharsono Eduardo Zabaleta Jean Pierre Carde Simon Litvak Alejandro Araya Armand Mouras | 1998 | Plant Molecular Biology1998，，4： | 1 |
| 12 | Neuroflament light and heterogeneity of disease progression in amyotrophic lateral sclerosis:development and validation of a prediction model to improve interventional trials显示文摘Background:Interventional trials in amyotrophic lateral sclerosis(ALS)sufer from the heterogeneity of the disease as it considerably reduces statistical power.We asked if blood neuroflament light chains(NfL)could be used to antici‑pate disease progression and increase trial power.Methods:In 125 patients with ALS from three independent prospective studies-one observational study and two interventional trials-we developed and externally validated a multivariate linear model for predicting disease pro‑gression,measured by the monthly decrease of the ALS Functional Rating Scale Revised(ALSFRS-R)score.We trained the prediction model in the observational study and tested the predictive value of the following parameters assessed at diagnosis:NfL levels,sex,age,site of onset,body mass index,disease duration,ALSFRS-R score,and monthly ALSFRS-R score decrease since disease onset.We then applied the resulting model in the other two study cohorts to assess the actual utility for interventional trials.We analyzed the impact on trial power in mixed-efects models and compared the performance of the NfL model with two currently used predictive approaches,which anticipate disease progression using the ALSFRS-R decrease during a three-month observational period(lead-in)or since disease onset(ΔFRS).Results:Among the parameters provided,the NfL levels(P<0.001)and the interaction with site of onset(P<0.01)contributed signifcantly to the prediction,forming a robust NfL prediction model(R=0.67).Model application in the trial cohorts confrmed its applicability and revealed superiority over lead-in andΔFRS-based approaches.The NfL model improved statistical power by 61%and 22%(95%confdence intervals:54%-66%,7%-29%).Conclusion:The use of the NfL-based prediction model to compensate for clinical heterogeneity in ALS could signif‑cantly increase the trial power.NCT00868166,registered March23,2009;NCT02306590,registered December 2,2014. | Simon Witzel Felix Frauhammer† Petra Steinacker David Devos Pierre‑François Pradat Vincent Meininger Stefen Halbgebauer Patrick Oeckl Joachim Schuster Simon Anders Johannes Dorst Markus Otto Albert C.Ludolph | 2021 | Translational Neurodegeneration2021，10，3： | 1 |
| 13 | The tail suspension test: A new method for screening antidepressants in mice显示文摘 | Lucien Steru Raymond Chermat Bernard Thierry Pierre Simon | 1985 | Psychopharmacology1985，，3： | 1 |
| 14 | The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy显示文摘 | Nadia A. Khan Brenda Hemmelgarn Robert J. Herman Simon W. Rabkin Finlay A. McAlister Chaim M. Bell Rhian M. Touyz Raj Padwal Lawrence A. Leiter Jeff L. Mahon Michael D. Hill Pierre Larochelle Ross D. Feldman Ernesto L. Schiffrin Norman R.C. Campbell Malco | 2008 | Canadian Journal of Cardiology2008，，6： | 1 |
| 15 | Dynamic Cooperative Advertising in a Channel 显示文摘 | Jorgensen Steffen Sigue Simon Pierre Zaccour Georges | 2000 | Journal of Retailing2000，76，1： | 1 |
| 16 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet2009，，9701： | 1 |
| 17 | Impairment of tapetum and mitochondria in engineered male-sterile tobacco plants显示文摘 | Michel Hernould S. Suharsono Eduardo Zabaleta Jean Pierre Carde Simon Litvak Alejandro Araya Armand Mouras | 1998 | Plant Molecular Biology1998，，4： | 1 |
| 18 | D- ynamic cooperative advertising in a channel 显示文摘 | Steffen JOrgensen Simon Pierre Sigue Georges Zaccour | 2000 | Journal of Retailing2000，76，1： | 1 |
| 19 | IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C显示文摘 | Tarik Asselah Simon De Muynck Philippe Bro?t Julien Masliah-Planchon Maud Blanluet Ivan Bièche Martine Lapalus Michelle Martinot-Peignoux Olivier Lada Emilie Estrabaud Qian Zhang Ahmed El Ray Dominique Vidaud Marie-Pierre Ripault Nathalie Boyer Pierre Bed | 2011 | Journal of Hepatology2011，，3： | 1 |
| 20 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet2009，，9701： | 1 |
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