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| 1 | Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn’s disease显示文摘We report a case of jejunoileal intussusception in a 42-year-old patient with Crohn's disease caused by a gastrointestinal stromal tumor. The patient complained of vague diffuse abdominal pain for a period of 4 mo. Intussusception was suspected at computer tomography and magnetic resonance imaging scans. Segmental resection of the small intestine was performed. Pathological examination of the surgical specimen revealed a gastrointestinal stromal tumor as well as aphthous ulcerations and areas of inflammation, which were characteristic of Crohn's disease. This is the f irst report of small bowel intussusception due to a gastrointestinal stromal tumor coexisting with Crohn's disease. | George E Theodoropoulos Dimitrios Linardoutsos Dimitrios Tsamis Paraskevas Stamopoulos Dimitrios Giannopoulos Flora Zagouri Nikolaos V Michalopoulos | 2009 | World Journal of Gastroenterology2009，15，41： | 7 |
| 2 | The role of Helicobacter pylori infection in hematological disorders显示文摘 | Panagiotis Papagiannakis Christos Michalopoulos Fani Papalexi Despoina Dalampoura Michael D. Diamantidis | 2013 | European Journal of Internal Medicine2013，，： | 5 |
| 3 | Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARSCoV- 2 infection显示文摘Severe acute respiratory syndrome coronavirus-2 and the related coronavirus disease-19(COVID-19)is a worldwide emerging situation,which was initially reported in December 2019 in Wuhan,China.Currently,more than 7258842 new cases,and more than 411879 deaths have been reported globally.This new highly transmitted coronavirus is responsible for the development of severe acute respiratory distress syndrome.Due to this disorder,a great number of patients are hospitalized in the intensive care unit followed by connection to extracorporeal membrane oxygenation for breath supporting and survival.Severe acute respiratory distress syndrome is mostly accompanied by the secretion of proinflammatory cytokines,including interleukin(IL)-2,IL-6,IL-7,granulocyte colony-stimulating factor(GSCF),interferon-inducible protein 10(IP10),monocyte chemotactic protein-1(MCP1),macrophage inflammatory protein 1A(MIP1A),and tumor necrosis factor alpha(TNF-α),an event which is known as“cytokine storm”.Further disease pathology involves a generalized modulation of immune responses,leading to fatal multiorgan failure.Currently,no specific treatment or vaccination against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has been developed.Mesenchymal stromal cells(MSCs),which are known for their immunosuppressive actions,could be applied as an alternative co-therapy in critically-ill COVID-19 patients.Specifically,MSCs can regulate the immune responses through the conversion of Th1 to Th2,activation of M2 macrophages,and modulation of dendritic cells maturation.These key immunoregulatory properties of MSCs may be exerted either by produced soluble factors or by cell-cell contact interactions.To date,several clinical trials have been registered to assess the safety,efficacy,and therapeutic potential of MSCs in COVID-19.Moreover,MSC treatment may be effective for the reversion of ground-glass opacity of damaged lungs and reduce the tissue fibrosis.Taking into account the multifunctional properties of MSCs,the proposed stem-cell-based therapy may be proven significantly effective in critically-ill COVID-19 patients.The current therapeutic strategy may improve the patient’s overall condition and in parallel may decrease the mortality rate of the current disease. | Panagiotis Mallis Efstathios Michalopoulos Theofanis Chatzistamatiou Catherine Stavropoulos-Giokas | 2020 | World Journal of Stem Cells2020，12，8： | 2 |
| 4 | Financial innovation and endogenous growth显示文摘 | Luc Laeven Ross Levine Stelios Michalopoulos | 2013 | Journal of Financial Intermediation2013，，： | 2 |
| 5 | Efficient differentiation of vascular smooth muscle cells from Wharton's Jelly mesenchymal stromal cells using human platelet lysate: A potential cell source for small blood vessel engineering显示文摘BACKGROUND The development of fully functional small diameter vascular grafts requires both a properly defined vessel conduit and tissue-specific cellular populations.Mesenchymal stromal cells(MSCs) derived from the Wharton's Jelly(WJ) tissue can be used as a source for obtaining vascular smooth muscle cells(VSMCs),while the human umbilical arteries(h UAs) can serve as a scaffold for blood vessel engineering.AIM To develop VSMCs from WJ-MSCs utilizing umbilical cord blood platelet lysate.METHODS WJ-MSCs were isolated and expanded until passage(P) 4. WJ-MSCs were properly defined according to the criteria of the International Society for Cell and Gene Therapy. Then, these cells were differentiated into VSMCs with the use of platelet lysate from umbilical cord blood in combination with ascorbic acid,followed by evaluation at the gene and protein levels. Specifically, gene expression profile analysis of VSMCs for ACTA2, MYH11, TGLN, MYOCD, SOX9,NANOG homeobox, OCT4 and GAPDH, was performed. In addition,immunofluorescence against ACTA2 and MYH11 in combination with DAPI staining was also performed in VSMCs. HUAs were decellularized and served as scaffolds for possible repopulation by VSMCs. Histological and biochemical analyses were performed in repopulated h UAs.RESULTS WJ-MSCs exhibited fibroblastic morphology, successfully differentiating into'osteocytes', 'adipocytes' and 'chondrocytes', and were characterized by positive expression(> 90%) of CD90, CD73 and CD105. In addition, WJ-MSCs were successfully differentiated into VSMCs with the proposed differentiation protocol. VSMCs successfully expressed ACTA2, MYH11, MYOCD, TGLN and SOX9. Immunofluorescence results indicated the expression of ACTA2 and MYH11 in VSMCs. In order to determine the functionality of VSMCs, h UAs were isolated and decellularized. Based on histological analysis, decellularized h UAs were free of any cellular or nuclear materials, while their extracellular matrix retained intact. Then, repopulation of decellularized h UAs with VSMCs was performed for 3 wk. Decellularized h UAs were repopulated efficiently by the VSMCs. Biochemical analysis revealed the increase of total hydroyproline and s GAG contents in repopulated h UAs with VSMCs. Specifically, total hydroxyproline and s GAG content after the 1 st, 2 nd and 3 rd wk was 71 ± 10, 74 ± 9 and 86 ± 8 μg hydroxyproline/mg of dry tissue weight and 2 ± 1, 3 ± 1 and 3 ± 1μg s GAG/mg of dry tissue weight, respectively. Statistically significant differences were observed between all study groups(P<0.05).CONCLUSION VSMCs were successfully obtained from WJ-MSCs with the proposed differentiation protocol. Furthermore, h UAs were efficiently repopulated by VSMCs. Differentiated VSMCs from WJ-MSCs could provide an alternative source of cells for vascular tissue engineering. | Panagiotis Mallis Aggeliki Papapanagiotou Michalis Katsimpoulas Alkiviadis Kostakis Gerasimos Siasos Eva Kassi Catherine Stavropoulos-Giokas Efstathios Michalopoulos | 2020 | World Journal of Stem Cells2020，12，3： | 2 |
| 6 | Liver regeneration显示文摘 | Michalopoulos GK DeFrances MC | | 0，，： | 2 |
| 7 | Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistent Klebsiella pneumoniae in critically ill patients: a prospective evaluation显示文摘 | Michalopoulos A Virtzili S Rafailidis P | 2010 | Clin Microbiollnfect2010，16，2： | 1 |
| 8 | Liver regeneration显示文摘 | Michalopoulos GK | 2007 | J Cell Physiol2007，213，2： | 1 |
| 9 | Vehicle Detection Video Through Image Processing: The Autoscope System 显示文摘 | MICHALOPOULOS P G | 1991 | IEEE Trans on Vehicular Technology1991，40，1： | 1 |
| 10 | Liver regeneration 显示文摘 | Michalopoulos GK | 2007 | J Cell Physiol2007，213，2： | 1 |
| 11 | Corrosion of reinforcing steel and low cycle fatigue behaviour显示文摘 | APOSTOLOPOULOS C A MICHALOPOULOS D | 2007 | Materials andCorrosion2007，58，6： | 1 |
| 12 | Hepatocyte growth factor 显示文摘 | Michalopoulos GK Zarnegar R | 1992 | Hepatology1992，15，1： | 1 |
| 13 | Treatment of Acineto- bacter infeetions显示文摘 | Michalopoulos A Falagas M E | 2010 | Expert Opin Pharmacother2010，11，5： | 1 |
| 14 | Improved estimation of traffic flow for real-time control 显示文摘 | Stephanedes V J Michalopoulos P G Plum R A | 1981 | Trans- portation Research Record1981，，795： | 1 |
| 15 | Hepatocyte regeneration in acute fulminant and nonfulminant hepatitia:a study of proliferation cell nucier antigen expression显示文摘 | WOLF H K MICHALOPOULOS G K | 1992 | Hepatology1992，15，： | 1 |
| 16 | Liver regeneration显示文摘 | Michalopoulos GK DeFrances MC | 1997 | Sdence1997，276，： | 1 |
| 17 | Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation显示文摘 | Xia Jinglin Dai Chunsun Michalopoulos G K | 2006 | Am J Pathol2006，168，5： | 1 |
| 18 | Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells显示文摘 | Han C Michalopoulos GK Wu T | 2006 | J Cell Physiol2006，207，1： | 1 |
| 19 | β-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification显示文摘 | Satdarshan P.S. Monga Hardarshan K. Monga Xinping Tan Karen Mulé Peter Pediaditakis George K. Michalopoulos | 2003 | Gastroenterology2003，，1： | 1 |
| 20 | Submucosal Anoderm-Preserving Hemorrhoidectomy Revisited: A Modified Technique for the Surgical Management of Hemorrhoidal Crisis显示文摘 | Theodoropoulos George E Michalopoulos Nikolaos V Linardoutsos Dimitrios Flessas Ioannis Tsamis Dimitrios Zografos George | 2013 | The American Surgeon2013，，11： | 1 |
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