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| 1 | Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis显示文摘AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes. | Mehdi Mohamadnejad Mehrnaz Namiri Mohamad Bagheri Seyed Masiha Hashemi Hossein Ghanaati Narges Zare Mehrjardi Saeed Kazemi Ashtiani Reza Malekzadeh Hossein Baharvand | 2007 | World Journal of Gastroenterology2007，13，24： | 74 |
| 2 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 3 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 4 | Predictive value and main determinants of abnormal features of intraoperative cholangiography during cholecystectomy显示文摘BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a routine diagnostic procedure.The current study aimed to address the main determinants of CBD stone diagnosis in IOC among an Iranian population.METHODS:In a retrospective review database-based study conducted in Taleghani Hospital in Tehran between 2006 and 2008,baseline data and perioperative information of 2060 patients (male to female ratio 542:1518,mean age 53.7 years) who were candidates for cholecystectomy and underwent concomitant IOC for confirming CBD stones were reviewed.The predictive power of this procedure for diagnosis of abnormal biliary ducts with the focus on biliary stones was determined.RESULTS:Overall mortality and morbidity following cholecystectomy in the study population were 0.6% and 2.6%,respectively.Both early mortality and morbidity due to cholecystectomy were higher in male than female.The prevalence of CBD stones in IOC was 3.4% (5.2% in male and 2.8% in female,P=0.008).Among those without gallstones,8.7% had CBD stones and only 3.1% had concomitant gallstones and CBD stones.The main predictors of stone appearance as an abnormal feature of IOC during cholecystectomy were:advanced age (OR=1.022,P=0.001),male gender (OR=1.498,P=0.050),history of abdominal surgery (OR=1.543,P=0.040) and preoperative endoscopic retrograde cholangiopancreatography (OR=5.400,P<0.001).CONCLUSIONS:IOC is a safe and accurate method for the assessment of bile duct anatomy and stones.Therefore,the routine use of IOC within cholecystectomy seems reasonable and is recommended. | Shahram Yousefpour Azary Heshmat Kalbasi Ali Setayesh Mirhadi Mousavi Asad Hashemi Mahsa Khodadoostan Mohammad Reza Zali Amir Houshang Mohammad Alizadeh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 11 |
| 5 | Microstructure and mechanical properties of Al/Cu/Mg laminated composite sheets produced by the ARB proces显示文摘In the present study, an Al/Cu/Mg multi-layered composite was produced by accumulative roll bonding(ARB) through seven passes, and its microstructure and mechanical properties were evaluated. The microstructure investigations show that plastic instability occurred in both the copper and magnesium reinforcements in the primary sandwich. In addition, a composite with a perfectly uniform distribution of copper and magnesium reinforcing layers was produced during the last pass. By increasing the number of ARB cycles, the microhardness of the layers including aluminum, copper, and magnesium was significantly increased. The ultimate tensile strength of the sandwich was enhanced continually and reached a maximum value of 355.5 MPa. This strength value was about 3.2, 2, and 2.1 times higher than the initial strength values for the aluminum, copper, and magnesium sheets, respectively. Investigation of tensile fracture surfaces during the ARB process indicated that the fracture mechanism changed to shear ductile at the seventh pass. | Davood Rahmatabadi Moslem Tayyebi Ramin Hashemi Ghader Faraji | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，5： | 10 |
| 6 | Smartphones,tele-ophthalmology,and VISION 2020显示文摘Telemedicine is an emerging field in recent medical achievements with rapid development.The 'smartphone' availability has increased in both developed and developing countries even among people in rural and remotes areas.Telebased services can be used for screening ophthalmic diseases and also monitoring patients with known diseases.Electronic ophthalmologic records of the patients including captured images by smartphones from anterior and posterior segments of the eye will be evaluated by ophthalmologists,and if patients require further evaluations,they will be referred to experts in the relevant field.Eye diseases such as cataract,glaucoma,age-related macular degeneration,diabetic retinopathy,and retinopathy of prematurity are the most common causes of blindness in many countries and beneficial use of teleophthalmology with smartphones will be a good way to achieve the aim of VISION 2020 all over the world.Numerous studies have shown that teleophthalmology is similar to the conventional eye care system in clinical outcomes and even provides more patient satisfaction as it saves time and cost.This review explains how teleophthalmology helps to improve patient outcomes through smartphones. | Mehrdad Mohammadpour Zahra Heidari Masoud Mirghorbani Hassan Hashemi | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 8 |
| 7 | TIRAP rs8177374 gene polymorphism increased the risk of pulmonary tuberculosis in Zahedan,southeast Iran显示文摘Objective:To evaluate the possible association between Toll-interleukin 1 receptor(TIR) domain containing adaptor protein(TIRAP;also known as MAI.) rsl893352 and rs8l77374(S180L) gene polymorphisms and pulmonary tuberculosis(PTB) in a sample of Iranian population.Methods:This case-control study was performed on 174 PTB and 177 healthy subjects.Tetra amplification refractory mutation systetn-polymerase chain reaction(T-AKMS-PCR) was used to detect the polymorphisms.Results:Our finding showed that neither the overall Ckisqaare comparison of PTB and control subjects nor the logistic regression analysis indicated any association between rsl893352 polymorphism and PTB.Regarding rs8l77374 polymorphism,the CT genotype as well as CT+TT increased the risk of PTB in comparison with CC genotype(OR=4.73,95%CI=2.65-8.45,P<0.0001 and OR=6.47,95%C1=3.68-11.38,P<0.0001.respectively).The rs8177374 T allele increased the risk of PTB in comparison with C allele(OR=4.21.95%CI=2.43-7.26,P<0.0001).Conclusions:Our finding indicates that TIRAP rs8177374 polymorphism is associated with PTB in a sample of Iranian population. | Mohammad Naderi Mohammad Hashemi Zahra Pourmontaseri Ebrahim Eskari-Nasab Gholamreza Bahari Mohsen Taheri | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，6： | 8 |
| 8 | An extended treatment protocol with pegylated interferon and ribavirin for hepatitis C recurrence after liver transplantation显示文摘AIM: To evaluate the efflicacy and tolerability of an extended treatment protocol and to determine the predictors of sustained virological response (SVR) after liver transplantation (LT).METHODS: Between August 2005 and November 2008, patients with recurrent hepatitis C virus (HCV) after LT were selected for treatment if liver biopsy showed at least grade 2 inflammation and/or stage 2 flibrosis. All patients were to receive pegylated interferon (PEG)/regimens combining ribavirin (RBV) for an additional 48 wk after HCV undetectability.RESULTS: Extended protocol treatment was initiated in thirty patients. Overall, 73% had end of treatmentresponse and 60% had SVR. Nineteen patients completed treatment per protocol, of them, sixteen (84%) had end of treatment response, and fourteen (74%) achieved SVR. Both early virological response and 24-week virological response were individually associated with SVR but this association was not signif icant on multivariate analysis. Eleven patients (37%) discontinued therapy due to adverse effects. Cytopenias were the most common and most severe adverse effect, and required frquent growth factor use, dose adjustments and treatment cessations. The risk of rejection was not increased.CONCLUSION: Recurrent HCV after LT can be safely treated with extended virological responseguided therpy using PEG/RBV, but requires close monitoring for treatment-related adverse effects, particularly cytopenias. | Nikroo Hashemi Victor Araya Kashif Tufail Laxmi Thummalakunta Eyob Feyssa Ashaur Azhar Mumtaz Niazi Jorge Ortiz | 2011 | World Journal of Hepatology2011，3，7： | 7 |
| 9 | Scientific and technical aspects of yogurt fortification:A review显示文摘Food fortification is one of the most important processes for improvement of the nutrients quality and quantity in food.It can be a very cost effective public health intervention.Due to the high consumption rate of dairy products such as yogurt,fortification of these products will effectively reduce or prevent diseases associated with nutritional deficiencies.The aim of this investigation is to study the technical aspects involved in production of different types of fortified yogurts and their role in disease prevention and correction of deficiencies.In this paper,firstly,fortification is defined and the main reasons behind carrying out this process are presented and then yogurt production process and a variety of minerals,vitamins,and functional ingredients which are used in the process are briefly discussed.©2015 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Hadi Hashemi Gahruie Mohammad Hadi Eskandari Gholamreza Mesbahi Mohammad Amin Hanifpour | 2015 | Food Science and Human Wellness2015，4，1： | 7 |
| 10 | The Effects of Multistrain Probiotic Compound on Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo‐Controlled Triple‐Blind Study显示文摘 | Ahmad Shavakhi Elham Tabesh Arezoo Yaghoutkar Houriye Hashemi Faezeh Tabesh Mahsa Khodadoostan Mohammad Minakari Sara Shavakhi Ali Gholamrezaei | 2013 | Helicobacter2013，，4： | 6 |
| 11 | Synthesis and antibacterial activity of Schiff bases of 5-substituted isatins显示文摘Based on the existing reports on the bioactive isatin derivatives, a number of Schiff bases were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and their structures were confirmed using spectroscopic methods such as NMR, IR and mass spectrometry. Furthermore, Nbenzylation of isatin followed by the Schiff base formation furnished a new series of compounds(11a–13c) which allowed the analysis of the effect of isatin N-substitution on the bioactivity of the resulting compounds. The antibacterial activity of the synthesized derivatives was evaluated using a microtiter plate method on a series of gram positive and gram negative bacterial strains. Compounds 2d, 3b, 5c and 6a were among the most potent derivatives against Pseudomonas aeruginosa(MIC = 6.25 μg/m L).Analysis of the structure–activity relationship showed that the incorporation of(thio)urea-based Schiff bases lead to more potent derivatives with a broader spectrum of antibacterial activity. In addition,highly lipophilic compounds such as 11a–12c did not show any measurable antibacterial activity, which implies that an optimal lipophilicity might be an important requirement for the antibacterial activity of the studied isatins. Finally, the finding that hydantoin derivatives of N-benzylisatins(13a–13c) still exhibit some antibacterial activity prompted us to consider exploring the bioactivity of more diverse derivatives of isatin-aminohydantoin Schiff bases(compounds 1a–1d) in our future studies. | Kamaleddin Haj Mohammad Ebrahim Tehrani Maryam Hashemi Maryam Hassan Farzad Kobarfard Shohreh Mohebbi | 2016 | Chinese Chemical Letters2016，27，2： | 6 |
| 12 | Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease显示文摘There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 m L/kg saline. Behavioral test(the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease. | Matin Ramezani Niloufar Darbandi Fariba Khodagholi Azam Hashemi | 2016 | Neural Regeneration Research2016，11，12： | 6 |
| 13 | Voltage rise mitigation for solar PV integration at LV grids Studies from PVNET.dk显示文摘Solar energy from photovoltaic(PV)is among the fastest developing renewable energy systems worldwide.Driven by governmental subsidies and technological development,Europe has seen a fast expansion of solar PV in the last few years.Among the installed PV plants,most of them are situated at the distribution systems and bring various operational challenges such as power quality and power flow management.The paper discusses the modelling requirements for PV system integration studies,as well as the possible techniques for voltage rise mitigation at low voltage(LV)grids for increasing PV penetration.Potential solutions are listed and preliminary results are presented. | Guangya YANG Francesco MARRA Miguel JUAMPEREZ Søren Bækhøj KJÆR Seyedmostafa HASHEMI JacobØSTERGAARD Hans Henrik IPSEN Kenn H.B.FREDERIKSEN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 5 |
| 14 | A systematic review of the effect of various interventions on reducing fatigue and sleepiness while driving显示文摘PurposeTo 当时,识别并且估价为减少疲劳和瞌睡估计干预财务的出版研究系统的评论寻找了的 driving.MethodsThis 下列电子数据库:Medline,科学直接, Scopus, EMBASE, PsycINFO,运输数据库, Cochrane, BIOSIS,知识的 ISI 网,专家道路损害杂志和澳大利亚的运输和道路索引数据库。另外的搜索包括了相关组织,包括的研究的参考书表,和在过去的 15 年以内出版的主要损害杂志的期的网站。如果他们为作为结果减少疲劳和瞌睡调查了干预 / 暴露财务,研究被包括,为瞌睡的缓解测量了任何潜在的干预并且用英语被写。因为 63 研究识别了的包括的 studies.ResultsOf 的异质,元分析没被尝试, 18 满足了包括标准。基于我们的评论的结果,当开车例如时,在世界上的许多干预被用来减少睡意行为(与旅客谈话,脸洗,听收音机,没有白酒使用,在下午12点的时候限制开车行为-上午6点等等),教育干预并且也在环境变化(例如抱怨声脱衣,V形臂章,可变消息符号,等等)。所有这些干预的效果上的元分析由于在方法论,在现在的评论的估计的 studies.ConclusionResults 报导的效果尺寸和干预的高异质是不可能的在世界的不同部分的显示出的各种各样的干预被用来催眠开车减少。尽管这些干预能与道路交通事故的高发生在国家被使用,每干预的精确效果仍然是未知的。进一步的研究根据每个国家的交通模式为每干预的效率和每干预的本地化的比较被要求。 | Seyed Saeed Hashemi Nazari Ali Moradi Khaled Rahmani | 2017 | Chinese Journal of Traumatology2017，20，5： | 5 |
| 15 | Evaluation of integration methods for hybrid simulation of complex structural systems through collapse显示文摘This study examines the performance of integration methods for hybrid simulation of large and complex structural systems in the context of structural collapse due to seismic excitations.The target application is not necessarily for real-time testing,but rather for models that involve large-scale physical sub-structures and highly nonlinear numerical models.Four case studies are presented and discussed.In the first case study,the accuracy of integration schemes including two widely used methods,namely,modified version of the implicit Newmark with fixed-number of iteration(iterative)and the operator-splitting(non-iterative)is examined through pure numerical simulations.The second case study presents the results of 10 hybrid simulations repeated with the two aforementioned integration methods considering various time steps and fixed-number of iterations for the iterative integration method.The physical sub-structure in these tests consists of a single-degree-of-freedom(SDOF)cantilever column with replaceable steel coupons that provides repeatable highlynonlinear behavior including fracture-type strength and stiffness degradations.In case study three,the implicit Newmark with fixed-number of iterations is applied for hybrid simulations of a 1:2 scale steel moment frame that includes a relatively complex nonlinear numerical substructure.Lastly,a more complex numerical substructure is considered by constructing a nonlinear computational model of a moment frame coupled to a hybrid model of a 1:2 scale steel gravity frame.The last two case studies are conducted on the same porotype structure and the selection of time steps and fixed number of iterations are closely examined in pre-test simulations.The generated unbalance forces is used as an index to track the equilibrium error and predict the accuracy and stability of the simulations. | Maikol Del Carpio R. M.Javad Hashemi Gilberto Mosqueda | 2017 | Earthquake Engineering and Engineering Vibration2017，16，4： | 4 |
| 16 | 径向压力辅助充液拉深锥形杯的工艺窗口图(英文)显示文摘起皱和破裂是锥形杯成形过程中的主要缺陷。径向压力辅助充液拉深是一步成形筒形件的板材液压成形技术。获得了径向压力辅助充液拉深Al1050-O、纯铜和DIN1623 St14钢板的工艺窗口图。该工艺窗口图可快速评估板材液压成形零件的可制造性。采用有限元方法对径向压力辅助充液拉深进行模拟,并研究压力路径和原始材料及其厚度的影响。通过实验对模拟结果进行验证。结果表明:对于初始厚度较薄和强度较高的板材,其成形性更好,最终产品的的厚度分布也更均匀。所得工艺窗口图可以预测在不同加载路径下合适的加工区间以及破裂或起皱的可能性。 | Abbas HASHEMI Mohammad HOSEINPOUR GOLLO S.M.Hossein SEYEDKASHI | 2015 | Transactions of Nonferrous Metals Society of China2015，25，9： | 4 |
| 17 | Analysis of the formation conditions and characteristics of interphase and random vanadium precipitation in a low-carbon steel during isothermal heat treatment显示文摘The characteristics of nanosized precipitates in steels depend on the heat-treatment parameters. The effects of characteristics of vanadium precipitates formed during isothermal heat treatment on the hardness of the ferrite matrix in low-carbon vanadium-alloyed steel were investigated through analysis of transmission electron microscopy images and microhardness measurements. The results show that, during isothermal holding in the temperature range from 675 to 750℃, only interphase precipitation occurs, whereas only random precipitation occurs in the ferrite matrix during holding at 600℃. Furthermore, during isothermal heat treatment between 600 and 675℃, both random and interphase precipitates occurred in the ferrite. Nanoscale vanadium carbides with different atomic ratios of vanadium(V) and carbon(C) were the dominant precipitates in the random and interphase precipitates. The sizes of random precipitation carbides were smaller than those of interphase ones. Also, the sample isothermally heat treated at 650℃ for 900s exhibited a higher hardness with a narrower hardness distribution. | Sayed Ghafar Hashemi B.Eghbali | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，3： | 4 |
| 18 | Interactive effects of drought stress and chitosan application on physiological characteristics and essential oil yield of Thymus daenensis Celak显示文摘Thymus daenensis, a perennial herb, is often grown in areas that experience drought conditions during its growing period. Application of chitosan may compensate for the negative impact of drought stress on the yield of oil and secondary metabolites in Thymus.The interactive effects of foliar application of chitosan and drought stress on dry matter,essential oil yield, and selected physiological characteristics including photosynthetic pigments, osmotic adjustment, and lipid peroxidation of Thymus were investigated in a two-year study from 2014 to 2015. Treatments consisted of 0, 200, and 400(iL L'1 chitosan applied to plants grown under field capacity, mild drought stress(50% field capacity), and severe drought stress(25% field capacity). Dry matter yield decreased substantially as drought stress intensified. However, essential oil content increased under stress conditions,with the highest essential oil yield obtained from plants under mild drought stress. Foliar application of chitosan compensated to some extent for dry matter and oil yield reduction of plants grown under drought stress. The highest essential oil yield(1.52 g plant-1) was obtained by application of 400 \iL L_1 chitosan under the mild stress condition in 2015 when plants were mature. The compensatory effect of chitosan in reducing the negative impact of stress conditions on dry matter and oil yield was due mainly to stimulation of osmotic adjustment through proline accumulation and reduction of lipid peroxidase level, which increased the integrity of cell membranes of thyme leaves. | Zohreh Emami Bistgani Seyed Ataollah Siadat Abdolmehdi Bakhshandeh Abdollah Ghasemi Pirbalouti Masoud Hashemi | 2017 | The Crop Journal2017，5，5： | 4 |
| 19 | Implementation of multilayer perceptron(MLP)and radial basis function(RBF)neural networks to predict solution gas-oil ratio of crude oil systems显示文摘Exact determination of pressure-volume-temperature(PVT)properties of the reservoir oils is necessary for reservoir calculations,reservoir performance prediction,and the design of optimal production conditions.The objective of this study is to develop intelligent and reliable models based on multilayer perceptron(MLP)and radial basis function(RBF)neural networks for estimating the solution gas–oil ratio as a function of bubble point pressure,reservoir temperature,oil gravity(API),and gas specific gravity.These models were developed and tested using a total of 710 experimental data sets representing the samples of crude oil from various geographical locations around the world.Performance of the developed MLP and RBF models were evaluated and investigated against a number of well-known empirical correlations using statistical and graphical error analyses.The results indicated that the proposed models outperform the considered empirical correlations,providing a strong agreement between predicted and experimental values,However,the developed RBF exhibited higher accuracy and efficiency compared to the proposed MLP model. | Aref Hashemi Fath Farshid Madanifar Masood Abbasia | 2020 | Petroleum2020，6，1： | 3 |
| 20 | Development of an artificial neural network model for prediction of bubble point pressure of crude oils显示文摘Bubble point pressure is one of the most important pressureevolumeetemperature properties of crude oil,and it plays an important role in reservoir and production engineering calculations.It can be precisely determined experimentally.Although,experimental methods present valid and reliable results,they are expensive,time-consuming,and require much care when taking test samples.Some equations of state and empirical correlations can be used as alternative methods to estimate reservoir fluid properties(e.g.,bubble point pressure);however,these methods have a number of limitations.In the present study,a novel numerical model based on artificial neural network(ANN)is proposed for the prediction of bubble point pressure as a function of solution gaseoil ratio,reservoir temperature,oil gravity(API),and gas specific gravity in petroleum systems.The model was developed and evaluated using 760 experimental data sets gathered from oil fields around the world.An optimization process was performed on networks with different structures.Based on the obtained results,a network with one hidden layer and six neurons was observed to be associated with the highest efficiency for predicting bubble point pressure.The obtained ANN model was found to be reliable for the prediction of bubble point pressure of crude oils with solution gaseoil ratios in the range of 8.61e3298.66 SCF/STB,temperatures between 74 and 341.6F,oil gravity values of 6e56.8 API and gas gravity values between 0.521 and 3.444.The performance of the developed model was compared against those of several well-known predictive empirical correlations using statistical and graphical error analyses.The results showed that the proposed ANN model outperforms all of the studied empirical correlations significantly and provides predictions in acceptable agreement with experimental data. | Aref Hashemi Fath Abdolrasoul Pouranfard Pouyan Foroughizadeh | 2018 | Petroleum2018，4，3： | 3 |
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