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| 1 | Effects of Experimental Conditions and Kinetics of Photodegradation of Methylene Blue over TiO2显示文摘 | WIDCHAYA Radchatawedchakoon ARAYA Thapol RATCHANEEKORN Wanchanthuek | 2014 | Chemical Research in Chinese Universities2014，30，1： | 10 |
| 2 | Helicobacter Pylori Infection and Lung Cancer: New Insights and Future Challenges显示文摘Helicobacter pylori(H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori has very high rates of infection in human populations, and it is estimated that over 50% of the world population is infected. Recently, certain extra-gastric manifestations, linked to H. pylori infection, have been widely investigated. Noteworthy, a growing body of evidences supports an association between H. pylori infection with lung cancer. The present review intend to highlight not only the most recent evidences supporting this association, but also some missed points, which must be considered to validate this emerging association. | Ileana GONZALEZ Paulina ARAYA Armando ROJAS | 2018 | 中国肺癌杂志2018，21，9： | 7 |
| 3 | An extended treatment protocol with pegylated interferon and ribavirin for hepatitis C recurrence after liver transplantation显示文摘AIM: To evaluate the efflicacy and tolerability of an extended treatment protocol and to determine the predictors of sustained virological response (SVR) after liver transplantation (LT).METHODS: Between August 2005 and November 2008, patients with recurrent hepatitis C virus (HCV) after LT were selected for treatment if liver biopsy showed at least grade 2 inflammation and/or stage 2 flibrosis. All patients were to receive pegylated interferon (PEG)/regimens combining ribavirin (RBV) for an additional 48 wk after HCV undetectability.RESULTS: Extended protocol treatment was initiated in thirty patients. Overall, 73% had end of treatmentresponse and 60% had SVR. Nineteen patients completed treatment per protocol, of them, sixteen (84%) had end of treatment response, and fourteen (74%) achieved SVR. Both early virological response and 24-week virological response were individually associated with SVR but this association was not signif icant on multivariate analysis. Eleven patients (37%) discontinued therapy due to adverse effects. Cytopenias were the most common and most severe adverse effect, and required frquent growth factor use, dose adjustments and treatment cessations. The risk of rejection was not increased.CONCLUSION: Recurrent HCV after LT can be safely treated with extended virological responseguided therpy using PEG/RBV, but requires close monitoring for treatment-related adverse effects, particularly cytopenias. | Nikroo Hashemi Victor Araya Kashif Tufail Laxmi Thummalakunta Eyob Feyssa Ashaur Azhar Mumtaz Niazi Jorge Ortiz | 2011 | World Journal of Hepatology2011，3，7： | 7 |
| 4 | Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora显示文摘An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media.Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E(1),in addition to previously identified pitholide B(2),pitholide D(3),pestalotin(LL-P880α)(4),PC-2(5),LL-P880β(6),tyrosol(7)and 4-oxo-4H-pyran-3-acetic acid(8).An endophytic fungus P.microspora from M.zapota and the isolation of compounds 1-5,7 and 8 from P.microspora are reported here for the first time. | G.R.Nalin Rathnayake N.Savitri Kumar Lalith Jayasinghe Hiroshi Araya Yoshinori Fujimoto | 2019 | Natural Products and Bioprospecting2019，9，6： | 4 |
| 5 | Long-lasting responses after discontinuation of nivolumab treatment for reasons other than tumor progression in patients with previously treated,advanced non-small cell lung cancer显示文摘Dear Editor,Nivolumab,an inhibitor of programmed cell death 1(PD-1),is an immune checkpoint inhibitor(ICI)that enhances T cell functions by preventing negative regulation of cancer immunity,and it has shown clinically significant efficacy and tolerability in various types of cancer.Based on the results of randomized phase III trials comparing nivolumab with docetaxel[1,2],nivolumab is now used in clinical practice for patients with previously treated advanced non-small cell lung cancer(NSCLC).Fur-thermore,the most recent Japan Lung Cancer Society guidelines include nivolumab monotherapy in the sys-temic treatment strategy for previously treated,locally advanced or metastatic NSCLC[3].However,ICIs induce characteristic immune-related adverse events(irAEs),which are not seen with conventional cytotoxic agents or molecular targeted agents.IrAEs can occur in any organ system,most typically the skin,lung,and gastrointesti-nal,hepatic,and endocrine systems. | Hideharu Kimura Tomoyuki Araya Taro Yoneda Hiroki Shirasaki Koji Kurokawa Tamami Sakai Hayato Koba Yuichi Tambo Shingo Nishikawa Takashi Sone Kazuo Kasahara | 2019 | Cancer Communications2019，39，1： | 3 |
| 6 | Effect of Mitochondrial Dysfunction on Carbon Metabolism and Gene Expression in Flower Tissues of Arabidopsis thaliana显示文摘我们描绘了带 ATP synthase 子单元的未编辑的形式的表示导致的一个 mitochondrial 机能障碍的转基因的植物的 transcriptomic 反应 9。A9 和 APETALA3 倡导者驾驶的 u-ATP9 transgene 导致减少在两氧举起和腺嘌核苷酸揭示的 mitochondrial 机能障碍(ATP,自动数据处理) 没有在 ATP/ADP 比率的变化的层次。而且,我们与伴随物在谷胱甘肽和 ascorbate 层次在 ROS 累积和减少测量了增加氧化压力反应。年轻 Arabidopsis 花的 transcriptome 分析,由 qRTPCR 和酶或功能的测试验证了,在 u-ATP9 植物的显示出的戏剧的变化。两根线在涉及碳,类脂化合物,和房间墙的各种各样的基因的表达式显示修正新陈代谢,建议重要新陈代谢的重新调整与一个 mitochondrial 机能障碍发生在植物。有趣地,涉及 mitochondrial 呼吸,蛋白质合成,和降级的抄本层次被影响。而且,为抄写因素和 DNA 有约束力的蛋白质编码的几 mRNAs 的层次也被改变。他们中的一些涉及应力和荷尔蒙回答,建议几个发信号小径重叠。确实, transcriptome 数据与乙烯, absicic 酸,和植物生长素信号 transduction 有关表明 mitochondrial 机能障碍戏剧性地改变涉及表明小径的基因的表示,包括那些。我们的数据建议在这份报告使用的 mitochondrial 机能障碍模型可能是有用的揭开在植物房间表明在原子核和线粒体之间的机制的 retrograde。 | Maria V. Busi Maria E. Gomez-Lobato Sebastian P. Rius Valeria R. Turowski Paula Casati Eduardo J. Zabaleta Diego F. Gomez-Casati Alejandro Araya | 2011 | Molecular Plant2011，4，1： | 2 |
| 7 | p-n型异质结催化剂Ag_2O-BiVO_4对微囊藻毒素(MC-RR)的光化学氧化机理研究(英文)显示文摘微囊藻毒素(MC-RR)是一种具有两个精氨酸结构的微囊藻毒素,它是由蓝藻细菌产生的一种能普遍被检测到的细胞毒素,近来由于其潜在的肝毒性受关注.在可见光(λ≥420 nm)照射条件下,以MC-RR为光催化降解污染物,对BiVO_4,Ag-BiVO_4,Ag_2O-BiVO_4和Ag/Ag_2O-BiVO_4光催化降解性能进行了比较研究.通过HPLC-MS测定了其中间产物,并分析了其可能的降解途径.结果表明,Ag的存在通过构筑p-n异质结光催化剂而提高了Ag/Ag_2O-BiVO_4的光催化效率.此外,Ag^0的存在极大地促进了MC-RR在光催化剂表面上的吸附作用.小鼠的毒理学实验表明,MC-RR经过光催化降解后毒性显着降低.由于水体富营养化形成的蓝绿藻促进微囊藻毒素的形成,这已成为全球关注的问题.被微囊藻毒素污染的饮用水除了会毒害野生动物,家畜和家禽外,还会损害人类肝脏,这也是肝癌的发病率高的原因.毒理学研究发现,微囊藻毒素通过结合到1A(PP1)和2A(PP2)上强烈地抑制蛋白磷酸酶的活性,从而导致肝细胞的损伤,引发原发性肿瘤.目前对光催化降解MC-RR的研究主要集中在紫外光催化氧化领域.采用太阳光中的紫外区或者近紫外区,利用传统的TiO_2光催化剂对MC-LR的光催化氧化研究;太阳光中只有极少部分(约4%)的紫外光,大部分(约43%)是可见光,因此,如何将光催化剂的吸收光谱拓宽至可见光区域,提高催化剂对可见光的利用率,进一步提高光催化降解MC-RR的能力,具有一定的理论和实际意义.钒酸铋是一类新型的p型可见光光催化剂,将其与n型半导体Ag_2O材料选择性的复合制备出p-n型异质结复合光催化剂能够显著地提高其光催化性能.本文将这种复合光催化剂的应用扩展到广泛检测到的毒素MC-RR的降解中,以实现可见光降解.发现Ag/Ag_2O-BiVO_4可以在可见光照射下有效光催化降解MC-RR.跟踪其降解中间产物,研究了其可能降解途径,并提出了在异质结催化剂表面上的光催化降解机理.催化剂表征结果表明,Ag_2O和BiVO_4形成有效的异质结界面,在降解中发挥重要作用.在该异质结结构中,Ag和Ag_2O作为电子受体以增强电荷载流子寿命并提高光催化活性.依据MC-RR氧化产物的结构、化学性质和降解体系中所检测到的产物,推测其可能的机理:Ag-Ag_2O-BiVO_4可见光光催化降解MC-RR是一个涉及到羟基自由基和超氧自由基的共同氧化作用,同时根据液相质谱对中间产物的鉴定,得到MC-RR两条主要的可能降解途径,其中主要涉及到Adda中不饱和碳碳双键和Mdha中烯键的氧化,以及各氨基酸之间肽键的水解.小鼠急性毒理实验表明,经光催化反应后MC-RR的毒性明显减小. | 吴春红 方艳芬 Araya Hailu Tirusew 向淼淼 黄应平 陈春城 | 2017 | Chinese Journal of Catalysis2017，38，2： | 2 |
| 8 | Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana显示文摘Plant root development is strongly affected by nutrient availability. Despite the importance of structure and function of roots in nutrient acquisition,statistical modeling approaches to evaluate dynamic and temporal modulations of root system architecture in response to nutrient availability have remained as widely open and exploratory areas in root biology. In this study,we developed a statistical modeling approach to investigate modulations of root system architecture in response to nitrogen availability. Mathematical models were designed for quantitative assessment of root growth and root branching phenotypes and their dynamic relationships based on hierarchical con figuration of primary and lateral roots formulating the fishbone-shaped root system architecture in Arabidopsis thaliana. Time-series datasets reporting dynamic changes in root developmental traits on different nitrate or ammonium concentrations were generated for statistical analyses. Regression analyses unraveled key parameters associated with:(i) inhibition of primary root growth under nitrogen limitation or on ammonium;(ii) rapid progression of lateral root emergence in response to ammonium; and(iii) inhibition of lateral root elongation in the presence of excess nitrate or ammonium. This study provides a statistical framework for interpreting dynamic modulation of root system architecture,supported by metaanalysis of datasets displaying morphological responses of roots to diverse nitrogen supplies. | Takao Araya Takuya Kubo Nicolaus von Wiren Hideki Takahashi | 2016 | Journal of Integrative Plant Biology2016，58，3： | 2 |
| 9 | 地震地形变观测系统的组成、发展及应用显示文摘简要介绍地震地形变观测系统的组成及地形变观测技术的发展,指出不同观测技术的时空特点,光纤和长基线应变仪等新技术的优点以及不同地形变观测技术进行联合观测的可行性和方法优势。通过对日本岐阜县安装的1500 m臂长应变仪与GNSS地球观测网(GEONET)中的连续观测站获取的应变进行比对的实例分析,得出从连续观测站获取的水平应变去趋势后与应变仪得到的连续应变结果基本一致,地震会引起应变异常,应变仪对环境因素的影响更敏感。实际工作中应注意发展优势观测技术,进行观测技术和研究方法的融合、提高监测密度,增强时空分辨率,提升地震前兆特征识别能力,更好地为科学防震减灾服务。 | 胡亚轩 Akito Araya 汪翠枝 刘文义 | 2020 | 地震科学进展2020，50，10： | 2 |
| 10 | The DDD pacemaker implanted intrvenously显示文摘 | Araya GV Lopez BL Gonzalez JA | 1995 | Arch Inst Cadiol Mex1995，65，2： | 1 |
| 11 | The novel formulation design of self-emulsifying drug delivery systems(SEDDS)type O/W microemulsionⅢ:the permeation mechanism of a poorly water soluble drug entrapped O/W microemulsion in rat isolated intestinal membrane by the Ussing chamber method显示文摘 | Araya H Tomita M Hayashi M | 2006 | Drug Metab Pharmacokinet2006，21，1： | 1 |
| 12 | Digestion rate of legume carbohy-drates and glycemic index of legume-based meals显示文摘 | ARAYA H PAK N VERA G | 2003 | International Journal of Food Sciences and Nutrition2003，54，2： | 1 |
| 13 | Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease 显示文摘 | Videla LA Rodrigo R Araya J | 2006 | Trends Mol Med2006，12，12： | 1 |
| 14 | Sonic hedgehog(SHH) role in dorsal midbrain proliferation in vertebrates显示文摘 | Carrnen Feijoo Pablo Lois Francisco Araya | 2007 | Developmental Biology2007，306，1： | 1 |
| 15 | Use and refuse of nasal CPAP in obstructive sleep apneas/hypopneas显示文摘 | Castillo JL Araya F Bustamante G | | 0，，12： | 1 |
| 16 | Ralph Hughes-John Deere Peanut Combines 显示文摘 | Araya K | 1997 | Machingery Feature1997，，6： | 1 |
| 17 | Immune parameters associated with early treatment effects of high-dose intravenous methylprednisolone in multiple sclerosis 显示文摘 | Wang HY Matsui M Araya S | 2003 | J Neurol Sci2003，216，1： | 1 |
| 18 | Quality of life after postconflict displacement in Ethiopia:comparing placement in a community setting with that in shelters显示文摘 | Mesfin Araya Jayanti Chotai Ivan H.Komproe | | 0，，07： | 1 |
| 19 | Squamous metaplasia amplifies pathologic epit helial-mesenchymal interactions in COPD patients显示文摘 | Araya J Cambier S Markovics JA | | 0，，： | 1 |
| 20 | T regulatorycell function in idiopathic minimal lesion nephrotic syndrome 显示文摘 | ARAYA C DIAZ L WASSERFALL C | 2009 | Pediatr Nephml2009，24，9： | 1 |
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