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| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 3 | Predictive value and main determinants of abnormal features of intraoperative cholangiography during cholecystectomy显示文摘BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a routine diagnostic procedure.The current study aimed to address the main determinants of CBD stone diagnosis in IOC among an Iranian population.METHODS:In a retrospective review database-based study conducted in Taleghani Hospital in Tehran between 2006 and 2008,baseline data and perioperative information of 2060 patients (male to female ratio 542:1518,mean age 53.7 years) who were candidates for cholecystectomy and underwent concomitant IOC for confirming CBD stones were reviewed.The predictive power of this procedure for diagnosis of abnormal biliary ducts with the focus on biliary stones was determined.RESULTS:Overall mortality and morbidity following cholecystectomy in the study population were 0.6% and 2.6%,respectively.Both early mortality and morbidity due to cholecystectomy were higher in male than female.The prevalence of CBD stones in IOC was 3.4% (5.2% in male and 2.8% in female,P=0.008).Among those without gallstones,8.7% had CBD stones and only 3.1% had concomitant gallstones and CBD stones.The main predictors of stone appearance as an abnormal feature of IOC during cholecystectomy were:advanced age (OR=1.022,P=0.001),male gender (OR=1.498,P=0.050),history of abdominal surgery (OR=1.543,P=0.040) and preoperative endoscopic retrograde cholangiopancreatography (OR=5.400,P<0.001).CONCLUSIONS:IOC is a safe and accurate method for the assessment of bile duct anatomy and stones.Therefore,the routine use of IOC within cholecystectomy seems reasonable and is recommended. | Shahram Yousefpour Azary Heshmat Kalbasi Ali Setayesh Mirhadi Mousavi Asad Hashemi Mahsa Khodadoostan Mohammad Reza Zali Amir Houshang Mohammad Alizadeh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 11 |
| 4 | TIRAP rs8177374 gene polymorphism increased the risk of pulmonary tuberculosis in Zahedan,southeast Iran显示文摘Objective:To evaluate the possible association between Toll-interleukin 1 receptor(TIR) domain containing adaptor protein(TIRAP;also known as MAI.) rsl893352 and rs8l77374(S180L) gene polymorphisms and pulmonary tuberculosis(PTB) in a sample of Iranian population.Methods:This case-control study was performed on 174 PTB and 177 healthy subjects.Tetra amplification refractory mutation systetn-polymerase chain reaction(T-AKMS-PCR) was used to detect the polymorphisms.Results:Our finding showed that neither the overall Ckisqaare comparison of PTB and control subjects nor the logistic regression analysis indicated any association between rsl893352 polymorphism and PTB.Regarding rs8l77374 polymorphism,the CT genotype as well as CT+TT increased the risk of PTB in comparison with CC genotype(OR=4.73,95%CI=2.65-8.45,P<0.0001 and OR=6.47,95%C1=3.68-11.38,P<0.0001.respectively).The rs8177374 T allele increased the risk of PTB in comparison with C allele(OR=4.21.95%CI=2.43-7.26,P<0.0001).Conclusions:Our finding indicates that TIRAP rs8177374 polymorphism is associated with PTB in a sample of Iranian population. | Mohammad Naderi Mohammad Hashemi Zahra Pourmontaseri Ebrahim Eskari-Nasab Gholamreza Bahari Mohsen Taheri | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，6： | 8 |
| 5 | Scientific and technical aspects of yogurt fortification:A review显示文摘Food fortification is one of the most important processes for improvement of the nutrients quality and quantity in food.It can be a very cost effective public health intervention.Due to the high consumption rate of dairy products such as yogurt,fortification of these products will effectively reduce or prevent diseases associated with nutritional deficiencies.The aim of this investigation is to study the technical aspects involved in production of different types of fortified yogurts and their role in disease prevention and correction of deficiencies.In this paper,firstly,fortification is defined and the main reasons behind carrying out this process are presented and then yogurt production process and a variety of minerals,vitamins,and functional ingredients which are used in the process are briefly discussed.©2015 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Hadi Hashemi Gahruie Mohammad Hadi Eskandari Gholamreza Mesbahi Mohammad Amin Hanifpour | 2015 | Food Science and Human Wellness2015，4，1： | 7 |
| 6 | The Effects of Multistrain Probiotic Compound on Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo‐Controlled Triple‐Blind Study显示文摘 | Ahmad Shavakhi Elham Tabesh Arezoo Yaghoutkar Houriye Hashemi Faezeh Tabesh Mahsa Khodadoostan Mohammad Minakari Sara Shavakhi Ali Gholamrezaei | 2013 | Helicobacter2013，，4： | 6 |
| 7 | Synthesis and antibacterial activity of Schiff bases of 5-substituted isatins显示文摘Based on the existing reports on the bioactive isatin derivatives, a number of Schiff bases were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and their structures were confirmed using spectroscopic methods such as NMR, IR and mass spectrometry. Furthermore, Nbenzylation of isatin followed by the Schiff base formation furnished a new series of compounds(11a–13c) which allowed the analysis of the effect of isatin N-substitution on the bioactivity of the resulting compounds. The antibacterial activity of the synthesized derivatives was evaluated using a microtiter plate method on a series of gram positive and gram negative bacterial strains. Compounds 2d, 3b, 5c and 6a were among the most potent derivatives against Pseudomonas aeruginosa(MIC = 6.25 μg/m L).Analysis of the structure–activity relationship showed that the incorporation of(thio)urea-based Schiff bases lead to more potent derivatives with a broader spectrum of antibacterial activity. In addition,highly lipophilic compounds such as 11a–12c did not show any measurable antibacterial activity, which implies that an optimal lipophilicity might be an important requirement for the antibacterial activity of the studied isatins. Finally, the finding that hydantoin derivatives of N-benzylisatins(13a–13c) still exhibit some antibacterial activity prompted us to consider exploring the bioactivity of more diverse derivatives of isatin-aminohydantoin Schiff bases(compounds 1a–1d) in our future studies. | Kamaleddin Haj Mohammad Ebrahim Tehrani Maryam Hashemi Maryam Hassan Farzad Kobarfard Shohreh Mohebbi | 2016 | Chinese Chemical Letters2016，27，2： | 6 |
| 8 | 径向压力辅助充液拉深锥形杯的工艺窗口图(英文)显示文摘起皱和破裂是锥形杯成形过程中的主要缺陷。径向压力辅助充液拉深是一步成形筒形件的板材液压成形技术。获得了径向压力辅助充液拉深Al1050-O、纯铜和DIN1623 St14钢板的工艺窗口图。该工艺窗口图可快速评估板材液压成形零件的可制造性。采用有限元方法对径向压力辅助充液拉深进行模拟,并研究压力路径和原始材料及其厚度的影响。通过实验对模拟结果进行验证。结果表明:对于初始厚度较薄和强度较高的板材,其成形性更好,最终产品的的厚度分布也更均匀。所得工艺窗口图可以预测在不同加载路径下合适的加工区间以及破裂或起皱的可能性。 | Abbas HASHEMI Mohammad HOSEINPOUR GOLLO S.M.Hossein SEYEDKASHI | 2015 | Transactions of Nonferrous Metals Society of China2015，25，9： | 4 |
| 9 | The influence of peroxisome proliferator-activated receptor γ 1 during differentiation of mouse embryonic stem cells to neural cells显示文摘 | Ali Ghoochani Khadijeh Shabani Maryam Peymani Kamran Ghaedi Fereshteh Karamali Khadijeh Karbalaei Somayeh Tanhaie Ahmad Salamian Abolghasem Esmaeili Sadegh Valian-Borujeni Mehrdad Hashemi Mohammad Hossein Nasr-Esfahani Hossein Baharvand | 2011 | Differentiation2011，，1： | 2 |
| 10 | Enhanced oil recovery from carbonate reservoirs by spontaneous imbibition of low salinity water显示文摘An experimental study was performed to investigate the impact of low salinity water on wettability alteration in carbonate core samples from southern Iranian reservoirs by spontaneous imbibition. In this paper, the effect of temperature, salinity,permeability and connate water were investigated by comparing the produced hydrocarbon curves. Contact angle measurements were taken to confirm the alteration of surface wettability of porous media. Oil recovery was enhanced by increasing the dilution ratio of sea water, and there existed an optimum dilution ratio at which the highest oil recovery was achieved. In addition, temperature had a very significant impact on oil recovery from carbonate rocks. Furthermore, oil recovery from a spontaneous imbibition process was directly proportional to the permeability of the core samples. The presence of connate water saturation inside the porous media facilitated oil production significantly. Also, the oil recovery from porous media was highly dependent on ion repulsion/attraction activity of the rock surface which directly impacts on the wettability conditions. Finally, the highest ion attraction percentage was measured for sodium while there was no significant change in pH for all experiments. | Mohammad Reza Zaeri Rohallah Hashemi Hamidreza Shahverdi Mehdi Sadeghi | 2018 | Petroleum Science2018，15，3： | 2 |
| 11 | Review of recycling waste plastics in asphalt paving materials显示文摘An ever-growing demand for depleted natural resources is one of the significant challenges facing the global asphalt pavement industry in building and maintaining global asphalt pavements.Because plastics are ubiquitous in the global economy,they are the latest in a series of high-profile materials to attract attention.Their low material recovery rates and the environmental impact of current disposal methods pose a threat to plastic recycling.Recycling plastic wastes in asphalt pavement is a possible approach to reducing environmental pressure and the demand for depleted natural resources.Many studies have proposed recycling plastic waste in asphalt pavement using dry-and wet-processed technologies.This review aims to comprehensively evaluate the feasibility of various recycled plastics in asphalt pavement concerning the properties of compatibility,storage stability,microstructure,thermo-rheology,and mechanical performance and to identify hallenges and recommendations for the future.This review discusses recent developments and the feasibility of using plastic wastes as modifiers or additives to asphalt binders or asphalt mixtures in dry and wet processes,focusing on different materials from waste streams,how to produce such modified materials,and the characteristics of plastic waste modified asphalt,thus contributing to the sustainable management of resources and production of useful paving materials. | Lingyun You Zhengwu Long Zhanping You Dongdong Ge Xu Yang Fu Xu Mohammad Hashemi Aboelkasim Diab | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，5： | 2 |
| 12 | The Effects of Multistrain Probiotic Compound on Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo‐Controlled Triple‐Blind Study显示文摘 | Ahmad Shavakhi Elham Tabesh Arezoo Yaghoutkar Houriye Hashemi Faezeh Tabesh Mahsa Khodadoostan Mohammad Minakari Sara Shavakhi Ali Gholamrezaei | 2013 | Helicobacter2013，，4： | 2 |
| 13 | Digital spiral object identification using random light显示文摘Photons that are entangled or correlated in orbital angular momentum have been extensively used for remote sensing,object identification and imaging.It has recently been demonstrated that intensity fluctuations give rise to the formation of correlations in the orbital angular momentum components and angular positions of random light.Here we demonstrate that the spatial signatures and phase information of an object with rotational symmetries can be identified using classical orbital angular momentum correlations in random light.The Fourier components imprinted in the digital spiral spectrum of the object,as measured through intensity correlations,unveil its spatial and phase information.Sharing similarities with conventional compressive sensing protocols that exploit sparsity to reduce the number of measurements required to reconstruct a signal,our technique allows sensing of an object with fewer measurements than other schemes that use pixel-by-pixel imaging.One remarkable advantage of our technique is that it does not require the preparation of fragile quantum states of light and operates at both low-and high-light levels.In addition,our technique is robust against environmental noise,a fundamental feature of any realistic scheme for remote sensing. | Zhe Yang Omar S Magaña-Loaiza Mohammad Mirhosseini Yiyu Zhou Boshen Gao Lu Gao Seyed Mohammad Hashemi Rafsanjani Gui-Lu Long Robert W Boyd | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 14 | The neuroprotective effect of olive leaf extract is related to improved blood–brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia显示文摘 | Fatemeh Mohagheghi Mohammad Reza Bigdeli Bahram Rasoulian Payman Hashemi Marzyeh Rashidi Pour | 2010 | Phytomedicine2010，，2： | 1 |
| 15 | A GIS-based time-dependent seismic source modeling of Northern Iran显示文摘The first step in any seismic hazard study is the definition of seismogenic sources and the estimation of magnitude-frequency relationships for each source.There is as yet no standard methodology for source modeling and many researchers have worked on this topic.This study is an effort to define linear and area seismic sources for Northern Iran.The linear or fault sources are developed based on tectonic features and characteristic earthquakes while the area sources are developed based on spatial distribution of small to moderate earthquakes.Time-dependent recurrence relationships are developed for fault sources using renewal approach while time-independent frequency-magnitude relationships are proposed for area sources based on Poisson process.GIS functionalities are used in this study to introduce and incorporate spatialtemporal and geostatistical indices in delineating area seismic sources.The proposed methodology is used to model seismic sources for an area of about 500 by 400 square kilometers around Tehran.Previous researches and reports are studied to compile an earthquake/fault catalog that is as complete as possible.All events are transformed to uniform magnitude scale; duplicate events and dependent shocks are removed.Completeness and time distribution of the compiled catalog is taken into account.The proposed area and linear seismic sources in conjunction with defined recurrence relationships can be used to develop time-dependent probabilistic seismic hazard analysis of Northern Iran. | Mahdi Hashemi Ali Asghar Alesheikh Mohammad Reza Zolfaghari | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 1 |
| 16 | Evaluation of UDP-glucuronosyltransferase 2B17 (UGT2B17) and dihydrofolate reductase (DHFR) genes deletion and the expression level of NGX6 mRNA in breast cancer显示文摘 | Ebrahim Eskandari-Nasab Mohammad Hashemi Hamzeh Rezaei Aliakbar Fazaeli Mohammad Ali Mashhadi Simin Sargholzaei Moghaddam Farshid Arbabi Mahdi Jahantigh Mohsen Taheri | 2012 | Molecular Biology Reports2012，，： | 1 |
| 17 | The Distribution of Corneal Thickness in a 40- to 64-Year-Old Population of Shahroud, Iran显示文摘 | Hassan Hashemi Soheila Asgari Shiva Mehravaran Mohammad Hassan Emamian Mohammad Shariati Akbar Fotouhi | 2011 | Cornea2011，，12： | 1 |
| 18 | Toll-like Receptor 1 Polymorphisms Increased the Risk of Pulmonary Tuberculosis in an Iranian Population Sample显示文摘A case-control study was carried out that involved 203 individuals diagnosed with pulmonary tuberculosis (PTB) and 203 healthy subjects. Genotyping of TLR1 rs5743551 and rs5743618 polymorphisms was done using polymerase chain reaction-restriction fragments length polymorphism assay. We found that TLR1 rs5743551 variant affected the risk of PTB in the codominant (OR=3.28, 95% CI=1.98-5.45, P<0.0001, GA vs. GG; OR=1.86, 95% CI=1.05-3.28, P=0.033, AA vs. GG) and dominant (OR=2.69, 95% CI=1.67-4.34, P<0.0001, GA+AA vs. GG) inheritance models tested. The A allele was associated with a higher risk of PTB than the G allele (OR=1.33, 95% CI=1.01-1.75, P=0.049). The TG genotype of the rs5743618 variant significantly increased the risk of PTB compared to the risk associated with the TT genotype (OR=3.29, 95% CI=1.82-5.97, P<0.0001). The G allele was associated with a higher risk of PTB than the T allele (OR=3.00, 95% CI=1.69-5.31, P=0.0001). Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample. Additional studies with larger sample sizes and involving subjects of different ethnicities are required to validate our present findings. | Mohammad Naderi Mohammad Hashemi Hamideh Mirshekari Gholamreza Bahari Mohsen Taheri | 2016 | Biomedical and Environmental Sciences2016，29，11： | 1 |
| 19 | White-to-White Corneal Diameter in the Tehran Eye Study显示文摘 | Hassan Hashemi Mehdi KhabazKhoob Kamran Yazdani Shiva Mehravaran Kazem Mohammad Akbar Fotouhi | 2010 | Cornea2010，，1： | 1 |
| 20 | Evaluation and comparison of SYBR Green I Real-Time PCR and TaqMan Real-Time PCR methods for quantitative assay of Listeria monocytogenes in nutrient broth and milk 显示文摘 | Hassan Dadkhah Mohammad Reza Bassami Saeed Hashemi | 2012 | African Journal of Microbiology Research2012，6，9： | 1 |
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