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| 1 | Diabetes mellitus and cognitive impairments显示文摘There is strong evidence that diabetes mellitus increases the risk of cognitive impairment and dementia. Insulin signaling dysregulation and small vessel disease in the base of diabetes may be important contributing factors in Alzheimer's disease and vascular dementia pathogenesis, respectively. Optimal glycemic control in type 1 diabetes and identification of diabetic risk factors and prophylactic approach in type 2 diabetes are very important in the prevention of cognitive complications. In addition, hypoglycemic attacks in children and elderly should be avoided. Anti-diabetic medications especially Insulin may have a role in the management of cognitive dysfunction and dementia but further investigation is needed to validate these findings. | Elham Saedi Mohammad Reza Gheini Firoozeh Faiz Mohammad Ali Arami | 2016 | World Journal of Diabetes2016，7，17： | 23 |
| 2 | Mesenchymal stem cells as a potent cell source for articular cartilage regeneration显示文摘Since articular cartilage possesses only a weak capac-ity for repair, its regeneration potential is considered one of the most important challenges for orthopedic surgeons. The treatment options, such as marrow stimulation techniques, fail to induce a repair tissue with the same functional and mechanical properties of native hyaline cartilage. Osteochondral transplantation is considered an effective treatment option but is as-sociated with some disadvantages, including donor-site morbidity, tissue supply limitation, unsuitable mechani-cal properties and thickness of the obtained tissue. Although autologous chondrocyte implantation results in reasonable repair, it requires a two-step surgical pro-cedure. Moreover, chondrocytes expanded in culture gradually undergo dedifferentiation, so lose morpho-logical features and specialized functions. In the search for alternative cells, scientists have found mesenchymal stem cells(MSCs) to be an appropriate cellular mate-rial for articular cartilage repair. These cells were origi-nally isolated from bone marrow samples and further investigations have revealed the presence of the cells in many other tissues. Furthermore, chondrogenic dif-ferentiation is an inherent property of MSCs noticedat the time of the cell discovery. MSCs are known to exhibit homing potential to the damaged site at which they differentiate into the tissue cells or secrete a wide spectrum of bioactive factors with regenerative proper-ties. Moreover, these cells possess a considerable im-munomodulatory potential that make them the general donor for therapeutic applications. All of these topics will be discussed in this review. | Mohamadreza Baghaban Eslaminejad Elham Malakooty Poor | 2014 | World Journal of Stem Cells2014，6，3： | 13 |
| 3 | Bone marrow-derived mesenchymal stem cells ameliorate sodium nitrite-induced hypoxic brain injury in a rat model显示文摘Sodium nitrite(Na NO2) is an inorganic salt used broadly in chemical industry. Na NO2 is highly reactive with hemoglobin causing hypoxia. Mesenchymal stem cells(MSCs) are capable of differentiating into a variety of tissue specific cells and MSC therapy is a potential method for improving brain functions. This work aims to investigate the possible therapeutic role of bone marrow-derived MSCs against Na NO2 induced hypoxic brain injury. Rats were divided into control group(treated for 3 or 6 weeks), hypoxic(HP) group(subcutaneous injection of 35 mg/kg Na NO2 for 3 weeks to induce hypoxic brain injury), HP recovery groups N-2 w R and N-3 w R(treated with the same dose of Na NO2 for 2 and 3 weeks respectively, followed by 4-week or 3-week self-recovery respectively), and MSCs treated groups N-2 w SC and N-3 w SC(treated with the same dose of Na NO2 for 2 and 3 weeks respectively, followed by one injection of 2 × 106 MSCs via the tail vein in combination with 4 week self-recovery or intravenous injection of Na NO2 for 1 week in combination with 3 week self-recovery). The levels of neurotransmitters(norepinephrine, dopamine, serotonin), energy substances(adenosine monophosphate, adenosine diphosphate, adenosine triphosphate), and oxidative stress markers(malondialdehyde, nitric oxide, 8-hydroxy-2′-deoxyguanosine, glutathione reduced form, and oxidized glutathione) in the frontal cortex and midbrain were measured using high performance liquid chromatography. At the same time, hematoxylin-eosin staining was performed to observe the pathological change of the injured brain tissue. Compared with HP group, pathological change of brain tissue was milder, the levels of malondialdehyde, nitric oxide, oxidized glutathione, 8-hydroxy-2′-deoxyguanosine, norepinephrine, serotonin, glutathione reduced form, and adenosine triphosphate in the frontal cortex and midbrain were significantly decreased, and glutathione reduced form/oxidized glutathione and adenosine monophosphate/adenosine triphosphate ratio were significantly increased in the MSCs treated groups. These findings suggest that bone marrow-derived MSCs exhibit neuroprotective effects against Na NO2-induced hypoxic brain injury through exerting anti-oxidative effects and providing energy to the brain. | Elham H.A.Ali Omar A.Ahmed-Farid Amany A.E.Osman | 2017 | Neural Regeneration Research2017，12，12： | 9 |
| 4 | Reduction of local scour around bridge pier groups using collars显示文摘In this paper reduction of scour around group of two and three piers using circular collar has been carried out for the case of clear-water flow over uniform sediment. The efficiency of collars, with different sizes and spaces between piers is studied through experiments in group of two and three piers. The result reveals that collar has more influence in reduction of scour depth in rear piers than the first pier. Also, when the spacing between the piers increases the area without protection between the piers is washed away resulting deeper scour holes at the rear piers. | Manouchehr HEIDARPOUR Hossein AFZALIMEHR Elham IZADINIA | 2010 | International Journal of Sediment Research2010，25，4： | 8 |
| 5 | Macrosomia in non-gestational diabetes pregnancy:glucose tolerance test characteristics and feto-maternal complications in tropical Asia Pacific Australia显示文摘Objective:To look into the glucose tolerance test characteristics and determine complications in non-gestational diabetes pregnant subjects.Methods:From 2006 to 2009 all non-gestational diabetes mellitus(non-CDM)pregnant women who delivered macrosomia at the North Australia's Townsville Hospital were retrospectively reviewed by extracting data from clinical record.Glucose tolerance tests results were analysed in the light of an earlier diagnosis of non-GDM.Results:Ninety-one non-CDM mothers with macrosomia were studied and compared with 41normoglycemic subjects without macrosomia.Of the subjects with non-GDM macrosomia,45(49.4%)had normal SO g glucose challenge test(GCT)without further testing,another 8(8.8%)had abnormal GCT but normal 75 g oral glucose tolerance test(OGTT).A total of 4(4.4%)subjects had normal GCT and OGTT.Interestingly.14 out of 16(87.5%)subjects who were tested with OGTT owing to past history of macrosomia had normal results but delivered macrosomic babies.Only 12 subjects had both GCT and OGTT,the rest of the cohort had either of the two tests.Subjects with non-CDM macrosomia had higher frequency of neonatal hypoglycaemia 34%as compared to 10%in nonmacrosomic babies(P=0.003).Other feto-maternal complications were similar in both groups.Conclussions:No significant pattern of glucose tolerance characteristics was identified in nonGDM mothers with macrosomic babies.In spite of being normoglycemic significant neonatal hypoglycaemia was recorded in non-GDM macrosomic babies.Further prospective studies on a larger population are needed to verify our findings. | Algenes Aranha Usman H Malabu Venkat Vangaveti Elham Saleh Reda Yong Mong Tan Kunwarjit Singh Sangla | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，6： | 7 |
| 6 | Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes显示文摘AIM: To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran. METHODS: A total of 2292 (1376 female, aged 18-75 year), were selected by systematic clustered random sampling from the cities and villages of Gonbad and Kalaleh in Golestan Province and invited to participate in the study. A comprehensive history regarding alcohol drinking and medication was taken. Body mass index (BMI), viral markers and ALT levels were measured. If ALT level was ≥ 40 U/L, it was rechecked twice within 6 mo. Those with ≥ 2 times elevation of ALT were considered as having persistently elevated ALT level. Non-alcoholic fatty liver disease (NAFLD) was diagnosed based on evidence of fatty liver upon sonography and excluding other etiology. RESULTS: A total of 2049 (1351 female) patients participated in the study, 162 (7.9%) had elevated ALT level at the first measurement. Persistently elevated ALT level was detected in 64 (3.1%) participants, with51 (79.6%) with no obvious etiology, six (9.3%) with Hepatitis B, four (6.2%) with Hepatitis C virus (HCV) infection and three (4.6%) with alcoholic hepatitis. The prevalence of NAFLD and alcoholic hepatitis was 2.04% (42 patients) and 0.1% (three), respectively. There was correlation between NAFLD and male gender, overweight, diabetes and living in an urban area [odds ratio = 3.03 (95% CI: 1.6-5.72), 4.21 (95% CI: 1.83-9.68), 2.86 (95% CI: 1.05-7.79) and 2.04 (95% CI: 1.00-4.16) respectively]. CONCLUSION: NAFLD is the most common cause of persistently elevated serum ALT level among the general population of Iran. | Raika Jamali Mahmoodreza Khonsari Shahin Merat Masoud Khoshnia Elham Jafari Alireza Bahram Kalhori Hassan Abolghasemi Sedighe Amini Mahtab Maghsoudlu Mohammad Reza Deyhim Houri Rezvan Akram Pourshams | 2008 | World Journal of Gastroenterology2008，14，18： | 7 |
| 7 | Comparative study of mechanical-electrical-thermal responses of pouch, cylindrical, and prismatic lithium-ion cells under mechanical abuse显示文摘In the study, mechanical abuse tests mainly in the form of indentation were performed on the cylindrical cell, pouch cell, and prismatic cell. The mechanical force-displacement response, open circuit voltage(OCV), and temperature distribution were recorded and compared. In spherical head indentation tests of the pouch and prismatic cell and lateral indentation of the cylindrical cell, the peak force is strongly correlated with OCV drop and local temperature increase. However, in flat-end cylinder indentation tests, the internal mechanical damage is progressively developed, and the OCV drop and the temperature increase occur before the peak force. The fracture surfaces of the post-mortem samples were examined to investigate the correlation between fracture patterns and internal short circuit(ISC) behaviors(OCVand temperature distribution). Two distinct fracture patterns were observed that the in-plane fracture induced by biaxial stretching and inter-layers' fracture induced by shearing. A strong correlation is observed between the number of shear fractures and OCV drop. An increase in the number of inter-layers' fractures increases the rate of OCV drop. Additionally, the fracture patterns influence the ISC area and location,thereby affecting the heat generation and conduction as well as the temperature distribution. | LI Wei XIA Yong CHEN GuanHua SAHRAEI Elham | 2018 | Science China(Technological Sciences)2018，61，10： | 7 |
| 8 | 聚乙烯基胺包裹Fe_3O_4@SiO_2磁性微球用于Knoevenagel缩合(英文)显示文摘Polyvinyl amine coated Fe3O4@SiO2 composite microspheres with a core‐shell structure were prepared and employed as a magnetic catalyst for Knoevenagel condensation under mild conditions. The catalyst can be readily recovered using a magnet and reused several times without loss in activity or selectivity. The performance of the magnetic base catalyst was compared with that of polyvinyl amine functionalized mesoporous SBA‐15, which showed that the magnetic nanoparticles gave improved reaction rate and yield. | Farzad Zamani Elham Izadi | 2014 | 催化学报2014，35，1： | 7 |
| 9 | The Effects of Multistrain Probiotic Compound on Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo‐Controlled Triple‐Blind Study显示文摘 | Ahmad Shavakhi Elham Tabesh Arezoo Yaghoutkar Houriye Hashemi Faezeh Tabesh Mahsa Khodadoostan Mohammad Minakari Sara Shavakhi Ali Gholamrezaei | 2013 | Helicobacter2013，，4： | 6 |
| 10 | Comparison of ultrasonography and radiography in diagnosis of rib fractures显示文摘肋骨破裂是源于钝胸损伤的最普通的骨胳的胸的损害。肋骨破裂的一半没在精确物理评估和拍之上被检测。最近, ultrasonography (USG ) 被调查了检测肋骨破裂。但是基于文学, USG 的实用性广泛地变化。这研究被进行与这代表性的研究,有次要的钝胸损伤的连续病人和怀疑的肋骨折断在位于马什哈德伊朗的阿訇 Reza 医院里介绍的 radiography.MethodsIn 比较在可能的肋骨破裂的察觉调查 USG 的角色,被 USG 和X光线照相术在2013年4月和2013年10月之间估计。X 光线照相术在胸设计和倾斜的肋骨看法在损伤的区域上集中了的 posteroanterior (PA ) 被执行。在拿 USG 和 X 光线照相术花的时间持续时间被记录。破裂的流行和地点由 USG 表明病人们被估计, X 光线照相术是怀疑的 compared.ResultsSixty 一个。到女比率的男性与一个平均数是 2.4:1 (43 个男人和 18 个女人)? 潲楳? | Elham Pishbin Koorosh Ahmadi Molood Foogardi Maryam Salehi Farrokh Seilanian Toosi Vafa Rahimi-Movaghar | 2017 | Chinese Journal of Traumatology2017，20，4： | 5 |
| 11 | Immunomodulatory effects of astragalus polysaccharide on Human peripheral blood mononuclear cells co-cultured with cervical cancer cell lineImmunomodulatory effects of astragalus polysaccharide on Human peripheral blood mononuclear cells co-cultured with cervical cancer cell line显示文摘OBJECTIVE:To investigate immunomodulatory effects of Astragalus polysaccharides(APS)on the co-culture of peripheral blood mononuclear cells(PBMCs)with He La cervical cancer cell line.METHODS:To assess the proliferation of PBMCs,carboxyfluorescein succinimidyl ester(CFSE)-labeled PBMCs were co-cultured with He La cells and treated with different concentrations of APS.Supernatants of cell culture were collected for cytokines assay via enzyme-linked immunosorbent assay(ELISA).The impact of APS on the proliferation of PBMCs,induction of regulatory T cells(Tregs),and myeloid-derived suppressor cells(MDSCs)was carried out by flow cytometry.RESULTS:It was observed that APS could increase the proliferation of PBMCs co-cultured with He La cells(P<0.05).However,APS had no significant effects on the induction of Tregs and MDSCs in the co-culture assay(P>0.05).Furthermore,ELISA results demonstrated that APS could decrease IL-10 and TGF-βconcentration(P<0.05).CONCLUSION:The above-mentioned characteristics showed that APS might be able to modulate immune responses and improve anti-tumor effects through increasing the proliferation of PBMCs and decreasing inhibitory cytokines secretion as critical mediators of immune suppression in the tumor microenvironment. | Elham Shokati Mohammad-Reza Shokri Kobra Entezami Samaneh Khorrami Mona Amani Morteza Motallebnezhad Elahe Safari | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 5 |
| 12 | Potential habitat modeling for reintroduction of three native plant species in central Iran显示文摘Potential habitat modeling of endemic species is an appropriate method to maintain biodiversity,ecosystem function and rehabilitation of rangeland ecosystems.Astragalus caragana,A.cyclophyllon and A.podolobus are endemic in Iran's rangelands and some neighboring countries.The three native species could endure environmental stresses due to their distinctive ecophysiological characteristics.They play important roles in sustainable pastures production,recreation and improvement.They suffer severe threat from many factors including;grazing,agriculture and invasive exotic species.We analyzed the potential habitat of three native plant species in central Iran basing on the grid map with the resolution of 1-km.We used inventory records from field surveys,herbarium collections and 22 environmental factors to explore the environmental influences on given species distribution by Maximum entropy(Maxent) model.Maxent is a species distribution model that uses species occurrence and environmental data for predicting potential species.The results of our study indicated species occurrence has strong correlation with environmental factors such as mean temperature of wettest season,elevation and precipitation of coldest season.We evaluated the model accuracy by AUC(area under the receiver operating characteristic curve) based on an independent test data set.AUC values indicated the high power of Maxent to create potential habitat map(AUCA.caragana=0.988,AUCA.cyclophyllon=0.927,AUCA.podolobus=0.923).It is important to consider that AUC values tend to be lower for species that have broad distribution scope,such as A.podolobus distribution.Most suitable potential habitat distributions of the three species were predicted in the western and southwestern parts of rangelands in Isfahan province.Visual comparisons of the actual distribution map of the three species with produced Maxent maps represent a good agreement.In general,the model demonstrated that the occurrence of the given species is highly probable when the elevation is between 2,200 and 3,000 m and mean temperature of wettest season less than 3°C.This model,therefore,can be applied to recognize potential sites for rangeland reclamation projects. | Elham G ARDESTANI Mostafa TARKESH Mehdi BASSIRI Mohammad R VAHABI | 2015 | Journal of Arid Land2015，7，3： | 5 |
| 13 | Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)has progressively increased in recent years and is now thefifth and the second most common cancer in the World and in Egypt,respectively.Much work has focused in the development of assays for detecting hepatic carcinogensis before the observance of hepatic focal lesions.Particular attention has been directed towards HCC-specific biomarkers for use in the early diagnosis of HCC and in the confirmation of radiological studies.Although a number of biomarkers have been identified,none have been considered reliable indicators of early HCC lesions.This review presents a few of the most relevant HCC biomarkers and suggests improvements to the accuracy of diagnostic assays through their combined use.Furthermore,we present an algorithm for the biomarker-based diagnosis of HCC and highlight its important role in the early prediction of HCC. | Mahmoud Khattab Magdy Fouad Elham Ahmed | 2015 | World Journal of Hepatology2015，7，23： | 5 |
| 14 | Effects of physical form of diet on nutrient digestibility, rumen fermentation, rumination,growth performance and protozoa population of finishing lambs显示文摘This study was conducted to compare effects of 3 physical forms of feed including mash(diet 1), pellet(diet 2) and complete feed block(CFB; diet 3) on digestion, fermentation and performance of lambs.Twenty-one lambs with an initial average body weight of 26 ± 2.5 kg and 6 ± 1.5 months of age were assigned through a completely randomized design to 3 treatments and 7 replicates. The experimental treatments had the same formulation. The results of present experiment showed that CFB significantly increased feed intake and nutrient digestibility(P < 0.05). There was no significant difference among the diets for rumen fluid pH, blood glucose, concentration of volatile fatty acids(P > 0.05), except acetic acid(P < 0.05). The rumen ammonia nitrogen(NH3-N), mixed rumen protozoa population(RPP), Entodiniums spp., Epidiniums spp., blood urea nitrogen(BUN) concentration, rumination time adjusted for dry matter(DM), neutral detergent fiber(NDF), acid detergent fiber(ADF) intake, and total body weight gain of lambs in CFB diet were the highest among all diets(P < 0.05). Feed conversion ratio at days 31 to 45 and whole experimental period were better in CFB than in other diets(P < 0.05). Overall, according to the findings of the present study, among 3 physical forms of the diets, CFB had the best efficiency due to improvement of nutrient digestibility, rumen fermentation and performance of lambs. Therefore, the CFB diet offers the best result in lambs compared with mash and pellet diets. | Elham Karimizadeh Morteza Chaji Tahereh Mohammadabadi | 2017 | Animal Nutrition2017，，2： | 5 |
| 15 | Radiological Aspect of Klippel-Trénaunay Syndrome:A Case Series With Review of Literature显示文摘Klippel-Trénaunay syndrome (KTS)is arare angio-osteo-hypertrophic syndrome characterized by vascular malformations,soft tissue and/or bone hypertrophy, and varicose veins.For the purpose of describing the imaging findings and elucidating the role of medical imaging in the diagnosis and assessment of patient with KTS,we have reviewed the imaging data of 14 KTS patients.The imaging features on different imaging modalities were analyzed.Unilateral lower limb involvement was evident in 71% of cases (n=10)and bilateral but asymmetric lower limb involvement in the remaining 29% of cases (n=4).The most commonly depicted imaging features were varicosities in 93% (n=13),muscle hypertrophy in 79%(n=11)and venous anomalies in 64%(n=9).Other less common imaging findings included lymphedema in 29%(n=4),arterial malformations 29%(n=4),soft tissue hemangiomas 21%(n=3),pelvic and thigh phleboliths 21%(n=3), venous aneurysrns 21%(n=3),bone abnormalities 14%(n=2)and lymphadenopathy 14%(n=2).A severe unilateral lower limb deformity resulting in contractures and muscle atrophy of the whole limb was depicted in 1 case.The pathognomonic marginal vein of Servelle was identified in 2 cases.AV shunt was highly suspected in 4 cases and was confirmed by DSA in 1 case,making Klippel-Trénaunay-Weber syndrome a more apt diagnosis.Associated ipsilateral duplicated renal artery:was found in 1 case.We have concluded that medical imaging is the cornerstone in the.diagnosis and assessment of severity and complications,follow-up and differentiation of KTS from other similar conditions.Different imaging modalities play complementary roles in the evaluation of KTS patients. | Osamah Alwalid Joyman Makamure Qi-guang CHENG Wen-jun WU Chao YANG Elham Samran Ping HAN Hui-min LIANG | 2018 | Current Medical Science2018，38，5： | 4 |
| 16 | Determination of organic compounds in water using dispersive liquid–liquid microextraction显示文摘 | Mohammad Rezaee Yaghoub Assadi Mohammad-Reza Milani Hosseini Elham Aghaee Fardin Ahmadi Sana Berijani | 2006 | Journal of Chromatography A2006，，1： | 4 |
| 17 | A novel and efficient multiparty quantum secret sharing scheme using entangled states显示文摘We proposed a novel and efficient multiparty quantum secret sharing scheme using entangled state which in that the number of parties can be arbitrary large.The state which we used,has special properties that make our scheme simple and safe.The operations which are needed to recover secret message,are only exclusive-or addition and complement operation.Moreover it is shown that this scheme is secure against eavesdropping.Also this scheme provides the best quantum bit efficiency compared with some famous quantum secret sharing schemes. | MASSOUD Hadian Dehkordi ELHAM Fattahi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 4 |
| 18 | Simultaneous use of cable and collar to prevent local scouring around bridge pier显示文摘到控制的各种各样的方法在桥牌附近搜索墩被建议了。在现在的学习,电报或领子和领子的应用程序试验性地被检验,作为对在光滑的圆形的桥墩的本地搜索的反措施,近到一致沉积运动的开始的阀值流动条件。结果证明电报和领子的同时的使用在减少 scour 深度有高效率。最好的配置被作出对有利的裁决 0.15 的电缆线码头直径比率和 15 的线角度 ??? ???????????????????? 六 ? 栠摹潲潬楧?????? ???? 吗?? | Elham IZADINIA Manouchehr HEIDARPOUR | 2012 | International Journal of Sediment Research2012，27，3： | 3 |
| 19 | An application of intuitionistic fuzzy sets in medicine显示文摘 | Bijan Davvaz Elham Hassani Sadrabadi | 2016 | International Journal of Biomathematics2016，9，3： | 3 |
| 20 | Biopsy-driven diagnosis in infants with cholestatic jaundice in Iran显示文摘AIM:To determine the frequencies of diagnoses confirmed by liver biopsy in infants with cholestasis in an Iranian pediatric hospital.METHODS:This was a retrospective study conducted in a tertiary referral children’s hospital in Iran.We retrieved all pathology reports of liver biopsies from children less than two years of age who had presented for evaluation of cholestatic jaundice from March 2001to March 2011.Additional specimen samples obtained from archived pathology blocks were reviewed by a pathologist blinded to the final diagnosis.These results were compared with the pathology reports from chart records to ensure consensus and eliminate any inconsistencies in final diagnoses.A structured checklist was used to gather information on multiple variables including age,sex,gestational age at birth,birth weight,age at which hyperbilirubinemia manifested,presence and identification of associated anomalies,clinical manifestations,and histological findings from liver biopsies.The baseline data are reported using descriptive statistics,and differences between groups were assessed by Fisher’s exact test and Student’s t test when indicated.RESULTS:Fifty-five cases(28 females;27 males)of infantile cholestasis(IC)were included in this study.The mean serum total bilirubin and direct bilirubin at presentation were 13.6±5.9 and 7.3±3.4,respectively.Forty cases(72.7%)were the product of term pregnancies.Common associated clinical findings were acholic stool in 33 cases(60.0%),hepatomegaly in30 cases(54.5%),and dark-colored urine in 21 cases(38.2%).Biliary atresia(BA)was the most frequent diagnosis,found in 32 cases(58.2%),followed by intrahepatic bile duct paucity found in 6 cases(10.9%),metabolic disease in 6 cases(10.9%),idiopathic neonatal hepatitis in 5 cases(9.1%),choledochal cyst in2 cases(3.6%),liver cirrhosis in 2 cases(3.6%),and progressive familial intrahepatic cholestasis and portal fibrosis each in 1 case(1.8%).The mean times for jaundice onset and liver biopsy were 43.8 and 102.0 d,respectively.In BA,the mean age at jaundice presentation was 21 d and for liver biopsy was 87.5 d,representing a mean delay of 66.5 d.CONCLUSION:A significant delay was found between IC presentation and liver biopsy,which is detrimental in conditions that can cause irreversible liver damage,such as BA. | Elham Talachian Ali Bidari Mitra Mehrazma Nahid Nick-khah | 2014 | World Journal of Gastroenterology2014，20，4： | 3 |
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