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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication显示文摘 | Nai-Yun Hsu Olha Ilnytska Georgiy Belov Marianita Santiana Ying-Han Chen Peter M. Takvorian Cyrilla Pau Hilde van der Schaar Neerja Kaushik-Basu Tamas Balla Craig E. Cameron Ellie Ehrenfeld Frank J.M. van Kuppeveld Nihal Altan-Bonnet | 2010 | Cell2010，，5： | 1 |
| 3 | NCIC CTG IND.190 Phase I Trial of Dalotuzumab (MK-0646) in Combination with Cisplatin and Etoposide in Extensive-Stage Small-Cell Lung Cancer显示文摘 | Peter M. Ellis Frances A. Shepherd Scott A. Laurie Glenwood D. Goss Martin Olivo Jean Powers Lesley Seymour Penelope A. Bradbury | 2014 | Journal of Thoracic Oncology2014，，3： | 1 |
| 4 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 5 | Flow analysis methods for the direct ultra-violet spectrophotometric measurement of nitrate and total nitrogen in freshwaters显示文摘 | Gentle Brady S Ellis Peter S Grace Michael R | | 0，，1： | 1 |
| 6 | A city initiative to improve the quality of life for urban youth: how evaluation contributed to efective social programming显示文摘 | Rex S Green Peter M Ellis Shirly S Lee | 2005 | Evaluation and Program Planning2005，，1： | 1 |
| 7 | Practice Parameters for the Management of Hemorrhoids (Revised)显示文摘 | Peter Cataldo M.D. C. Neal Ellis M.D. Sharon Gregorcyk M.D. Neil Hyman M.D. W. Donald Buie M.D. James Church M.D. Jeffrey Cohen M.D. Phillip Fleshner M.D. John Kilkenny M.D. Clifford Ko M.D. David Levien M.D. Richard Nelson M.D. Graham Newstead M.D. Charl | 2005 | Diseases of the Colon & Rectum2005，，2： | 1 |
| 8 | Challenges and progress towards understanding the role of effectors in plant–fungal interactions显示文摘 | Maryam Rafiqi Jeffrey G Ellis Victoria A Ludowici Adrienne R Hardham Peter N Dodds | 2012 | Current Opinion in Plant Biology2012，，4： | 1 |
| 9 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 10 | How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?显示文摘 | Satti Beharry Lynda Ellis Mary Corey Margaret Marcon Peter Durie | 2002 | The Journal of Pediatrics2002，，1： | 1 |
| 11 | Practice Parameters for Colon Cancer显示文摘 | Daniel Otchy Neil H. Hyman Clifford Simmang Thomas Anthony Donald W. Buie Peter Cataldo James Church Jeffrey Cohen Frederick Dentsman Neal C. Ellis John W. Kilkenny Clifford Ko Richard Moore Charles Orsay Ronald Place Janice Rafferty Jan Rakinic Paul Savo | 2004 | Diseases of the Colon & Rectum2004，，： | 1 |
| 12 | An evaluation of HACCP implementation status in UK small and medium enterprises in food manufacturing显示文摘 | Fielding L M Ellis L Beveridge C Peters A C | 2005 | International Journal of Environmental Health Research2005，15，2： | 1 |
| 13 | 针灸治疗慢性头痛的初级保健:大样本、实用的随机试验显示文摘目的 与“不用针灸”对比,确定“使用针 灸”的治疗方法对慢性头痛患者的头痛、健康状 况及无病时间的影响。 设计 随机对照试验。 试验场所 英格兰和威尔士的开业医生诊所。 受试对象 401位慢性头痛患者,主要是偏 头痛患者。 干预 患者被随机分配进入针灸治疗组(在 3个月内接受12次针灸治疗)和对照组(接受常 规治疗)。 主要结果测定指标 治疗前、治疗后3个月 及12个月对头痛积分,SF-36健康状况及用药量 进行评估。每3个月对治疗方法作1次评估。头 痛积分即判定疗效的主要终点指标。 结果 针灸组治疗后12个月的头痛积分(针 灸组161例患者,平均头痛积分为16.2,标准差 13.7,比治疗前减少34%)比对照组低(对照组140 例患者,平均头痛积分为22.3,标准差17.0,比 治疗前减少16%)。两种方法调整后的差异为4.6 (95%可信区间为2.2-7.0;P=0.0002)。对于包 含缺失数据的灵敏度分析,该结果也是肯定的。 针灸组的患者每年少头痛22(8-38)天。尽管达到 统计学差异的项目仅有生理功能、精力和健康改 变等,SF-36的资料也有利于针灸组。与对照组相 比,针灸组的患者减少了15%的服药量(P=0.02), 减少了25%的就诊量(P=0.10),同时减少15%的 病休时间(P=0.2)。 结论 针灸在初级保健中用于治疗慢性头痛, 特别是偏头痛,可以产生与临床相关的持久益 处。应当考虑扩大英国国家医疗保险体系中针灸 治疗的范围。 | Andrew J Vickers Rebecca W Rees Catherine E Zollman Rob McCarney Claire Smith Nadia Ellis Peter Fisher Robbert Van Haselen 宋军 | 2005 | 英国医学杂志中文版2005，8，2： | 1 |
| 14 | Urbanization for everyone: benefits of urbanization in indonesia~s rural regions显示文摘 | Jennifer Day Peter Ellis | 2013 | Journal of Urban Planning and Development2013，，40： | 1 |
| 15 | Mapping MHC-encoded susceptibility and resistance in primary sclerosing cholangitis: The role of MICA polymorphism显示文摘 | Suzanne Norris Elli Kondeatis Robert Collins Jack Satsangi Mike Clare Roger Chapman Henry Stephens Phillip Harrison Robert Vaughan Peter Donaldson | 2001 | Gastroenterology2001，，6： | 1 |
| 16 | Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy显示文摘 | Sean M. Bagshaw Stephen Lapinsky Sandra Dial Yaseen Arabi Peter Dodek Gordon Wood Paul Ellis Jorge Guzman John Marshall Joseph E. Parrillo Yoanna Skrobik Anand Kumar | 2009 | Intensive Care Medicine2009，，5： | 1 |
| 17 | Temperature variability and the yield of annual crops显示文摘 | Timothy R Wheeler Peter Q Craufurd Richard H Ellis John R Porter P.V Vara Prasad | 2000 | Agriculture, Ecosystems and Environment2000，，1： | 1 |
| 18 | Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line显示文摘 | A.-M. Engelbrecht M. Mattheyse B. Ellis B. Loos M. Thomas R. Smith S. Peters C. Smith K. Myburgh | 2007 | Cancer Letters2007，，1： | 1 |
| 19 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Hypertension: Journal of the American Heart Association2003，，5： | 1 |
| 20 | Practice parameters for the management of hemorrhoids(Revised)显示文摘 | Peter Cataldo C Neal Ellis Sharon Gregorcyk | 2005 | Dis Colon Rectum2005，48，： | 1 |
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