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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review显示文摘BACKGROUND Gastrointestinal schwannomas are slow-growing benign mesenchymal neoplasms that originate from Schwann cells of the nerve sheath of Auerbach′s plexus or less frequently from Meissner′s plexus.The main differential diagnosis of gastric schwannomas are the gastrointestinal stromal tumors(GISTs),which are classified by their immunohistochemistry.The treatment of choice for gastric schwannomas is surgery where laparoscopy plays an important role.Wedge resection,subtotal or total gastrectomy can be done.In its counterpart,esophageal schwannomas are benign tumors of the esophagus that are very uncommon since they comprise less than 2%of all esophageal tumors.The main differential diagnosis is the leiomyoma which corresponds to the most common benign esophageal tumor,followed by GIST.The treatment consists on tumoral enucleation or esophagectomy.AIM To review the available literature about gastrointestinal schwannomas;especially lesions from de stomach and esophagus,including diagnosis,treatment,and follow up,as well as,reporting our institutional experience.METHODS A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines.The following databases were used for reviewing process:Pub Med,Ovid,MEDLINE,and Scopus.Only English language manuscripts were included.All gastrointestinal schwannomas specifically located in the esophagus and stomach were included.Cases that did not report long-term follow-up were excluded.RESULTS Gastric localization showed a higher prevalence in both,the literature review and our institution:94.95%(n=317)and 83%(n=5)respectively.With a follow-up with disease-free survival greater than 36 mo in most cases:62.01%(n=80)vs66.66%(n=4).In both groups,the median size was>4.1 cm.Surgical treatment is curative in most cases CONCLUSION Schwannoma must be taken into account in the differential diagnosis of gastrointestinal mesenchymal tumors.It has a good prognosis,and most are benign.A disease-free survival of more than 36 mo can be achieved by surgery. | Jesús Morales-Maza Francisco Ulises Pastor-Sifuentes Germán E Sánchez-Morales Emilio Sanchez-Garcia Ramos Oscar Santes Uriel Clemente-Gutiérrez Adriana Simoneta Pimienta-Ibarra Heriberto Medina-Franco | 2019 | World Journal of Gastrointestinal Oncology2019，11，9： | 7 |
| 3 | Performance Improvement of Artificial Neural Network Model in Short-term Forecasting of Wind Farm Power Output显示文摘Due to the low dispatchability of wind power,the massive integration of this energy source in power systems requires short-term and very short-term wind power output forecasting models to be as efficient and stable as possible.A study is conducted in the present paper of potential improvements to the performance of artificial neural network(ANN)models in terms of efficiency and stability.Generally,current ANN models have been developed by considering exclusively the meteorological information of the wind farm reference station,in addition to selecting a fixed number of time periods prior to the forecasting.In this respect,new ANN models are proposed in this paper,which are developed by:varying the number of prior 1-h periods(periods prior to the forecasting hour)chosen for the input layer parameters;and/or incorporating in the input layer data from a second weather station in addition to the wind farm reference station.It has been found that the model performance is always improved when data from a second weather station are incorporated.The mean absolute relative error(MARE)of the new models is reduced by up to 7.5%.Furthermore,the longer the forecasting horizon,the greater the degree of improvement. | Sergio Velázquez Medina Ulises Portero Ajenjo | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 6 |
| 4 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 5 | Fabrication of sharp silicon hollow microneedles by deep-reactive ion etching towards minimally invasive diagnostics显示文摘Microneedle technologies have the potential for expanding the capabilities of wearable health monitoring from physiology to biochemistry.This paper presents the fabrication of silicon hollow microneedles by a deep-reactive ion etching(DRIE)process,with the aim of exploring the feasibility of microneedle-based in-vivo monitoring of biomarkers in skin fluid.Such devices shall have the ability to allow the sensing elements to be integrated either within the needle borehole or on the backside of the device,relying on capillary filling of the borehole with dermal interstitial fluid(ISF)for transporting clinically relevant biomarkers to the sensor sites.The modified DRIE process was utilized for the anisotropic etching of circular holes with diameters as small as 30μm to a depth of>300μm by enhancing ion bombardment to efficiently remove the fluorocarbon passivation polymer.Afterward,isotropic wet and/or dry etching was utilized to sharpen the needle due to faster etching at the pillar top,achieving tip radii as small as 5μm.Such sharp microneedles have been demonstrated to be sufficiently robust to penetrate porcine skin without needing any aids such as an impact-insertion applicator,with the needles remaining mechanically intact after repetitive penetrations.The capillary filling of DRIE-etched through-wafer holes with water has also been demonstrated,showing the feasibility of use to transport the analyte to the target sites. | Yan Li Hang Zhang Ruifeng Yang Yohan Laffitte Ulises Schmill Wenhan Hu Moufeed Kaddoura Eric J.M.Blondeel Bo Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 6 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 7 | 稠油的成因、预测和深水开采——AAPG和AMGP稠油研讨会的回顾和技术摘要显示文摘 | Barry Jay Katz Javier J. Meneses-Rocha Ulises Herna'ndez-Romano 刘春(编译) 刘锐(校) | 2009 | 海洋地质动态2009，25，3： | 2 |
| 8 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 9 | Chinese Ocean Policies Towards the South China Sea in a Transitional Period, 1946-1952 显示文摘 | Ulises Granados | 2006 | The China Review2006，，： | 1 |
| 10 | Novel domino reactions in β-carbolines with triple bonded dienophiles显示文摘 | Alvaro G G Gema D Ulises A | 2008 | Tetrahedron Lett2008，49，38： | 1 |
| 11 | Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid显示文摘 | Ulises Garza-Ramos Humberto Barrios Maria Jose Hernandez-Vargas Teresa Rojas-Moreno Fernando Reyna-Flores Perla Tinoco Victor Othon Laurent Poirel Patrice Nordmann Vincent Cattoir Guillermo Ruiz-Palacios Jose Luis Fernandez Rosa Isela Santamaria Patricia | 2012 | Journal of Antimicrobial Chemotherapy2012，，7： | 1 |
| 12 | Oxygen transfer and mixing in mechanically agitated airlift bioreactors显示文摘 | Chisti Yu Ulises J HazaJa | 2002 | Biochemical Engineering Journal2002，10，： | 1 |
| 13 | Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid显示文摘 | Ulises G R Humberto B Maria Jose H V | 2012 | Antimicrob Chemother2012，67，7： | 1 |
| 14 | Fault diagnosis scheme for opencircuit faults in field-oriented control induction motor drives显示文摘 | Diego Rivelino Espinoza-Trejo Daniel Ulises Campos-Delgado Guillermo Bossio Ernesto Bárcenas JoséEnrique HernándezDíez Luis Felipe Lugo-Cordero | 2013 | IET Power Electroncis2013，6，5： | 1 |
| 15 | Effects of metoclopramide on gastric motility measured by short-term bio-impedance显示文摘AIM:To analyze the accuracy of short-term bio-impedance as a means of measuring gastric motility.METHODS: We evaluated differences in the short-term electrical bio-impedance signal from the gastric region in the following conditions: (1) fasting state, (2) after the administration of metoclopramide (a drug that induces an increase in gastric motility) and (3) after food ingestion in 23 healthy volunteers. We record-ed the real component of the electrical impedance signal from the gastric region for 1000 s. We performed a Fast Fourier Transform (FFT) on this data and then compared the signal among the fasting, medicated, and postprandial conditions using the median of the area under the curve, the relative area under the curve and the main peak activity.RESULTS: The median of the area under the curve of the frequency range in the region between 2-8 cycles per minute (cpm) decreased from 4.7 cpm in the fasting condition to 4.0 cpm in the medicated state (t=3.32, P=0.004). This concurred with the decrease seen in the relative area under the FFT curve in the region from 4 to 8 cpm from 38.3% to 26.6% (t=2.81, P=0.012) and the increase in area in the region from 2 to 4 cpm from 22.4% to 27.7%, respectively (t=-2.5, P=0.022). Finally the main peak position also decreased in the region from 2 to 8 cpm. Main peak activity in the fasting state was 4.72 cpm and declined to 3.45 cpm in the medicated state (t=2.47, P=0.025). There was a decrease from the fasting state to the postprandial state at 3.02 cpm (t=4.0, P=0.0013). CONCLUSION: Short-term electrical bio-impedance can assess gastric motility changes in individuals experiencing gastric stress by analyzing the area medians and relative areas under the FFT curve. | María-Raquel Huerta-Franco Miguel Vargas-Luna Kathleen M Capaccione Etna Yaez-Roldán Ulises Hernández-Ledezma Ismael Morales-Mata Teodoro Córdova-Fraga | 2009 | World Journal of Gastroenterology2009，15，38： | 1 |
| 16 | Friction stir welding of titanium alloy TiAI6V4 to aluminium alloy AA2024-T3 显示文摘 | Ulrike Dressier Gerhard Biallas Ulises Alfaro Mercado | 2009 | Materials Science and Engineering A2009，526，： | 1 |
| 17 | Coronary artery aneurysms and ectasia: role of coronary CT angiography显示文摘 | Mariana DZ Ulises BP Mary CHZ | 2009 | RadioGraphics2009，29，7： | 1 |
| 18 | Hepatic follicular dendritic cell sarcoma without epstein-barr vires expression显示文摘 | Ulises T William G Cristina R | 2005 | Arch Pathol Lab Med2005，129，11： | 1 |
| 19 | Concept Formation in WWTP by Means of Classification Techniques: A Compared Study显示文摘 | Miquel Sànchez Ulises Cortés Javier Béjar Joan De Grácia Javier Lafuente Manel Poch | 1997 | Applied Intelligence1997，，2： | 1 |
| 20 | A NEW CRYPTOGONIMID (DIGENEA) FROM THE MAYAN CICHLID, CICHLASOMA UROPHTHALMUS (OSTEICHTHYES: CICHLIDAE), IN SEVERAL LOCALITIES OF THE YUCATáN PENINSULA, MEXICO显示文摘 | Razo-Mendivil Ulises Rosas-Valdez Rogelio de León Gerardo Pérez-Ponce | 2008 | The Journal of Parasitology2008，，6： | 1 |
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