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| 1 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 2 | 丹麦风电的未来显示文摘丹麦是世界风电行业的领跑者。介绍了丹麦大力发展风电的驱动力,描述了风电发展给电力行业以及人民生活带来的影响,阐述了风电的社会经济效益。详细论述了丹麦通过负荷经济调度、电力进出口以及上下调制电能产量从而实现了电力消费的20%来自于风能。为实现欧盟的'20-20-20'目标,电网基础设施建设、灵活的生产与消费以及智能电网方案将为可再生能源尤其是风电的发展提供坚强的平台。负荷经济调度在新的方案下是实现社会经济效益最大化的有效措施。 | Peter Jorgensen | 2011 | 能源技术经济2011，23，3： | 9 |
| 3 | 膀胱自扩大术治疗高反射性神经原性膀胱显示文摘目的探讨膀胱自扩大手术治疗高反射性神经原性膀胱的方法及疗效。方法6例患者,男5例,女1例,年龄5~36岁,平均28岁。尿动力学检查显示6例均为膀胱反射亢进,逼尿肌括约肌协同失调。病程5~10年,平均6年。对6例患者的手术方法,手术前后膀胱容量,肾功能以及临床症状进行回顾分析。结果手术时间100~180min,平均120min。安全膀胱容量术前(182±52)ml,术后3个月(315±65)ml,术后10个月(420±105)ml,手术前后比较差异有统计学意义(P<0.01)。术后导尿间歇平均4h(3~5h),术前5例尿失禁患者尿失禁消失4例,1例经口服抗胆碱药物后症状明显改善。术前4例肾功能异常者3例恢复正常,1例改善。结论膀胱自扩大术结合清洁间歇自家导尿治疗高反射性小容量膀胱是一种简便,可靠的方法。 | 魏金星 张雪培 王智勇 武玉东 杨锦建 高建光 文建国 Jorgensen Trols M | 2005 | 中华泌尿外科杂志2005，26，6： | 6 |
| 4 | Pharmacological interventions for improved colonic anastomotic healing:A meta-analysis显示文摘AIM:To identify pharmaceuticals for the prophylaxis of anastomotic leakage(AL),we systematically reviewed studies on anastomosis repair after colorectal surgery.METHODS:We searched PubMed and EMBASE for articles published between January 1975 and December 2012.We included studies in English with the primary purpose of promoting healing of anastomoses made in the colon or rectum under uncomplicated conditions.We excluded studies on adverse events from interventions,nutritional interventions or in situ physical supporting biomaterials.The primary outcome was biomechanical strength or AL.We performed meta-analyses on therapeutic agents investigated by three or more independent research groups using the same outcome.The DerSimonian-Laird method for random effects was applied with P < 0.05.RESULTS:Of the 56 different therapeutic agents assessed,7 met our inclusion criteria for the metaanalysis.The prostacyclin analog iloprost increased the weighted mean of the early bursting pressure of colonic anastomoses in male rats by 60 mmHg(95%CI:30-89) vs the controls,and the immunosuppressant tacrolimus increased this value by 29 mmHg(95%CI:4-53) vs the controls.Erythropoietin showed an enhancement of bursting pressure by 45 mmHg(95%CI:14-76).The anabolic compound growth hormone augmented the anastomotic strength by 21 mmHg(95%CI:7-35),possibly via the up-regulation of insulin-like growth factor-1,as this growth factor increased the bursting pressure by 61 mmHg(95%CI:43-79) via increased collagen deposition.Hyperbaric oxygen therapy increased the bursting pressure by 24 mmHg(95%CI:13-34).Broad-spectrum matrix metalloproteinase inhibitors increased the bursting pressure by 48 mmHg(95%CI:31-66) on postoperative days 3-4.In the only human study,the AL incidence was not significantly reduced in the 103 colorectal patients treated with aprotinin(11.7%) compared with the 113 placebo-treated patients(9.7%).CONCLUSION:This systematic review identified only one randomized clinical trial and seven therapeutic agents from pre-clinical models that could be explored further for the prophylaxis of AL after colorectal surgery. | Mari Nanna φines Peter-Martin Krarup Lars Nannestad Jorgensen Magnus Sven Agren | 2014 | World Journal of Gastroenterology2014，20，35： | 5 |
| 5 | Bone mineral density in lifelong trained male football players compared with young and elderly untrained men显示文摘Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched men.Methods: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were measured.Results: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to UY.Conclusion: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despite an age difference of 47 years. | Marie Hagman Eva Wulff Helge Therese Hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 6 | Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men显示文摘新兴的证据建议饮食的脂肪可以影响阴囊的功能。然而,大多数这域上的出版文学为阴囊的功能把精液质量参数用作唯一的代理。我们在健康的年轻西班牙的人之中与传播繁殖荷尔蒙层次和阴囊的体积检验了胖吸入的协会。这是在在西班牙的 Murcia 区域在 2010 年 10 月和 2011 年 11 月之间进行的 209 个健康男志愿者之中的代表性的研究。参加者在生活方式上完成了问询表,饮食,并且吸烟,并且各经历了物理考试,并且提供了一件血样品。线性回归被用来检验在每种丰满的酸类型和繁殖荷尔蒙层次和阴囊的体积之间的协会。Monounsaturated 丰满的酸吸入相反地与计算免费睾丸激素,全部的睾丸激素,和 inhibin B 的浆液血层次被联系。一个积极协会在多元不堡和的吸入之间被观察丰满的酸,特别地 omega-6 多元不堡和丰满的酸,和 luteinizing 荷尔蒙集中。另外, trans 的吸入丰满的酸与更低的全部的睾丸激素和计算免费睾丸激素集中被联系(P 趋势 = 0.01 和 0.02,分别地) 。omega-3 多元不堡和的吸入丰满的酸断然与阴囊的体积有关当时 omega-6 多元不堡和的吸入丰满的酸和 trans 丰满的酸相反地与阴囊的体积有关。这些数据建议那胖吸入,并且特别地终止 3 的吸入,终止 6,并且 trans 丰满的酸,可以影响阴囊的功能。 | Lidia Minguez-Alarcon Jorge E Chavarro JJaime Mendiola Manuela Roca Cigdem Tanrikut Jesus Vioque Niels Jorgensen Alberto M Torres-Cantero | 2017 | Asian Journal of Andrology2017，19，2： | 5 |
| 7 | 结肠癌术后吻合口瘘与患者不良结局有关显示文摘结肠癌术后吻合口瘘是否可增加病情复发风险,目前尚无翔实证据。哥本哈根大学Peter-Martin Krarup博士等人进行了一项研究,该研究对象为经结肠癌根治性切除手术治疗后存活120天的结肠癌患者,目的为考查结肠癌术后吻合口瘘对患者病情复发与长期死亡的影响。这项研究结果发表于2013年9月16日在线出版的《外科学年鉴》( Annals of Surgery )杂志上。 这是一项对登记于丹麦结直肠癌研究组数据库中的9333例患者进行的前瞻性研究。研究结果表明,患者结肠癌术后吻合口瘘发生率为6.4%,有744例患者于120天内死亡。在其余的8589例患者中,有861例(10.0%)出现局部复发,但与结肠癌术后吻合口瘘无关。1281例(14.9%)患者出现远端复发,远端复发常发生于结肠癌术后吻合口瘘后。结肠癌术后吻合口瘘也与患者远期死亡率有关。在2841例III期患者中,结肠癌术后吻合口瘘与辅助化疗可能性增加和初始治疗延迟有关。 | Krarup PM Nordholm-Carstensen A Jorgensen LN | 2013 | 中华结直肠疾病电子杂志2013，2，4： | 4 |
| 8 | 扩声系统语言清晰度的测量显示文摘 | Morten Jorgensen 谭建军 | 2005 | 电声技术2005，29，11： | 4 |
| 9 | 益生菌对仔猪肠道病原体的抑制作用显示文摘在所有初生哺乳动物中,初生仔猪是发育状况较不成熟的物种之一,仔猪的能量储备非常低,生殖系统尚未发育完全,因而,仔猪对营养物质的摄入和吸收对其生长及后期的潜在繁殖性能都有巨大影响。 | 张弦(译) 唐彩琰(校) 何闪(制图表) Jens Jorgensen | 2021 | 国外畜牧学(猪与禽)2021，41，3： | 3 |
| 10 | Hepatic progenitor cell activation in liver repair显示文摘The liver possesses an extraordinary ability to regenerate after injury.Hepatocyte-driven liver regeneration is the default pathway in response to mild-to-moderate acute liver damage.When replication of mature hepatocytes is blocked,facultative hepatic progenitor cells(HPCs),also referred to as oval cells(OCs)in rodents,are activated.HPC/OCs have the ability to proliferate clonogenically and differentiate into several lineages including hepatocytes and bile ductal epithelia.This is a conserved liver injury response that has been studied in many species ranging from mammals(rat,mouse,and human)to fish.In addition,improper HPC/OC activation is closely associated with fibrotic responses,characterized by myofibroblast activation and extracellular matrix production,in many chronic liver diseases.Matrix remodeling and metalloprotease activities play an important role in the regulation of HPC/OC proliferation and fibrosis progression.Thus,understanding molecular mechanisms underlying HPC/OC activation has therapeutic implications for rational design of anti-fibrotic therapies. | Adam Bria Jorgensen Marda Junmei Zhou Xiaowei Sun Qi Cao Bryon E.Petersen Liya Pi | 2017 | Liver Research2017，1，2： | 3 |
| 11 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 12 | Haploid barley from the intergenetic cross Hordeum vulagre×Psathyrostachys fragilis显示文摘 | von Bothmer R Jacobsen N Jorgensen R B | 1984 | Euphytica1984，33，： | 2 |
| 13 | Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisi- tion regulated by microRNAs显示文摘骨头和软骨正在被产生通过信号的过多的一致行动的 de novo。这些对为系特定的区别招募的干细胞(SC ) 起作用,与代表在整个他们的寿命的各种各样的功能的细胞的显型。信号被荷尔蒙和生长因素和保证合适的建模并且骨头和软骨改变的机械力量(GF ) 显示,由于在 SC,造骨细胞, chondrocytes,以及骨破折和另外的房间类型的土生土长、规划的新陈代谢(例如 T 助手房间) 。 | Jan O GORDELADZE Farida DJOUAD Jean-Marc BRONDELLO Daniele NOEL Isabelle DUROUX-RICHARD Florence APPARAILLY Christian JORGENSEN | 2009 | Acta Pharmacologica Sinica2009，30，10： | 2 |
| 14 | Genetic and Developmental Control of Anthocyanin Biosynthesis显示文摘 | H K Dooner T P Robbins R A Jorgensen | 1991 | Annual Review of Genetics1991，，： | 2 |
| 15 | Is MRCP equivalent to ERCP for diagnosing biliary obstruction in orthotopic liver transplant recipients? A meta-analysis显示文摘 | Jennifer E. Jorgensen Akbar K. Waljee Michael L. Volk Christopher J. Sonnenday Grace H. Elta Mahmoud M. Al-Hawary Amit G. Singal Jason R. Taylor B. Joseph Elmunzer | 2011 | Gastrointestinal Endoscopy2011，，5： | 2 |
| 16 | 美国理论生态学研究动态显示文摘当今,由于人们对资源、环境等世界性问题的日益关注,因而生态学的发展越来越受到重视。但是,在生态学繁荣发展的背后,却隐藏着一个危机,即对生态学理论的研究还很不够。现在在美国,理论生态学的研究正逐渐地受到重视,其中著名的对生态学的发展起过重要作用,并首先倡导生态数学建模及系统分析研究工作的美国能源部。 | 宋波 赵士洞 Clive D. Jorgensen | 1992 | 生态学杂志1992，11，1： | 2 |
| 17 | Cell swelling activates cloned Ca2 + -activated K + channels: a role tor the F-actin cytoskeleton显示文摘 | Jorgensen NK Pedersen SF Rasmussen HB | 2003 | Biochim Biophys Acta2003，1615，12： | 2 |
| 18 | The effect of biogenic amine production by single bacterial cultures and metabiosis on coldsmoked salmon显示文摘 | Jorgensen L V Huss H H Dalgaard P | 2000 | J Appl Microbiol2000，89，： | 2 |
| 19 | The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsy显示文摘 | KD Lindor C Bru RA Jorgensen J Rakela JM Bordas JB Gross J Rodes DB McGill CC Reading EM James JW Charboneau J Ludwig KP Batts AR Zinsmeister | 1996 | Hepatology1996，，5： | 2 |
| 20 | The viability of isolated rabbit nasal mucosa in the Ussing chamber, and the permeability of insulin across the membrane 显示文摘 | Bechgard E Gizurarson S Jorgensen L | 1992 | Int of Pharm1992，87，： | 1 |
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