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| 1 | Mediterranean diet and nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet(MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and antioxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition. | Caterina Anania Francesco Massimo Perla Francesca Olivero Lucia Pacifico Claudio Chiesa | 2018 | World Journal of Gastroenterology2018，24，19： | 19 |
| 2 | 故宫藏乾隆朝漆纱隔心工艺探究显示文摘故宫乾隆花园符望阁一层明间南向宝座的栏杆罩镶嵌着一组精美绝伦貌如金纱窗的漆纱隔心。类似的隔扇装修不仅在故宫,甚至全国范围内也是独一无二的。符望阁保护修复过程中,发现漆纱隔心存在损毁严重、工艺失传、复制难度大等问题。为对该组漆纱进行研究,运用剖面显微分析、扫描电镜与能谱仪分析、显微红外光谱及多种色谱-质谱联用等实验室科技手段,明确了漆纱由内而外'织物纱芯-双面贴纸样-双面上漆贴金-双面纸样上施绘'四层基本结构关系,以及单侧14个亚层所用的无机、有机材料,为漆纱的保护和复制提供了科学依据。 | 李越 包嫒迪 BUCK Susan LLUVERAS-TENORIO Anna TAMBURINI Diego DEGANO Ilaria COLOMBINI Maria Perla | 2019 | 文物保护与考古科学2019，31，1： | 3 |
| 3 | Association of nonalcoholic fatty liver disease and liver cancer显示文摘AIM:To investigate the association between nonalcoholic fatty liver disease(NAFLD) and liver cancer,and NAFLD prevalence in different liver tumors.METHODS:This is a retrospective study of the clinical,laboratory and histological data of 120 patients diagnosed with primary or secondary hepatic neoplasms and treated at a tertiary center where they underwent hepatic resection and/or liver transplantation,with subsequent evaluation of the explant or liver biopsy.The following criteria were used to exclude patients from the study:a history of alcohol abuse,hepatitis B or C infection,no tumor detected in the liver tissue examined by histological analysis,and the presence of chronic autoimmune hepatitis,hemochromatosis,Wilson's disease,or hepatoblastoma.The occurrence of NAFLD and the association with its known risk factors were studied.The risk factors considered were diabetes mellitus,impaired glucose tolerance,impaired fasting glucose,body mass index,dyslipidemia,and arterial hypertension.Presence of reticulin fibers in the hepatic neoplasms was assessed by histological analysis using slide-mounted specimens stained with either hematoxylin and eosin or Masson's trichrome and silver impregnation.Analysis of tumor-free liver parenchyma was carried out to determine the association between NAFLD and its histological grade.RESULTS:No difference was found in the association of NAFLD with the general population(34.2% and 30.0% respectively,95%CI:25.8-43.4).Evaluation by cancer type showed that NAFLD was more prevalent in patients with liver metastasis of colorectal cancer than in patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma(OR = 3.99,95%CI:1.78-8.94,P < 0.001 vs OR = 0.60,95%CI:0.18-2.01,P = 0.406 and OR = 0.70,95%CI:0.18-2.80,P = 0.613,respectively).There was a higher prevalence of liver fibrosis in patients with hepatocellular carcinoma(OR = 3.50,95%CI:1.06-11.57,P = 0.032).Evaluation of the relationship between the presence of NAFLD,nonalcoholic steatohepatitis,and liver fibrosis,and their risk factors,showed no significant statistical association for any of the tumors studied.CONCLUSION:NAFLD is more common in patients with liver metastases caused by colorectal cancer. | Perla Oliveira Schulz Fabio Goncalves Ferreira Maria de Fátima Araújo Nascimento Andrea Vieira Mauricio Alves Ribeiro André Ibrahim David Luiz Arnaldo Szutan | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 4 | SARS-CoV-2 involvement in central nervous system tissue damage显示文摘As the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to spread globally,it became evident that the SARS-CoV-2 virus infects multiple organs including the brain.Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes.Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood,several theories have been suggested including direct and indirect pathways induced by the virus.One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route.Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells.Nevertheless,the indirect mechanisms,including blood-clotting abnormalities and prolonged activation of the immune system,can result in further tissue and organ damages seen during the course of the disease.This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients. | Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah HFarran Abdullah Shaito Esber SSaba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 5 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 6 | Fractalkine (CX3CLI) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signal induces aortic smooth muscle cell proliferation through an autocrine pathway 显示文摘 | Chandrasekar B Mummidi S Perla R P | 2003 | Biochem J2003，373，2： | 1 |
| 7 | Ultrasound-assisted lumbar plexus block in a patient with scoliosis显示文摘 | Factor D Perlas A | 2010 | Reg Aneath Pain Med2010，35，6： | 1 |
| 8 | Ultrasound-guided supr- aclavicular brachial plexus block 显示文摘 | Chan V W Perlas A Rawson R | 2003 | Anesth Analg2003，97，5： | 1 |
| 9 | Validation of a mathematical model for ultrasound assessment of gastric volume by gastroscopic examination显示文摘 | Perlas A Mitsakakis N Liu L | 2013 | Anesth Analg2013，116，2： | 1 |
| 10 | Genital Tract Infections, Bacterial Vaginosis, HIV, and Reproductive Health Issues among Lima-Based Clandestine Female Sex Workers显示文摘 | M. E. Perla Annette E. Ghee Sixto Sánchez R. Scott McClelland Annette L. Fitzpatrick Luis Suárez-Ognio Javier R. Lama Jorge Sánchez Gregory T. Spear | 2012 | Infectious Diseases in Obstetrics and Gynecology2012，，： | 1 |
| 11 | Structure, stability and activity of RuSz supported on alumina 显示文摘 | Perla C V Ramireza J Maug6 F | 2008 | J Catal2008，260，： | 1 |
| 12 | Biological recycling of used baby diapers in a small-scale composting system显示文摘 | Rosa M. Espinosa-Valdemar Perla X. Sotelo-Navarro Xochitl Quecholac-Pi?a Mariel A. García-Rivera Margarita Beltrán-Villavicencio Sara Ojeda-Benítez Alethia Vázquez-Morillas | 2014 | Resources, Conservation & Recycling2014，，： | 1 |
| 13 | The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration显示文摘 | Gurniak C B Perlas E Witke W | 2005 | Dev Biol2005，278，1： | 1 |
| 14 | Ultrasound-guided supracla- vicular brachial plexus block 显示文摘 | Chan VW Perlas A Rawson R | 2003 | Anesth Analg2003，97，5： | 1 |
| 15 | Ultrasound guidance improves success rate of axillary brachial plexus block显示文摘 | CHAN V W PERLAS A MCCARTNEY C J | 2007 | Can J Anaesth2007，54，3： | 1 |
| 16 | Household dietary strategies to enhance the content and bioavailability of iron,zinc and calcium of selectedrice-and maize-based Phillippine complementary foods显示文摘 | Perlas L.A Gibson R.S | | 0，，04： | 1 |
| 17 | Ultrasound-guided supraclavicular block:outcome of 510 consecutive cases显示文摘 | Perlas A Lobo G Lo N | 2009 | Reg Anesth Pain Med2009，34，2： | 1 |
| 18 | Complexation of Cu(II) ions with the lowest generation poly(amidoamine) -OH dendrimers: A molecular simulation study 显示文摘 | Francisco T V Perla B Balbuena | 2005 | Phys Chem B2005，109，12： | 1 |
| 19 | Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid显示文摘 | Ulises Garza-Ramos Humberto Barrios Maria Jose Hernandez-Vargas Teresa Rojas-Moreno Fernando Reyna-Flores Perla Tinoco Victor Othon Laurent Poirel Patrice Nordmann Vincent Cattoir Guillermo Ruiz-Palacios Jose Luis Fernandez Rosa Isela Santamaria Patricia | 2012 | Journal of Antimicrobial Chemotherapy2012，，7： | 1 |
| 20 | Brachial plexus examination and localization using ultrasound and electrical stimulation:a volunteer study显示文摘 | Perlas A Chan VW Simons M | 2003 | Anesthesiology2003，99，2： | 1 |
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