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| 1 | Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells显示文摘The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin,a polymer of N-acetylglucosamine.Chitin is the structural component of fungi,crustaceans,insects and parasitic nematodes,but is completely absent in mammals.Exposure to antigens containing chitin-or chitin-like structures sometimes induces strong T helper type-I responses in mammals,which may be associated with the induction of mammalian chitinases.Chitinase 3-like-1(CHI3L1) ,a member of the mammalian chitinase family,is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease,hepatitis and asthma.In addition,CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma,colon cancer,breast cancer and malignant melanoma.Although the exact function of CHI3L1 in inflammation and cancer is still largely unknown,CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix.CHI3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling pathways.Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells. | Katrin Eurich Mayuko Segawa Satoko Toei-Shimizu Emiko Mizoguchi | 2009 | World Journal of Gastroenterology2009，15，42： | 9 |
| 2 | 越南山茶×金花茶杂交种的子叶培养显示文摘开黄花的金花茶C,Chrysantha(二倍体)与其他物种的种间杂交,在用种子培育杂交种植株上的尝试己被证明是不成功的在我们的杂交试验中,将越南山茶(六倍体)和金花茶进行五次人工控制授粉处理,成功地获得了含有三粒可育的种子的两个成熟蒴果。将这些可育的种子的成熟子叶置于BA3mg/L+NAA1.0mg/L的MS培养基上进行离体培养,经过六个月时间的缓慢增殖,把它转移到椰乳10%+GA_3 1mg/L的MS培养基上,子叶表面形成大量的浅黄色或浅绿色的芽点。这些发生出来的芽只有4.3%(6/138)形成5厘米以上的带叶小植株发育成苗。由根的分生细胞的核形态特征可以看出,这此新生植株是越南山茶和金花茶的杂交种。 | SHINSAKU NADAMITSU YOSHIAKI ANDOH KATSUHIKO KONDO NICHIHARU SEGAWA 薛原 | 1991 | 广西林业科技1991，20，4： | 5 |
| 3 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 4 | The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells显示文摘 | Kaoru Mitsui Yoshimi Tokuzawa Hiroaki Itoh Kohichi Segawa Mirei Murakami Kazutoshi Takahashi Masayoshi Maruyama Mitsuyo Maeda Shinya Yamanaka | 2003 | Cell2003，，5： | 3 |
| 5 | The Main Progress of Perovskite Solar Cells in 2020-2021显示文摘Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the world.Both the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by step.This review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free PSCs.Moreover,a brief discussion on the development of PSC modules and its challenges toward practical application is provided. | Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 6 | The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells显示文摘 | Kaoru Mitsui Yoshimi Tokuzawa Hiroaki Itoh Kohichi Segawa Mirei Murakami Kazutoshi Takahashi Masayoshi Maruyama Mitsuyo Maeda Shinya Yamanaka | 2003 | Cell2003，，5： | 2 |
| 7 | How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living‐donor liver transplantation: strategy for donor safety with a smaller‐size graft and excellent recipient results显示文摘 | Tomohide Hori Yasuhiro Ogura Kohei Ogawa Toshimi Kaido Hajime Segawa Hideaki Okajima Takayuki Kogure Shinji Uemoto | 2012 | Clin Transplant2012，，3： | 2 |
| 8 | 从灾后应急处理反思防灾医院建筑的设计——以日本石卷红十字医院为例显示文摘2011年3月11日东日本发生大地震,石卷市震度为6级弱,并且市中心受到海啸侵袭。石卷红十字医院有幸没有受到海水的侵袭,并作为防灾据点医院发挥了积极的作用。防灾据点病院是日本灾害发生时医疗救援活动的中心医院。主要为重症患者提供急救医疗、向受灾地派遣医疗救援队和借贷应急救援医疗器械三项任务。本文记录了石卷红十字医院是如何在灾害时继续医疗活动的,并对医院建筑及设备设置进行总结和反思。 | 濑川宽 SEGAWA Yutaka | 2015 | 中国医院建筑与装备2015，16，11： | 2 |
| 9 | Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population显示文摘 | Masahide Nagano Motoyuki Nakamura Kenyu Sato Fumitaka Tanaka Toshie Segawa Katsuhiko Hiramori | 2004 | Atherosclerosis2004，，1： | 2 |
| 10 | Skull metastasis from hepatocellular carcinoma with chronic hepatitis B显示文摘A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver.Magnetic resonance imaging showed bone metastasis in the thoracic vertebrae.Assays for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade A.Our diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis B.He was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for HCC.But he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and died.Dissection showed HCC with multiple bone metastases.The liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular type.In the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting plates.Piecemeal necrosis was not obvious.No fibrosis was noted.An 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial bone.The lesion was osteolytic and showed invasion into the dura mater.Neither the subdural cavity nor the brain showed involvement from the metastatic tumor.However,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of life.Therefore,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC. | Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 2 |
| 11 | One-Pot Room-Temperature Synthesis of Mg Containing MCM-41 Mesoporous Silica for Aldol Reactions显示文摘One-pot synthesis of Mg containing MCM-41(Mg-MCM-41) materials was respectively carried out by a room temperature(RT) method and a hydrothermal(HT) method for aldol condensation of 4-nitrobenzaldehyde and acetone and self-condensation of acetone. The RT method can prepare MCM-41 materials containing large amounts of Mg while maintaining the structural characteristics of MCM-41 even at very low Si/Mg ratios(large Mg loadings), but the HT method cannot. The RT method can also give more active catalysts than the HT method, because the catalysts prepared by the RT method are more basic than those prepared by the HT one. The characterization indicates that Mg atoms in the Mg-MCM-41 prepared by the RT method exist as MgO disperses well on the wall surface of pores, while those in Mg-MCM-41 prepared by the HT method are included in the bulk with a smectite-like structure. | Shin-Ichiro Fujita Shinji Segawa Kazuki Kawashima Xuejing Nie Tomoki Erata Masahiko Arai | 2018 | Journal of Materials Science & Technology2018，34，12： | 2 |
| 12 | Ultraviolet spontaneous and stimulated emissions from ZnO microcrystallite thin films at room temperature显示文摘 | P. Zu Z.K. Tang G.K.L. Wong M. Kawasaki A. Ohtomo H. Koinuma Y. Segawa | 1997 | Solid State Communications1997，，8： | 2 |
| 13 | A clinicopathologic study of gastric mucosa-associated lymphoid tissue lymphoma显示文摘 | SEGAWA K OKAMURA S | 2000 | Cancer2000，88，10： | 1 |
| 14 | Visfatin in adipocytes is upregulated by hypoxia through HIF1 alpha-dependent mechanism显示文摘 | Segawa K Fukuhara A Hosogai N | 2006 | Biocbem Biophys Res Commun2006，349，3： | 1 |
| 15 | Rapid quantitation of immunog-lobulin G antibodiesspecific for blood group antigens A and B by surface plasmon resonance显示文摘 | Kimura S Yurugi K Segawa H | 2005 | Transfusion2005，45，： | 1 |
| 16 | Removal of the VegetationEffect from LANDSAT TM and GER Imaging SpectroradiometerData显示文摘 | Okada K Segawa K Hayashi I | 1993 | ISPRS Journal of Photogrammetry and Remote Sensing1993，48，6： | 1 |
| 17 | The role of the phrenic nerves in stress response in upper abdominal surgery 显示文摘 | Segawa H Mori K Kasai K | 1996 | Anesth Analg1996，82，： | 1 |
| 18 | Aromatase expression in stromal cells of endometrioid endometrial cancer correlates with poor survival显示文摘 | Segawa T Shozu M Murakami K | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 19 | Expressioncloning and characterization of a transporter for largeneutral amino acids activated by the heavy chain of 4F2antigen (CD98)显示文摘 | Kanai Y Segawa H Miyamoto Ki | 1998 | J Biol Chem1998，273，23： | 1 |
| 20 | Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity显示文摘 | SEGAWA H FUKASAWA Y MIYAMOTO K | 1999 | J Biol Chem1999，274，19： | 1 |
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