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	题名	作者	年代	出处	被引量
1	Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis.	Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete	2012	World Journal of Gastroenterology2012，18，11：	6
2	Industrial ecology: a new field or only a metaphor?显示文摘	John Ehrenfeld	2004	Journal of Cleaner Production2004，，8：	3
3	新型的三爪卡盘显示文摘装有新型润滑系统和可换衬套的快换三爪卡盘,满足了对车削工件高经济性能的生产加工要求,减少了生产辅助时间。	Jrg Ehrenfeld	2004	现代制造2004，，21：	2
4	Industrial Ecology in Practice: the Evolution of Interdependence at Kalundborg 显示文摘	Ehrenfeld J Gertler N	1997	Journal of Industrial Ecology1997，，：	1
5	Evaluating wetlands within an urban context显示文摘	Joan G Ehrenfeld		0，，15：	1
6	Defining the Limits of Restoration:The Need for Realistic Goals显示文摘	Ehrenfeld J G	2000	Restoration Ecology2000，，8：	1
7	Newgenerationofinactivatedpoliovirusvaccines for universal immunization after eradication ofpoliomyelitis显示文摘	ChumakovK EhrenfeldE	2008	ClinInfectDis2008，47，12：	1
8	Cardiac nurses coping with stress显示文摘	Ehrenfeld M Cheifetz FR	1990	J Adv Nurs1990，15，9：	1
9	Evaluating wetlands within an urban context 显示文摘	Ehrenfeld JG	2000	Ecological Engineering2000，15，：	1
10	2D-infrared thermography monitoring of ultrasound-assis- ted polymerization of water-soluble monomer in a gel process显示文摘	Rigolini Julien Bombled Florine Ehrenfeld Francis	2011	Macromoleeules2011，44，11：	1
11	Exotic plant species alter the microbial community structure and function in the soil显示文摘	KOURTEV PS EHRENFELD JG HAGGBLOM M	2002	Ecology2002，83，11：	1
12	Experimental analysis of the effect of exotic and native plant species on the structure and function of soil microbial communities显示文摘	KOURTEV P S EHRENFELD J G t-IAGGELOM M	2003	Soil Biology and Biochemistry2003，35，7：	1
13	Oxidation of Ammonium to Nitrite Under Iron-Reducing Conditions in Wetland Soils: Laboratory, Field Demonstrations, and Push-Pull Rate Determination显示文摘	Junu Shrestha Jeremy J. Rich Joan G. Ehrenfeld Peter R. Jaffe	2009	Soil Science2009，，3：	1
14	Invasive species and the soil:Effects on organisms and ecosystem processes 显示文摘	EHRENFELD J G SCOTT N	2001	EcologicalApplications2001，11，5：	1
15	The risk and outcomes of epidural hematomas after perioperative and obstetric epidural catheterization: a report from the Multicenter Perioperative Outcomes Group Research Consortium 显示文摘	Bateman B T Mhyre J M Ehrenfeld J	2013	Anesth Analg2013，116，6：	1
16	Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication显示文摘	Nai-Yun Hsu Olha Ilnytska Georgiy Belov Marianita Santiana Ying-Han Chen Peter M. Takvorian Cyrilla Pau Hilde van der Schaar Neerja Kaushik-Basu Tamas Balla Craig E. Cameron Ellie Ehrenfeld Frank J.M. van Kuppeveld Nihal Altan-Bonnet	2010	Cell2010，，5：	1
17	Evaluating wetlands within an urban context显示文摘	Ehrenfeld J G	2000	Ecological Economics2000，，15：	1
18	The Dual Association between Lymphoma and Autoimmunity显示文摘	Ehrenfeld M Abu Shakra M Buskila D	2001	Blood Cells Mol Dis2001，27，4：	1
19	Industrial ecology: A framework for product and process design显示文摘	Ehrenfeld J R	1997	J Cleaner Production1997，5，12：	1
20	Exotic plant species alter the microbial community structure and func- tion in the soil显示文摘	Kourtev P S Ehrenfeld J G H/iggblom M	2002	Ecology2002，83，：	1

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