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| 1 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 2 | Use of isolated Roux loop for pancreaticojejunostomy reconstruction after pancreaticoduodenectomy显示文摘AIM: To evaluate the efficacy of the isolated Roux loop technique in decreasing the frequency of pancreaticojejunal anastomosis failure. METHODS: We retrospectively reviewed 88 consecutive patients who underwent pancreaticoduodenectomy (standard or pylorus-preserving). Single jejunal loop was used in 42 patients (SL group) while isolated Roux loop was used in 46 patients (RL group). Demographic characteristics (age, gender) and perioperative results (major/minor complications, mortality, hospital stay) were compared between the two groups. RESULTS: Mortality was almost equal in both groups and overall mortality was 2.27%. Leak rate from the pancreaticojejunal anastomosis and hospital stay were lower in the RL group without significant difference. Morbidity was 39.1% in the RL group, insignificantly higherthan the SL group. Operative time was almost 30 min longer in the RL group. CONCLUSION: The isolated Roux loop, although an equally safe alternative, does not present advantages over the traditional use of a single jejunal loop. Randomized controlled studies are required to further clarify its efficacy. | Konstantinos Ballas Nikolaos Symeonidis Savvas Rafailidis Theodoros Pavlidis Georgios Marakis Nikolaos Mavroudis Athanasios Sakantamis | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Effect of early propranolol administration on portal hypertensive gastropathy in cirrhotic rats显示文摘AIM:To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats. METHODS:For the development of liver cirrhosis and portal hypertensive gastropathy,60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein,followed by phenobarbital and carbon tetrachloride(CCl4) administration.After two weeks of CCl4 administration, the rats were randomly separated into two groups.In group A,propranolol was continuously administered intragastrically throughout the study,whereas in group B normal saline(placebo)was administered instead. Hemodynamic studies and vascular morphometric analysis of gastric sections were performed after complete induction of cirrhosis. RESULTS:Vascular morphometric studies showed higher numbers of vessels in all mucosal layers in the control group.Statistical analysis revealed a significantly higher total vascular surface in the control group compared to the propranolol group,but with no statistically significant difference between the mean vascular surfaces between the groups.Our study clearly shows that the increased mucosal blood flow is manifested by a marked increase of vessel count. CONCLUSION:Early propranolol's administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy. | Savas Rafailidis Charalampos Demertzidis Konstantinos Ballas Michail Alatsakis Nikolaos Symeonidis Theodoros Pavlidis Kyriakos Psarras Valentini Tzioufa-Asimakopoulou Athanassios Sakadamis | 2009 | World Journal of Gastroenterology2009，15，34： | 3 |
| 4 | 室内宽带多输入多输出抽头时延线新模型研究显示文摘根据室内无线电波传播规律和实测数据,研究建立了一个新的抽头时延线模型,该模型可以简单有效地估计视距和非视距路径下室内平均功率时延谱,并与实验结果一致.在广义平稳非相关散射信道前提下,通过分析抽头时延模型频率相关系数、抽头系数分布和相关性、抽头多普勒频谱等特性参数,给出了评估抽头时延线模型的新方法.文中建立的信道模型和参数,对于室内多输入多输出无线信道模拟仿真有较为重要的意义. | 赵雄文 李艺伟 Balla Moussa Coulibaly 关利华 刘盛尧 | 2014 | 电波科学学报2014，29，6： | 2 |
| 5 | Effect of hydrocele on appendix testis in children显示文摘这研究的目的是在孩子在结构的完整和附录睾丸的类固醇受体表达式模式上调查阴囊积水的一个提高的静水力学的压力的效果。26 个阴囊的附器从男孩被获得(在 13 和 79 个月之间年老,平均数 40 月) 因为阴囊积水或先天的腹股沟的脱肠,经历了外科的探索。阴囊的附器的织物节与 hematoxylin 曙红被染色。Immunohistochemistry 和 immunofluorescence 激光显微镜学用 monoclonal 老鼠被执行对雄激素的反人的受体和雌激素受体。病人们被划分成三个组:组 A (n = 8 ) 有没有阴囊积水的腹股沟脱肠的代表的病人,用作控制组织;组 B (n = 7 ) 有传达阴囊积水的代表的病人;并且组织 C (n = 11 ) 有 noncommunicating 阴囊积水的代表的病人。附录睾丸的织物节在组 A 在所有病人表示了雄激素和雌激素受体, B,和上皮的破坏不是现在。雄激素受体的存在(11 中的二个, P < 0.001 ) 并且雌激素受体(11 中的四个, P = 0.006 ) 更低,有上皮的破坏的附录睾丸的数字更高(11 中的八个, P = 0.001 ) 在组 C。我们证明那腹股沟脱肠和交流阴囊积水没影响受体表示模式和阴囊的附器的解剖结构,而 noncommunicating 阴囊积水引起了由类固醇受体和上皮的表面的破坏的缺席显示了的损坏。阴囊的附器的生理的角色的更好的理解可以与 noncommunicating 阴囊积水在病人改变外科的治疗的指示。 | Tamas Jozsa Andrea Telek Balazs Kutasy Matyas Benyo Gabor Csanadi Ilona Kovacs Gyorgy Balla Tibor Flasko Laszlo Csernoch Csongor Kiss | 2009 | Asian Journal of Andrology2009，11，6： | 2 |
| 6 | Stabilization of erythrocyte membranes by polyamines显示文摘 | Mohandas N Marton L J | 1983 | Pro Nat Acad Sci1983，80，： | 1 |
| 7 | Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol显示文摘 | Delanian S Balla Meldas S Lefaix JL | 1999 | J Clin Oncol1999，17，10： | 1 |
| 8 | Direct laser process- ing of a tantalum coating on titanium for bone replace- ment structures 显示文摘 | Balla VK Banerjee S Bose S | 2010 | Acta Biomater2010，6，6： | 1 |
| 9 | Elevated human epididymis protein 4 concentrations inchronic kidney disease显示文摘 | Béla Nagy Jr Krasznai ZT Balla H | 2012 | Ann Clin Biochem2012，49，4： | 1 |
| 10 | Dietary self-efficacy:Determinant of compliance behaviors and biochemical outcomes in hemodialysis patients显示文摘 | Zrinyi M Juhasz M Balla J | 2003 | Nephrol Dial Transplant2003，18，： | 1 |
| 11 | Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model显示文摘 | Lalountas M Ballas K D Michalakis A | | 0，，： | 1 |
| 12 | Induction of heme oxygenase is a ralpid,protective reslponse in rhabdomyolysis in the rat显示文摘 | Balla G | 1992 | J Clin Invest1992，90，1： | 1 |
| 13 | anti-K antibody mimicking an alloantibody显示文摘 | Viggiano E Clary NL Ballas SK | 1982 | Transfusion1982，22，： | 1 |
| 14 | Induction of hemecxygenase is a rapid, protective response in rhabdomyolysis in the rat 显示文摘 | Nath KA Balla G Veroellotfi GM | 1992 | J Clin Invest1992，90，： | 1 |
| 15 | P300 in mild cognitive impairment and in dementia 显示文摘 | Egerh6zi A Glaub T Balla P | 2008 | Psychiatr Hung2008，23，5： | 1 |
| 16 | Diagnosis of goose circovirus infection in Hungarian geese samples using poly- merase chain reaction and dot blot hybridization tests 显示文摘 | Balla N W Smyth J A Weston J H | 2004 | Avian Pathol2004，33，1： | 1 |
| 17 | Immunostimulatory oligodeoxynueleotides containing CpG motifs enhance the efficacy of moneclonal antibody therapy of lymphoma显示文摘 | Wooldridge JE Ballas Z Krieg AM | | 0，，08： | 1 |
| 18 | Multiple sclerosis and autoimmune diseases 显示文摘 | BAKER H W BALLA J I MACKAY I R | 1972 | Aus N Z J Med1972，2，： | 1 |
| 19 | Molecular basis of asymptomatic β-thalassaemia major in an African American individual显示文摘 | Cai S P Gabuzda T | 1997 | Am J Med Genet1997，69，2： | 1 |
| 20 | Altered wound healing in mice lacking a functional osteopontin gene(spp1)显示文摘 | Liaw L Birk DE Ballas CB | 1998 | J Clin Invest1998，101，7： | 1 |
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