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| 1 | Apolipoprotein J as a predictive biomarker for restenosis after carotid endarterectomy: a retrospective study显示文摘颈动脉 endarterectomy (CEA ) 是为在大多数病人的击预防的一种有效外科的选择。在 CEA 以后的狭窄能导致重新干预和不利事件,但是预言狭窄的因素糟糕被理解。Apolipoprotein J (ApoJ ) 被认为是脉管的狭窄的一个新奇预兆的因素并且与与动脉粥样硬化和房间周期阶段有关的很多过程被联系。这研究的目的是阐明在内部颈动脉动脉(集成通信适配器) 的 Apo J 的预兆的价值狭窄追随者 CEA。都检验的这回顾的研究有希望地为在一个 2 年的时期上在我们的外科的部门经历了 CEA 的病人收集了数据。100 个病人的浆液 ApoJ 层次被检验;经历了 CEA 的 56 个病人包括了脉管的组(VG ) ,并且经历了次要的外科的 44 个病人包括了控制组(CG ) 。ApoJ 样品外科手术前地被获得,在外科的过程以后并且在 1, 6 和 12 个月的 24 h 此后在后续期间。在在 CG 和 VG 之间的 ApoJ 层次的外科手术前的差别是统计上 signifcant;吝啬的价值是 39.11 并且每个方法的能力在正常之间区别吗?? | Anastasios MASKANAKIS Nikolaos PATELIS Georgios KARAOLANIS Spyridon DAVAKIS Dimitrios SCHIZAS Despina PERREA Chris KLONARIS Sotirios GEORGOPOULOS Theodoros LIAKAKOS Chris BAKOYIANNIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 6 |
| 2 | Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity显示文摘AIM: Acute hepatitis may seldom have a fulminant course.In the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 post-HCTx.RESULTS: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (PAB<0.05, PAc<0.05, P80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation. | Charalampos Pilichos Despina Perrea Maria Demonakou Athena Preza Ismini Donta | 2004 | World Journal of Gastroenterology2004，10，14： | 2 |
| 3 | Biomechanical characteristics of bone in streptozotocin-induced diabetic rats:An in-vivo randomized controlled experimental study显示文摘AIM: To investigate the in vivo effects of type Ⅰdiabetes on the mechanical strength of tibial bone in a rodent model.METHODS: The biomechanical effect of diabetes on the structural integrity of the tibia in streptozotocin induced diabetic Wistar rats was analysed. Induction of diabetes was achieved by an intra-peritoneal injection and confirmed by measuring serial blood glucose levels(> 150 mg/d L). After 8 wk the tibiae were harvested and compared to a control group. Biomechanical analysis of harvested tibiae was performed using a threepoint bending technique on a servo hydraulic MTS 858 MiniB ionix frame. Maximum force applied to failure(N), stiffness(N × mm) and energy absorbed(N/mm) were recorded and plotted on load displacement curves. A displacement control loading mode of 1 mm/min was selected to simulate quasi-static loading conditions. Measurements from load-displacement curves were directly compared between groups.RESULTS: Fourteen streptozotocin induced diabetic Wistar rats were compared against nineteen non-diabetic controls. An average increase of 155.2 g in body weight was observed in the control group compared with only 5 g in the diabetic group during the experimental study period. Levels of blood glucose increased to 440.25 mg/d L in the diabetic group compared to 116.62 mg/d L in the control group.The biomechanical results demonstrate a highly significant reduction in the maximum load to failure from 69.5 N to 58 N in diabetic group compared to control(P = 0.011). Energy absorption to fracture was reduced from 28.2 N in the control group to 23.5 N in the diabetic group(P = 0.082). No significant differences were observed between the groups for bending stiffness.CONCLUSION: Streptozotocin-induced diabetes in rodents reduces the maximum force and energy absorption to failure of bone, suggesting a predisposition for fracture risk. | Nektarios Korres Eleftherios Tsiridis George Pavlou Athanasios Mitsoudis Despina N Perrea Aristedes B Zoumbos | 2013 | World Journal of Orthopedics2013，4，3： | 2 |
| 4 | Matrixmetalloproteinases and diabetic vascular complications 显示文摘 | Kadoglou N P Daskalopoulou S S Perrea D | 2005 | Angiology2005，56，2： | 1 |
| 5 | Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes显示文摘 | Kadoglou NP Perrea D Iliadis F | | 0，，3： | 1 |
| 6 | Carotid artery athemsclerosis: what is the evidence for drug action? 显示文摘 | Daskalopoulou SS Daskalopoulos ME Perrea D | 2007 | Curt Pharm Des2007，13，11： | 1 |
| 7 | Effects of lipid-lowering drugs on adiponeetin显示文摘 | Perelas A Tsoulkani A Perrea D | 2010 | Chn' Vase Pharmaeol2010，8，6： | 1 |
| 8 | Carotid artery athemsclerosis:what is the evidence for drug action显示文摘 | Daskalopoulou SS Daskalopoulos ME Perrea D | 2007 | Curr Pharm Des2007，13，11： | 1 |
| 9 | Assessment of Prealbumin in Hemodialysis and Renal-Transplant Patients显示文摘 | Stavroula Chrysostomou Chalalambos Stathakis George Petrikkos George Daikos Athina Gompou Despina Perrea | 2010 | Journal of Renal Nutrition2010，，1： | 1 |
| 10 | 白细胞端粒长度缩短较动脉粥样硬化的临床表现提前出现:血液和肌肉模型显示文摘白细胞端粒长度与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)相关。目前还不清楚这种关系是否源于出生时天生较短的白细胞端粒长度(leukocy tetelomere length,LTL)和(或)之后较快的LTL消耗。LTL代表高增殖性造血系统中的端粒长度,而骨骼肌中的端粒长度(muscle tetelomere length,MTL)代表最低限度复制的组织。 | Benetos A Toupance S Gautier S Labat C Kimura M Rossi PM Settembre N Hubert J Frimat L Bertrand B Boufi M Flecher X Sadoul N Eschwege P Kessler ML Tzanetakou IP Doulamis IP Konstantopoulos PS Tzani AI Korou LM Gkogkos A Perreas KG Menenakos E Samanidis G Vasiloglou-Gkanis M Kark JD Malikov S Verhulst S Aviv A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，1： | 1 |
| 11 | Relationship of changes in Cystatin-C with serum ereatinine and estimat- ed glomerular fihration rate in kidney transplantation 显示文摘 | Gompou A Perrea D Karatzas T | 2015 | Transplant Proe2015，47，6： | 1 |
| 12 | Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes 显示文摘 | Kadoglou NP Perrea D Iliadis F | 2007 | Diabetes Care2007，30，3： | 1 |
| 13 | Exercise re- duces resistin and inflammatory cytokines in patients with type 2 diabetes显示文摘 | KADOGLOU N P PERREA D ILIADIS F | 2007 | Diabetes Care2007，30，3： | 1 |
| 14 | Virtual reality simulators and training in laparoseopic surgery 显示文摘 | Yiannakopoulou E Nikiteas N Perrea D | 2015 | Int J Surg2015，13，： | 1 |
| 15 | Correlation between lipid abnormalities and immunosuppressive therapy in renal transplant recipients with stable renal function显示文摘 | Perrea DN Moulakakis KG Poulakou MV | 2008 | Int Urol Nephrol2008，40，2： | 1 |
| 16 | Effect of laparoscopic surgery on oxidative stress response:systematic review显示文摘 | Yiannakopoulou ECh Nikiteas N Perrea D | 2013 | Surg Laparosc Endosc Percutan Tech2013，23，2： | 1 |
| 17 | Relationship of changes in cystatin-C with serum creatinine and estimat- ed glomerular filtration rate in kidney transplantation 显示文摘 | Gompou A Perrea D Karatzas T | 2015 | Transplant Proc2015，47，6： | 1 |
| 18 | Masked hypertension and atherogenesis:the impact on adiponectin and resistin plasma levels显示文摘 | Papadopoulos DP Perrea D Thomopoulos C | 2009 | J Clin Hypertens(Greenwich)2009，11，2： | 1 |
| 19 | Correlation between lipid abnormalities and immunosuppressive therapy in renal transplant recipients with stable renal function显示文摘 | Perrea DN Moulakakis KG Poulakou MV | 2008 | Int Urol Nephrol2008，40，2： | 1 |
| 20 | Correlation between lipid abnormalities and immunosuppressive therapy in renal transplant recipients with stable renal function显示文摘 | Perrea DN Moulakakis KG Poulakou MV | 2008 | Int Urol Nephrol2008，40，4： | 1 |
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